Research Topics
Genomes and Genes
| Christopher P CrumSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
BRCA, the oviduct, and the space and time continuum of pelvic serous carcinogenesisChristopher P Crum
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Int J Gynecol Cancer 22:S29-34. 2012..The potential promise of these discoveries is "targeted prevention" by discovering of multiple pathways integral to carcinogenesis and successfully preventing malignancy by interrupting one or a few of these pathways...
The oviduct and ovarian cancer: causality, clinical implications, and "targeted prevention"Christopher P Crum
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Clin Obstet Gynecol 55:24-35. 2012..This alternative to detect early malignancy is a new paradigm in the quest to prevent this deadly disease...- Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epitheliumLifang Zhang
Obstetrics and Gynecology Department, Peking University People s Hospital, Beijing, China
Reprod Biol Endocrinol 8:74. 2010..The major objective of this study was to explore and determine whether platelet activating factor (PAF) and receptor associated networking pathways might significantly induce malignant potential in BRCA1-mutant at-risk epithelial cells... 
The distal fallopian tube: a new model for pelvic serous carcinogenesisChristopher P Crum
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Curr Opin Obstet Gynecol 19:3-9. 2007....- Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancerChristopher P Crum
Department of Pathology, Brigham and Womens Hospital, 75 Francis Street, Boston, MA 02115, USA
Clin Med Res 5:35-44. 2007.... - Vaccines for cervical cancerChristopher P Crum
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer J 9:368-76. 2003..However, success will require identifying and circumventing the mechanisms by which tumor cells evade the immune system... - Intercepting pelvic cancer in the distal fallopian tube: theories and realitiesChristopher P Crum
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Mol Oncol 3:165-70. 2009..The challenges and unmet needs unmasked by this paradigm shift in ovarian cancer research are discussed... - Hertig and beyond: a systematic and practical approach to the endometrial biopsyChristopher P Crum
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Adv Anat Pathol 10:301-18. 2003..Algorithms for the laboratory management of cyclic changes, dysfunctional bleeding, and mixed-pattern endometria are provided, as are pitfalls in interpretation and exclusion of neoplasia... - p63 in epithelial survival, germ cell surveillance, and neoplasiaChristopher P Crum
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Annu Rev Pathol 5:349-71. 2010..Whether tumorigenic pathways are also involved, and to what extent, is a subject of both promise and controversy that remains to be resolved... - Squamous morules are functionally inert elements of premalignant endometrial neoplasiaMing Chieh Lin
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Mod Pathol 22:167-74. 2009..Even isolated morules should be carefully followed, however, to exclude a coexisting undersampled, or occult, glandular lesion... - Advances in the recognition of tubal intraepithelial carcinoma: applications to cancer screening and the pathogenesis of ovarian cancerYonghee Lee
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston
Adv Anat Pathol 13:1-7. 2006..A protocol for sectioning and extensively examining the fimbriated end (SEE-FIM), and its rationale, is described... - A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutationsAnn K Folkins
The Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Gynecol Oncol 109:168-73. 2008..This study compared the prevalence of p53 signatures in ovarian cortical inclusion cysts (CICs) and fallopian tubes from BRCA+ women and explored their relationship... - Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reductionMichael J Callahan
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Clin Oncol 25:3985-90. 2007..To review the frequency and location of malignancies detected after prophylactic salpingo-oophorectomy in women with BRCA mutations... - Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer preventionJoseph W Carlson
Department of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
J Clin Oncol 26:4160-5. 2008..This study examined the frequency of STIC in PPSC and its clinical outcome in BRCA-positive women... - A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasiaMichael Herfs
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Pathol 229:460-8. 2013..It also provides new targets in animal models to determine why the SC junction is uniquely susceptible to carcinogenic HPV infection... - The Li-Fraumeni syndrome (LFS): a model for the initiation of p53 signatures in the distal Fallopian tubeWa Xian
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Pathol 220:17-23. 2010..This is in keeping with a general model of carcinogenesis, in which different and often independent risk factors operate at multiple points in the serous carcinogenic spectrum... - Polymerase chain reaction detection of HPV in squamous carcinoma of the oropharynxElin S Agoston
Dept of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Clin Pathol 134:36-41. 2010..However, it is imperative that appropriate sensitivity controls be in place for such assays... - Serous carcinogenesis in the fallopian tube: a descriptive classificationElke Jarboe
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 27:1-9. 2008..Combined with recent reports associating STICs with pelvic serous cancer, this continuum of epithelial change validates the SCAT sequence and the fimbrial secretory cell as the site of origin for many serous carcinomas... - Type-specific HPV testing as a predictor of high-grade squamous intraepithelial lesion outcome after cytologic abnormalitiesFabiola Medeiros
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02130, USA
J Low Genit Tract Dis 9:154-9. 2005..HPV 53 merits designation as a high-risk HPV based only [corrected] on the proportion of CIN 2,3 in follow-up biopsy... - Coexisting intraepithelial serous carcinomas of the endometrium and fallopian tube: frequency and potential significanceElke A Jarboe
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 28:308-15. 2009.... - Serous tubal intraepithelial carcinoma: diagnostic reproducibility and its implicationsJoseph W Carlson
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 29:310-4. 2010..In view of these findings, a diagnosis of STIC should be corroborated by a second pathologist, if feasible... - Epidemiologic correlates of ovarian cortical inclusion cysts (CICs) support a dual precursor pathway to pelvic epithelial cancerAnn K Folkins
Divisionsof Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Gynecol Oncol 115:108-11. 2009..Many ovarian carcinomas are presumed to arise within ovarian cortical inclusion cysts (CICs). This study examined the frequency of ovarian CICs in relation to epidemiologic risk factors in women with BRCA1 and BRCA2 (BRCA+) mutations... - Superficial (early) endocervical adenocarcinoma in situ: a study of 12 cases and comparison to conventional AISAgnieszka Witkiewicz
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 29:1609-14. 2005..Superficial AIS should be suspected in endocervical columnar epithelium with segmental nuclear hyperchromasia with mitotic activity, and confirmed by biomarker staining (p16 and Mib-1) if the pathologist is uncertain of the diagnosis... - Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationshipDavid W Kindelberger
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Surg Pathol 31:161-9. 2007.... - The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndromeFabiola Medeiros
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
Am J Surg Pathol 30:230-6. 2006..Investigative strategies targeting the fimbriated end of the fallopian tube should further define its role in the pathogenesis of familial and sporadic ovarian serous carcinomas... - PAX2-null secretory cell outgrowths in the oviduct and their relationship to pelvic serous cancerCharles M Quick
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Mod Pathol 25:449-55. 2012..We propose a unique co-variable in benign oviductal epithelium-the PAX2-null SCOUT-that reflects underlying dysregulation in genes linked to serous neoplasia... - Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cellsAgnieszka K Witkiewicz
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
Hum Pathol 36:154-61. 2005..Similar patterns are seen in cervical neoplasia, suggesting a link between benign and neoplastic cervical epithelial differentiation... - Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tubeEleanor Y Chen
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Pathol 222:110-6. 2010.... - Clinical outcome in diagnostically ambiguous foci of 'gland crowding' in the endometriumEric C Huang
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Mod Pathol 23:1486-91. 2010..It underscores the importance of follow-up when some but not all of the criteria for EIN are encountered in the appropriate clinical setting... - Evidence for a latent precursor (p53 signature) that may precede serous endometrial intraepithelial carcinomaElke A Jarboe
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Mod Pathol 22:345-50. 2009..The significance of p53 signatures in benign conditions (polyps) remains to be determined. The role of the p53 signature in early serous neoplasia is discussed... - Risk factors for a serous cancer precursor ("p53 signature") in women with inherited BRCA mutationsAasia Saleemuddin
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Gynecol Oncol 111:226-32. 2008..This study examined the relationship of putative ovarian cancer risk factors with the presence of p53 signatures in women with BRCA mutations (BRCA+)... - Atypical glandular cells of undetermined significance. Outcome predictions based on human papillomavirus testingJeffrey F Krane
Divisions of Women's and Perinatal Pathology and Cytology, Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA
Am J Clin Pathol 121:87-92. 2004..However, noncervical or other HPV-negative glandular neoplasia must be considered in all patients with AGC, particularly older patients... - The impact of tissue block sampling on the detection of p53 signatures in fallopian tubes from women with BRCA 1 or 2 mutations (BRCA+) and controlsKarishma K Mehra
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Mod Pathol 24:152-6. 2011..Attention to this detail is critical when exploring risk factors germane to early serous carcinogenesis... - Intercepting early pelvic serous carcinoma by routine pathological examination of the fimbriaDana R Semmel
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Mod Pathol 22:985-8. 2009..The rationale for this strategy, and its potential effect on early detection and in uncovering persons or families potentially at risk for ovarian cancer, is discussed... - STICS, SCOUTs and p53 signatures; a new language for pelvic serous carcinogenesisKarishma Mehra
Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Front Biosci (Elite Ed) 3:625-34. 2011..This will challenge conventional thinking about ovarian carcinogenesis but will provide a new template for studies of ovarian cancer prevention... - Histologic and immunohistochemical decision-making in endometrial adenocarcinomaLesley Lomo
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Mod Pathol 21:937-42. 2008..Because p53 is an important marker for endometrial adenocarcinoma outcome, and cannot be predicted in advance in indeterminate cases, p53 immunostaining should be employed in cases with observer disagreement in a binary system... - p63 Is essential for the proliferative potential of stem cells in stratified epitheliaMakoto Senoo
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Cell 129:523-36. 2007..Together, these data identify p63 as a key, lineage-specific determinant of the proliferative capacity in stem cells of stratified epithelia... - Precursors to pelvic serous carcinoma and their clinical implicationsAnn K Folkins
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Gynecol Oncol 113:391-6. 2009..The data supporting a candidate precursor, the implications of these findings for early detection and prevention of pelvic serous carcinoma and the caveats, are discussed... - Biomarkers in diagnostic obstetric and gynecologic pathology: a reviewMarisa R Nucci
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA
Adv Anat Pathol 10:55-68. 2003.... - Loss of p63 expression is associated with tumor progression in bladder cancerMarshall J Urist
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Am J Pathol 161:1199-206. 2002..These data indicate that in contrast to the skin and prostate, p63 is not required for formation of a bladder epithelium but is indispensable for the specific differentiation of a transitional urothelium... - Dynamics of human papillomavirus infection between biopsy and excision of cervical intraepithelial neoplasia: results from the ZYC101a protocolChristopher P Crum
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusettsm USA
J Infect Dis 189:1348-54. 2004..Little is known about the dynamics of human papillomavirus (HPV) during the follow-up of cervical intraepithelial neoplasia (CIN) 2/3 after biopsy... - High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expressionMichael H Roh
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA
Mod Pathol 23:1316-24. 2010..PAX2 and PTEN, in addition to p53 and p16(ink4), comprise a potentially important gene combination in high-grade pelvic carcinogenesis... - Stathmin-1 expression as a complement to p16 helps identify high-grade cervical intraepithelial neoplasia with increased specificityBrooke E Howitt
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 37:89-97. 2013..Further studies correlating STMN staining with lesion persistence or morphologic progression, in the context of CIN grade, are warranted... - A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancerMichael Herfs
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 109:10516-21. 2012.... - A weakly positive human papillomavirus Hybrid Capture II result correlates with a significantly lower risk of cervical intraepithelial neoplasia 2,3 after atypical squamous cells of undetermined significance cytologyElke A Jarboe
Division of Cytopathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
J Low Genit Tract Dis 14:174-8. 2010..0 or higher are scored positive for hrHPV. We tested the hypothesis that hrHPV positives with low-positive RLU ratios (1-10) had a lower prevalence of cervical intraepithelial neoplasia 2,3 (CIN 2,3) on histologic follow-up... - The borderline or weakly positive Hybrid Capture II HPV test: a statistical and comparative (PCR) analysisJerome M Federschneider
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Mass 02115, USA
Am J Obstet Gynecol 191:757-61. 2004..The proportion of cases at risk is low (<3%). Nevertheless, this information may be germane to the interpretation and reporting of marginally positive HCII test values... - Early vulvar squamous neoplasia: advances in classification, diagnosis, and differential diagnosisFabiola Medeiros
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Adv Anat Pathol 12:20-6. 2005..Recognition of these five categories is germane to proper management of women with squamous lesions of the vulva... - Expression of candidate tumor markers in ovarian carcinoma and benign ovary: evidence for a link between epithelial phenotype and neoplasiaRonny Drapkin
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA
Hum Pathol 35:1014-21. 2004..This immunophenotype is preserved in ovarian carcinomas, suggesting that Müllerian metaplasia signals the acquisition of these markers and that their expression is maintained in ovarian carcinomas that originate from this epithelium... - Serous tubal intraepithelial carcinoma and the dominant ovarian mass: clues to serous tumor origin?Michael H Roh
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 33:376-83. 2009..Nevertheless, the shared immunophenotype suggests a common cell of origin for all categories, irrespective of site... - Age-specific detection of high risk HPV DNA in cytologically normal, computer-imaged ThinPrep Pap samplesEdmund S Cibas
Department of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Gynecol Oncol 104:702-6. 2007..The objective of this study was to determine the rate of HR HPV DNA positivity in women ages 30 and over with a cytologically negative liquid-based Pap test result... - Digital quantification of precursor frequency in the fallopian tube and its significanceJonathan G Bijron
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Mod Pathol 25:1654-61. 2012..This has important implications for assessing precursor frequency both in the fallopian tube and in other organs-such as prostate, pancreas and colon-where epithelial precursors are integral to carcinogenesis... - Cervical cancer screening: from the Papanicolaou smear to the vaccine eraChristopher P Crum
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 21:224s-230s. 2003..If so, previous strategies may become obsolete as the balance of cervical cancer prevention shifts from traditional screening to primary prevention coupled with HPV testing... - Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosisHongwei Bai
Department of Pathology, Brigham and Women's Hospital, and the Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
Hum Pathol 34:559-64. 2003..Whether CSKs are associated with other forms of HPV infection remains to be determined... - Fallopian tube correlates of ovarian serous borderline tumorsAnna R Laury
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Surg Pathol 35:1759-65. 2011..Further study is warranted to clarify the relationship of the oviduct to serous neoplasia... - Endocervical adenocarcinoma in situ with ovarian metastases: a unique variant with potential for long-term survivalMartin C Chang
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 29:88-92. 2010..Extensive, recurring AIS is a rare variant that may be unique for its risk of coincident ovarian involvement. However, ovarian spread, albeit rare, does not invariably result in an adverse outcome... - Obstetric and perinatal complications in placentas with fetal thrombotic vasculopathyAasia Saleemuddin
Department of Pathology, Harvard Medical School, Boston, MA, USA
Pediatr Dev Pathol 13:459-64. 2010..This study points to abnormal fetal circulation, either in the form of congenital heart disease or oligohydramnios predisposing to cord compression, as a risk factor for FTV... - Endometrial glandular dysplasia with frequent p53 gene mutation: a genetic evidence supporting its precancer nature for endometrial serous carcinomaLin Jia
Department of Pathology, Arizona Cancer Center, University of Arizona College of Medicine, Tucson, AZ 85724, USA
Clin Cancer Res 14:2263-9. 2008..The purpose of this study is to determine if EmGD is genetically linked to ESC and if it can be used for early detection... - Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibromaVeerle Bossuyt
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 27:390-7. 2008..Whether the shared tumor phenotype in these 2 organs is coincidental or interdependent bears further investigation... - Vulvar acanthosis with altered differentiation: a precursor to verrucous carcinoma?Alessandra F Nascimento
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 28:638-43. 2004..The possibility that vulvar acanthosis with altered differentiation is a precursor to, or a risk factor for, vulvar carcinoma, merits further study... - p63 protects the female germ line during meiotic arrestEun Kyung Suh
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 444:624-8. 2006..These findings have implications for understanding female germ line fidelity, the regulation of fertility and the evolution of tumour suppressor mechanisms... - Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumorsMartin C Chang
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Children s Hospital Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 28:347-55. 2009..The inclusion of these markers should therefore be considered in cases of pure or mixed ovarian germ cell tumors that are difficult to classify, and to exclude nongerm cell tumor mimics... - Redefining early cervical neoplasia: recent progressMarisa R Nucci
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02445, USA
Adv Anat Pathol 14:1-10. 2007..In addition, practical issues in the diagnosis and management of squamous epithelial lesions, particularly the recognition of nonconventional variants and the application of biomarkers, are discussed... - p53 autoantibodies as potential detection and prognostic biomarkers in serous ovarian cancerKaren S Anderson
Cancer Vaccine Center, Department of Medical Oncology, Dana Farber Cancer Institute, HIM416, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 19:859-68. 2010..This study examined the value of serum p53 autoantibodies (p53-AAb) as detection and prognostic biomarkers in ovarian cancer... - Using the rate of positive high-risk HPV test results for ASC-US together with the ASC-US/SIL ratio in evaluating the performance of cytopathologistsEdmund S Cibas
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Clin Pathol 129:97-101. 2008..Both indicators together provide useful feedback to cytopathologists. We provide a working schema for interpreting perturbations in these indicators to assist in improving the quality of gynecologic cytology interpretations... - p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tractTan A Ince
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Pathol 161:1111-7. 2002..The second is necessary for the generation of multipotential reserve cells in the cervix and may be operative in other epithelial stromal interactions integral to the emergence of uterine basal cells later in life... - CA125 immune complexes in ovarian cancer patients with low CA125 concentrationsDaniel W Cramer
Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin Chem 56:1889-92. 2010..Because CA125 and MUC1 are related members of the mucin family, we sought to determine whether CICs might also exist for CA125 and interfere with its clinical assay... - PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activityVictor Pena-Cruz
Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Invest Dermatol 130:2222-30. 2010..Thus the PD-1 pathway is active in iLCs and inhibits iLC activities, but expression of receptor and ligands reverses upon maturation and PD-L1 and PD-L2 on mLC function to inhibit T-cell responses... - Histological 'progression' from low (LSIL) to high (HSIL) squamous intraepithelial lesion is an uncommon event and an indication for quality assurance reviewEleanor Y Chen
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Mod Pathol 23:1045-51. 2010..A diagnosis of HSIL following an LSIL should always be reviewed, as this diagnostic pairing may more likely be associated with a diagnostic error... - Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNAEllen E Sheets
Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
Am J Obstet Gynecol 188:916-26. 2003.... - Human papillomaviruses, expression of p16, and early endocervical glandular neoplasiaLutz Riethdorf
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
Hum Pathol 33:899-904. 2002..Because endometrial glandular epithelia may also express p16, the diagnostic application of p16 immunohistochemistry to cytological samples is uncertain... - Progress in the management of gynecologic cancer: consensus summary statementStephen A Cannistra
Department of Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Massachusetts General Hospital, Boston, USA
J Clin Oncol 21:129s-132s. 2003 - BRAF in papillary thyroid carcinoma of ovary (struma ovarii)Jason Schmidt
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 31:1337-43. 2007..In this study, we explored the possible role of these genes in the development of BSO and MSO... - Influence of margin status and radiation on recurrence after radical hysterectomy in Stage IB cervical cancerAkila N Viswanathan
Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
Int J Radiat Oncol Biol Phys 65:1501-7. 2006..To examine the relationship between margin status and local recurrence (LR) or any recurrence after radical hysterectomy (RH) in women treated with or without radiotherapy (RT) for Stage IB cervical carcinoma... - The significance of the Papanicolaou smear diagnosis of low-grade squamous intraepithelial lesion cannot exclude high-grade squamous intraepithelial lesionSelim M Nasser
Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer 99:272-6. 2003..Its use appears warranted. Women with this diagnosis merit appropriate clinical follow-up to exclude HSIL... - Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomasRonny Drapkin
Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Cancer Res 65:2162-9. 2005..Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types of EOCs... - Kappa statistics to measure interrater and intrarater agreement for 1790 cervical biopsy specimens among twelve pathologists: qualitative histopathologic analysis and methodologic issuesAnais Malpica
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Gynecol Oncol 99:S38-52. 2005..Our findings will aid both the correlations with optical measurements using fluorescence and reflectance spectroscopy and the quantitative histopathologic analysis of these study specimens... - Managing atypical squamous cells of undetermined significance (ASCUS): human papillomavirus testing, ASCUS subtyping,or follow-up cytology?Sara A Hughes
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Boston, Mass 02115, USA
Am J Obstet Gynecol 186:396-403. 2002.... - Symposium part 1: Should the Bethesda System terminology be used in diagnostic surgical pathology?: PointChristopher P Crum
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 22:5-12. 2003.... - Human papillomaviruses. Applications, caveats and preventionChristopher P Crum
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Reprod Med 47:519-28; discussion 528-9. 2002..If successful, such programs could radically alter the number of women requiring triage for preinvasive disease and initiate a progressive decline in cervical cancer incidence... - ZYC101a for treatment of high-grade cervical intraepithelial neoplasia: a randomized controlled trialFrancisco Garcia
Department of Obstetrics and Gynecology, University of Arizona Health Sciences Center, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
Obstet Gynecol 103:317-26. 2004..ZYC101a contains plasmid-DNA-encoding fragments derived from the E6 and E7 proteins of human papillomavirus (HPV) 16 and 18, and is formulated within small biodegradable microparticles... - Type-specific testing for human papillomavirusChristopher P Crum
N Engl J Med 349:614-5. 2003 - Prognostic significance of lymph node variables and human papillomavirus DNA in invasive vulvar carcinomaAlvaro P Pinto
Department of Pathology, Hospital de Clinicas, Universidade Federal do Parana, Curitiba, PR, Brazil
Gynecol Oncol 92:856-65. 2004..The present study investigates the influence of lymph node pathological features and HPV DNA status on the prognosis of vulvar invasive tumors... - NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changesIrene Georgakoudi
G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Cancer Res 62:682-7. 2002.... - The beginning of the end for cervical cancer?Christopher P Crum
N Engl J Med 347:1703-5. 2002 - Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformationClaudio Talora
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Genes Dev 16:2252-63. 2002.... - p16INK4A expression as biomarker for HPV 16-related vulvar neoplasiasSabine Riethdorf
, , Hamburg, Germany
Hum Pathol 35:1477-83. 2004..These disparate patterns of p16 expression underscore 2 different mechanisms for p16 expression in HPV-related and HPV-unrelated vulvar carcinomas... - Biomarker (ProEx C, p16(INK4A), and MiB-1) distinction of high-grade squamous intraepithelial lesion from its mimicsAlvaro P Pinto
Department of Pathology, Federal University of Parana, Curitiba, Parana, Brazil
Mod Pathol 21:1067-74. 2008..ProEx C appears to provide an equivalent level of sensitivity and a higher level of specificity for HSIL alone or in conjunction with p16. Its principal value may be in providing a lower false positive rate for NoSIL relative to MiB-1... - HPV testing. Visible expectations and hidden realitiesJerome M Federschneider
Am J Clin Pathol 120:483-4. 2003 - Innovations in understanding the biology of cervical cancerJudith K Wolf
Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 98:2064-9. 2003..Identification of molecular changes in cervical cancer and knowledge about the importance of HPV infection in cervical cancer can lead to new therapies to treat existing cervical cancer and, in the long term, prevent the disease... - Laboratory management of CIN 2: the consensus is consensusChristopher P Crum
Am J Clin Pathol 130:162-4. 2008 - Spectroscopic diagnosis and imaging of invisible pre-cancerKamran Badizadegan
Massachusetts Institute of Technology Laser Biomedical Research Center, USA
Faraday Discuss 126:265-79; discussion 303-11. 2004..The combination of the TMS/FastEEM and LSS imaging instrument will constitute a powerful new diagnostic tool, with LSS imaging to provide wide area surveillance and the TMS probe to provide detailed information on suspect tissue sites... - Telomerase: promise and challengeTan A Ince
Hum Pathol 35:393-5. 2004 - Eosinophilic dysplasia of the cervix: a newly recognized variant of cervical squamous intraepithelial neoplasiaLinglei Ma
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8070, USA
Am J Surg Pathol 28:1474-84. 2004..Since ED possesses histologic features of both dysplasia and metaplasia, we speculate that it may arise from metaplastic cervical squamous epithelium that has subsequently become infected with intermediate- or high-risk HPV... - A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expressionYonghee Lee
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Pathol 38:1003-13. 2007..p63 staining patterns in trophoblastic tumors reflect timing of neoplastic transformation during trophoblastic differentiation... - Trimodal spectroscopy for the detection and characterization of cervical precancers in vivoIrene Georgakoudi
G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA
Am J Obstet Gynecol 186:374-82. 2002....
Research Grants
- Cellular gene expression in HPV associated neoplasiaChristopher Crum; Fiscal Year: 2002..Such methods, if successful, could conceivably revolutionize the approach to cervical cancer prevention by broadening the conditions under which screening could be conducted. ..
- p53 signatures and pelvic serous carcinomaChristopher Crum; Fiscal Year: 2007....