RACHAEL ANN CLARK

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint A novel method for the isolation of skin resident T cells from normal and diseased human skin
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Invest Dermatol 126:1059-70. 2006
  2. pmc Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T-cell exhaustion in reducing T-cell responses
    Mitra Dowlatshahi
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 133:1879-89. 2013
  3. pmc Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas
    Ahmed E Gehad
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Invest Dermatol 132:2642-51. 2012
  4. pmc Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 4:117ra7. 2012
  5. ncbi request reprint Gone but not forgotten: lesional memory in psoriatic skin
    Rachael A Clark
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Invest Dermatol 131:283-5. 2011
  6. pmc High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, Boston, MA 02115, USA
    Blood 117:1966-76. 2011
  7. pmc Regulation gone wrong: a subset of Sézary patients have malignant regulatory T cells
    Rachael A Clark
    Harvard Skin Disease Research Center and the Department of Dermatology, Brigham and Women s Hospital, EBRC Room 505A, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2747-50. 2009
  8. pmc Skin-resident T cells: the ups and downs of on site immunity
    Rachael A Clark
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 130:362-70. 2010
  9. pmc Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
    Rachael A Clark
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 205:2221-34. 2008
  10. ncbi request reprint Meeting report of immunology and skin disease: new perspectives
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, Boston, Massachusetts 02115, USA
    J Invest Dermatol 127:1838-41. 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint A novel method for the isolation of skin resident T cells from normal and diseased human skin
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Invest Dermatol 126:1059-70. 2006
    ..This method also allowed efficient isolation of malignant T cells from the skin lesions of cutaneous T cell lymphoma and the isolation of tumor-infiltrating lymphocytes from primary squamous cell carcinomas and melanoma metastases...
  2. pmc Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T-cell exhaustion in reducing T-cell responses
    Mitra Dowlatshahi
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 133:1879-89. 2013
    ..Agents that stimulate T-cell activity, block regulatory T cell function, or inhibit PD-1 signaling may be effective in the treatment of this highly malignant skin cancer...
  3. pmc Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas
    Ahmed E Gehad
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Invest Dermatol 132:2642-51. 2012
    ..The iNOS inhibitors and other therapies that reduce NO production may therefore be effective in the treatment of SCCs and their premalignant precursor lesions, actinic keratoses...
  4. pmc Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 4:117ra7. 2012
    ....
  5. ncbi request reprint Gone but not forgotten: lesional memory in psoriatic skin
    Rachael A Clark
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Invest Dermatol 131:283-5. 2011
    ..By understanding this "invisible lesion," we may be one step closer to curing psoriasis...
  6. pmc High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, Boston, MA 02115, USA
    Blood 117:1966-76. 2011
    ....
  7. pmc Regulation gone wrong: a subset of Sézary patients have malignant regulatory T cells
    Rachael A Clark
    Harvard Skin Disease Research Center and the Department of Dermatology, Brigham and Women s Hospital, EBRC Room 505A, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2747-50. 2009
    ..Clonal malignant T cells showed increased expression of the Treg-associated transcription factor FOXP3 and demethylation of the FOXP3 gene locus, and T cells from at least some of these patients suppressed T-cell proliferation in vitro...
  8. pmc Skin-resident T cells: the ups and downs of on site immunity
    Rachael A Clark
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 130:362-70. 2010
    ..This review summarizes the current understanding of how skin-resident T cells contribute to normal and aberrant immunity in the skin...
  9. pmc Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
    Rachael A Clark
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 205:2221-34. 2008
    ..TLR7 agonists neutralized both of these strategies, supporting their use in SCCs and other tumors with similar immune defects...
  10. ncbi request reprint Meeting report of immunology and skin disease: new perspectives
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, Boston, Massachusetts 02115, USA
    J Invest Dermatol 127:1838-41. 2007
  11. pmc IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, Boston, MA 02115, USA
    Blood 109:194-202. 2007
    ....
  12. ncbi request reprint Old meets new: the interaction between innate and adaptive immunity
    Rachael Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin, Disease Research Center, Boston, Massachusetts, USA
    J Invest Dermatol 125:629-37. 2005
    ....
  13. pmc Skin-derived interleukin-7 contributes to the proliferation of lymphocytes in cutaneous T-cell lymphoma
    Kei Ichi Yamanaka
    Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 107:2440-5. 2006
    ..These observations led us to postulate that IL-7 produced by skin cells contributes to the survival and proliferation of T cells within skin lesions and is likely the source of elevated circulating IL-7 in CTCL...
  14. ncbi request reprint The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors
    Kazuki Hirahara
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:4488-94. 2006
    ..Therefore, the majority of true circulating Treg express functional skin-homing receptors, and human Treg may regulate local immune responses in normal human skin...
  15. ncbi request reprint The vast majority of CLA+ T cells are resident in normal skin
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and Harvard Skin Disease Research Center, Boston, MA 02115, USA
    J Immunol 176:4431-9. 2006
    ..These findings demonstrate that there is a large pool of memory T cells in normal skin that can initiate and perpetuate immune reactions in the absence of T cell recruitment from the blood...
  16. pmc Human skin cells support thymus-independent T cell development
    Rachael A Clark
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Clin Invest 115:3239-49. 2005
    ..Skin and bone marrow biopsies can thus be used to generate de novo functional and diverse T cell populations for potential therapeutic use in immunosuppressed patients...

Research Grants4

  1. T cell production from a skin derived thymus construct
    Rachael Clark; Fiscal Year: 2007
    ..It takes advantage of the many resources available to me in the laboratory of Dr. Thomas Kupper and in the Harvard Medical School environment. ..
  2. Immune Evasion in Human Squamous Cell Carcinomas of the Skin
    RACHAEL ANN CLARK; Fiscal Year: 2010
    ..Because impaired T cell homing and recruitment of regulatory T cells occur in many human malignancies, findings and novel therapies arising from this work should be applicable to the treatment of other types of human cancer. ..
  3. Immune Evasion in Human Squamous Cell Carcinomas of the Skin
    Rachael Clark; Fiscal Year: 2009
    ..Because impaired T cell homing and recruitment of regulatory T cells occur in many human malignancies, findings and novel therapies arising from this work should be applicable to the treatment of other types of human cancer. ..