Michael Costigan

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Neuropathic pain: a maladaptive response of the nervous system to damage
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Neurosci 32:1-32. 2009
  2. ncbi request reprint Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity
    Robert S Griffin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 27:8699-708. 2007
  3. pmc Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1
    Michael Costigan
    F M Kirby Neurobiology Centre, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Brain 133:2519-27. 2010
  4. doi request reprint Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats
    Charles Mills
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Eur J Neurosci 27:937-46. 2008
  5. pmc COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice
    Daniel Vardeh
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 119:287-94. 2009
  6. pmc GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord
    Charles D Mills
    Neural Plasticity Research Group, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Mol Cell Neurosci 36:185-94. 2007
  7. pmc Analgesia by inhibiting tetrahydrobiopterin synthesis
    Michael Costigan
    FM Kirby Neurobiology Center, Children s Hospital Boston, and Department of Neurobiology, Harvard Medical School, 3 Blackfan Circle, CLS 12260, Boston, MA 02115, USA
    Curr Opin Pharmacol 12:92-9. 2012
  8. pmc The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling
    Chi H E Ma
    F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 31:18391-400. 2011
  9. ncbi request reprint GCH1, BH4 and pain
    Alban Latremoliere
    FM Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Curr Pharm Biotechnol 12:1728-41. 2011
  10. ncbi request reprint GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
    Irmgard Tegeder
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4309, Charlestown, Massachusetts 02129, USA
    Nat Med 12:1269-77. 2006

Research Grants

  1. The genetic basis of pain sensitivity
    Michael Costigan; Fiscal Year: 2006

Detail Information

Publications14

  1. pmc Neuropathic pain: a maladaptive response of the nervous system to damage
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Neurosci 32:1-32. 2009
    ..Treatment needs to move from merely suppressing symptoms to a disease-modifying strategy aimed at both preventing maladaptive plasticity and reducing intrinsic risk...
  2. ncbi request reprint Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity
    Robert S Griffin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 27:8699-708. 2007
    ..We conclude that induction of the complement cascade in spinal cord microglia after peripheral nerve injury contributes to neuropathic pain through the release and action of the C5a anaphylatoxin peptide...
  3. pmc Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1
    Michael Costigan
    F M Kirby Neurobiology Centre, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Brain 133:2519-27. 2010
    ..Screening for this allele could help define those individuals prone to a transition to persistent pain, and thus requiring therapeutic strategies or lifestyle changes that minimize nerve injury...
  4. doi request reprint Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats
    Charles Mills
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Eur J Neurosci 27:937-46. 2008
    ..Furthermore, although Ro5-4864 is only a very weak promoter of survival in adult neurons, it significantly enhances regeneration and functional recovery in adults...
  5. pmc COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice
    Daniel Vardeh
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 119:287-94. 2009
    ..Mechanical pain is a major symptom of most inflammatory conditions, such as postoperative pain and arthritis, and induction of COX2 in neural cells in the CNS seems to contribute to this...
  6. pmc GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord
    Charles D Mills
    Neural Plasticity Research Group, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Mol Cell Neurosci 36:185-94. 2007
    ..We conclude that peripheral nerve injury upregulates GDNF signaling pathway components and that exogenous GDNF treatment selectively promotes axonal growth of injury-primed sensory neurons in a concentration-dependent fashion...
  7. pmc Analgesia by inhibiting tetrahydrobiopterin synthesis
    Michael Costigan
    FM Kirby Neurobiology Center, Children s Hospital Boston, and Department of Neurobiology, Harvard Medical School, 3 Blackfan Circle, CLS 12260, Boston, MA 02115, USA
    Curr Opin Pharmacol 12:92-9. 2012
    ..SPR is part of the BH4 synthesis cascade and is also upregulated by nerve injury. Inhibiting SPR will reduce BH4 levels and therefore should act as an analgesic. We propose SSZ as a novel anti-neuropathic pain medicine...
  8. pmc The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling
    Chi H E Ma
    F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 31:18391-400. 2011
    ..Our data suggest a positive modulatory contribution of RGMb and BMP signaling to neurite extension in vitro and early axonal regrowth after nerve injury in vivo and a negative effect of Noggin...
  9. ncbi request reprint GCH1, BH4 and pain
    Alban Latremoliere
    FM Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Curr Pharm Biotechnol 12:1728-41. 2011
    ..We explain the nature of the GCH1 reduced-function haplotype and set out the potential for a ' BH4 blocking' drug as a novel analgesic...
  10. ncbi request reprint GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
    Irmgard Tegeder
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4309, Charlestown, Massachusetts 02129, USA
    Nat Med 12:1269-77. 2006
    ..BH4 is therefore an intrinsic regulator of pain sensitivity and chronicity, and the GTP cyclohydrolase haplotype is a marker for these traits...
  11. ncbi request reprint The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity
    Fumimasa Amaya
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:12852-60. 2006
    ..9-/- mice. Na(v)1.9 is, we conclude, an effector of the hypersensitivity produced by multiple inflammatory mediators on nociceptor peripheral terminals and therefore plays a key role in mediating peripheral sensitization...
  12. pmc Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice
    Chi Him Eddie Ma
    Program in Neurobiology and F M Kirby Neurobiology Center, Children s Hospital Boston, and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 121:4332-47. 2011
    ..Thus, absence of motor recovery after nerve damage may result from a failure of synapse reformation after prolonged denervation rather than a failure of axonal growth...
  13. ncbi request reprint High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 13th Street, Building 149 4309, Charlestown, MA 02129, USA
    Mol Cell Neurosci 24:106-16. 2003
    ..Decreased levels of RGS3 and RGS4 in injured sensory neurons is likely to result in an increased GPCR sensitivity, and therefore contribute to alterations in cellular function seen after such lesions...
  14. pmc Exploiting microarrays to reveal differential gene expression in the nervous system
    Robert S Griffin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Genome Biol 4:105. 2003
    ..This article highlights what is needed to get the most out of microarrays in terms of accurately and effectively revealing differential gene expression and regulation in the nervous system...

Research Grants1

  1. The genetic basis of pain sensitivity
    Michael Costigan; Fiscal Year: 2006
    ....