- Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy
Audrey Y Chu
Center for Cardiovascular Disease Prevention, the Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
Circ Cardiovasc Genet 5:676-85. 2012
..Data are sparse regarding genetic determinants of Lp-PLA(2) mass and activity, and no prior data are available addressing genetic determinants of statin-induced changes for this proinflammatory biomarker...
- Pharmacogenetic determinants of statin-induced reductions in C-reactive protein
Audrey Y Chu
Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
Circ Cardiovasc Genet 5:58-65. 2012
..However, whether different mechanisms underlie statin-induced CRP and LDL-C reduction is unknown...
- Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
BMJ 348:g1610. 2014
..To examine the interactions between genetic predisposition and consumption of fried food in relation to body mass index (BMI) and obesity...
- Novel locus including FGF21 is associated with dietary macronutrient intake
Audrey Y Chu
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
Hum Mol Genet 22:1895-902. 2013
..9 × 10(-9)). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake...
- Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
Daniel I Chasman
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Hum Mol Genet 21:5329-43. 2012
..The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general...
- Sugar-sweetened beverages and genetic risk of obesity
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 367:1387-96. 2012
..Temporal increases in the consumption of sugar-sweetened beverages have paralleled the rise in obesity prevalence, but whether the intake of such beverages interacts with the genetic predisposition to adiposity is unknown...