Audrey Y Chu

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein-Related Measures
    Audrey Y Chu
    From the Division of Preventive Medicine A Y C, F G, S M, P M R, D I C, Division of Cardiovascular Medicine S M, P M R, Division of Genetics D I C, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Personalised Healthcare and Biomarkers AstraZeneca Research and Development, Alderley Park, United Kingdom B J B Observational Research Center, AstraZeneca Research and Development, Mölndal B D, F N and Unit of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden F N
    Circ Cardiovasc Genet 8:688-95. 2015
  2. doi request reprint Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy
    Audrey Y Chu
    Center for Cardiovascular Disease Prevention, the Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Circ Cardiovasc Genet 5:676-85. 2012
  3. doi request reprint Pharmacogenetic determinants of statin-induced reductions in C-reactive protein
    Audrey Y Chu
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circ Cardiovasc Genet 5:58-65. 2012
  4. pmc Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    BMJ 348:g1610. 2014
  5. pmc Novel locus including FGF21 is associated with dietary macronutrient intake
    Audrey Y Chu
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Hum Mol Genet 22:1895-902. 2013
  6. doi request reprint Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium
    Caren E Smith
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Mol Nutr Food Res 59:1373-83. 2015
  7. pmc Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
    Daniel I Chasman
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Hum Mol Genet 21:5329-43. 2012
  8. pmc Sugar-sweetened beverages and genetic risk of obesity
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 367:1387-96. 2012

Detail Information

Publications8

  1. doi request reprint Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein-Related Measures
    Audrey Y Chu
    From the Division of Preventive Medicine A Y C, F G, S M, P M R, D I C, Division of Cardiovascular Medicine S M, P M R, Division of Genetics D I C, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Personalised Healthcare and Biomarkers AstraZeneca Research and Development, Alderley Park, United Kingdom B J B Observational Research Center, AstraZeneca Research and Development, Mölndal B D, F N and Unit of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden F N
    Circ Cardiovasc Genet 8:688-95. 2015
    ..However, it is unknown how these genetic variants influence statin-induced changes in LDL subfractions and non-HDL-C...
  2. doi request reprint Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy
    Audrey Y Chu
    Center for Cardiovascular Disease Prevention, the Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Circ Cardiovasc Genet 5:676-85. 2012
    ..Data are sparse regarding genetic determinants of Lp-PLA(2) mass and activity, and no prior data are available addressing genetic determinants of statin-induced changes for this proinflammatory biomarker...
  3. doi request reprint Pharmacogenetic determinants of statin-induced reductions in C-reactive protein
    Audrey Y Chu
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circ Cardiovasc Genet 5:58-65. 2012
    ..However, whether different mechanisms underlie statin-induced CRP and LDL-C reduction is unknown...
  4. pmc Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    BMJ 348:g1610. 2014
    ..To examine the interactions between genetic predisposition and consumption of fried food in relation to body mass index (BMI) and obesity...
  5. pmc Novel locus including FGF21 is associated with dietary macronutrient intake
    Audrey Y Chu
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Hum Mol Genet 22:1895-902. 2013
    ..9 × 10(-9)). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake...
  6. doi request reprint Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium
    Caren E Smith
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Mol Nutr Food Res 59:1373-83. 2015
    ..We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid...
  7. pmc Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
    Daniel I Chasman
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Hum Mol Genet 21:5329-43. 2012
    ..The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general...
  8. pmc Sugar-sweetened beverages and genetic risk of obesity
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 367:1387-96. 2012
    ..Temporal increases in the consumption of sugar-sweetened beverages have paralleled the rise in obesity prevalence, but whether the intake of such beverages interacts with the genetic predisposition to adiposity is unknown...