Research Topics
Genomes and GenesSpecies | K H CostenbaderSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritisElizabeth W Karlson
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Res Ther 11:R97. 2009....
A pravastatin dose-escalation study in systemic lupus erythematosusKaren H Costenbader
Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Rheumatol Int 27:1071-7. 2007..Pravastatin reduced LDL and total cholesterol levels approximately the same degree observed in normal individuals, but the effect appeared blunted in those on modest doses of glucocorticoids and those with higher BMI...- Cigarette smoking and autoimmune disease: what can we learn from epidemiology?K H Costenbader
Division of Rheumatology, Immunology and Allergy, Section of Clinical Sciences, PBB B3, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Lupus 15:737-45. 2006.... - Osteoporosis and cardiovascular disease care in systemic lupus erythematosus according to new quality indicatorsKristina L Demas
George Washington School of Medicine, Washington, DC, USA
Semin Arthritis Rheum 40:193-200. 2010..We evaluated care according to these proposed QIs for osteoporosis and cardiovascular disease (CVD) in patients with SLE in our rheumatology practice... - Factors determining participation in prevention trials among systemic lupus erythematosus patients: a qualitative studyKaren H Costenbader
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 57:49-55. 2007..Our goal was to determine factors that patients with SLE consider in deciding about participating in prevention trials, to uncover concerns about SLE trials, and to investigate how study design and purpose affect participation decisions... - Reproductive and menopausal factors and risk of systemic lupus erythematosus in womenKaren H Costenbader
Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, and Harvard School of Public Health, Boston, Massachusetts 02115, USA
Arthritis Rheum 56:1251-62. 2007..This study was carried out to examine associations between female reproductive and menopausal factors and the development of SLE... - Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in womenK H Costenbader
Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Ann Rheum Dis 67:530-5. 2008..Vitamin D has immune-modulating effects and may protect against the development of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)... - Discordance between erythrocyte sedimentation rate and C-reactive protein measurements: clinical significanceK H Costenbader
Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
Clin Exp Rheumatol 25:746-9. 2007..C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are common measures of systemic inflammation. Our goal was to identify clinical factors associated with CRP/ESR discordance... - Geographic variation in rheumatoid arthritis incidence among women in the United StatesKaren H Costenbader
Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Arch Intern Med 168:1664-70. 2008..The geographic variation in rheumatoid arthritis (RA) incidence in the United States is unknown... - Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in womenKaren H Costenbader
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Epidemiol 172:205-16. 2010..In these large, prospective cohorts of women, antioxidant intake was not associated with the risk of developing either rheumatoid arthritis or systemic lupus erythematosus... - Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupus nephritis in the US from 1995 to 2006Karen H Costenbader
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 63:1681-8. 2011.... - Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smokingKaren H Costenbader
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Res Ther 10:R52. 2008..We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large prospective cohorts, adjusting for confounding factors and testing for interactions with smoking... - Barriers to a trial of atherosclerosis prevention in systemic lupus erythematosusKaren H Costenbader
Brigham and Women s Hospital, Boston, MA 02115, USA
Arthritis Rheum 53:718-23. 2005..We describe our experience in recruiting and retaining patients with SLE in this trial... - Statin therapy in rheumatoid arthritisKaren H Costenbader
Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
South Med J 98:534-40; quiz 541, 572. 2005..Recent studies show that statins may provide mild anti-inflammatory benefit in rheumatoid arthritis, in addition to reducing cardiovascular risk... 
SLE - Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosusKaren H Costenbader
The Robert B, Brigham Arthritis and Musculoskeletal Disease Clinical Research Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
Arthritis Res Ther 5:178-9. 2003..Studies from several centers have shown that suboptimal risk factor management and barriers to acceptance of these measures must also be studied further...- Immunosenescence and rheumatoid arthritis: does telomere shortening predict impending disease?Karen H Costenbader
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Autoimmun Rev 10:569-73. 2011.... - Cardiac risk factor awareness and management in patients with systemic lupus erythematosusKaren H Costenbader
Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 51:983-8. 2004..To assess awareness and management of traditional cardiac risk factors (CRFs) in patients with systemic lupus erythematosus (SLE) and physicians... - Epstein-Barr virus and rheumatoid arthritis: is there a link?Karen H Costenbader
Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Arthritis Res Ther 8:204. 2006..In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein-Barr virus and rheumatoid arthritis is reviewed... - Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in womenKaren H Costenbader
Division of Rheumatology, Immunology, and Allergy, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Am J Med 119:503.e1-9. 2006.... 
Quantifying anti-cyclic citrullinated peptide titres: clinical utility and association with tobacco exposure in patients with rheumatoid arthritisD M Lee
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 552B, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
Ann Rheum Dis 68:201-8. 2009..To determine the significance of quantitative levels of antibodies to cyclic citrullinated peptides (anti-CCP) in a population of patients with rheumatoid arthritis (RA)...- Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritisE W Karlson
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
Ann Rheum Dis 69:54-60. 2010..To address the effect of dosage, a case-control study nested within two prospective cohorts to determine the interaction between heavy smoking and the HLA-SE was conducted... - Is birthweight associated with risk of rheumatoid arthritis? Data from a large cohort studyL A Mandl
Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York City, New York 10021, USA
Ann Rheum Dis 68:514-8. 2009..We examine whether the fetal environment, as reflected by birthweight, could modulate an individual's future risk of rheumatoid arthritis (RA)... - A controlled comparison of brachial artery flow mediated dilation (FMD) and digital pulse amplitude tonometry (PAT) in the assessment of endothelial function in systemic lupus erythematosusJ Aizer
Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York 10021, USA
Lupus 18:235-42. 2009..FMD did not correlate with PAT except in SLE cases with a history of Raynaud's. Correlation between FMD and PAT may be stronger in populations with greater variation in endothelial function and more cardiovascular risk factors... - Anti-cyclic citrullinated peptide revised criteria for the classification of rheumatoid arthritisK P Liao
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Ann Rheum Dis 67:1557-61. 2008..We developed and tested the performance characteristics of new criteria for RA classification, incorporating anti-CCP... - Exposure to maternal smoking and incident SLE in a prospective cohort studyJ F Simard
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Lupus 18:431-5. 2009..0, 95% CI: 0.8 to 1.3) in combined analyses. Early-life exposure to cigarette smoke due to mothers' or fathers' smoking was not associated with increased risk of adult-onset SLE in women... - What can epidemiology tell us about systemic lupus erythematosus?J F Simard
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Int J Clin Pract 61:1170-80. 2007..While epidemiologic research has contributed an enormous amount to our understanding of the disease and its pathogenesis, there are many more avenues of epidemiologic research that deserve to be pursued... - Identification and validation of lupus nephritis cases using administrative dataL B Chibnik
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Lupus 19:741-3. 2010..This strategy may offer a sound method of identifying patients with lupus nephritis for health services research in addition to serving as a model for using claims data as a way to better understand rare diseases such as lupus... - Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexateYvonne C Lee
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Rheumatology (Oxford) 48:613-7. 2009..We examined the association between candidate single nucleotide polymorphisms (SNPs) and disease activity in RA patients on MTX... - The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibilityYvonne C Lee
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 60:1250-4. 2009..The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility... - Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studiesElizabeth W Karlson
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Rheum 60:641-52. 2009..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)... - Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis riskSoumya Raychaudhuri
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Nat Genet 41:1313-8. 2009..0008 replication, P = 4 x 10(-6) overall) and FCGR2A (rs12746613, P = 0.0022 replication, P = 2 x 10(-5) overall). Many of these loci are also associated to other immunologic diseases... - Epidemiology: Interpreting studies of interactions between RA risk factorsElizabeth W Karlson
Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Nat Rev Rheumatol 6:72-3. 2010..As recent epidemiological evidence shows, deciphering these interactions demands consideration of the analytical approach used... - Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus projectElizabeth W Karlson
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 56:244-54. 2007..Our goal was to assess association of residential proximity to hazardous waste sites and genetic variation in 3 glutathione Stransferase (GST) genes (GSTM1, GSTT1, and GSTP1) with age at diagnosis of SLE... - Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysisKaren H Costenbader
Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 50:849-57. 2004..We performed an extensive search of the medical literature for all studies examining this relationship, and performed a meta-analysis to arrive at a more precise estimate of effect... - Alcohol consumption and markers of inflammation in women with preclinical rheumatoid arthritisBing Lu
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 62:3554-9. 2010..To examine the association between alcohol consumption and markers of inflammation in preclinical rheumatoid arthritis (RA)... - Cigarette smoking and systemic lupus erythematosus: a smoking gun?Karen H Costenbader
Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Boston, MA 02115, USA
Autoimmunity 38:541-7. 2005..5 [95% CI 1.09, 2.08]), but no increased risk associated with past smoking. The strengths and weaknesses of these data and potential implications are discussed... - Dyspnoea in a young woman with active systemic lupus erythematosusDerrick J Todd
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Arthritis Center, Boston, Massachusetts 02115, USA
Lupus 18:777-84. 2009..Despite recent advances in therapy, mortality has not improved substantially (48% overall survival versus 53% survival in reports published since 1993)... - Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activityJose C Crispin
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 62:1431-7. 2010.... - Systemic lupus erythematosus and the risk of cardiovascular disease: results from the nurses' health studyA Elisabeth Hak
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 61:1396-402. 2009..Systemic lupus erythematosus (SLE) has been associated with an increased risk of cardiovascular disease. However, prospective population-based data addressing this association have been lacking... - Perinatal factors and adult-onset lupusJulia F Simard
Department of Epidemiology, Harvard University School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Arthritis Rheum 59:1155-61. 2008..Therefore, we evaluated the role of birth weight, being breastfed, and preterm birth on the incidence of SLE in participants in the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHSII)... - Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban womenAxel Finckh
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 54:3648-54. 2006..To assess the risk of systemic lupus erythematosus (SLE) associated with occupational exposure to silica dust and organic solvents in an urban population... - Co-existing sarcoidosis, systemic lupus erythematosus and the antiphospholipid antibody syndrome: case reports and discussion from the Brigham and Women's Hospital Lupus CenterD R Wesemann
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Lupus 18:202-5. 2009..The association of sarcoidosis, SLE and APS is unique and may present difficult therapeutic options, as well as to shed light on their immunopathogenesis... - High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American womenE W Karlson
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Lupus 14:832-6. 2005..These results suggest that the CSQ has adequate sensitivity and specificity and could be used in population studies to screen African-American women for SLE... - Early life factors and adult-onset rheumatoid arthritisJulia F Simard
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
J Rheumatol 37:32-7. 2010..We investigated the association of preterm birth and being breastfed with the incidence of rheumatoid arthritis (RA) in 2 large prospective cohorts... - Disparities in lupus care and outcomesKristina L Demas
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Curr Opin Rheumatol 21:102-9. 2009..We summarize the current knowledge of the disparities observed in SLE and highlight recent research that aims to dissect the causes of these disparities and identify the potentially modifiable factors contributing to them... - Exposure to traffic pollution and increased risk of rheumatoid arthritisJaime E Hart
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Environ Health Perspect 117:1065-9. 2009..Particulate air pollution, especially of traffic origin, has been linked to systemic inflammation in many studies... - Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lociEli A Stahl
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Nat Genet 42:508-14. 2010..An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles... - Designing an intervention for women with systemic lupus erythematosus from medically underserved areas to improve care: a qualitative studyC H Feldman
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Lupus 22:52-62. 2013..Systemic lupus erythematosus (lupus) disproportionately affects women, racial/ethnic minorities and low-income populations. We held focus groups for women from medically underserved communities to discuss interventions to improve care... - Abatacept in the treatment of rheumatoid arthritisD J Todd
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Int J Clin Pract 61:494-500. 2007..We also address the role of abatacept in the greater context of biological therapy for RA... - Treatment and management of early RA: A primary care primerKaren H Costenbader
Harvard Medical School, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA USA
J Fam Pract 56:S1-7; quiz S8. 2007.... - C-reactive protein, anti-C-reactive protein antibodies and clinical atherosclerosisBarbara J Rosenau
Division of Rheumatology, Immunology, and Allergy, Department of Medicine and the Division of Laboratory Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Vasc Med 13:25-8. 2008..These observations suggest that anti-CRP antibody is not involved in atherosclerosis, and may represent an epiphenomenon... - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-2006. A 43-year-old woman with painful nodules on the fingertips, shortness of breath, and fatigueKaren H Costenbader
Department of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, USA
N Engl J Med 355:1263-72. 2006 - The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological reportTuhina Neogi
Boston University School of Medicine, Boston, Massachusetts, USA
Arthritis Rheum 62:2582-91. 2010..The aim of Phase 2 of the development process was to achieve expert consensus on the clinical and laboratory variables that should contribute to the final criteria set... - Defining lupus cases for clinical studies: the Boston weighted criteria for the classification of systemic lupus erythematosusKaren H Costenbader
Robert B. Brigham Arthritis and Musculoskeletal Disease Clinical Research Center, Boston, Massachusetts, USA
J Rheumatol 29:2545-50. 2002..This reflects the inclusion of patients with objective findings of SLE but less than 4 ACR criteria. Our Boston Criteria system could minimize selection bias and increase the generalizability of clinical SLE studies... - Characteristics of patients with systemic lupus erythematosus (SLE) and non-Hodgkin's lymphoma (NHL)Jennifer K King
Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Rehab Center Room 32 59, Los Angeles, CA 90095, USA
Clin Rheumatol 26:1491-4. 2007.... - Comparison of threshold cutpoints and continuous measures of anti-cyclic citrullinated peptide antibodies in predicting future rheumatoid arthritisLori B Chibnik
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
J Rheumatol 36:706-11. 2009..While the anti-CCP level is commonly dichotomized for clinical use, the best threshold for and utility of the titer as a continuous variable to predict development of RA are uncertain... - Development and initial validation of a self-assessed lupus organ damage instrumentKaren H Costenbader
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
Arthritis Care Res (Hoboken) 62:559-68. 2010..Trained physicians must complete it, thus limiting utility where this is impossible... - Do female hormones affect the onset or severity of rheumatoid arthritis?Karen H Costenbader
Arthritis Rheum 59:299-301. 2008 - Common variants at CD40 and other loci confer risk of rheumatoid arthritisSoumya Raychaudhuri
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nat Genet 40:1216-23. 2008..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)... - Risk of serious infections and malignancies with anti-TNF antibody therapy in rheumatoid arthritisKaren H Costenbader
JAMA 296:2201; author reply 2203-4. 2006
Research Grants
- Sociodemographic Disparities in Lupus Nephritis: Healthcare Access and OutcomesKaren Costenbader; Fiscal Year: 2009..S., often causing kidney failure. The reasons why some groups suffer worse outcomes are not known. We will investigate how differences in healthcare access are related to "gaps" in outcomes for lupus kidney disease. ..
- Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint PainKaren H Costenbader; Fiscal Year: 2010....
- Novel Biomarkers and Causal Pathways in RA SusceptbilityKaren H Costenbader; Fiscal Year: 2010....
- Sociodemographic Disparities in Lupus Nephritis: Healthcare Access and OutcomesKaren H Costenbader; Fiscal Year: 2010..S., often causing kidney failure. The reasons why some groups suffer worse outcomes are not known. We will investigate how differences in healthcare access are related to "gaps" in outcomes for lupus kidney disease. ..