Affiliation: Massachusetts General Hospital
- Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's diseaseSara Cipriani
Neurology Department, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 7:e37331. 2012..Our findings correlate intracellular urate content in dopaminergic neurons with their toxin resistance in a cellular model of PD and suggest a facilitative role for astrocytes in the neuroprotective effect of urate...
- Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosisSara Cipriani
Massachusetts General Hospital, 114 16th Street, Boston, MA 02129, USA
Biomark Med 4:701-12. 2010..In this article we review the convergent biological, epidemiological and clinical data that identify urate as a promising biomarker of the risk, diagnosis and prognosis of PD...
- Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegenerationXiqun Chen
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Proc Natl Acad Sci U S A 110:300-5. 2013..Together our data support a neuroprotective role of endogenous urate in dopaminergic neurons and strengthen the rationale for developing urate-elevating strategies as potential disease-modifying therapy for PD...
- Protection of dopaminergic cells by urate requires its accumulation in astrocytesSara Cipriani
Molecular Neurobiology Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA 02129, USA
J Neurochem 123:172-81. 2012..These data indicate that urate might act within astrocytes to trigger release of molecule(s) that are protective for dopaminergic cells...