Daniel Chung

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines
    Eva Maria Duerr
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1223-30. 2012
  2. ncbi request reprint The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications
    Daniel C Chung
    Gastrointestinal Unit, GI Cancer Genetics Service, GRJ 825, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Ann Intern Med 138:560-70. 2003
  3. ncbi request reprint Detection of stool DNA mutations before and after treatment of colorectal neoplasia
    Sapna Syngal
    Division of Population Sciences, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer 106:277-83. 2006
  4. ncbi request reprint Mechanisms of Cables 1 gene inactivation in human ovarian cancer development
    Hideo Sakamoto
    Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachussetts 02114, USA
    Cancer Biol Ther 7:180-88. 2008
  5. ncbi request reprint The Cables gene on chromosome 18Q regulates colon cancer progression in vivo
    Sandra D Kirley
    Department of Urology, Massachusetts General Hospital, Boston 02114, USA
    Cancer Biol Ther 4:861-3. 2005
  6. ncbi request reprint Correlation of polyp number and family history of colon cancer with germline MYH mutations
    Won Seok Jo
    Gastrointestinal Unit and Department of Medicine, Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 3:1022-8. 2005
  7. pmc The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Pathol 171:1509-19. 2007
  8. ncbi request reprint Knowledge and attitudes about microsatellite instability testing among high-risk individuals diagnosed with colorectal cancer
    Sharon L Manne
    Division of Population and Medical Science, Fox Chase Cancer Center, 333 Cottman Avenue, P1100 Philadelphia, PA 19111, USA
    Cancer Epidemiol Biomarkers Prev 16:2110-7. 2007
  9. ncbi request reprint Celecoxib for the prevention of sporadic colorectal adenomas
    Monica M Bertagnolli
    Brigham and Women s Hospital, Boston, USA
    N Engl J Med 355:873-84. 2006
  10. ncbi request reprint Molecular genetics of neuroendocrine tumors
    Eva Maria Duerr
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Best Pract Res Clin Endocrinol Metab 21:1-14. 2007

Research Grants

Collaborators

Detail Information

Publications39

  1. pmc Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines
    Eva Maria Duerr
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1223-30. 2012
    ..In summary, oncogenic KRAS can downregulate Bmp4 through a transcriptional pathway that depends on ERK. These findings point to a unique link between two pathways that are frequently altered in colon cancer...
  2. ncbi request reprint The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications
    Daniel C Chung
    Gastrointestinal Unit, GI Cancer Genetics Service, GRJ 825, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Ann Intern Med 138:560-70. 2003
    ..The study of HNPCC has provided an example of the powerful interplay between molecular genetics and clinical care...
  3. ncbi request reprint Detection of stool DNA mutations before and after treatment of colorectal neoplasia
    Sapna Syngal
    Division of Population Sciences, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer 106:277-83. 2006
    ....
  4. ncbi request reprint Mechanisms of Cables 1 gene inactivation in human ovarian cancer development
    Hideo Sakamoto
    Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachussetts 02114, USA
    Cancer Biol Ther 7:180-88. 2008
    ..Together these findings suggest that multiple mechanisms underlie the loss of Cables 1 expression in ovarian cancer cells, supporting the hypothesis that Cables 1 is a tumor suppressor in human ovarian cancer...
  5. ncbi request reprint The Cables gene on chromosome 18Q regulates colon cancer progression in vivo
    Sandra D Kirley
    Department of Urology, Massachusetts General Hospital, Boston 02114, USA
    Cancer Biol Ther 4:861-3. 2005
    ..These data coupled with previous observations support the hypothesis that Cables is a relevant target of the chromosome 18q deletions frequently seen in human colorectal cancer...
  6. ncbi request reprint Correlation of polyp number and family history of colon cancer with germline MYH mutations
    Won Seok Jo
    Gastrointestinal Unit and Department of Medicine, Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 3:1022-8. 2005
    ..Our goal was to determine the detection rate of germline MYH mutations in a high-risk gastrointestinal cancer clinic population by using polyp number as a selection criterion...
  7. pmc The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Pathol 171:1509-19. 2007
    ..Loss of Cables expression in 65% of CRCs suggests that it is a common event in colonic carcinogenesis, with promoter methylation and LOH appearing to be important mechanisms of Cables gene inactivation...
  8. ncbi request reprint Knowledge and attitudes about microsatellite instability testing among high-risk individuals diagnosed with colorectal cancer
    Sharon L Manne
    Division of Population and Medical Science, Fox Chase Cancer Center, 333 Cottman Avenue, P1100 Philadelphia, PA 19111, USA
    Cancer Epidemiol Biomarkers Prev 16:2110-7. 2007
    ..More distressed patients, patients who perceive themselves at higher risk for cancer recurrence, and patients with metastatic disease might be less motivated to have the MSI test...
  9. ncbi request reprint Celecoxib for the prevention of sporadic colorectal adenomas
    Monica M Bertagnolli
    Brigham and Women s Hospital, Boston, USA
    N Engl J Med 355:873-84. 2006
    ....
  10. ncbi request reprint Molecular genetics of neuroendocrine tumors
    Eva Maria Duerr
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Best Pract Res Clin Endocrinol Metab 21:1-14. 2007
    ..However, our understanding of the molecular biology of these tumors remains far from complete. In this review we highlight some of the key approaches, findings and implications of these genetic studies...
  11. pmc Sharing genetic test results in Lynch syndrome: communication with close and distant relatives
    Elena M Stoffel
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Gastroenterol Hepatol 6:333-8. 2008
    ..Clinical genetic testing can help direct cancer screening for members of Lynch syndrome families; however, there is limited information about family communication of genetic test results...
  12. ncbi request reprint Increased growth rate, delayed senescense and decreased serum dependence characterize cables-deficient cells
    Sandra D Kirley
    Department of Urology and Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cancer Biol Ther 4:654-8. 2005
    ..Cables(-/-) MEFs were able to proliferate in low serum concentrations. These data provide convincing evidence that Cables plays a role in the regulation of cell proliferation and survival...
  13. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 34-2003. A 45-year-old woman with a family history of colonic polyps and cancer
    Daniel C Chung
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 349:1750-60. 2003
  14. pmc Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    Christopher G Willett
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Med 10:145-7. 2004
    ..These data indicate that VEGF blockade has a direct and rapid antivascular effect in human tumors...
  15. ncbi request reprint Genetics of hereditary colorectal cancer
    Won Seok Jo
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Semin Oncol 32:11-23. 2005
    ..The introduction and refinement of genetic testing has provided a new and invaluable tool for the diagnosis and assessment of cancer risk for suspected cases of hereditary colon cancer...
  16. ncbi request reprint Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines
    Fernando S Velayos
    Division of Gastroenterology and Colorectal Cancer Prevention Program, University of California, San Francisco, CA, USA
    Am J Gastroenterol 100:1143-9. 2005
    ..We sought to determine the rate of MSI in adenomas removed from individuals under 40 yr of age over a 5-yr period in a university general gastroenterology practice...
  17. ncbi request reprint Hereditary colorectal cancer syndromes: an overview
    Eunice L Kwak
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Clin Colorectal Cancer 6:340-4. 2007
    ....
  18. pmc Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth
    Kotoyo Fujiki
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 135:907-16, 916.e1-2. 2008
    ..The molecular alterations that underlie carcinoid tumor pathogenesis remain poorly defined. The homeobox gene HOXC6 was highly up-regulated in human gastrointestinal carcinoid tumors, and we sought to define its pathogenic role...
  19. pmc Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Natl Cancer Inst 100:1282-9. 2008
    ....
  20. ncbi request reprint Hypoxia inducible factor-1 independent pathways in tumor angiogenesis
    Yusuke Mizukami
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    Clin Cancer Res 13:5670-4. 2007
    ..Understanding the full spectrum of molecular pathways that control tumor angiogenesis is critical for the optimal design of targeted therapies...
  21. ncbi request reprint Microsatellite instability is frequently observed in rectal cancer and influenced by neoadjuvant chemoradiation
    Michael Y Choi
    Int J Radiat Oncol Biol Phys 68:1584. 2007
  22. doi request reprint Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells
    Madoka Yamazaki
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Hokkaido 078 8510, Japan
    Cancer Sci 99:1131-8. 2008
    ..Targeting SHH would be a novel therapeutic approach that can inhibit not only proliferation of cancer cells but also EPC-mediated angiogenesis...
  23. ncbi request reprint Case records of the Massachusetts General Hospital. Case 22-2007. A woman with a family history of gastric and breast cancer
    Daniel C Chung
    Gastroenterology Unit, Massachusetts General Hospital, USA
    N Engl J Med 357:283-91. 2007
  24. ncbi request reprint Stool DNA testing and colon cancer prevention: another step forward
    Daniel C Chung
    Ann Intern Med 149:509-10. 2008
  25. ncbi request reprint The management of small polyps found by virtual colonoscopy: results of a decision analysis
    Chin Hur
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Gastroenterol Hepatol 5:237-44. 2007
    ..Decision-analytic techniques were used to compare the outcomes of 2 management strategies for smaller (6-9 mm) polyps discovered by CTC...
  26. ncbi request reprint Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations
    Maite Herraiz
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 5:367-73. 2007
    ..The optimal approach for thyroid cancer screening has not been established. We sought to define the prevalence of thyroid cancer and the role of screening ultrasound in FAP patients...
  27. ncbi request reprint A new syndrome of hereditary congenital corneal opacities, cornea guttata, and corectopia
    Jeong Min Hwang
    Genetic Eye Disease, Cole Eye Institute, Cleveland Clinic Foundation, OH 44195, USA
    Arch Ophthalmol 121:1053-4. 2003
  28. ncbi request reprint Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer
    Yusuke Mizukami
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 64:1765-72. 2004
    ..These findings suggest the existence of multiple mechanisms regulating the hypoxic induction of VEGF in colon cancer...
  29. ncbi request reprint Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia
    Xiaoboo Zhang
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital Harvard Medical, 70 Blossom St, Boston, MA 02114, USA
    Diabetes 54:712-9. 2005
    ..Cyclin D1 may thus be considered a potential candidate to augment the beta-cell population ex vivo as a prelude to islet transplantation for diabetes...
  30. ncbi request reprint Mutational analysis of PPARG as a candidate tumour suppressor gene in enteropancreatic endocrine tumours
    Jessica Costa-Guda
    Center for Molecular Medicine and Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Clin Endocrinol (Oxf) 62:603-6. 2005
    ..Therefore, we sought to examine PPARG for intragenic inactivating mutations, the evidence needed to rigorously establish it as a tumour suppressor in EPETs...
  31. ncbi request reprint Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta
    Jingnan Li
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Gastroenterology 128:1907-18. 2005
    ..We have previously shown that these 2 pathways can cooperate to regulate vascular endothelial growth factor (VEGF) gene expression. The goal of this study was to define the molecular basis for this interaction...
  32. ncbi request reprint Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells
    Yusuke Mizukami
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Med 11:992-7. 2005
    ..Thus, compensatory pathways can be activated to preserve the tumor angiogenic response, and strategies that inhibit HIF-1alpha may be most effective when IL-8 is simultaneously targeted...
  33. ncbi request reprint Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients
    Christopher G Willett
    J Clin Oncol 23:8136-9. 2005
  34. ncbi request reprint Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis
    Won Seok Jo
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Cancer Biol Ther 4:1361-6. 2005
    ..Collectively, these findings suggest that activation of the Wnt pathway rather than K-ras plays a more important role in the downregulation of TSP-1 observed in colon cancer...
  35. ncbi request reprint Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc
    Yusuke Mizukami
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 281:13957-63. 2006
    ..Collectively, these findings suggest an alternative mechanism for the hypoxic induction of VEGF in colon cancer that does not depend upon HIF-1alpha but instead requires the activation of PI3K/Rho/ROCK and c-Myc...
  36. ncbi request reprint Colorectal cancer screening: today and tomorrow
    Kenneth E Hung
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    South Med J 99:240-6; quiz 247-9. 2006
    ..Here, we review the current screening modalities and guidelines for patients at average, moderate, and high risk for colorectal cancer. New experimental modalities are also introduced...
  37. ncbi request reprint The serrated polyp comes of age
    Gregory Y Lauwers
    Gastroenterology 131:1631-4. 2006
  38. ncbi request reprint Case records of the Massachusetts General Hospital. Case 37-2006. A 19-year-old woman with thyroid cancer and lower gastrointestinal bleeding
    Daniel C Chung
    Departments of Medicine, Massachusetts General Hospital and Harvard Medical School, USA
    N Engl J Med 355:2349-57. 2006
  39. ncbi request reprint Mutational analysis of Smad3, a candidate tumor suppressor implicated in TGF-beta and menin pathways, in parathyroid adenomas and enteropancreatic endocrine tumors
    Trisha M Shattuck
    Center for Molecular Medicine and Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, Connecticut 06030, USA
    J Clin Endocrinol Metab 87:3911-4. 2002
    ..Because inactivating somatic mutation is the hallmark of an authentic tumor suppressor, Smad3 is unlikely to function as a classical tumor suppressor gene in the pathogenesis of sporadic parathyroid or enteropancreatic endocrine tumors...

Research Grants9

  1. Genetic Regulation of Angiogenesis in Colonic Polyps
    Daniel Chung; Fiscal Year: 2006
    ....
  2. Genetic Regulation of Angiogenesis in Colonic Polyps
    Daniel Chung; Fiscal Year: 2007
    ..A better understanding of the complete spectrum of angiogenic pathways activated in the colonic epithelium is a prerequisite for the rational design and application of targeted anti- angiogenic approaches. ..
  3. Genetic Regulation of Angiogenesis in Colonic Polyps
    Daniel C Chung; Fiscal Year: 2010
    ..A better understanding of the complete spectrum of angiogenic pathways activated in the colonic epithelium is a prerequisite for the rational design and application of targeted anti- angiogenic approaches. ..