Karen H Costenbader

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Cigarette smoking and systemic lupus erythematosus: a smoking gun?
    Karen H Costenbader
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Boston, MA 02115, USA
    Autoimmunity 38:541-7. 2005
  2. pmc Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis
    Elizabeth W Karlson
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Care Res (Hoboken) 65:1147-56. 2013
  3. pmc Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage, 2000-2004
    Candace H Feldman
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 65:753-63. 2013
  4. pmc Ambient air pollution exposures and risk of rheumatoid arthritis
    Jaime E Hart
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 65:1190-6. 2013
  5. pmc Variation in initial kidney replacement therapy for end-stage renal disease due to lupus nephritis in the United States
    Amy Devlin
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 63:1642-53. 2011
  6. pmc End-stage renal disease due to lupus nephritis among children in the US, 1995-2006
    Linda T Hiraki
    Harvard School of Public Health and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Rheum 63:1988-97. 2011
  7. pmc Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study
    Elizabeth V Arkema
    Correspondence to Dr Elizabeth V Arkema, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, 9th Floor, Boston, MA 02115
    Ann Rheum Dis 72:506-11. 2013
  8. pmc Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 10:R52. 2008
  9. pmc Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset
    Lori B Chibnik
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e24380. 2011
  10. pmc Early life factors and adult-onset rheumatoid arthritis
    Julia F Simard
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Rheumatol 37:32-7. 2010

Detail Information

Publications63

  1. ncbi request reprint Cigarette smoking and systemic lupus erythematosus: a smoking gun?
    Karen H Costenbader
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Boston, MA 02115, USA
    Autoimmunity 38:541-7. 2005
    ..5 [95% CI 1.09, 2.08]), but no increased risk associated with past smoking. The strengths and weaknesses of these data and potential implications are discussed...
  2. pmc Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis
    Elizabeth W Karlson
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Care Res (Hoboken) 65:1147-56. 2013
    ..We developed rheumatoid arthritis (RA) risk models based on validated environmental factors (E), genetic risk scores (GRS), and gene-environment interactions (GEI) to identify factors that can improve accuracy and reclassification...
  3. pmc Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage, 2000-2004
    Candace H Feldman
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 65:753-63. 2013
    ..This study was undertaken to investigate the epidemiology and sociodemographics of SLE and LN in the low-income US Medicaid population...
  4. pmc Ambient air pollution exposures and risk of rheumatoid arthritis
    Jaime E Hart
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 65:1190-6. 2013
    ..Herein, we examined whether long-term exposures to specific air pollutants were associated with RA risk among women in the Nurses' Health Study (NHS)...
  5. pmc Variation in initial kidney replacement therapy for end-stage renal disease due to lupus nephritis in the United States
    Amy Devlin
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 63:1642-53. 2011
    ..We aimed to identify sociodemographic and clinical factors associated with variation in initial kidney replacement therapies among LN ESRD patients...
  6. pmc End-stage renal disease due to lupus nephritis among children in the US, 1995-2006
    Linda T Hiraki
    Harvard School of Public Health and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Rheum 63:1988-97. 2011
    ..To identify predictors of wait-listing for kidney transplantation, kidney transplantation, and mortality among children with lupus nephritis-associated end-stage renal disease (ESRD)...
  7. pmc Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study
    Elizabeth V Arkema
    Correspondence to Dr Elizabeth V Arkema, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, 9th Floor, Boston, MA 02115
    Ann Rheum Dis 72:506-11. 2013
    ..To examine the association between ultraviolet-B (UV-B) light exposure and rheumatoid arthritis (RA) risk among women in two large prospective cohort studies, the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHSII)...
  8. pmc Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 10:R52. 2008
    ..We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large prospective cohorts, adjusting for confounding factors and testing for interactions with smoking...
  9. pmc Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset
    Lori B Chibnik
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e24380. 2011
    ..Cumulative genetic profiles can help identify individuals at high-risk for developing RA. We examined the impact of 39 validated genetic risk alleles on the risk of RA phenotypes characterized by serologic and erosive status...
  10. pmc Early life factors and adult-onset rheumatoid arthritis
    Julia F Simard
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Rheumatol 37:32-7. 2010
    ..We investigated the association of preterm birth and being breastfed with the incidence of rheumatoid arthritis (RA) in 2 large prospective cohorts...
  11. ncbi request reprint Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    Eli A Stahl
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 42:508-14. 2010
    ..An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles...
  12. pmc Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies
    Elizabeth W Karlson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 60:641-52. 2009
    ..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)...
  13. pmc A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res Ther 11:R97. 2009
    ....
  14. pmc Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupus nephritis in the US from 1995 to 2006
    Karen H Costenbader
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 63:1681-8. 2011
    ....
  15. pmc Ambient air pollution exposures and risk of rheumatoid arthritis: results from the Swedish EIRA case-control study
    Jaime E Hart
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Rheum Dis 72:888-94. 2013
    ..We examined whether long-term exposures to air pollution were associated with the risk of RA in the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study...
  16. pmc Dietary intake of vitamin D during adolescence and risk of adult-onset systemic lupus erythematosus and rheumatoid arthritis
    Linda T Hiraki
    Harvard School of Public Health and Brigham and Women s Hospital, Boston, MA 02115, USA
    Arthritis Care Res (Hoboken) 64:1829-36. 2012
    ....
  17. ncbi request reprint A pravastatin dose-escalation study in systemic lupus erythematosus
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Rheumatol Int 27:1071-7. 2007
    ..Pravastatin reduced LDL and total cholesterol levels approximately the same degree observed in normal individuals, but the effect appeared blunted in those on modest doses of glucocorticoids and those with higher BMI...
  18. ncbi request reprint Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus project
    Elizabeth W Karlson
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 56:244-54. 2007
    ..Our goal was to assess association of residential proximity to hazardous waste sites and genetic variation in 3 glutathione Stransferase (GST) genes (GSTM1, GSTT1, and GSTP1) with age at diagnosis of SLE...
  19. pmc Prevalence, incidence, and demographics of systemic lupus erythematosus and lupus nephritis from 2000 to 2004 among children in the US Medicaid beneficiary population
    Linda T Hiraki
    Harvard School of Public Health and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Rheum 64:2669-76. 2012
    ..To investigate the nationwide prevalence, incidence, and sociodemographics of systemic lupus erythematosus (SLE) and lupus nephritis among children in the US Medicaid beneficiary population...
  20. pmc Systemic lupus erythematosus and the risk of cardiovascular disease: results from the nurses' health study
    A Elisabeth Hak
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 61:1396-402. 2009
    ..Systemic lupus erythematosus (SLE) has been associated with an increased risk of cardiovascular disease. However, prospective population-based data addressing this association have been lacking...
  21. doi request reprint Outcomes in hospitalized pediatric patients with systemic lupus erythematosus
    Mary Beth F Son
    Division of Immunology, Boston Children s Hospital, 300 Longwood Ave, Boston, MA 02115
    Pediatrics 133:e106-13. 2014
    ..We investigated associations between sociodemographic factors and volume of annual inpatient hospital admissions with hospitalization characteristics and poor outcomes among patients with childhood-onset SLE...
  22. pmc Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity
    Jose C Crispin
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 62:1431-7. 2010
    ....
  23. pmc Alcohol consumption and markers of inflammation in women with preclinical rheumatoid arthritis
    Bing Lu
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 62:3554-9. 2010
    ..To examine the association between alcohol consumption and markers of inflammation in preclinical rheumatoid arthritis (RA)...
  24. pmc Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women
    Karen H Costenbader
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 172:205-16. 2010
    ..In these large, prospective cohorts of women, antioxidant intake was not associated with the risk of developing either rheumatoid arthritis or systemic lupus erythematosus...
  25. pmc Comparison of threshold cutpoints and continuous measures of anti-cyclic citrullinated peptide antibodies in predicting future rheumatoid arthritis
    Lori B Chibnik
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Rheumatol 36:706-11. 2009
    ..While the anti-CCP level is commonly dichotomized for clinical use, the best threshold for and utility of the titer as a continuous variable to predict development of RA are uncertain...
  26. pmc Perinatal factors and adult-onset lupus
    Julia F Simard
    Department of Epidemiology, Harvard University School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Arthritis Rheum 59:1155-61. 2008
    ..Therefore, we evaluated the role of birth weight, being breastfed, and preterm birth on the incidence of SLE in participants in the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHSII)...
  27. pmc Association of discoid lupus erythematosus with other clinical manifestations among patients with systemic lupus erythematosus
    Joseph F Merola
    Department of Medicine, Division of Rheumatology, Allergy and Immunology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02118, USA
    J Am Acad Dermatol 69:19-24. 2013
    ..Cutaneous discoid lupus erythematosus (DLE) among patients with systemic lupus erythematosus (SLE) may be associated with less severe disease and with low frequency of nephritis and end-stage renal disease (ESRD)...
  28. pmc Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Rheumatology (Oxford) 48:613-7. 2009
    ..We examined the association between candidate single nucleotide polymorphisms (SNPs) and disease activity in RA patients on MTX...
  29. pmc Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
    Soumya Raychaudhuri
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 41:1313-8. 2009
    ..0008 replication, P = 4 x 10(-6) overall) and FCGR2A (rs12746613, P = 0.0022 replication, P = 2 x 10(-5) overall). Many of these loci are also associated to other immunologic diseases...
  30. ncbi request reprint Factors determining participation in prevention trials among systemic lupus erythematosus patients: a qualitative study
    Karen H Costenbader
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 57:49-55. 2007
    ..Our goal was to determine factors that patients with SLE consider in deciding about participating in prevention trials, to uncover concerns about SLE trials, and to investigate how study design and purpose affect participation decisions...
  31. pmc Exposure to traffic pollution and increased risk of rheumatoid arthritis
    Jaime E Hart
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Environ Health Perspect 117:1065-9. 2009
    ..Particulate air pollution, especially of traffic origin, has been linked to systemic inflammation in many studies...
  32. pmc The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility
    Yvonne C Lee
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 60:1250-4. 2009
    ..The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility...
  33. pmc Geographic variation in rheumatoid arthritis incidence among women in the United States
    Karen H Costenbader
    Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Arch Intern Med 168:1664-70. 2008
    ..The geographic variation in rheumatoid arthritis (RA) incidence in the United States is unknown...
  34. doi request reprint The epidemiology of atherosclerotic cardiovascular disease among patients with SLE: a systematic review
    Sara R Schoenfeld
    Department of Medicine, Massachusetts General Hospital, Boston, MA 02115, USA
    Semin Arthritis Rheum 43:77-95. 2013
    ....
  35. ncbi request reprint Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 119:503.e1-9. 2006
    ....
  36. ncbi request reprint Barriers to a trial of atherosclerosis prevention in systemic lupus erythematosus
    Karen H Costenbader
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Arthritis Rheum 53:718-23. 2005
    ..We describe our experience in recruiting and retaining patients with SLE in this trial...
  37. ncbi request reprint Cardiac risk factor awareness and management in patients with systemic lupus erythematosus
    Karen H Costenbader
    Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 51:983-8. 2004
    ..To assess awareness and management of traditional cardiac risk factors (CRFs) in patients with systemic lupus erythematosus (SLE) and physicians...
  38. pmc A prospective study of periodontal disease and risk of rheumatoid arthritis
    Elizabeth V Arkema
    Department of Epidemology, Harvard School of Public Health, Boston, MA, USA
    J Rheumatol 37:1800-4. 2010
    ..To test for an association between periodontal disease (PD) and incident rheumatoid arthritis (RA) in a large prospective cohort...
  39. ncbi request reprint Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban women
    Axel Finckh
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 54:3648-54. 2006
    ..To assess the risk of systemic lupus erythematosus (SLE) associated with occupational exposure to silica dust and organic solvents in an urban population...
  40. ncbi request reprint Reproductive and menopausal factors and risk of systemic lupus erythematosus in women
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Arthritis Rheum 56:1251-62. 2007
    ..This study was carried out to examine associations between female reproductive and menopausal factors and the development of SLE...
  41. pmc Development and initial validation of a self-assessed lupus organ damage instrument
    Karen H Costenbader
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    Arthritis Care Res (Hoboken) 62:559-68. 2010
    ..Trained physicians must complete it, thus limiting utility where this is impossible...
  42. ncbi request reprint Comparison of the 1987 American College of Rheumatology and the 2010 American College of Rheumatology/European League against Rheumatism criteria for classification of rheumatoid arthritis in the Nurses' Health Study cohorts
    Shanthini Kasturi
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Rheumatol Int 34:407-11. 2014
    ..Using the 2010 ACR/EULAR criteria alone had decreased sensitivity, and seronegative RA cases would be excluded in particular. Combined use of both will be necessary to maximize inclusion and allow sensitivity analyses. ..
  43. ncbi request reprint The association between silica exposure and development of ANCA-associated vasculitis: systematic review and meta-analysis
    José A Gómez-Puerta
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, United States Electronic address
    Autoimmun Rev 12:1129-35. 2013
    ..We aimed to conduct a systematic review of the existing studies and meta-analysis of their results...
  44. ncbi request reprint Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 50:849-57. 2004
    ..We performed an extensive search of the medical literature for all studies examining this relationship, and performed a meta-analysis to arrive at a more precise estimate of effect...
  45. doi request reprint Epidemiology: Interpreting studies of interactions between RA risk factors
    Elizabeth W Karlson
    Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Nat Rev Rheumatol 6:72-3. 2010
    ..As recent epidemiological evidence shows, deciphering these interactions demands consideration of the analytical approach used...
  46. pmc Disparities in lupus care and outcomes
    Kristina L Demas
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Rheumatol 21:102-9. 2009
    ..We summarize the current knowledge of the disparities observed in SLE and highlight recent research that aims to dissect the causes of these disparities and identify the potentially modifiable factors contributing to them...
  47. doi request reprint Sexual disparities in the incidence and course of SLE and RA
    Sara K Tedeschi
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Harvard Medical School, 75 Francis Street, Boston, MA, USA
    Clin Immunol 149:211-8. 2013
    ..This article reviews current hypotheses regarding the potential impact of sex hormones and genetics on disease pathogenesis, incidence, and severity of SLE and RA. ..
  48. doi request reprint Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?
    Karen H Costenbader
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA
    Autoimmun Rev 11:604-9. 2012
    ....
  49. pmc Epstein-Barr virus serologic abnormalities and risk of rheumatoid arthritis among women
    Barbara L Goldstein
    Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Autoimmunity 45:161-8. 2012
    ..Epstein-Barr virus (EBV) infection and the immune response may be involved in the pathogenesis of rheumatoid arthritis (RA). Past studies have suggested an association between EBV and RA...
  50. doi request reprint C-reactive protein, anti-C-reactive protein antibodies and clinical atherosclerosis
    Barbara J Rosenau
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine and the Division of Laboratory Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Vasc Med 13:25-8. 2008
    ..These observations suggest that anti-CRP antibody is not involved in atherosclerosis, and may represent an epiphenomenon...
  51. pmc Epstein-Barr virus and rheumatoid arthritis: is there a link?
    Karen H Costenbader
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 8:204. 2006
    ..In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein-Barr virus and rheumatoid arthritis is reviewed...
  52. ncbi request reprint Treatment and management of early RA: A primary care primer
    Karen H Costenbader
    Harvard Medical School, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA USA
    J Fam Pract 56:S1-7; quiz S8. 2007
    ....
  53. ncbi request reprint Defining lupus cases for clinical studies: the Boston weighted criteria for the classification of systemic lupus erythematosus
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Disease Clinical Research Center, Boston, Massachusetts, USA
    J Rheumatol 29:2545-50. 2002
    ..We developed and evaluated the ability of a weighted classification system to identify a broader spectrum of patients with lupus...
  54. pmc SLE - Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus
    Karen H Costenbader
    The Robert B, Brigham Arthritis and Musculoskeletal Disease Clinical Research Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Res Ther 5:178-9. 2003
    ..Studies from several centers have shown that suboptimal risk factor management and barriers to acceptance of these measures must also be studied further...
  55. ncbi request reprint Characteristics of patients with systemic lupus erythematosus (SLE) and non-Hodgkin's lymphoma (NHL)
    Jennifer K King
    Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Rehab Center Room 32 59, Los Angeles, CA 90095, USA
    Clin Rheumatol 26:1491-4. 2007
    ....
  56. pmc The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological report
    Tuhina Neogi
    Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 62:2582-91. 2010
    ..The aim of Phase 2 of the development process was to achieve expert consensus on the clinical and laboratory variables that should contribute to the final criteria set...
  57. ncbi request reprint Statin therapy in rheumatoid arthritis
    Karen H Costenbader
    Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    South Med J 98:534-40; quiz 541, 572. 2005
    ..Recent studies show that statins may provide mild anti-inflammatory benefit in rheumatoid arthritis, in addition to reducing cardiovascular risk...
  58. pmc Immunosenescence and rheumatoid arthritis: does telomere shortening predict impending disease?
    Karen H Costenbader
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Autoimmun Rev 10:569-73. 2011
    ....
  59. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-2006. A 43-year-old woman with painful nodules on the fingertips, shortness of breath, and fatigue
    Karen H Costenbader
    Department of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, USA
    N Engl J Med 355:1263-72. 2006
  60. pmc Does vitamin D affect risk of developing autoimmune disease?: a systematic review
    Martin A Kriegel
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Semin Arthritis Rheum 40:512-531.e8. 2011
    ..We evaluated the epidemiologic evidence that vitamin D may be related to human autoimmune disease risk...
  61. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  62. ncbi request reprint Do female hormones affect the onset or severity of rheumatoid arthritis?
    Karen H Costenbader
    Arthritis Rheum 59:299-301. 2008
  63. ncbi request reprint Risk of serious infections and malignancies with anti-TNF antibody therapy in rheumatoid arthritis
    Karen H Costenbader
    JAMA 296:2201; author reply 2203-4. 2006