Christopher P Crum

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint BRCA, the oviduct, and the space and time continuum of pelvic serous carcinogenesis
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Int J Gynecol Cancer 22:S29-34. 2012
  2. pmc The oviduct and ovarian cancer: causality, clinical implications, and "targeted prevention"
    Christopher P Crum
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin Obstet Gynecol 55:24-35. 2012
  3. pmc Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium
    Lifang Zhang
    Obstetrics and Gynecology Department, Peking University People s Hospital, Beijing, China
    Reprod Biol Endocrinol 8:74. 2010
  4. ncbi request reprint The distal fallopian tube: a new model for pelvic serous carcinogenesis
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Obstet Gynecol 19:3-9. 2007
  5. doi request reprint p63 in epithelial survival, germ cell surveillance, and neoplasia
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Pathol 5:349-71. 2010
  6. pmc Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer
    Christopher P Crum
    Department of Pathology, Brigham and Womens Hospital, 75 Francis Street, Boston, MA 02115, USA
    Clin Med Res 5:35-44. 2007
  7. ncbi request reprint Hertig and beyond: a systematic and practical approach to the endometrial biopsy
    Christopher P Crum
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Adv Anat Pathol 10:301-18. 2003
  8. pmc Intercepting pelvic cancer in the distal fallopian tube: theories and realities
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Mol Oncol 3:165-70. 2009
  9. ncbi request reprint Vaccines for cervical cancer
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer J 9:368-76. 2003
  10. pmc Squamous morules are functionally inert elements of premalignant endometrial neoplasia
    Ming Chieh Lin
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mod Pathol 22:167-74. 2009

Research Grants

  1. Cellular gene expression in HPV associated neoplasia
    Christopher Crum; Fiscal Year: 2002
  2. p53 signatures and pelvic serous carcinoma
    Christopher Crum; Fiscal Year: 2007

Detail Information

Publications99

  1. doi request reprint BRCA, the oviduct, and the space and time continuum of pelvic serous carcinogenesis
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Int J Gynecol Cancer 22:S29-34. 2012
    ..The potential promise of these discoveries is "targeted prevention" by discovering of multiple pathways integral to carcinogenesis and successfully preventing malignancy by interrupting one or a few of these pathways...
  2. pmc The oviduct and ovarian cancer: causality, clinical implications, and "targeted prevention"
    Christopher P Crum
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin Obstet Gynecol 55:24-35. 2012
    ..This alternative to detect early malignancy is a new paradigm in the quest to prevent this deadly disease...
  3. pmc Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium
    Lifang Zhang
    Obstetrics and Gynecology Department, Peking University People s Hospital, Beijing, China
    Reprod Biol Endocrinol 8:74. 2010
    ..The major objective of this study was to explore and determine whether platelet activating factor (PAF) and receptor associated networking pathways might significantly induce malignant potential in BRCA1-mutant at-risk epithelial cells...
  4. ncbi request reprint The distal fallopian tube: a new model for pelvic serous carcinogenesis
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Obstet Gynecol 19:3-9. 2007
    ....
  5. doi request reprint p63 in epithelial survival, germ cell surveillance, and neoplasia
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Pathol 5:349-71. 2010
    ..Whether tumorigenic pathways are also involved, and to what extent, is a subject of both promise and controversy that remains to be resolved...
  6. pmc Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer
    Christopher P Crum
    Department of Pathology, Brigham and Womens Hospital, 75 Francis Street, Boston, MA 02115, USA
    Clin Med Res 5:35-44. 2007
    ....
  7. ncbi request reprint Hertig and beyond: a systematic and practical approach to the endometrial biopsy
    Christopher P Crum
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Adv Anat Pathol 10:301-18. 2003
    ..Algorithms for the laboratory management of cyclic changes, dysfunctional bleeding, and mixed-pattern endometria are provided, as are pitfalls in interpretation and exclusion of neoplasia...
  8. pmc Intercepting pelvic cancer in the distal fallopian tube: theories and realities
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Mol Oncol 3:165-70. 2009
    ..The challenges and unmet needs unmasked by this paradigm shift in ovarian cancer research are discussed...
  9. ncbi request reprint Vaccines for cervical cancer
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer J 9:368-76. 2003
    ..However, success will require identifying and circumventing the mechanisms by which tumor cells evade the immune system...
  10. pmc Squamous morules are functionally inert elements of premalignant endometrial neoplasia
    Ming Chieh Lin
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mod Pathol 22:167-74. 2009
    ..Even isolated morules should be carefully followed, however, to exclude a coexisting undersampled, or occult, glandular lesion...
  11. ncbi request reprint Advances in the recognition of tubal intraepithelial carcinoma: applications to cancer screening and the pathogenesis of ovarian cancer
    Yonghee Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston
    Adv Anat Pathol 13:1-7. 2006
    ..A protocol for sectioning and extensively examining the fimbriated end (SEE-FIM), and its rationale, is described...
  12. pmc A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations
    Ann K Folkins
    The Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Gynecol Oncol 109:168-73. 2008
    ..This study compared the prevalence of p53 signatures in ovarian cortical inclusion cysts (CICs) and fallopian tubes from BRCA+ women and explored their relationship...
  13. doi request reprint Through the glass darkly: intraepithelial neoplasia, top-down differentiation, and the road to ovarian cancer
    Christopher P Crum
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA, 02115, USA
    J Pathol 231:402-12. 2013
    ..Both will be critical to expectations from prophylactic salpingectomy and future approaches to pelvic serous cancer prevention...
  14. pmc Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer prevention
    Joseph W Carlson
    Department of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Clin Oncol 26:4160-5. 2008
    ..This study examined the frequency of STIC in PPSC and its clinical outcome in BRCA-positive women...
  15. ncbi request reprint Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction
    Michael J Callahan
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Oncol 25:3985-90. 2007
    ..To review the frequency and location of malignancies detected after prophylactic salpingo-oophorectomy in women with BRCA mutations...
  16. doi request reprint A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia
    Michael Herfs
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pathol 229:460-8. 2013
    ..It also provides new targets in animal models to determine why the SC junction is uniquely susceptible to carcinogenic HPV infection...
  17. pmc The Li-Fraumeni syndrome (LFS): a model for the initiation of p53 signatures in the distal Fallopian tube
    Wa Xian
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pathol 220:17-23. 2010
    ..This is in keeping with a general model of carcinogenesis, in which different and often independent risk factors operate at multiple points in the serous carcinogenic spectrum...
  18. ncbi request reprint Type-specific HPV testing as a predictor of high-grade squamous intraepithelial lesion outcome after cytologic abnormalities
    Fabiola Medeiros
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02130, USA
    J Low Genit Tract Dis 9:154-9. 2005
    ..This study addressed whether type-specific HPV testing predicts risk of biopsy outcome of high-grade cervical intraepithelial neoplasia (CIN 2,3)...
  19. ncbi request reprint Serous carcinogenesis in the fallopian tube: a descriptive classification
    Elke Jarboe
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 27:1-9. 2008
    ..Combined with recent reports associating STICs with pelvic serous cancer, this continuum of epithelial change validates the SCAT sequence and the fimbrial secretory cell as the site of origin for many serous carcinomas...
  20. ncbi request reprint Polymerase chain reaction detection of HPV in squamous carcinoma of the oropharynx
    Elin S Agoston
    Dept of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Clin Pathol 134:36-41. 2010
    ..However, it is imperative that appropriate sensitivity controls be in place for such assays...
  21. doi request reprint Cervical squamocolumnar junction-specific markers define distinct, clinically relevant subsets of low-grade squamous intraepithelial lesions
    Michael Herfs
    Department of Pathology, Division of Women s and Perinatal Pathology Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA Department of Pathology, Cedar Sinai Medical Center, Los Angeles, CA Department of Pathology, GIGA Cancer, University of Liege, Liege, Belgium Genome Institute of Singapore, ASTAR The Jackson Laboratory for Genomic Medicine, CT The Jackson Laboratory for Genomic Medicine, The University of Connecticut School of Medicine, CT
    Am J Surg Pathol 37:1311-8. 2013
    ..Thus, SCJ biomarkers in conjunction with histology may segregate LSILs with very low risk of HSIL outcome and conceivably could be used as a management tool to reduce excess allocation of resources to the follow-up of these lesions. ..
  22. pmc Epidemiologic correlates of ovarian cortical inclusion cysts (CICs) support a dual precursor pathway to pelvic epithelial cancer
    Ann K Folkins
    Divisionsof Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Gynecol Oncol 115:108-11. 2009
    ..Many ovarian carcinomas are presumed to arise within ovarian cortical inclusion cysts (CICs). This study examined the frequency of ovarian CICs in relation to epidemiologic risk factors in women with BRCA1 and BRCA2 (BRCA+) mutations...
  23. doi request reprint Coexisting intraepithelial serous carcinomas of the endometrium and fallopian tube: frequency and potential significance
    Elke A Jarboe
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 28:308-15. 2009
    ....
  24. ncbi request reprint Superficial (early) endocervical adenocarcinoma in situ: a study of 12 cases and comparison to conventional AIS
    Agnieszka Witkiewicz
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:1609-14. 2005
    ..Superficial AIS should be suspected in endocervical columnar epithelium with segmental nuclear hyperchromasia with mitotic activity, and confirmed by biomarker staining (p16 and Mib-1) if the pathologist is uncertain of the diagnosis...
  25. doi request reprint Serous tubal intraepithelial carcinoma: diagnostic reproducibility and its implications
    Joseph W Carlson
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 29:310-4. 2010
    ..In view of these findings, a diagnosis of STIC should be corroborated by a second pathologist, if feasible...
  26. ncbi request reprint Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship
    David W Kindelberger
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 31:161-9. 2007
    ....
  27. ncbi request reprint Phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia
    Alvaro P Pinto
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mod Pathol 26:1498-507. 2013
    ..These results support further studies to assess the potential of p-S6 as a biomarker to identify vulvar lesions at risk of progressing to invasive cancer. ..
  28. pmc Evidence for a latent precursor (p53 signature) that may precede serous endometrial intraepithelial carcinoma
    Elke A Jarboe
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mod Pathol 22:345-50. 2009
    ..The significance of p53 signatures in benign conditions (polyps) remains to be determined. The role of the p53 signature in early serous neoplasia is discussed...
  29. ncbi request reprint The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome
    Fabiola Medeiros
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 30:230-6. 2006
    ..Investigative strategies targeting the fimbriated end of the fallopian tube should further define its role in the pathogenesis of familial and sporadic ovarian serous carcinomas...
  30. doi request reprint PAX2-null secretory cell outgrowths in the oviduct and their relationship to pelvic serous cancer
    Charles M Quick
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mod Pathol 25:449-55. 2012
    ..We propose a unique co-variable in benign oviductal epithelium-the PAX2-null SCOUT-that reflects underlying dysregulation in genes linked to serous neoplasia...
  31. pmc Intercepting early pelvic serous carcinoma by routine pathological examination of the fimbria
    Dana R Semmel
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mod Pathol 22:985-8. 2009
    ..The rationale for this strategy, and its potential effect on early detection and in uncovering persons or families potentially at risk for ovarian cancer, is discussed...
  32. ncbi request reprint Atypical glandular cells of undetermined significance. Outcome predictions based on human papillomavirus testing
    Jeffrey F Krane
    Divisions of Women s and Perinatal Pathology and Cytology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Clin Pathol 121:87-92. 2004
    ..However, noncervical or other HPV-negative glandular neoplasia must be considered in all patients with AGC, particularly older patients...
  33. pmc Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube
    Eleanor Y Chen
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pathol 222:110-6. 2010
    ....
  34. doi request reprint The impact of tissue block sampling on the detection of p53 signatures in fallopian tubes from women with BRCA 1 or 2 mutations (BRCA+) and controls
    Karishma K Mehra
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mod Pathol 24:152-6. 2011
    ..Attention to this detail is critical when exploring risk factors germane to early serous carcinogenesis...
  35. doi request reprint Clinical outcome in diagnostically ambiguous foci of 'gland crowding' in the endometrium
    Eric C Huang
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Mod Pathol 23:1486-91. 2010
    ..It underscores the importance of follow-up when some but not all of the criteria for EIN are encountered in the appropriate clinical setting...
  36. ncbi request reprint Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cells
    Agnieszka K Witkiewicz
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 36:154-61. 2005
    ..Using antibodies to basal cell markers, we analyzed biopsies with MGH to profile the distribution and evolution of reserve cells and their relationship to these epithelial components...
  37. pmc Risk factors for a serous cancer precursor ("p53 signature") in women with inherited BRCA mutations
    Aasia Saleemuddin
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Gynecol Oncol 111:226-32. 2008
    ..This study examined the relationship of putative ovarian cancer risk factors with the presence of p53 signatures in women with BRCA mutations (BRCA+)...
  38. doi request reprint Digital quantification of precursor frequency in the fallopian tube and its significance
    Jonathan G Bijron
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mod Pathol 25:1654-61. 2012
    ..This has important implications for assessing precursor frequency both in the fallopian tube and in other organs-such as prostate, pancreas and colon-where epithelial precursors are integral to carcinogenesis...
  39. ncbi request reprint p63 Is essential for the proliferative potential of stem cells in stratified epithelia
    Makoto Senoo
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:523-36. 2007
    ..Together, these data identify p63 as a key, lineage-specific determinant of the proliferative capacity in stem cells of stratified epithelia...
  40. pmc Loss of p63 expression is associated with tumor progression in bladder cancer
    Marshall J Urist
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Pathol 161:1199-206. 2002
    ..These data indicate that in contrast to the skin and prostate, p63 is not required for formation of a bladder epithelium but is indispensable for the specific differentiation of a transitional urothelium...
  41. doi request reprint Histologic and immunohistochemical decision-making in endometrial adenocarcinoma
    Lesley Lomo
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mod Pathol 21:937-42. 2008
    ..Because p53 is an important marker for endometrial adenocarcinoma outcome, and cannot be predicted in advance in indeterminate cases, p53 immunostaining should be employed in cases with observer disagreement in a binary system...
  42. ncbi request reprint STICS, SCOUTs and p53 signatures; a new language for pelvic serous carcinogenesis
    Karishma Mehra
    Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Front Biosci (Elite Ed) 3:625-34. 2011
    ..This will challenge conventional thinking about ovarian carcinogenesis but will provide a new template for studies of ovarian cancer prevention...
  43. doi request reprint Precursors to pelvic serous carcinoma and their clinical implications
    Ann K Folkins
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Gynecol Oncol 113:391-6. 2009
    ..The data supporting a candidate precursor, the implications of these findings for early detection and prevention of pelvic serous carcinoma and the caveats, are discussed...
  44. ncbi request reprint Biomarkers in diagnostic obstetric and gynecologic pathology: a review
    Marisa R Nucci
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA
    Adv Anat Pathol 10:55-68. 2003
    ....
  45. ncbi request reprint Dynamics of human papillomavirus infection between biopsy and excision of cervical intraepithelial neoplasia: results from the ZYC101a protocol
    Christopher P Crum
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusettsm USA
    J Infect Dis 189:1348-54. 2004
    ..Little is known about the dynamics of human papillomavirus (HPV) during the follow-up of cervical intraepithelial neoplasia (CIN) 2/3 after biopsy...
  46. doi request reprint High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression
    Michael H Roh
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA
    Mod Pathol 23:1316-24. 2010
    ..PAX2 and PTEN, in addition to p53 and p16(ink4), comprise a potentially important gene combination in high-grade pelvic carcinogenesis...
  47. ncbi request reprint Outcome of unexpected adnexal neoplasia discovered during risk reduction salpingo-oophorectomy in women with germ-line BRCA1 or BRCA2 mutations
    James R Conner
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, USA
    Gynecol Oncol 132:280-6. 2014
    ..This study computed the risk of clinically silent adnexal neoplasia in women with germ-line BRCA1 or BRCA2 mutations (BRCA(m+)) and determined recurrence risk...
  48. doi request reprint Endometrial glandular dysplasia with frequent p53 gene mutation: a genetic evidence supporting its precancer nature for endometrial serous carcinoma
    Lin Jia
    Department of Pathology, Arizona Cancer Center, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Clin Cancer Res 14:2263-9. 2008
    ..The purpose of this study is to determine if EmGD is genetically linked to ESC and if it can be used for early detection...
  49. doi request reprint Stathmin-1 expression as a complement to p16 helps identify high-grade cervical intraepithelial neoplasia with increased specificity
    Brooke E Howitt
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 37:89-97. 2013
    ..Further studies correlating STMN staining with lesion persistence or morphologic progression, in the context of CIN grade, are warranted...
  50. pmc A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer
    Michael Herfs
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:10516-21. 2012
    ....
  51. doi request reprint A weakly positive human papillomavirus Hybrid Capture II result correlates with a significantly lower risk of cervical intraepithelial neoplasia 2,3 after atypical squamous cells of undetermined significance cytology
    Elke A Jarboe
    Division of Cytopathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Low Genit Tract Dis 14:174-8. 2010
    ..0 or higher are scored positive for hrHPV. We tested the hypothesis that hrHPV positives with low-positive RLU ratios (1-10) had a lower prevalence of cervical intraepithelial neoplasia 2,3 (CIN 2,3) on histologic follow-up...
  52. ncbi request reprint The borderline or weakly positive Hybrid Capture II HPV test: a statistical and comparative (PCR) analysis
    Jerome M Federschneider
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Am J Obstet Gynecol 191:757-61. 2004
    ..Recent studies have hypothesized that laboratory contamination may influence interpretation of Hybrid Capture II (HCII) human papillomavirus (HPV) detection assay values...
  53. ncbi request reprint Serous tubal intraepithelial carcinoma and the dominant ovarian mass: clues to serous tumor origin?
    Michael H Roh
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 33:376-83. 2009
    ..Nevertheless, the shared immunophenotype suggests a common cell of origin for all categories, irrespective of site...
  54. ncbi request reprint Early vulvar squamous neoplasia: advances in classification, diagnosis, and differential diagnosis
    Fabiola Medeiros
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Adv Anat Pathol 12:20-6. 2005
    ..Recognition of these five categories is germane to proper management of women with squamous lesions of the vulva...
  55. ncbi request reprint Expression of candidate tumor markers in ovarian carcinoma and benign ovary: evidence for a link between epithelial phenotype and neoplasia
    Ronny Drapkin
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Hum Pathol 35:1014-21. 2004
    ..This immunophenotype is preserved in ovarian carcinomas, suggesting that Müllerian metaplasia signals the acquisition of these markers and that their expression is maintained in ovarian carcinomas that originate from this epithelium...
  56. ncbi request reprint Age-specific detection of high risk HPV DNA in cytologically normal, computer-imaged ThinPrep Pap samples
    Edmund S Cibas
    Department of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Gynecol Oncol 104:702-6. 2007
    ..The objective of this study was to determine the rate of HR HPV DNA positivity in women ages 30 and over with a cytologically negative liquid-based Pap test result...
  57. ncbi request reprint Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis
    Hongwei Bai
    Department of Pathology, Brigham and Women s Hospital, and the Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Hum Pathol 34:559-64. 2003
    ..Whether CSKs are associated with other forms of HPV infection remains to be determined...
  58. ncbi request reprint Cervical cancer screening: from the Papanicolaou smear to the vaccine era
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 21:224s-230s. 2003
    ..If so, previous strategies may become obsolete as the balance of cervical cancer prevention shifts from traditional screening to primary prevention coupled with HPV testing...
  59. doi request reprint Endocervical adenocarcinoma in situ with ovarian metastases: a unique variant with potential for long-term survival
    Martin C Chang
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 29:88-92. 2010
    ..Extensive, recurring AIS is a rare variant that may be unique for its risk of coincident ovarian involvement. However, ovarian spread, albeit rare, does not invariably result in an adverse outcome...
  60. ncbi request reprint Vulvar acanthosis with altered differentiation: a precursor to verrucous carcinoma?
    Alessandra F Nascimento
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 28:638-43. 2004
    ..The possibility that vulvar acanthosis with altered differentiation is a precursor to, or a risk factor for, vulvar carcinoma, merits further study...
  61. ncbi request reprint p63 protects the female germ line during meiotic arrest
    Eun Kyung Suh
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 444:624-8. 2006
    ..These findings have implications for understanding female germ line fidelity, the regulation of fertility and the evolution of tumour suppressor mechanisms...
  62. doi request reprint Obstetric and perinatal complications in placentas with fetal thrombotic vasculopathy
    Aasia Saleemuddin
    Department of Pathology, Harvard Medical School, Boston, MA, USA
    Pediatr Dev Pathol 13:459-64. 2010
    ..This study points to abnormal fetal circulation, either in the form of congenital heart disease or oligohydramnios predisposing to cord compression, as a risk factor for FTV...
  63. pmc Fallopian tube correlates of ovarian serous borderline tumors
    Anna R Laury
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 35:1759-65. 2011
    ..Further study is warranted to clarify the relationship of the oviduct to serous neoplasia...
  64. doi request reprint Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibroma
    Veerle Bossuyt
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 27:390-7. 2008
    ..Whether the shared tumor phenotype in these 2 organs is coincidental or interdependent bears further investigation...
  65. pmc p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract
    Tan A Ince
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 161:1111-7. 2002
    ..The second is necessary for the generation of multipotential reserve cells in the cervix and may be operative in other epithelial stromal interactions integral to the emergence of uterine basal cells later in life...
  66. pmc p53 autoantibodies as potential detection and prognostic biomarkers in serous ovarian cancer
    Karen S Anderson
    Cancer Vaccine Center, Department of Medical Oncology, Dana Farber Cancer Institute, HIM416, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:859-68. 2010
    ..This study examined the value of serum p53 autoantibodies (p53-AAb) as detection and prognostic biomarkers in ovarian cancer...
  67. pmc CA125 immune complexes in ovarian cancer patients with low CA125 concentrations
    Daniel W Cramer
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Chem 56:1889-92. 2010
    ..Because CA125 and MUC1 are related members of the mucin family, we sought to determine whether CICs might also exist for CA125 and interfere with its clinical assay...
  68. doi request reprint Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumors
    Martin C Chang
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Children s Hospital Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 28:347-55. 2009
    ..The inclusion of these markers should therefore be considered in cases of pure or mixed ovarian germ cell tumors that are difficult to classify, and to exclude nongerm cell tumor mimics...
  69. ncbi request reprint Redefining early cervical neoplasia: recent progress
    Marisa R Nucci
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02445, USA
    Adv Anat Pathol 14:1-10. 2007
    ..In addition, practical issues in the diagnosis and management of squamous epithelial lesions, particularly the recognition of nonconventional variants and the application of biomarkers, are discussed...
  70. ncbi request reprint Using the rate of positive high-risk HPV test results for ASC-US together with the ASC-US/SIL ratio in evaluating the performance of cytopathologists
    Edmund S Cibas
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Clin Pathol 129:97-101. 2008
    ..Both indicators together provide useful feedback to cytopathologists. We provide a working schema for interpreting perturbations in these indicators to assist in improving the quality of gynecologic cytology interpretations...
  71. pmc PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity
    Victor Pena-Cruz
    Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Invest Dermatol 130:2222-30. 2010
    ..Thus the PD-1 pathway is active in iLCs and inhibits iLC activities, but expression of receptor and ligands reverses upon maturation and PD-L1 and PD-L2 on mLC function to inhibit T-cell responses...
  72. ncbi request reprint Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA
    Ellen E Sheets
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Obstet Gynecol 188:916-26. 2003
    ....
  73. doi request reprint Histological 'progression' from low (LSIL) to high (HSIL) squamous intraepithelial lesion is an uncommon event and an indication for quality assurance review
    Eleanor Y Chen
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mod Pathol 23:1045-51. 2010
    ..A diagnosis of HSIL following an LSIL should always be reviewed, as this diagnostic pairing may more likely be associated with a diagnostic error...
  74. ncbi request reprint Human papillomaviruses, expression of p16, and early endocervical glandular neoplasia
    Lutz Riethdorf
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 33:899-904. 2002
    ..Because endometrial glandular epithelia may also express p16, the diagnostic application of p16 immunohistochemistry to cytological samples is uncertain...
  75. ncbi request reprint Progress in the management of gynecologic cancer: consensus summary statement
    Stephen A Cannistra
    Department of Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Brigham and Women s Hospital, Dana Farber Cancer Institute, and Massachusetts General Hospital, Boston, USA
    J Clin Oncol 21:129s-132s. 2003
  76. ncbi request reprint Influence of margin status and radiation on recurrence after radical hysterectomy in Stage IB cervical cancer
    Akila N Viswanathan
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 65:1501-7. 2006
    ..To examine the relationship between margin status and local recurrence (LR) or any recurrence after radical hysterectomy (RH) in women treated with or without radiotherapy (RT) for Stage IB cervical carcinoma...
  77. ncbi request reprint BRAF in papillary thyroid carcinoma of ovary (struma ovarii)
    Jason Schmidt
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:1337-43. 2007
    ..In this study, we explored the possible role of these genes in the development of BSO and MSO...
  78. ncbi request reprint The significance of the Papanicolaou smear diagnosis of low-grade squamous intraepithelial lesion cannot exclude high-grade squamous intraepithelial lesion
    Selim M Nasser
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 99:272-6. 2003
    ..In such cases, a diagnosis of LSIL cannot exclude HSIL is rendered. The objective of the current study was to assess the positive predictive value (PPV) for HSIL in follow-up cervical biopsies for these cases...
  79. ncbi request reprint Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas
    Ronny Drapkin
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Res 65:2162-9. 2005
    ..Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types of EOCs...
  80. ncbi request reprint Managing atypical squamous cells of undetermined significance (ASCUS): human papillomavirus testing, ASCUS subtyping,or follow-up cytology?
    Sara A Hughes
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Am J Obstet Gynecol 186:396-403. 2002
    ....
  81. ncbi request reprint Symposium part 1: Should the Bethesda System terminology be used in diagnostic surgical pathology?: Point
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 22:5-12. 2003
    ....
  82. ncbi request reprint Kappa statistics to measure interrater and intrarater agreement for 1790 cervical biopsy specimens among twelve pathologists: qualitative histopathologic analysis and methodologic issues
    Anais Malpica
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gynecol Oncol 99:S38-52. 2005
    ....
  83. ncbi request reprint Human papillomaviruses. Applications, caveats and prevention
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Reprod Med 47:519-28; discussion 528-9. 2002
    ..If successful, such programs could radically alter the number of women requiring triage for preinvasive disease and initiate a progressive decline in cervical cancer incidence...
  84. ncbi request reprint ZYC101a for treatment of high-grade cervical intraepithelial neoplasia: a randomized controlled trial
    Francisco Garcia
    Department of Obstetrics and Gynecology, University of Arizona Health Sciences Center, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
    Obstet Gynecol 103:317-26. 2004
    ..ZYC101a contains plasmid-DNA-encoding fragments derived from the E6 and E7 proteins of human papillomavirus (HPV) 16 and 18, and is formulated within small biodegradable microparticles...
  85. ncbi request reprint p16INK4A expression as biomarker for HPV 16-related vulvar neoplasias
    Sabine Riethdorf
    Institut für Tumorbiologie, Universitätsklinikum Eppendorf, Hamburg, Germany
    Hum Pathol 35:1477-83. 2004
    ..These disparate patterns of p16 expression underscore 2 different mechanisms for p16 expression in HPV-related and HPV-unrelated vulvar carcinomas...
  86. ncbi request reprint The beginning of the end for cervical cancer?
    Christopher P Crum
    N Engl J Med 347:1703-5. 2002
  87. pmc Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation
    Claudio Talora
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 16:2252-63. 2002
    ....
  88. ncbi request reprint Biomarker (ProEx C, p16(INK4A), and MiB-1) distinction of high-grade squamous intraepithelial lesion from its mimics
    Alvaro P Pinto
    Department of Pathology, Federal University of Parana, Curitiba, Parana, Brazil
    Mod Pathol 21:1067-74. 2008
    ..ProEx C appears to provide an equivalent level of sensitivity and a higher level of specificity for HSIL alone or in conjunction with p16. Its principal value may be in providing a lower false positive rate for NoSIL relative to MiB-1...
  89. ncbi request reprint Type-specific testing for human papillomavirus
    Christopher P Crum
    N Engl J Med 349:614-5. 2003
  90. ncbi request reprint HPV testing. Visible expectations and hidden realities
    Jerome M Federschneider
    Am J Clin Pathol 120:483-4. 2003
  91. ncbi request reprint Prognostic significance of lymph node variables and human papillomavirus DNA in invasive vulvar carcinoma
    Alvaro P Pinto
    Department of Pathology, Hospital de Clinicas, Universidade Federal do Parana, Curitiba, PR, Brazil
    Gynecol Oncol 92:856-65. 2004
    ..The present study investigates the influence of lymph node pathological features and HPV DNA status on the prognosis of vulvar invasive tumors...
  92. ncbi request reprint NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes
    Irene Georgakoudi
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cancer Res 62:682-7. 2002
    ....
  93. ncbi request reprint Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo
    Irene Georgakoudi
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Am J Obstet Gynecol 186:374-82. 2002
    ....
  94. ncbi request reprint A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression
    Yonghee Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 38:1003-13. 2007
    ..p63 staining patterns in trophoblastic tumors reflect timing of neoplastic transformation during trophoblastic differentiation...
  95. doi request reprint Laboratory management of CIN 2: the consensus is consensus
    Christopher P Crum
    Am J Clin Pathol 130:162-4. 2008
  96. ncbi request reprint Innovations in understanding the biology of cervical cancer
    Judith K Wolf
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 98:2064-9. 2003
    ..Identification of molecular changes in cervical cancer and knowledge about the importance of HPV infection in cervical cancer can lead to new therapies to treat existing cervical cancer and, in the long term, prevent the disease...
  97. ncbi request reprint Spectroscopic diagnosis and imaging of invisible pre-cancer
    Kamran Badizadegan
    Massachusetts Institute of Technology Laser Biomedical Research Center, USA
    Faraday Discuss 126:265-79; discussion 303-11. 2004
    ..The combination of the TMS/FastEEM and LSS imaging instrument will constitute a powerful new diagnostic tool, with LSS imaging to provide wide area surveillance and the TMS probe to provide detailed information on suspect tissue sites...
  98. ncbi request reprint Telomerase: promise and challenge
    Tan A Ince
    Hum Pathol 35:393-5. 2004
  99. ncbi request reprint Eosinophilic dysplasia of the cervix: a newly recognized variant of cervical squamous intraepithelial neoplasia
    Linglei Ma
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8070, USA
    Am J Surg Pathol 28:1474-84. 2004
    ..Since ED possesses histologic features of both dysplasia and metaplasia, we speculate that it may arise from metaplastic cervical squamous epithelium that has subsequently become infected with intermediate- or high-risk HPV...

Research Grants3

  1. Cellular gene expression in HPV associated neoplasia
    Christopher Crum; Fiscal Year: 2002
    ..Such methods, if successful, could conceivably revolutionize the approach to cervical cancer prevention by broadening the conditions under which screening could be conducted. ..
  2. p53 signatures and pelvic serous carcinoma
    Christopher Crum; Fiscal Year: 2007
    ....