K H Costenbader

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res Ther 11:R97. 2009
  2. ncbi request reprint A pravastatin dose-escalation study in systemic lupus erythematosus
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Rheumatol Int 27:1071-7. 2007
  3. ncbi request reprint Cigarette smoking and autoimmune disease: what can we learn from epidemiology?
    K H Costenbader
    Division of Rheumatology, Immunology and Allergy, Section of Clinical Sciences, PBB B3, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Lupus 15:737-45. 2006
  4. pmc Osteoporosis and cardiovascular disease care in systemic lupus erythematosus according to new quality indicators
    Kristina L Demas
    George Washington School of Medicine, Washington, DC, USA
    Semin Arthritis Rheum 40:193-200. 2010
  5. ncbi request reprint Factors determining participation in prevention trials among systemic lupus erythematosus patients: a qualitative study
    Karen H Costenbader
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 57:49-55. 2007
  6. ncbi request reprint Reproductive and menopausal factors and risk of systemic lupus erythematosus in women
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Arthritis Rheum 56:1251-62. 2007
  7. pmc Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women
    K H Costenbader
    Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ann Rheum Dis 67:530-5. 2008
  8. ncbi request reprint Discordance between erythrocyte sedimentation rate and C-reactive protein measurements: clinical significance
    K H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Clin Exp Rheumatol 25:746-9. 2007
  9. pmc Geographic variation in rheumatoid arthritis incidence among women in the United States
    Karen H Costenbader
    Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Arch Intern Med 168:1664-70. 2008
  10. pmc Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women
    Karen H Costenbader
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 172:205-16. 2010

Detail Information

Publications60

  1. pmc A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res Ther 11:R97. 2009
    ....
  2. ncbi request reprint A pravastatin dose-escalation study in systemic lupus erythematosus
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Rheumatol Int 27:1071-7. 2007
    ..Pravastatin reduced LDL and total cholesterol levels approximately the same degree observed in normal individuals, but the effect appeared blunted in those on modest doses of glucocorticoids and those with higher BMI...
  3. ncbi request reprint Cigarette smoking and autoimmune disease: what can we learn from epidemiology?
    K H Costenbader
    Division of Rheumatology, Immunology and Allergy, Section of Clinical Sciences, PBB B3, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Lupus 15:737-45. 2006
    ....
  4. pmc Osteoporosis and cardiovascular disease care in systemic lupus erythematosus according to new quality indicators
    Kristina L Demas
    George Washington School of Medicine, Washington, DC, USA
    Semin Arthritis Rheum 40:193-200. 2010
    ..We evaluated care according to these proposed QIs for osteoporosis and cardiovascular disease (CVD) in patients with SLE in our rheumatology practice...
  5. ncbi request reprint Factors determining participation in prevention trials among systemic lupus erythematosus patients: a qualitative study
    Karen H Costenbader
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 57:49-55. 2007
    ..Our goal was to determine factors that patients with SLE consider in deciding about participating in prevention trials, to uncover concerns about SLE trials, and to investigate how study design and purpose affect participation decisions...
  6. ncbi request reprint Reproductive and menopausal factors and risk of systemic lupus erythematosus in women
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Arthritis Rheum 56:1251-62. 2007
    ..This study was carried out to examine associations between female reproductive and menopausal factors and the development of SLE...
  7. pmc Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women
    K H Costenbader
    Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ann Rheum Dis 67:530-5. 2008
    ..Vitamin D has immune-modulating effects and may protect against the development of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)...
  8. ncbi request reprint Discordance between erythrocyte sedimentation rate and C-reactive protein measurements: clinical significance
    K H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Clin Exp Rheumatol 25:746-9. 2007
    ..C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are common measures of systemic inflammation. Our goal was to identify clinical factors associated with CRP/ESR discordance...
  9. pmc Geographic variation in rheumatoid arthritis incidence among women in the United States
    Karen H Costenbader
    Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Arch Intern Med 168:1664-70. 2008
    ..The geographic variation in rheumatoid arthritis (RA) incidence in the United States is unknown...
  10. pmc Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women
    Karen H Costenbader
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 172:205-16. 2010
    ..In these large, prospective cohorts of women, antioxidant intake was not associated with the risk of developing either rheumatoid arthritis or systemic lupus erythematosus...
  11. pmc Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupus nephritis in the US from 1995 to 2006
    Karen H Costenbader
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 63:1681-8. 2011
    ....
  12. pmc Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 10:R52. 2008
    ..We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large prospective cohorts, adjusting for confounding factors and testing for interactions with smoking...
  13. ncbi request reprint Barriers to a trial of atherosclerosis prevention in systemic lupus erythematosus
    Karen H Costenbader
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Arthritis Rheum 53:718-23. 2005
    ..We describe our experience in recruiting and retaining patients with SLE in this trial...
  14. ncbi request reprint Statin therapy in rheumatoid arthritis
    Karen H Costenbader
    Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    South Med J 98:534-40; quiz 541, 572. 2005
    ..Recent studies show that statins may provide mild anti-inflammatory benefit in rheumatoid arthritis, in addition to reducing cardiovascular risk...
  15. pmc SLE - Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus
    Karen H Costenbader
    The Robert B, Brigham Arthritis and Musculoskeletal Disease Clinical Research Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Res Ther 5:178-9. 2003
    ..Studies from several centers have shown that suboptimal risk factor management and barriers to acceptance of these measures must also be studied further...
  16. pmc Immunosenescence and rheumatoid arthritis: does telomere shortening predict impending disease?
    Karen H Costenbader
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Autoimmun Rev 10:569-73. 2011
    ....
  17. ncbi request reprint Cardiac risk factor awareness and management in patients with systemic lupus erythematosus
    Karen H Costenbader
    Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 51:983-8. 2004
    ..To assess awareness and management of traditional cardiac risk factors (CRFs) in patients with systemic lupus erythematosus (SLE) and physicians...
  18. pmc Epstein-Barr virus and rheumatoid arthritis: is there a link?
    Karen H Costenbader
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 8:204. 2006
    ..In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein-Barr virus and rheumatoid arthritis is reviewed...
  19. ncbi request reprint Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 119:503.e1-9. 2006
    ....
  20. doi request reprint Quantifying anti-cyclic citrullinated peptide titres: clinical utility and association with tobacco exposure in patients with rheumatoid arthritis
    D M Lee
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 552B, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Ann Rheum Dis 68:201-8. 2009
    ..To determine the significance of quantitative levels of antibodies to cyclic citrullinated peptides (anti-CCP) in a population of patients with rheumatoid arthritis (RA)...
  21. pmc Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis
    E W Karlson
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Ann Rheum Dis 69:54-60. 2010
    ..To address the effect of dosage, a case-control study nested within two prospective cohorts to determine the interaction between heavy smoking and the HLA-SE was conducted...
  22. pmc Is birthweight associated with risk of rheumatoid arthritis? Data from a large cohort study
    L A Mandl
    Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York City, New York 10021, USA
    Ann Rheum Dis 68:514-8. 2009
    ..We examine whether the fetal environment, as reflected by birthweight, could modulate an individual's future risk of rheumatoid arthritis (RA)...
  23. pmc A controlled comparison of brachial artery flow mediated dilation (FMD) and digital pulse amplitude tonometry (PAT) in the assessment of endothelial function in systemic lupus erythematosus
    J Aizer
    Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York 10021, USA
    Lupus 18:235-42. 2009
    ..FMD did not correlate with PAT except in SLE cases with a history of Raynaud's. Correlation between FMD and PAT may be stronger in populations with greater variation in endothelial function and more cardiovascular risk factors...
  24. pmc Anti-cyclic citrullinated peptide revised criteria for the classification of rheumatoid arthritis
    K P Liao
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Rheum Dis 67:1557-61. 2008
    ..We developed and tested the performance characteristics of new criteria for RA classification, incorporating anti-CCP...
  25. pmc Exposure to maternal smoking and incident SLE in a prospective cohort study
    J F Simard
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Lupus 18:431-5. 2009
    ..0, 95% CI: 0.8 to 1.3) in combined analyses. Early-life exposure to cigarette smoke due to mothers' or fathers' smoking was not associated with increased risk of adult-onset SLE in women...
  26. ncbi request reprint What can epidemiology tell us about systemic lupus erythematosus?
    J F Simard
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Clin Pract 61:1170-80. 2007
    ..While epidemiologic research has contributed an enormous amount to our understanding of the disease and its pathogenesis, there are many more avenues of epidemiologic research that deserve to be pursued...
  27. pmc Identification and validation of lupus nephritis cases using administrative data
    L B Chibnik
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lupus 19:741-3. 2010
    ..This strategy may offer a sound method of identifying patients with lupus nephritis for health services research in addition to serving as a model for using claims data as a way to better understand rare diseases such as lupus...
  28. pmc Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Rheumatology (Oxford) 48:613-7. 2009
    ..We examined the association between candidate single nucleotide polymorphisms (SNPs) and disease activity in RA patients on MTX...
  29. pmc The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility
    Yvonne C Lee
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 60:1250-4. 2009
    ..The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility...
  30. pmc Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies
    Elizabeth W Karlson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 60:641-52. 2009
    ..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)...
  31. pmc Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
    Soumya Raychaudhuri
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 41:1313-8. 2009
    ..0008 replication, P = 4 x 10(-6) overall) and FCGR2A (rs12746613, P = 0.0022 replication, P = 2 x 10(-5) overall). Many of these loci are also associated to other immunologic diseases...
  32. doi request reprint Epidemiology: Interpreting studies of interactions between RA risk factors
    Elizabeth W Karlson
    Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Nat Rev Rheumatol 6:72-3. 2010
    ..As recent epidemiological evidence shows, deciphering these interactions demands consideration of the analytical approach used...
  33. ncbi request reprint Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus project
    Elizabeth W Karlson
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 56:244-54. 2007
    ..Our goal was to assess association of residential proximity to hazardous waste sites and genetic variation in 3 glutathione Stransferase (GST) genes (GSTM1, GSTT1, and GSTP1) with age at diagnosis of SLE...
  34. ncbi request reprint Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 50:849-57. 2004
    ..We performed an extensive search of the medical literature for all studies examining this relationship, and performed a meta-analysis to arrive at a more precise estimate of effect...
  35. pmc Alcohol consumption and markers of inflammation in women with preclinical rheumatoid arthritis
    Bing Lu
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 62:3554-9. 2010
    ..To examine the association between alcohol consumption and markers of inflammation in preclinical rheumatoid arthritis (RA)...
  36. ncbi request reprint Cigarette smoking and systemic lupus erythematosus: a smoking gun?
    Karen H Costenbader
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Boston, MA 02115, USA
    Autoimmunity 38:541-7. 2005
    ..5 [95% CI 1.09, 2.08]), but no increased risk associated with past smoking. The strengths and weaknesses of these data and potential implications are discussed...
  37. doi request reprint Dyspnoea in a young woman with active systemic lupus erythematosus
    Derrick J Todd
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Arthritis Center, Boston, Massachusetts 02115, USA
    Lupus 18:777-84. 2009
    ..Despite recent advances in therapy, mortality has not improved substantially (48% overall survival versus 53% survival in reports published since 1993)...
  38. pmc Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity
    Jose C Crispin
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 62:1431-7. 2010
    ....
  39. pmc Systemic lupus erythematosus and the risk of cardiovascular disease: results from the nurses' health study
    A Elisabeth Hak
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 61:1396-402. 2009
    ..Systemic lupus erythematosus (SLE) has been associated with an increased risk of cardiovascular disease. However, prospective population-based data addressing this association have been lacking...
  40. pmc Perinatal factors and adult-onset lupus
    Julia F Simard
    Department of Epidemiology, Harvard University School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Arthritis Rheum 59:1155-61. 2008
    ..Therefore, we evaluated the role of birth weight, being breastfed, and preterm birth on the incidence of SLE in participants in the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHSII)...
  41. ncbi request reprint Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban women
    Axel Finckh
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 54:3648-54. 2006
    ..To assess the risk of systemic lupus erythematosus (SLE) associated with occupational exposure to silica dust and organic solvents in an urban population...
  42. pmc Designing an intervention for women with systemic lupus erythematosus from medically underserved areas to improve care: a qualitative study
    C H Feldman
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lupus 22:52-62. 2013
    ..Systemic lupus erythematosus (lupus) disproportionately affects women, racial/ethnic minorities and low-income populations. We held focus groups for women from medically underserved communities to discuss interventions to improve care...
  43. doi request reprint Co-existing sarcoidosis, systemic lupus erythematosus and the antiphospholipid antibody syndrome: case reports and discussion from the Brigham and Women's Hospital Lupus Center
    D R Wesemann
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Lupus 18:202-5. 2009
    ..The association of sarcoidosis, SLE and APS is unique and may present difficult therapeutic options, as well as to shed light on their immunopathogenesis...
  44. ncbi request reprint High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women
    E W Karlson
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lupus 14:832-6. 2005
    ..These results suggest that the CSQ has adequate sensitivity and specificity and could be used in population studies to screen African-American women for SLE...
  45. doi request reprint Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    Eli A Stahl
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 42:508-14. 2010
    ..An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles...
  46. pmc Early life factors and adult-onset rheumatoid arthritis
    Julia F Simard
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Rheumatol 37:32-7. 2010
    ..We investigated the association of preterm birth and being breastfed with the incidence of rheumatoid arthritis (RA) in 2 large prospective cohorts...
  47. pmc Exposure to traffic pollution and increased risk of rheumatoid arthritis
    Jaime E Hart
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Environ Health Perspect 117:1065-9. 2009
    ..Particulate air pollution, especially of traffic origin, has been linked to systemic inflammation in many studies...
  48. pmc Disparities in lupus care and outcomes
    Kristina L Demas
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Rheumatol 21:102-9. 2009
    ..We summarize the current knowledge of the disparities observed in SLE and highlight recent research that aims to dissect the causes of these disparities and identify the potentially modifiable factors contributing to them...
  49. ncbi request reprint Abatacept in the treatment of rheumatoid arthritis
    D J Todd
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Int J Clin Pract 61:494-500. 2007
    ..We also address the role of abatacept in the greater context of biological therapy for RA...
  50. doi request reprint C-reactive protein, anti-C-reactive protein antibodies and clinical atherosclerosis
    Barbara J Rosenau
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine and the Division of Laboratory Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Vasc Med 13:25-8. 2008
    ..These observations suggest that anti-CRP antibody is not involved in atherosclerosis, and may represent an epiphenomenon...
  51. ncbi request reprint Treatment and management of early RA: A primary care primer
    Karen H Costenbader
    Harvard Medical School, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA USA
    J Fam Pract 56:S1-7; quiz S8. 2007
    ....
  52. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-2006. A 43-year-old woman with painful nodules on the fingertips, shortness of breath, and fatigue
    Karen H Costenbader
    Department of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, USA
    N Engl J Med 355:1263-72. 2006
  53. pmc The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological report
    Tuhina Neogi
    Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 62:2582-91. 2010
    ..The aim of Phase 2 of the development process was to achieve expert consensus on the clinical and laboratory variables that should contribute to the final criteria set...
  54. ncbi request reprint Defining lupus cases for clinical studies: the Boston weighted criteria for the classification of systemic lupus erythematosus
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Disease Clinical Research Center, Boston, Massachusetts, USA
    J Rheumatol 29:2545-50. 2002
    ..We developed and evaluated the ability of a weighted classification system to identify a broader spectrum of patients with lupus...
  55. ncbi request reprint Characteristics of patients with systemic lupus erythematosus (SLE) and non-Hodgkin's lymphoma (NHL)
    Jennifer K King
    Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Rehab Center Room 32 59, Los Angeles, CA 90095, USA
    Clin Rheumatol 26:1491-4. 2007
    ....
  56. pmc Comparison of threshold cutpoints and continuous measures of anti-cyclic citrullinated peptide antibodies in predicting future rheumatoid arthritis
    Lori B Chibnik
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Rheumatol 36:706-11. 2009
    ..While the anti-CCP level is commonly dichotomized for clinical use, the best threshold for and utility of the titer as a continuous variable to predict development of RA are uncertain...
  57. pmc Development and initial validation of a self-assessed lupus organ damage instrument
    Karen H Costenbader
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    Arthritis Care Res (Hoboken) 62:559-68. 2010
    ..Trained physicians must complete it, thus limiting utility where this is impossible...
  58. ncbi request reprint Do female hormones affect the onset or severity of rheumatoid arthritis?
    Karen H Costenbader
    Arthritis Rheum 59:299-301. 2008
  59. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  60. ncbi request reprint Risk of serious infections and malignancies with anti-TNF antibody therapy in rheumatoid arthritis
    Karen H Costenbader
    JAMA 296:2201; author reply 2203-4. 2006

Research Grants4

  1. Sociodemographic Disparities in Lupus Nephritis: Healthcare Access and Outcomes
    Karen Costenbader; Fiscal Year: 2009
    ..S., often causing kidney failure. The reasons why some groups suffer worse outcomes are not known. We will investigate how differences in healthcare access are related to "gaps" in outcomes for lupus kidney disease. ..
  2. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2010
    ....
  3. Novel Biomarkers and Causal Pathways in RA Susceptbility
    Karen H Costenbader; Fiscal Year: 2010
    ....
  4. Sociodemographic Disparities in Lupus Nephritis: Healthcare Access and Outcomes
    Karen H Costenbader; Fiscal Year: 2010
    ..S., often causing kidney failure. The reasons why some groups suffer worse outcomes are not known. We will investigate how differences in healthcare access are related to "gaps" in outcomes for lupus kidney disease. ..