Research Topics
| Lee CohenSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Venlafaxine in the treatment of postpartum depressionL S Cohen
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Clin Psychiatry 62:592-6. 2001..Incomplete recognition and treatment of puerperal illness place women at risk for chronic depression and may have adverse effects on child development...
Treatment of mood disorders during pregnancy and postpartumLee S Cohen
Perinatal and Reproductive Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
Psychiatr Clin North Am 33:273-93. 2010..This article reviews the diagnosis and treatment guidelines of mood disorders during pregnancy and postpartum, with specific reference to the use of psychotropic medications during this critical time...- Gender-specific considerations in the treatment of mood disorders in women across the life cycleLee S Cohen
Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 64:18-29. 2003.... - Diagnosis and treatment of depression during pregnancyLee S Cohen
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
CNS Spectr 9:209-16. 2004..Treatment options during pregnancy are reviewed in the context of developing the most appropriate risk/benefit decision for individual patients with past or current depression who either anticipate pregnancy or who become pregnant... - Reintroduction of antidepressant therapy across pregnancy in women who previously discontinued treatment. A preliminary retrospective studyLee S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Psychother Psychosom 73:255-8. 2004..Pregnancy has frequently been described as a time of emotional well-being conferring 'protection' against psychiatric disorders. However, data to support this impression are sparse... - Relapse of depression during pregnancy following antidepressant discontinuation: a preliminary prospective studyL S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Arch Womens Ment Health 7:217-21. 2004..Pregnancy has frequently been referred to as a time of emotional well-being for patients. However, systematic data about the risk for relapse of depression during pregnancy are sparse... - Efficacy and tolerability of premenstrual use of venlafaxine (flexible dose) in the treatment of premenstrual dysphoric disorderLee S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital MGH, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 24:540-3. 2004..05 for all comparisons, Wilcoxon tests). Intermittent treatment was well tolerated. This preliminary report suggests that premenstrual use of venlafaxine is an efficacious and well-tolerated treatment for premenstrual dysphoric disorder... - Paroxetine controlled release for premenstrual dysphoric disorder: a double-blind, placebo-controlled trialLee S Cohen
Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
Psychosom Med 66:707-13. 2004..This study was designed to assess the efficacy and tolerability of multiple doses of paroxetine controlled release (CR) in PMDD... - Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cyclesLee S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, 02114, USA
Arch Gen Psychiatry 63:385-90. 2006..However, it is unclear whether this period is one of increased risk for major depressive disorder, particularly for women who have not had a previous episode of depression... - Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatmentLee S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
JAMA 295:499-507. 2006..However, systematic delineation of risk of relapse in women who maintain or discontinue pharmacological treatment during pregnancy is necessary... - Diagnosis and management of mood disorders during the menopausal transitionLee S Cohen
Department of Perinatal and Reproductive Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med 118:93-7. 2005..The benefits and risks of using hormonal and nonhormonal strategies for the management of depression and other menopause-related somatic symptoms are critically reviewed... - Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary reportLee S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program and Vicent Memorail Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 160:1519-22. 2003..The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women... - Premenstrual daily fluoxetine for premenstrual dysphoric disorder: a placebo-controlled, clinical trial using computerized diariesLee S Cohen
Perinatal Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Obstet Gynecol 100:435-44. 2002..To evaluate premenstrual daily dosing with fluoxetine for treatment of premenstrual dysphoric disorder... - Prevalence and predictors of premenstrual dysphoric disorder (PMDD) in older premenopausal women. The Harvard Study of Moods and CyclesLee S Cohen
Harvard Medical School, Boston, MA, USA
J Affect Disord 70:125-32. 2002..Consistent data on the prevalence and predictors of premenstrual dysphoric disorder (PMDD) in the general population are lacking... - Eszopiclone in patients with insomnia during perimenopause and early postmenopause: a randomized controlled trialClaudio N Soares
Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada, and Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
Obstet Gynecol 108:1402-10. 2006..To evaluate eszopiclone 3 mg for treatment of insomnia in perimenopausal and early postmenopausal women, as well as the impact of insomnia treatment on mood, menopause-related symptoms, and quality of life... 
The association of depressive, anxiety, and stress symptoms and postpartum relapse to smoking: a longitudinal studyElyse R Park
Tobacco Research and Treatment Center, Institute for Health Policy, and Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
Nicotine Tob Res 11:707-14. 2009..The aim of this prospective repeated measures, mixed-methods observational study was to assess whether depressive, anxiety, and stress symptoms are associated with postpartum relapse to smoking...- Saliva estriol levels in women with and without prenatal antidepressant treatmentRita Suri
Mood Disorders Research Program, Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, Los Angeles, California 90095, USA
Biol Psychiatry 64:533-7. 2008..This study measured saliva levels of estriol, a hormone that increases exponentially in the few weeks before spontaneous labor, in pregnant women with and without antidepressant treatment... - Management of bipolar disorder during pregnancy and the postpartum periodKimberly A Yonkers
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Am J Psychiatry 161:608-20. 2004..The authors summarize knowledge regarding the management of bipolar disorder during pregnancy and the postpartum period, with a focus on managing mania, hypomania, and the psychotic components of the illness... - Mood disturbance in pregnancy and the mode of deliveryJennifer Wu
Department of Obstetrics and Gynecology Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Obstet Gynecol 187:864-7. 2002..05 and a beta =.2, we had the power to detect a 7.5% difference between our two groups. CONCLUSION: Data from this study did not support a relationship between depressive symptoms during pregnancy and mode of delivery... - Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal womenHadine Joffe
Women s Center for Behavioral Endocrinology, McLean Hospital, Harvard Medical School, Boston, MA, USA
Menopause 13:411-22. 2006.... - Case records of the Massachusetts General Hospital. Case 24-2008. A 35-year-old woman with postpartum confusion, agitation, and delusionsAdele C Viguera
Department of Psychiatry, Massachusetts General Hospital, USA
N Engl J Med 359:509-15. 2008 - Menstrual dysfunction prior to onset of psychiatric illness is reported more commonly by women with bipolar disorder than by women with unipolar depression and healthy controlsHadine Joffe
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 67:297-304. 2006..However, it is not always clear whether such abnormalities, reflecting disruption of the hypothalamic-pituitary-gonadal (HPG) axis, are caused by psychotropic treatments or associated with the disorder per se... - Lithium in breast milk and nursing infants: clinical implicationsAdele C Viguera
Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Simches Research Bldg, Second Fl, Suite 2200, 185 Cambridge St, Boston, MA 02114, USA
Am J Psychiatry 164:342-5. 2007..Current practice guidelines discourage use of lithium during breast-feeding, despite limited data. This study aimed to quantify lithium exposure in nursing infants... - Birth outcomes following prenatal exposure to antidepressantsKimberly H Pearson
Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 68:1284-9. 2007..Antidepressant use during pregnancy and the peripartum period is common despite the absence of clear evidence-based guidelines to direct clinical use of these compounds... - Treatment of bipolar disorder during pregnancyLee S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Boston, MA, USA
J Clin Psychiatry 68:4-9. 2007.... - Risk of recurrence in women with bipolar disorder during pregnancy: prospective study of mood stabilizer discontinuationAdele C Viguera
Cleveland Clinic Neurological Institute, Department of Psychiatry and Psychology, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Psychiatry 164:1817-24; quiz 1923. 2007..This study estimated the risk of recurrence of mood episodes among women with a history of bipolar disorder who continued or discontinued treatment with mood stabilizers during pregnancy... - Treatment of depression and menopause-related symptoms with the serotonin-norepinephrine reuptake inhibitor duloxetineHadine Joffe
Perinatal and Reproductive Psychiatry Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass 02114, USA
J Clin Psychiatry 68:943-50. 2007..Treatment strategies that target all of these symptoms together have not been investigated to date... - Treatment of premenstrual worsening of depression with adjunctive oral contraceptive pills: a preliminary reportHadine Joffe
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 68:1954-62. 2007..Oral contraceptive pills (OCPs) stabilize reproductive hormones and treat premenstrual dysphoric disorder. Management of depression that breaks through premenstrually has not been studied... - Paroxetine versus placebo for women in midlife after hormone therapy discontinuationClaudio N Soares
Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, Boston, USA
Am J Med 121:159-162.e1. 2008..This study examines the efficacy of paroxetine controlled-release versus placebo for the treatment of women with vasomotor symptoms after discontinuing hormone therapy... - Longitudinal follow-up of reproductive and metabolic features of valproate-associated polycystic ovarian syndrome features: A preliminary reportHadine Joffe
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 60:1378-81. 2006..5% of 86 women. We now determine whether polycystic ovarian syndrome (PCOS) features reverse on valproate discontinutation... - Pharmacologic treatment of postpartum women with new-onset major depressive disorder: a randomized controlled trial with paroxetineKimberly A Yonkers
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
J Clin Psychiatry 69:659-65. 2008..The current study determined the relative efficacy of paroxetine compared to placebo in the treatment of acute postpartum MDD... - Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri- and postmenopausal women: impact on depression, vasomotor symptoms, sleep, and quality of lifeClaudio N Soares
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
Menopause 13:780-6. 2006..To examine the efficacy and tolerability of escitalopram (ESCIT) compared to estrogen and progestogen therapy (EPT) for the treatment of symptomatic peri- and postmenopausal women... - Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorderHadine Joffe
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 59:1078-86. 2006..The development of PCOS features after initiation of valproate was therefore examined in women with bipolar disorder using a standardized definition of PCOS... - Expert guidelines for the treatment of severe PMS, PMDD, and comorbidities: the role of SSRIsMeir Steiner
Department of Psychiatry and Behavioral Neurosciences, McMaster University, Women s Health Concerns Clinic, St Joseph s Hospital, Hamilton, Ontario, Canada
J Womens Health (Larchmt) 15:57-69. 2006.... - Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptomsClaudio N Soares
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, 02114, USA
J Clin Psychiatry 64:473-9. 2003..It is still unclear whether the use of antidepressants alone may alleviate menopause-related mood and vasomotor symptoms or enhance the response observed with short-term use of estrogen therapy... - The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrationsZachary N Stowe
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta GA, USA
J Clin Psychiatry 64:73-80. 2003..CONCLUSION: These results extend previous studies by demonstrating the utility of breast milk analysis in interpreting infant serum concentrations and minimizing infant exposure... - Depression and its influence on reproductive endocrine and menstrual cycle markers associated with perimenopause: the Harvard Study of Moods and CyclesBernard L Harlow
Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
Arch Gen Psychiatry 60:29-36. 2003..Few studies have determined the impact of a lifetime history of major depression on an early transition to menopause... - Reproductive decisions by women with bipolar disorder after prepregnancy psychiatric consultationAdele C Viguera
Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
Am J Psychiatry 159:2102-4. 2002..This study ascertained family planning decisions by women with bipolar disorder after psychiatric consultation... - Vasomotor symptoms are associated with depression in perimenopausal women seeking primary careHadine Joffe
Perinatal and Reproductive Psychiatry Program, Reproductive Endocrine Unit, and Medical Service, Massachusetts General Hospital, Boston, MA, USA
Menopause 9:392-8. 2002..To compare the relationship between vasomotor symptoms (hot flushes and night sweats) and depression in perimenopausal women with that in postmenopausal and older premenopausal women... - Managing bipolar disorder during pregnancy: weighing the risks and benefitsAdele C Viguera
Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Can J Psychiatry 47:426-36. 2002..Challenges for the clinical management of bipolar disorder (BD) during pregnancy are multiple and complex and include competing risks to mother and offspring... - Efficacy of 17beta-estradiol on depression: is estrogen deficiency really necessary?Claudio N Soares
J Clin Psychiatry 63:451; author reply 451-2. 2002 - Sex differences in clinical response to olanzapine compared with haloperidolJill M Goldstein
Harvard Institute of Psychiatric Epidemiology and Genetics, Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, MMHC, Boston, MA 02115, USA
Psychiatry Res 110:27-37. 2002..Finally, premenopausal women had a significantly better treatment response than postmenopausal women, regardless of treatment and chronicity... - A putative relationship between valproic acid and polycystic ovarian syndrome: implications for treatment of women with seizure and bipolar disordersHadine Joffe
Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WACC 815, Boston, MA 02114, USA
Harv Rev Psychiatry 11:99-108. 2003 - Depression during pregnancy: diagnosis and treatment optionsRuta Nonacs
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 63:24-30. 2002..Nonpharmacologic and pharmacologic treatment options are reviewed, and guidelines for treating depression during pregnancy are presented... - Bupropion SR for the treatment of postpartum depression: a pilot studyRuta M Nonacs
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital MGH, Boston, 02114, USA
Int J Neuropsychopharmacol 8:445-9. 2005..5 (range 37.5-300). Bupropion SR was well tolerated, and no subjects discontinued treatment as a result of medication side-effects. Bupropion SR represents an effective and well-tolerated antidepressant for the treatment of PPD... - Assessment and treatment of depression during pregnancy: an updateRuta Nonacs
Perinatal and Reproductive Psychiatry Clinical Research Program, Clinical Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Psychiatr Clin North Am 26:547-62. 2003..Such a process will lead to thoughtful treatment choices, which with close clinical follow-up can minimize the risk for maternal morbidity... - Assessment and treatment of hot flushes and menopausal mood disturbanceHadine Joffe
Department of Psychiatry, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WACC, Boston, MA 02114, USA
Psychiatr Clin North Am 26:563-80. 2003..As further evidence of the benefits of psychoactive medications for menopausal symptoms is established, the choice between using hormonal and nonhormonal therapies for management of menopausal symptoms will continue to evolve... - Impact of oral contraceptive pill use on premenstrual mood: predictors of improvement and deteriorationHadine Joffe
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, 15 Parkman Street, WACC, Boston, MA 02114, USA
Am J Obstet Gynecol 189:1523-30. 2003..The purpose of this study was to estimate risk factors for the deterioration and improvement of premenstrual mood disturbance with oral contraceptive pill use... - Early life menstrual characteristics and pregnancy experiences among women with and without major depression: the Harvard study of moods and cyclesBernard L Harlow
Obstetrics and Gynecology Epidemiology Center at Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
J Affect Disord 79:167-76. 2004..Other than premenstrual dysphoria, few studies have examined the extent to which basic characteristics of the menstrual cycle and the occurrence of other reproductive landmarks impact on the risk of major depression... - Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancyD Jeffrey Newport
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Psychiatry 162:2162-70. 2005.... - Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participantsClaudia F Baldassano
Bipolar Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Bipolar Disord 7:465-70. 2005..To examine gender differences in a large sample of patients with bipolar illness... - Antidepressant response and well-being in pre-, peri- and postmenopausal women with major depressive disorder treated with fluoxetinePaolo Cassano
The Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Psychother Psychosom 74:362-5. 2005..We assessed the impact of menopausal status on treatment response and well-being in a cohort of outpatient women with major depressive disorder (DSM-III-R criteria), who received treatment with fluoxetine (20 mg/day for 8 weeks)... - Quetiapine in treatment-resistant obsessive-compulsive disorderLee S Cohen
J Am Acad Child Adolesc Psychiatry 42:623-4. 2003 - Dysfunctional attitudes and episodes of major depression: Predictive validity and temporal stability in never-depressed, depressed, and recovered womenMichael W Otto
Center for Anxiety and Related Disorders, Boston University, MA 02215, USA
J Abnorm Psychol 116:475-83. 2007..N. Weissman & A. T. Beck, 1978) when the formerly depressed and never-depressed cohorts were considered separately. Implications for cognitive theories are discussed...
Research Grants
- Risk and Predictors of Postpartum DepressionLee Cohen; Fiscal Year: 2007..Cohen, Nonacs and Otto), the Women's Life Center and Mood Disorders Research Program at UCLA (Dr. AItshuler, Dr. Hendrick), and the Emory Women's Mental Health Program at Emory University School of Medicine (Dr. Stowe). ..
- RELAPSE AND PREDICTORS OF DEPRESSION IN PREGNANCYLee Cohen; Fiscal Year: 2003..Delineating of these subgroups provides an opportunity to screen for women "at risk" for relapse and allows for thoughtful treatment plan. ..