Daniel Cramer

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Non-genomic biomarkers of risk in ovarian cancer
    Simone P Pinheiro
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Dis Markers 23:355-66. 2007
  2. pmc Polymorphisms of MUC16 (CA125) and MUC1 (CA15.3) in relation to ovarian cancer risk and survival
    Kristina A Williams
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 9:e88334. 2014
  3. pmc Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk
    Daniel W Cramer
    Department of Obstetrics, Gynecology and Reproductive Biology, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, 221 Longwood Ave, RFB365, Boston, MA, 02115, USA
    Cancer Causes Control 24:1911-23. 2013
  4. pmc Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, AB, Canada
    BMC Cancer 13:28. 2013
  5. pmc The epidemiology of endometrial and ovarian cancer
    Daniel W Cramer
    Department of Obstetrics and Gynecology, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hematol Oncol Clin North Am 26:1-12. 2012
  6. pmc Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium
    Lifang Zhang
    Obstetrics and Gynecology Department, Peking University People s Hospital, Beijing, China
    Reprod Biol Endocrinol 8:74. 2010
  7. pmc Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men
    Joyce Y Tung
    Human Embryonic Stem Cell Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94143, USA
    Reprod Biol Endocrinol 4:40. 2006
  8. pmc Serum and follicular fluid organochlorine concentrations among women undergoing assisted reproduction technologies
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Environ Health 8:32. 2009
  9. ncbi request reprint The epidemiology of endometriosis
    Daniel W Cramer
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann N Y Acad Sci 955:11-22; discussion 34-6, 396-406. 2002
  10. ncbi request reprint Presence of talc in pelvic lymph nodes of a woman with ovarian cancer and long-term genital exposure to cosmetic talc
    Daniel W Cramer
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Obstet Gynecol 110:498-501. 2007

Detail Information

Publications70

  1. pmc Non-genomic biomarkers of risk in ovarian cancer
    Simone P Pinheiro
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Dis Markers 23:355-66. 2007
  2. pmc Polymorphisms of MUC16 (CA125) and MUC1 (CA15.3) in relation to ovarian cancer risk and survival
    Kristina A Williams
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 9:e88334. 2014
    ..To examine single nucleotide polymorphism (SNPs) in MUC16 (CA125) and MUC1 (CA15.3) in relation to ovarian cancer risk and survival...
  3. pmc Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk
    Daniel W Cramer
    Department of Obstetrics, Gynecology and Reproductive Biology, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, 221 Longwood Ave, RFB365, Boston, MA, 02115, USA
    Cancer Causes Control 24:1911-23. 2013
    ..Test the hypothesis that puerperal mastitis may alter immunity related to the mucin (MUC) family of glycoproteins and lower risk of ovarian cancer...
  4. pmc Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, AB, Canada
    BMC Cancer 13:28. 2013
    ..Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations...
  5. pmc The epidemiology of endometrial and ovarian cancer
    Daniel W Cramer
    Department of Obstetrics and Gynecology, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hematol Oncol Clin North Am 26:1-12. 2012
    ..Careful selection of patients for prophylactic oophorectomy for those women who are coming to hysterectomy for benign disease is an additional measure to consider for ovarian cancer...
  6. pmc Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium
    Lifang Zhang
    Obstetrics and Gynecology Department, Peking University People s Hospital, Beijing, China
    Reprod Biol Endocrinol 8:74. 2010
    ..The major objective of this study was to explore and determine whether platelet activating factor (PAF) and receptor associated networking pathways might significantly induce malignant potential in BRCA1-mutant at-risk epithelial cells...
  7. pmc Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men
    Joyce Y Tung
    Human Embryonic Stem Cell Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94143, USA
    Reprod Biol Endocrinol 4:40. 2006
    ..Recently, we showed that there are several common polymorphisms within the DAZL gene that are associated with age at ovarian failure/menopause and sperm count...
  8. pmc Serum and follicular fluid organochlorine concentrations among women undergoing assisted reproduction technologies
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Environ Health 8:32. 2009
    ....
  9. ncbi request reprint The epidemiology of endometriosis
    Daniel W Cramer
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann N Y Acad Sci 955:11-22; discussion 34-6, 396-406. 2002
    ....
  10. ncbi request reprint Presence of talc in pelvic lymph nodes of a woman with ovarian cancer and long-term genital exposure to cosmetic talc
    Daniel W Cramer
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Obstet Gynecol 110:498-501. 2007
    ..Although epidemiologic studies suggest talc use may increase ovarian cancer risk, there is no proof that talc used externally reaches the pelvis...
  11. ncbi request reprint Conditions associated with antibodies against the tumor-associated antigen MUC1 and their relationship to risk for ovarian cancer
    Daniel W Cramer
    Epidemiology Center, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:1125-31. 2005
    ....
  12. ncbi request reprint Determinants of early follicular phase gonadotrophin and estradiol concentrations in women of late reproductive age
    D W Cramer
    Obstetrics and Gynecology Epidemiology Center, Boston, MA 02115, USA
    Hum Reprod 17:221-7. 2002
    ..FSH and estradiol measured during the menstrual (basal) phase of cycles predict the success of infertility treatment; but the role of these hormones as markers for ovarian reserve in normal populations needs further study...
  13. ncbi request reprint Carotenoids, antioxidants and ovarian cancer risk in pre- and postmenopausal women
    D W Cramer
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Int J Cancer 94:128-34. 2001
    ..Food items most strongly related to decreased risk for ovarian cancer were raw carrots and tomato sauce. Consumption of fruits, vegetables and food items high in carotene and lycopene may reduce the risk of ovarian cancer...
  14. pmc Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens
    Daniel W Cramer
    Brigham and Women s Hospital, Ob Gyn, Division of Epidemiology, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 4:365-74. 2011
    ..Despite many promising new markers for ovarian cancer, CA125 remains the single-best biomarker in the phase II and phase III specimens tested in this study...
  15. pmc Epidemiologic perspective on immune-surveillance in cancer
    Daniel W Cramer
    Obsterics Gynecology Epidemiology Center, Department of Obsterics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Opin Immunol 23:265-71. 2011
    ..We review recently published data that suggest that immune mechanisms underlie most of these observed epidemiologic associations with cancer risk...
  16. pmc Correlates of the preoperative level of CA125 at presentation of ovarian cancer
    Daniel W Cramer
    Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
    Gynecol Oncol 119:462-8. 2010
    ..We examined the effect of epidemiologic variables and tumor features on CA125 at diagnosis and their effects on survival...
  17. pmc CA125 immune complexes in ovarian cancer patients with low CA125 concentrations
    Daniel W Cramer
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Chem 56:1889-92. 2010
    ..Because CA125 and MUC1 are related members of the mucin family, we sought to determine whether CICs might also exist for CA125 and interfere with its clinical assay...
  18. pmc Serum prolactin and TSH in an in vitro fertilization population: is there a link between fertilization and thyroid function?
    D W Cramer
    Ob Gyn Epidemiology Center, Department of Obstetrics, Gynecology and Reproductive Biology, 221 Longwood Avenue, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Assist Reprod Genet 20:210-5. 2003
    ..Measurements of TSH and prolactin are generally included in the evaluation of female infertility, but their value in women coming to in vitro fertilization (IVF) has been questioned...
  19. pmc p53 autoantibodies as potential detection and prognostic biomarkers in serous ovarian cancer
    Karen S Anderson
    Cancer Vaccine Center, Department of Medical Oncology, Dana Farber Cancer Institute, HIM416, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:859-68. 2010
    ..This study examined the value of serum p53 autoantibodies (p53-AAb) as detection and prognostic biomarkers in ovarian cancer...
  20. pmc Polymorphisms in the vitamin D receptor and risk of ovarian cancer in four studies
    Shelley S Tworoger
    Channing Laboratory, Boston, MA 02115, USA
    Cancer Res 69:1885-91. 2009
    ..34-1.28), and among women with the Ff or ff genotype the OR was 0.71 (95% CI, 0.43-1.18). Our results of an association with the Fok1 VDR polymorphism further support a role of the vitamin D pathway in ovarian carcinogenesis...
  21. pmc A proteomic analysis of IVF follicular fluid in women <or=32 years old
    Stephanie J Estes
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115 5804, USA
    Fertil Steril 92:1569-78. 2009
    ..To address the lack of predictors of IVF success by using proteomic biometrics...
  22. ncbi request reprint Serum and follicular fluid hormone levels during in vitro fertilization after short- or long-course treatment with a gonadotropin-releasing hormone agonist
    Y Y Bo-Abbas
    Reproductive Endocrine Unit, National Center for Infertility Research, Massachusetts General Hospital, Boston, USA
    Fertil Steril 75:694-9. 2001
    ..CONCLUSION(S): Serum LH and FF A are significantly higher in the flare regimen in comparison with the down-regulation regimen. Circulating LH appears to play a role in determining FF A concentration...
  23. ncbi request reprint Reproductive hormones, cancers, and conditions in relation to a common genetic variant of luteinizing hormone
    D W Cramer
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Reprod 15:2103-7. 2000
    ..While there is no evidence from this study that v-LH increases risk for ovarian or breast cancer, we conclude that possession of v-LH may impact on some aspects of reproductive history and LH concentrations...
  24. pmc Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10
    Bridget Charbonneau
    Authors Affiliations Departments of Health Sciences Research, Division of Epidemiology, Medical Oncology, Health Sciences Research, Division of Biomedical Statistics and Informatics, Immunology, and Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, Minnesota Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, Florida Channing Division of Network Medicine, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut Department of Clinical Science, University of Bergen Departments of Gynecology and Obstetrics, and Pathology, Haukeland University Hospital, Bergen, Norway Departments for Health Evidence, Urology, and Gynaecology, Radboud University Medical Centre, Nijmegen Comprehensive Cancer Center The Netherlands, Utrecht, the Netherlands Cancer Epidemiology Centre, The Cancer Council Victoria Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, Department of Pathology, and Sir Peter MacCallum Department of Oncology, Austin and Repatriation Medical Centre
    Cancer Res 74:852-61. 2014
    ..Our results extend the evidence that borderline tumors may have a distinct genetic etiology. Further investigation of how these SNPs might modify ovarian cancer associations with other inflammation-related risk factors is warranted...
  25. ncbi request reprint Prevalence and predictors of depressive symptoms in older premenopausal women: the Harvard Study of Moods and Cycles
    B L Harlow
    Harvard Medical School, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Arch Gen Psychiatry 56:418-24. 1999
    ..The Harvard Study of Moods and Cycles is a community-based cohort study designed to evaluate the relationship between major depression and changes in menstrual and ovarian function...
  26. ncbi request reprint Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use
    J Lucero
    Department of Obstetrics and Gynecology, University of California at San Francisco Medical Center, San Francisco, California, USA
    Fertil Steril 76:723-9. 2001
    ..CONCLUSION(S): Coffee consumption and total caffeine use may increase early follicular phase E2 levels independent of related habits of alcohol or tobacco use...
  27. pmc Application of protein microarrays for multiplexed detection of antibodies to tumor antigens in breast cancer
    Karen S Anderson
    Cancer Vaccine Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Proteome Res 7:1490-9. 2008
    ..Here, we present the first demonstration of the application of programmable protein microarray ELISAs for the rapid identification of breast cancer autoantibodies...
  28. pmc Integrated analysis of multiple microarray datasets identifies a reproducible survival predictor in ovarian cancer
    Panagiotis A Konstantinopoulos
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18202. 2011
    ..Public data integration may help overcome challenges in clinical implementation of microarray profiles. We integrated several ovarian cancer datasets to identify a reproducible predictor of survival...
  29. ncbi request reprint Ethnic background and in vitro fertilization outcomes
    K Bendikson
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Int J Gynaecol Obstet 88:342-6. 2005
    ..To compare IVF outcomes among women of different ethnic backgrounds...
  30. ncbi request reprint Prospective study of talc use and ovarian cancer
    D M Gertig
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 92:249-52. 2000
    ..In this study, we conducted a prospective analysis of perineal talc use and the risk of ovarian cancer...
  31. ncbi request reprint Leptin in relation to carcinoma in situ of the breast: a study of pre-menopausal cases and controls
    C S Mantzoros
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cancer 80:523-6. 1999
    ..73-4.21) for the second control-defined tertile and 1.54 (0.46-5.16) for the third control-defined tertile relative to the first. Thus, leptin does not appear to increase the risk of pre-menopausal breast cancer in situ substantially...
  32. ncbi request reprint Recent trends in assisted reproductive techniques and associated outcomes
    D W Cramer
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Obstet Gynecol 95:61-6. 2000
    ..We examined recent trends in success rates for assisted reproduction and determined the influence of changes in patient selection and treatment characteristics on these trends...
  33. ncbi request reprint Genital talc exposure and risk of ovarian cancer
    D W Cramer
    Obstetrics Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Cancer 81:351-6. 1999
    ....
  34. ncbi request reprint Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology
    S C Mok
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1458-64. 2001
    ..We used microarray technology to identify overexpressed genes for secretory proteins as potential serum biomarkers and selected prostasin, a serine protease normally secreted by the prostate gland, for further study...
  35. ncbi request reprint A candidate precursor to serous carcinoma that originates in the distal fallopian tube
    Y Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pathol 211:26-35. 2007
    ....
  36. ncbi request reprint Psychotropic medication use and risk of epithelial ovarian cancer
    B L Harlow
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 7:697-702. 1998
    ....
  37. ncbi request reprint A case-control study of galactose consumption and metabolism in relation to ovarian cancer
    D W Cramer
    Ob Gyn Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:95-101. 2000
    ..62-76.60). We conclude that, whereas adult consumption of lactose carries no clear risk for the disease, certain genetic or biochemical features of galactose metabolism may influence disease risk for particular types of ovarian cancer...
  38. pmc Ovarian cancer risk in relation to medical visits, pelvic examinations and type of health care provider
    Haim A Abenhaim
    School of Public Health, Harvard University, Boston, Mass, USA
    CMAJ 176:941-7. 2007
    ..Whether the current recommendations for ovarian cancer prevention and screening (annual history and physical examination) are effective has not been evaluated. We examined the relation between health care use and the risk of ovarian cancer...
  39. ncbi request reprint Does tubal sterilization influence the subsequent risk of menorrhagia or dysmenorrhea?
    Bernard L Harlow
    Department of Obstetrics and Gynecology, the Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Fertil Steril 77:754-60. 2002
    ..To evaluate the relation between tubal ligation, change in menstrual cycle characteristics, and early follicular phase hormones...
  40. pmc Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2436-44. 2008
    ..These results suggest that women with certain genetic variants may have a higher risk of ovarian cancer associated with genital talc use. Additional research is needed on these interactions and the underlying biological mechanisms...
  41. ncbi request reprint Osteopontin as a potential diagnostic biomarker for ovarian cancer
    Jae Hoon Kim
    Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
    JAMA 287:1671-9. 2002
    ..Analyses involving complementary DNA (cDNA) microarray data can be used to identify up-regulated genes in cancer cells, whose products may then be further validated as potential biomarkers...
  42. ncbi request reprint Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies
    Roberta B Ness
    University of Pittsburgh School of Public Health, Pittsburgh, PA 15261, USA
    Am J Epidemiol 155:217-24. 2002
    ..10, 2.71) and unknown cause of infertility (OR = 1.19, 95% CI: 1.00, 1.40) increased cancer risk. These data suggest a role for specific biologic causes of infertility, but not for fertility drugs in overall risk for ovarian cancer...
  43. pmc Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer
    Margarita Aponte
    Laboratory of Gynecologic Oncology and Epidemiology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Dana Farber Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 68:5839-48. 2008
    ..We suggest that PAFR is an essential upstream target of Src and other signal pathways to control the PAF-mediated cancer progression...
  44. ncbi request reprint Incessant ovulation, mucin 1 immunity, and risk for ovarian cancer
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:30-5. 2007
    ..In this study, we examined whether the total number of ovulatory cycles decreases the likelihood of anti-MUC1 antibodies and provides an immune basis for the association between "incessant ovulation" and ovarian cancer risk...
  45. pmc Genetic variation in the progesterone receptor gene and ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 161:442-51. 2005
    ..76, 95% confidence interval: 0.62, 0.92). Associations were similar after stratifying by ovarian cancer histologies and risk factors...
  46. ncbi request reprint Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry
    Bin Ye
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Dana Farber Harvard Cancer Center, Boston, MA 02115, USA
    Clin Cancer Res 9:2904-11. 2003
    ..The objective of this study was to identify and characterize new serum biomarkers in ovarian cancer patients using mass spectrometric protein profiling and specific immunological assays...
  47. ncbi request reprint Osteopontin as an adjunct to CA125 in detecting recurrent ovarian cancer
    John O Schorge
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    Clin Cancer Res 10:3474-8. 2004
    ..The purpose of this study was to test the hypothesis that OPN is a clinically useful adjunct to CA125 in detecting recurrent ovarian cancer...
  48. ncbi request reprint Identification of epithelial cell adhesion molecule autoantibody in patients with ovarian cancer
    Jae Hoon Kim
    Department of Obstetrics, Gynecology and Reproductive Biology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 9:4782-91. 2003
    ..090 in 26 normal women. This investigation has shown that the Ep-CAM autoantibody was found to be associated with ovarian cancer and suggested that future research assessing its clinical usefulness would be worthwhile...
  49. ncbi request reprint Risk of ovarian cancer in the United States in relation to anthropometric measures: does the association depend on menopausal status?
    Hannah Kuper
    International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, UK
    Cancer Causes Control 13:455-63. 2002
    ..To elucidate the association between anthropometric measures and ovarian cancer risk...
  50. ncbi request reprint Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence
    Bin Ye
    Laboratory of Gynecologic Oncology and Epidemiology, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Dana Farber Cancer Center, USA
    Cancer Lett 251:43-52. 2007
    ..This combined epidemiological and biological data provide supportive evidence for further studies of the chemopreventive or therapeutic effects of Ginkgo and ginkgolides on ovarian cancer...
  51. ncbi request reprint Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine
    Bin Ye
    Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Dana Farber Cancer Center, 221 Longwood Avenue, LMRC 601B, Boston, MA 02115, USA
    Clin Cancer Res 12:432-41. 2006
    ..The objective was to identify and characterize low molecular weight proteins/peptides in urine and their posttranslational modifications that might be used as a screening tool for ovarian cancer...
  52. pmc Blood and urine markers for ovarian cancer: a comprehensive review
    Kathryn L Terry
    Ob Gyn Center Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, MA, USA
    Dis Markers 20:53-70. 2004
  53. pmc Androgen receptor cytosine, adenine, guanine repeats, and haplotypes in relation to ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:5974-81. 2005
    ..Our results suggest that possession of two long AR alleles (> or = 22 CAG repeats) may be associated with increased risk of ovarian cancer compared with women with two short AR alleles (<22 CAG repeats)...
  54. ncbi request reprint A prospective study of dietary lactose and ovarian cancer
    Kathleen M Fairfield
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Int J Cancer 110:271-7. 2004
    ..Our findings provide some support for the hypothesis that lactose intake increases risk of epithelial ovarian cancer. However, the observed excess risk appeared limited to the serous subtype of ovarian cancer in our study...
  55. ncbi request reprint Early life menstrual characteristics and pregnancy experiences among women with and without major depression: the Harvard study of moods and cycles
    Bernard L Harlow
    Obstetrics and Gynecology Epidemiology Center at Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Affect Disord 79:167-76. 2004
    ..Other than premenstrual dysphoria, few studies have examined the extent to which basic characteristics of the menstrual cycle and the occurrence of other reproductive landmarks impact on the risk of major depression...
  56. ncbi request reprint Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States)
    Francesmary Modugno
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cancer Causes Control 14:439-46. 2003
    ..To determine whether oral contraceptive (OC) use, childbearing, breastfeeding and tubal ligation differ between ovarian cancer cases with and without a BRCA1/2 mutation...
  57. ncbi request reprint Interaction between CYP1A1 polymorphic variants and dietary exposures influencing ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:187-90. 2003
    ..Significant interaction may exist between polymorphic variants of CYP1A1 and caffeine that could explain weak or inconsistent associations between caffeine and ovarian cancer when genotype has not been considered...
  58. ncbi request reprint Human progesterone receptor polymorphisms and implantation failure during in vitro fertilization
    Daniel W Cramer
    Department of Obstetrics, Gynecology and Reproductive Biology, Ob Gyn Epidemiology Center, 221 Longwood Avenue, Brigham and Women s Hospital, Boston, MA, USA
    Am J Obstet Gynecol 189:1085-92. 2003
    ..Polymorphic variants of the human progesterone receptor gene have been described, but their potential influence on in vitro fertilization outcome have not been studied...
  59. ncbi request reprint Characteristics of patients with endometriosis in the United States and the United Kingdom
    Wendy Kuohung
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Fertil Steril 78:767-72. 2002
    ..To investigate differences in characteristics of patients with endometriosis in the United States and the United Kingdom...
  60. ncbi request reprint Pooling of case specimens to create standard serum sets for screening cancer biomarkers
    Steven J Skates
    Biostatistics Center, Massachusetts General Hospital, Boston, USA
    Cancer Epidemiol Biomarkers Prev 16:334-41. 2007
    ..We describe the creation and use of standard serum sets developed from healthy donors and pooled sera from ovarian, breast, and endometrial cancer cases...
  61. ncbi request reprint Effects of lifetime exercise on the outcome of in vitro fertilization
    Stephanie N Morris
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital and Harvard Medical, Boston, Massachusetts, USA
    Obstet Gynecol 108:938-45. 2006
    ..To estimate whether exercise before the first cycle of in vitro fertilization (IVF) affects cycle outcomes...
  62. ncbi request reprint Risk of spontaneous abortion in women with childhood exposure to parental cigarette smoke
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Epidemiol 166:571-5. 2007
    ..Future large studies of pregnancy loss are needed that can distinguish women's tobacco smoke exposure in childhood from that taking place in utero...
  63. ncbi request reprint Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer
    Elizabeth I O Garner
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Cancer Res 62:3058-62. 2002
    ..Confirmation in other populations and further exploration of potential pathogenetic mechanisms will be necessary...
  64. ncbi request reprint The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome
    Fabiola Medeiros
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 30:230-6. 2006
    ..Investigative strategies targeting the fimbriated end of the fallopian tube should further define its role in the pathogenesis of familial and sporadic ovarian serous carcinomas...
  65. doi request reprint The "reverse capture" autoantibody microarray : an innovative approach to profiling the autoantibody response to tissue-derived native antigens
    Joshua R Ehrlich
    Molecular Urology Laboratory, Division of Urology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 441:175-92. 2008
    ..Here, we present a detailed description of the "reverse capture" autoantibody microarray for use with tissue-derived native antigens...
  66. pmc Consortium analysis of 7 candidate SNPs for ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
    Int J Cancer 123:380-8. 2008
    ..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...
  67. ncbi request reprint Variants in Deleted in AZoospermia-Like (DAZL) are correlated with reproductive parameters in men and women
    Joyce Y Tung
    Department of Obstetrics, Program in Human Embryonic Stem Cell Biology, Center for Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94143, USA
    Hum Genet 118:730-40. 2006
    ..Single SNP and haplotype analysis suggested that SNPs in the DAZL gene may act jointly to affect common reproductive characteristics in the human population...
  68. ncbi request reprint Talc and anti-MUC1 antibodies
    Joshua Muscat
    Cancer Epidemiol Biomarkers Prev 14:2679; author reply 2680. 2005
  69. ncbi request reprint Association of galactose-1-phosphate uridyltransferase activity and N314D genotype with the risk of ovarian cancer
    Marc T Goodman
    Epidemiology Section, Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Am J Epidemiol 156:693-701. 2002
    ..42, 1.41). This study did not support the hypothesis that reduced galactose metabolism is a risk factor for ovarian cancer, although increased GALT activity attenuated the inverse association of oral contraceptive pill use with risk...
  70. ncbi request reprint The epidemiology of endometriosis
    Stacey A Missmer
    Ob Gyn Epidemiology Center, Brigham and Women s Hospital, 121 Longwood Avenue, Boston, MA 02115, USA
    Obstet Gynecol Clin North Am 30:1-19, vii. 2003
    ..Finally, they offer a brief interpretation of these findings and suggest hypotheses for future research...

Research Grants34

  1. Partners Southwestern Clinical Epidemiology/Validation
    Daniel Cramer; Fiscal Year: 2007
    ....
  2. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2006
    ..Our continued goal is to identify modifiable risk factors and chemo preventive agents for a common and lethal cancer in women. ..
  3. Risk for New onset of Depression in Perimenopausal Women
    Daniel Cramer; Fiscal Year: 2005
    ..abstract_text> ..
  4. OVARIAN CANCER RISK AND HYPERGONADOTROPIC HYPOGONADISM
    Daniel Cramer; Fiscal Year: 1999
    ..The investigators point out that only large, comprehensive epidemiologic studies capable of examining these factors within histologic subtypes are likely to succeed in identifying preventive mechanisms. ..
  5. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2004
    ..Our continued goal is to identify modifiable risk factors and chemo preventive agents for a common and lethal cancer in women. ..
  6. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2007
    ..Our continued goal is to identify modifiable risk factors and chemo preventive agents for a common and lethal cancer in women. ..
  7. MUC-1 related cancer immunity: determinants and predictive significance
    Daniel Cramer; Fiscal Year: 2007
    ..The findings of our study could provide the basis for developing a safe cancer- preventing vaccine for ovarian cancer and perhaps other MUC1-expressing tumors. ..
  8. Risk for New onset of Depression in Perimenopausal Women
    Daniel Cramer; Fiscal Year: 2007
    ..abstract_text> ..
  9. OVARIAN CANCER RISK AND HYPERGONADOTROPIC HYPOGONADISM
    Daniel Cramer; Fiscal Year: 2002
    ..The investigators point out that only large, comprehensive epidemiologic studies capable of examining these factors within histologic subtypes are likely to succeed in identifying preventive mechanisms. ..
  10. EPIDEMIOLOGIC AND BIOLOGIC PREDICTORS OF IVF SUCCESS
    Daniel Cramer; Fiscal Year: 2000
    ....
  11. OVARIAN CANCER RISK AND HYPERGONADOTROPIC HYPOGONADISM
    Daniel Cramer; Fiscal Year: 2000
    ..The investigators point out that only large, comprehensive epidemiologic studies capable of examining these factors within histologic subtypes are likely to succeed in identifying preventive mechanisms. ..
  12. OVARIAN CANCER RISK AND HYPERGONADOTROPIC HYPOGONADISM
    Daniel Cramer; Fiscal Year: 1993
    ..The role of galactose rich foods in ovarian cancer etiology is particularly important because of a substantial increase in the use of these foods in the United States...
  13. MUC-1 related cancer immunity: determinants and predictive significance
    Daniel Cramer; Fiscal Year: 2006
    ..The findings of our study could provide the basis for developing a safe cancer- preventing vaccine for ovarian cancer and perhaps other MUC1-expressing tumors. ..
  14. Risk for New onset of Depression in Perimenopausal Women
    Daniel Cramer; Fiscal Year: 2009
    ..abstract_text> ..
  15. MUC-1 related cancer immunity: determinants and predictive significance
    Daniel Cramer; Fiscal Year: 2009
    ..The findings of our study could provide the basis for developing a safe cancer- preventing vaccine for ovarian cancer and perhaps other MUC1-expressing tumors. ..
  16. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2005
    ..Our continued goal is to identify modifiable risk factors and chemo preventive agents for a common and lethal cancer in women. ..
  17. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2003
    ..Our continued goal is to identify modifiable risk factors and chemo preventive agents for a common and lethal cancer in women. ..
  18. EPIDEMIOLOGIC AND BIOLOGIC PREDICTORS OF IVF SUCCESS
    Daniel Cramer; Fiscal Year: 2002
    ....
  19. EPIDEMIOLOGIC AND BIOLOGIC PREDICTORS OF IVF SUCCESS
    Daniel Cramer; Fiscal Year: 1999
    ....
  20. OVARIAN CANCER RISK AND HYPERGONADOTROPIC HYPOGONADISM
    Daniel Cramer; Fiscal Year: 1992
    ..The role of galactose rich foods in ovarian cancer etiology is particularly important because of a substantial increase in the use of these foods in the United States...
  21. EPIDEMIOLOGIC AND BIOLOGIC PREDICTORS OF IVF SUCCESS
    Daniel Cramer; Fiscal Year: 2001
    ....
  22. OVARIAN CANCER RISK AND HYPERGONADOTROPIC HYPOGONADISM
    Daniel Cramer; Fiscal Year: 2001
    ..The investigators point out that only large, comprehensive epidemiologic studies capable of examining these factors within histologic subtypes are likely to succeed in identifying preventive mechanisms. ..