Niteesh K Choudhry

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint The implications of therapeutic complexity on adherence to cardiovascular medications
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Arch Intern Med 171:814-22. 2011
  2. doi request reprint Untangling the relationship between medication adherence and post-myocardial infarction outcomes: medication adherence and clinical outcomes
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Electronic address
    Am Heart J 167:51-58.e5. 2014
  3. doi request reprint Implementing randomized effectiveness trials in large insurance systems
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, USA
    J Clin Epidemiol 66:S5-11. 2013
  4. ncbi request reprint A systematic review of reference pricing: implications for US prescription drug spending
    Joy Li Yueh Lee
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am J Manag Care 18:e429-37. 2012
  5. doi request reprint The impact of reducing cardiovascular medication copayments on health spending and resource utilization
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 60:1817-24. 2012
  6. doi request reprint Cost-related medication underuse: prevalence among hospitalized managed care patients
    Niteesh K Choudhry
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    J Hosp Med 7:104-9. 2012
  7. pmc Measuring concurrent adherence to multiple related medications
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Manag Care 15:457-64. 2009
  8. pmc Drug company-sponsored patient assistance programs: a viable safety net?
    Niteesh K Choudhry
    Brigham and Women s Hospital BWH, Division of Pharmacoepidemiology and Pharmacoeconomics, in Boston, Massachusetts, USA
    Health Aff (Millwood) 28:827-34. 2009
  9. pmc Trends in adherence to secondary prevention medications in elderly post-myocardial infarction patients
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 17:1189-96. 2008
  10. doi request reprint Comparison of the impact of the Atrial Fibrillation Follow-Up Investigation of Rhythm Management trial on prescribing patterns: a time-series analysis
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Ann Pharmacother 42:1563-72. 2008

Collaborators

Detail Information

Publications96

  1. ncbi request reprint The implications of therapeutic complexity on adherence to cardiovascular medications
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Arch Intern Med 171:814-22. 2011
    ..Our objective was to estimate the extent of prescribing and filling complexity in patients prescribed a cardiovascular medication and to evaluate its association with adherence...
  2. doi request reprint Untangling the relationship between medication adherence and post-myocardial infarction outcomes: medication adherence and clinical outcomes
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Electronic address
    Am Heart J 167:51-58.e5. 2014
    ..This study quantifies the relationship between medication adherence and post-myocardial infarction (MI) adverse coronary events...
  3. doi request reprint Implementing randomized effectiveness trials in large insurance systems
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, USA
    J Clin Epidemiol 66:S5-11. 2013
    ..Studies designed to evaluate these issues are frequently conducted in large insurance systems. We sought to describe the challenges faced when conducting trials in this context...
  4. ncbi request reprint A systematic review of reference pricing: implications for US prescription drug spending
    Joy Li Yueh Lee
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am J Manag Care 18:e429-37. 2012
    ..These results suggest that reference pricing may be an attractive policy strategy for the US healthcare system...
  5. doi request reprint The impact of reducing cardiovascular medication copayments on health spending and resource utilization
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 60:1817-24. 2012
    ..The aim of this study was to evaluate the impact of reductions in statin and clopidogrel copayments on cardiovascular resource utilization, major coronary events, and insurer spending...
  6. doi request reprint Cost-related medication underuse: prevalence among hospitalized managed care patients
    Niteesh K Choudhry
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    J Hosp Med 7:104-9. 2012
    ..Estimates of cost-related medication underuse come largely from surveys of ambulatory patients. Hospitalized patients may be vulnerable to cost-related underuse and its consequences, but have been subject to little investigation...
  7. pmc Measuring concurrent adherence to multiple related medications
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Manag Care 15:457-64. 2009
    ..To propose standardized methods for measuring concurrent adherence to multiple related medications and to apply these definitions to a cohort of patients with diabetes mellitus...
  8. pmc Drug company-sponsored patient assistance programs: a viable safety net?
    Niteesh K Choudhry
    Brigham and Women s Hospital BWH, Division of Pharmacoepidemiology and Pharmacoeconomics, in Boston, Massachusetts, USA
    Health Aff (Millwood) 28:827-34. 2009
    ..A better understanding of PAPs might clarify their role in improving access to medications, the adequacy of existing public programs, and their impact on cost-effective medication use...
  9. pmc Trends in adherence to secondary prevention medications in elderly post-myocardial infarction patients
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 17:1189-96. 2008
    ..Poor levels of medication adherence for patients with coronary heart disease (CHD) have been documented but it is unclear whether adherence has improved over time...
  10. doi request reprint Comparison of the impact of the Atrial Fibrillation Follow-Up Investigation of Rhythm Management trial on prescribing patterns: a time-series analysis
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Ann Pharmacother 42:1563-72. 2008
    ..Because of superior safety and lower cost, rate control is now the recommended strategy for the management of most elderly, high-risk AF patients...
  11. pmc Rationale and design of the Post-MI FREEE trial: a randomized evaluation of first-dollar drug coverage for post-myocardial infarction secondary preventive therapies
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am Heart J 156:31-6. 2008
    ..Removing patient out-of-pocket drug costs may increase adherence, improve clinical outcomes, and even reduce overall health costs for high-risk patients. The existing data are inadequate to assess whether this strategy is effective...
  12. doi request reprint The economic consequences of non-evidence-based clopidogrel use
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am Heart J 155:904-9. 2008
    ..However, little is known about the appropriateness of that use. Overuse of clopidogrel could have important implications for health care quality and drug expenditures...
  13. pmc Cost-effectiveness of providing full drug coverage to increase medication adherence in post-myocardial infarction Medicare beneficiaries
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Circulation 117:1261-8. 2008
    ....
  14. pmc Statins in elderly patients with acute coronary syndrome: an analysis of dose and class effects in typical practice
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Heart 93:945-51. 2007
    ..To compare the effectiveness of statins of different treatment intensity used to treat elderly patients with acute coronary syndrome (ACS) in typical care settings...
  15. ncbi request reprint Should patients receive secondary prevention medications for free after a myocardial infarction? An economic analysis
    Niteesh K Choudhry
    Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Health Aff (Millwood) 26:186-94. 2007
    ..Our analysis suggests that covering combination therapy for such patients will save both lives and money...
  16. pmc Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis
    Niteesh K Choudhry
    Harvard Medical School and Brigham and Women s Hospital, Boston 02120, USA
    BMJ 332:141-5. 2006
    ..To quantify the influence of physicians' experiences of adverse events in patients with atrial fibrillation who were taking warfarin...
  17. doi request reprint Assessing the evidence for value-based insurance design
    Niteesh K Choudhry
    Harvard Medical School, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Health Aff (Millwood) 29:1988-94. 2010
    ..Maximizing the benefits of value-based insurance design will require mechanisms to target appropriate copayment reductions, offset short-run cost outlays, and expand its use to other health services...
  18. ncbi request reprint Warfarin prescribing in atrial fibrillation: the impact of physician, patient, and hospital characteristics
    Niteesh K Choudhry
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Am J Med 119:607-15. 2006
    ..The study investigated the determinants of warfarin use in patients with atrial fibrillation (AF)...
  19. doi request reprint Full coverage for preventive medications after myocardial infarction
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    N Engl J Med 365:2088-97. 2011
    ..Adherence to medications that are prescribed after myocardial infarction is poor. Eliminating out-of-pocket costs may increase adherence and improve outcomes...
  20. doi request reprint At Pitney Bowes, value-based insurance design cut copayments and increased drug adherence
    Niteesh K Choudhry
    Harvard Medical School, USA
    Health Aff (Millwood) 29:1995-2001. 2010
    ..Our study thus provides an empirical basis for the use of this approach to improve the quality of health care...
  21. doi request reprint The cost-effectiveness of C-reactive protein testing and rosuvastatin treatment for patients with normal cholesterol levels
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 57:784-91. 2011
    ..We sought to evaluate the cost-effectiveness of applying the JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) trial results into clinical practice...
  22. pmc State generic substitution laws can lower drug outlays under Medicaid
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Health Aff (Millwood) 29:1383-90. 2010
    ..Although these consent requirements are probably intended to increase patient autonomy, policy makers should consider the sizable opportunity costs...
  23. pmc Prevalence of atrial fibrillation and warfarin use in older patients receiving hemodialysis
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Nephrol 25:341-53. 2012
    ..Little is known about the use of warfarin in hemodialysis (HD) patients with atrial fibrillation (AF). We studied temporal trends of AF among older HD patients, and of warfarin use among those with AF...
  24. pmc Effectiveness and safety of warfarin initiation in older hemodialysis patients with incident atrial fibrillation
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 6:2662-8. 2011
    ..Although generally recommended in atrial fibrillation (AF) patients, the effectiveness and safety of oral anticoagulation in dialysis patients with AF is unknown...
  25. doi request reprint Patient, physician, and payment predictors of statin adherence
    David C Chan
    Department of Medicine, Division of General Internal Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Med Care 48:196-202. 2010
    ..Although many patient, physician, and payment predictors of adherence have been described, knowledge of their relative strength and overall ability to explain adherence is limited...
  26. pmc Adjuvant vancomycin for antibiotic prophylaxis and risk of Clostridium difficile infection after coronary artery bypass graft surgery
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 146:472-8. 2013
    ..Intravenous vancomycin exposure has been identified as an independent risk factor for CDI, but this is controversial. It is not known whether vancomycin administered for surgical site infection prophylaxis increases the risk of CDI...
  27. doi request reprint Patterns of medication initiation in newly diagnosed diabetes mellitus: quality and cost implications
    Nihar R Desai
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Med 125:302.e1-7. 2012
    ..We aimed to evaluate temporal trends in the use of specific drugs for the initial management of type 2 diabetes and to estimate the economic consequences of non-recommended care...
  28. pmc Modes of delivery for interventions to improve cardiovascular medication adherence
    Sarah L Cutrona
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA, USA
    Am J Manag Care 16:929-42. 2010
    ..To determine the optimal modes of delivery for interventions to improve adherence to cardiovascular medications...
  29. pmc Type of stress ulcer prophylaxis and risk of nosocomial pneumonia in cardiac surgical patients: cohort study
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMJ 347:f5416. 2013
    ..To examine the relation between the type of stress ulcer prophylaxis administered and the risk of postoperative pneumonia in patients undergoing coronary artery bypass grafting...
  30. doi request reprint Comparative effectiveness of preventative therapy for venous thromboembolism after coronary artery bypass graft surgery
    Alexander Kulik
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Circ Cardiovasc Interv 5:590-6. 2012
    ..Controversy exists regarding the optimal preventative therapy for venous thromboembolism (VTE) after coronary artery bypass graft (CABG) surgery. We sought to compare the effectiveness and safety of the most commonly used regimens...
  31. ncbi request reprint Healthcare information technology interventions to improve cardiovascular and diabetes medication adherence
    Alexander S Misono
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Manag Care 16:SP82-92. 2010
    ..To determine the efficacy of healthcare information technology (HIT) interventions in improving adherence...
  32. pmc Can improved prescription medication labeling influence adherence to chronic medications? An evaluation of the Target pharmacy label
    William H Shrank
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street Suite 3030, Boston, MA 02120, USA
    J Gen Intern Med 24:570-8. 2009
    ..A new prescription medication labeling system was implemented by Target pharmacies in May 2005 and aimed to improve readability and understanding...
  33. doi request reprint Full prescription coverage versus usual prescription coverage after coronary artery bypass graft surgery: analysis from the post-myocardial infarction free Rx event and economic evaluation (FREEE) randomized trial
    Alexander Kulik
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA A K, N R D, W H S, E M A, R J G, R L, N K C Lynn Heart and Vascular Institute, Boca Raton Regional Hospital, Boca Raton, FL A K Charles E Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL A K Aetna, Hartford, CT L R and CVS Caremark, Woonsocket, RI T B
    Circulation 128:S219-25. 2013
    ..Because adherence to medical therapy is low among patients treated with coronary artery bypass graft surgery (CABG), we evaluated the impact of providing full prescription coverage to this patient subgroup...
  34. doi request reprint Warnings without guidance: patient responses to an FDA warning about ezetimibe
    William H Shrank
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston 02120, USA
    Med Care 50:479-84. 2012
    ..We investigated the proportion of patients who discontinued therapy and switched to a clinically appropriate alternative after the FDA communication...
  35. doi request reprint Patterns and predictors of generic narrow therapeutic index drug use among older adults
    Joshua J Gagne
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Am Geriatr Soc 61:1586-91. 2013
    ..To ascertain predictors of initiation of brand-name versus generic narrow therapeutic index (NTI) drugs...
  36. doi request reprint Cost-effectiveness of genotype-guided warfarin dosing for patients with atrial fibrillation
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Circ Cardiovasc Qual Outcomes 2:429-36. 2009
    ..However, the effectiveness of genotyping in improving anticoagulation control and reducing major bleeding has not yet been compellingly demonstrated. Genotyping currently costs $400 to $550...
  37. doi request reprint The epidemiology of prescriptions abandoned at the pharmacy
    William H Shrank
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    Ann Intern Med 153:633-40. 2010
    ..Understanding the epidemiology and correlates of prescription abandonment may have an important effect on health care quality...
  38. pmc Rationale and design of the Study Assessing the Effect of Cardiovascular Medications Provided as Low-cost, Evidence-based Generic Samples (SAMPLES) trial
    William H Shrank
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am Heart J 157:613-9. 2009
    ..Highly effective generic cardiovascular medications are frequently underused, leading to greater overall drug costs and cost-related nonadherence...
  39. doi request reprint Group-based trajectory models: a new approach to classifying and predicting long-term medication adherence
    Jessica M Franklin
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Med Care 51:789-96. 2013
    ..The purpose of this study was to evaluate the use of a novel method, group-based trajectory models, for classifying patients by their long-term adherence...
  40. pmc Comparative cost-effectiveness of interventions to improve medication adherence after myocardial infarction
    Kouta Ito
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Health Serv Res 47:2097-117. 2012
    ..To evaluate the comparative cost-effectiveness of interventions to improve adherence to evidence-based medications among postmyocardial infarction (MI) patients...
  41. doi request reprint Targeting cardiovascular medication adherence interventions
    Sarah L Cutrona
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    J Am Pharm Assoc (2003) 52:381-97. 2012
    ..To determine whether adherence interventions should be administered to all medication takers or targeted to nonadherers...
  42. pmc Is there a relationship between patient beliefs or communication about generic drugs and medication utilization?
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Med Care 47:319-25. 2009
    ..Insurers and policymakers strive to stimulate more cost-effective prescribing and, increasingly, are educating beneficiaries about generics...
  43. pmc Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison
    Joshua J Gagne
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    BMJ 347:f5307. 2013
    ..To evaluate whether smoking status is associated with the efficacy of antiplatelet treatment in the prevention of cardiovascular events...
  44. doi request reprint The use of generic drugs in prevention of chronic disease is far more cost-effective than thought, and may save money
    William H Shrank
    CVS Caremark Harvard Partnership to Improve Medication Adherence, Brigham and Women s Hospital, Boston, MA, USA
    Health Aff (Millwood) 30:1351-7. 2011
    ..As the nation attempts to find strategies to improve population health without adding to the unsustainably high cost of care, policy makers should focus on ensuring that patients have access to essential generic medications...
  45. pmc Comparative efficacy and safety of new oral anticoagulants in patients with atrial fibrillation
    Sebastian Schneeweiss
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Circ Cardiovasc Qual Outcomes 5:480-6. 2012
    ..We sought to compare the efficacy and safety of the 3 new agents based on data from their published warfarin-controlled randomized trials, using the method of adjusted indirect comparisons...
  46. pmc A cohort study of thiazolidinediones and fractures in older adults with diabetes
    Daniel H Solomon
    Division of Rheumatology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Clin Endocrinol Metab 94:2792-8. 2009
    ..Recent results from several randomized controlled trials find an increased risk of fracture with TZDs compared with other oral antidiabetic agents...
  47. doi request reprint Trouble getting started: predictors of primary medication nonadherence
    Michael A Fischer
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Med 124:1081.e9-22. 2011
    ..The advent of electronic prescribing (e-prescribing) systems provides the opportunity to track initial prescriptions and identify nonadherence that may have previously been undetected...
  48. doi request reprint The consequences of requesting "dispense as written"
    William H Shrank
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Med 124:309-17. 2011
    ..Patients also can make these requests. Little is known about the frequency and correlates of dispense as written requests or their association with medication filling...
  49. doi request reprint Adherence to statin therapy in elderly patients after hospitalization for coronary revascularization
    Alexander Kulik
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 107:1409-14. 2011
    ..Given the health and economic consequences of nonadherence, these findings highlight the need for developing cost-effective strategies to improve medication adherence after coronary revascularization...
  50. doi request reprint Trends in insulin initiation and treatment intensification among patients with type 2 diabetes
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA
    J Gen Intern Med 29:320-7. 2014
    ....
  51. doi request reprint The impact of medication adherence on coronary artery disease costs and outcomes: a systematic review
    Asaf Bitton
    Division of General Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Med 126:357.e7-357.e27. 2013
    ..We sought to systematically review the literature on this topic area with a focus on quantified cost and clinical outcomes related to adherence...
  52. ncbi request reprint The international pharmaceutical market as a source of low-cost prescription drugs for U.S. patients
    Aaron S Kesselheim
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Intern Med 148:614-9. 2008
    ....
  53. doi request reprint Gender and racial disparities in adherence to statin therapy: a meta-analysis
    Jennifer Lewey
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am Heart J 165:665-78, 678.e1. 2013
    ..Our objective was to evaluate the effect of race/ethnicity and gender on adherence to statin therapy for primary or secondary prevention...
  54. pmc Physician effectiveness in interventions to improve cardiovascular medication adherence: a systematic review
    Sarah L Cutrona
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
    J Gen Intern Med 25:1090-6. 2010
    ..Medications for the prevention and treatment of cardiovascular disease save lives but adherence is often inadequate. The optimal role for physicians in improving adherence remains unclear...
  55. doi request reprint Are caregivers adherent to their own medications?
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    J Am Pharm Assoc (2003) 51:492-8. 2011
    ..To explore caregiver adherence to chronic medications and predictors of appropriate medication use...
  56. doi request reprint Cost-effectiveness of oral anticoagulants for treatment of atrial fibrillation
    William J Canestaro
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Circ Cardiovasc Qual Outcomes 6:724-31. 2013
    ..New anticoagulants may improve health outcomes in patients with atrial fibrillation, but it is unclear whether their use is cost-effective...
  57. doi request reprint Variations in pill appearance of antiepileptic drugs and the risk of nonadherence
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    JAMA Intern Med 173:202-8. 2013
    ..We sought to determine whether switching among different-appearing antiepileptic drugs (AEDs) is associated with increased rates of medication nonpersistence, which can have serious medical, financial, and social consequences...
  58. pmc A systematic review of adherence to cardiovascular medications in resource-limited settings
    Ashna D K Bowry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    J Gen Intern Med 26:1479-91. 2011
    ..To evaluate prevalence and predictors of non-adherence to cardiovascular medications in this context, we systematically reviewed the peer-reviewed literature...
  59. pmc Variation in initiating secondary prevention after myocardial infarction by hospitals and physicians, 1997 through 2004
    Andrea V Margulis
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 20:1088-97. 2011
    ....
  60. doi request reprint Conflict of interest in oncology publications: a survey of disclosure policies and statements
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Cancer 118:188-95. 2012
    ..The authors sought to define current disclosure policies and how they relate to disclosure statements provided by authors in major oncology journals...
  61. doi request reprint Physician perceptions about generic drugs
    William H Shrank
    Brigham and Women s Hospital and Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Boston, MA, USA
    Ann Pharmacother 45:31-8. 2011
    ..With constrained health-care resources, there is a need to understand barriers to cost-effective medication use...
  62. pmc Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome
    Jeremy A Rassen
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    Circulation 120:2322-9. 2009
    ..Recent studies have raised concerns about the reduced efficacy of clopidogrel when used concurrently with proton pump inhibitors (PPIs), but those studies may have overestimated the risk...
  63. pmc Clinical equivalence of generic and brand-name drugs used in cardiovascular disease: a systematic review and meta-analysis
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    JAMA 300:2514-26. 2008
    ..Use of generic drugs, which are bioequivalent to brand-name drugs, can help contain prescription drug spending. However, there is concern among patients and physicians that brand-name drugs may be clinically superior to generic drugs...
  64. doi request reprint Meta-analysis of the efficacy and safety of clopidogrel plus aspirin as compared to antiplatelet monotherapy for the prevention of vascular events
    Ashna D K Bowry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Cardiol 101:960-6. 2008
    ....
  65. pmc An evaluation of the relationship between the implementation of a newly designed prescription drug label at Target pharmacies and health outcomes
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Med Care 47:1031-5. 2009
    ..A new prescription medication labeling system was implemented by Target pharmacies in May 2005 and aimed to improve health outcomes...
  66. ncbi request reprint Impact of Medicaid prior authorization on angiotensin-receptor blockers: can policy promote rational prescribing?
    Michael A Fischer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Health Aff (Millwood) 26:800-7. 2007
    ..3 percent per quarter; alternative approaches were unsuccessful. These findings have important implications for the development of rational drug reimbursement policy under Medicare Part D and other health insurance plans...
  67. pmc Trends in drug prescribing for osteoporosis after hip fracture, 1995-2004
    Suzanne M Cadarette
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    J Rheumatol 35:319-26. 2008
    ..To examine trends in osteoporosis drug prescribing after hip fracture from 1995 to 2004...
  68. doi request reprint Impact of statin use on outcomes after coronary artery bypass graft surgery
    Alexander Kulik
    Brigham and Women s Hospital, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
    Circulation 118:1785-92. 2008
    ....
  69. doi request reprint Impediments to adherence to post myocardial infarction medications
    Nihar R Desai
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Curr Cardiol Rep 15:322. 2013
    ....
  70. doi request reprint Barriers to insulin progression among patients with type 2 diabetes: a systematic review
    Jennifer M Polinski
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Diabetes Educ 39:53-65. 2013
    ..progression among patients with type 2 diabetes: (1) What are the patient, provider, and health system barriers to insulin progression? (2) Do insulin progression barriers differ between insulin-naive and insulin-experienced patients?..
  71. pmc Preoperative statin use and postoperative acute kidney injury
    Steven M Brunelli
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Med 125:1195-1204.e3. 2012
    ..The purpose of this study was to evaluate whether preoperative statin use is associated with a decreased risk of postoperative acute kidney injury...
  72. pmc Statin utilization in nursing home patients after cardiac hospitalization
    Seema Parikh
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Gen Intern Med 25:1293-9. 2010
    ..Coronary artery disease (CAD) is highly prevalent in nursing home residents and is associated with a substantial clinical and economic burden. Statins reduce mortality and hospitalization rates in older patients with CAD...
  73. pmc A blueprint for pharmacy benefit managers to increase value
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont St, Ste 3030, Boston, MA 02120, USA
    Am J Manag Care 15:87-93. 2009
    ..Incentives for PBMs to promote value should drive innovation and improve health outcomes...
  74. ncbi request reprint Physicians' perceptions of relevant prescription drug costs: do costs to the individual patient or to the population matter most?
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Ste 3030, Boston, MA 02120, USA
    Am J Manag Care 12:545-51. 2006
    ..We evaluated physicians' perceptions about relevant costs for prescription drugs and the importance of communication about these costs...
  75. ncbi request reprint The variability and quality of medication container labels
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St, Ste 3030, Boston, MA 02120, USA
    Arch Intern Med 167:1760-5. 2007
    ..Medication errors occur frequently, and poor medication labeling is cited as a potential cause. We assessed the format, content, and variability of prescription drug container labels dispensed in the community...
  76. doi request reprint Atrioventricular nodal ablation in atrial fibrillation: a meta-analysis and systematic review
    Neal A Chatterjee
    Department of Medicine and the Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA 02411, USA
    Circ Arrhythm Electrophysiol 5:68-76. 2012
    ..Additionally, the impact of AVNA in patients with reduced systolic function is of growing interest...
  77. pmc Patients' perceptions of generic medications
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, at Brigham and Women s Hospital Harvard Medical School in Boston, Massachusetts, USA
    Health Aff (Millwood) 28:546-56. 2009
    ..These findings underscore the challenge that providers, insurers, and policymakers face in stimulating the cost-effective use of medications...
  78. ncbi request reprint Systematic review: the relationship between clinical experience and quality of health care
    Niteesh K Choudhry
    Harvard Medical School and Harvard Pilgrim Health Care, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Intern Med 142:260-73. 2005
    ..However, evidence suggests that there is an inverse relationship between the number of years that a physician has been in practice and the quality of care that the physician provides...
  79. ncbi request reprint Over-the-counter statins
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Ann Intern Med 142:910-3. 2005
    ..quot;..
  80. ncbi request reprint Effect of the Women's Health Initiative on osteoporosis therapy and expenditure in Medicaid
    Jacob A Udell
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    J Bone Miner Res 21:765-71. 2006
    ..Prescribing changes dramatically increased Medicaid spending on osteoporosis therapy over the last decade and requires further evaluation of cost effectiveness...
  81. doi request reprint Pulmonary vein isolation with complex fractionated atrial electrogram ablation for paroxysmal and nonparoxysmal atrial fibrillation: A meta-analysis
    Robert M Hayward
    Department of Medicine and Cardiac Arrhythmia Service, Massachusetts General Hospital Heart Center, Boston, Massachusetts, USA
    Heart Rhythm 8:994-1000. 2011
    ..Ablation of complex fractionated atrial electrograms (CFAEs) in addition to PVI has been advocated as a means to improve procedural outcomes, but the benefit remains unclear...
  82. pmc Online social networking by patients with diabetes: a qualitative evaluation of communication with Facebook
    Jeremy A Greene
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Gen Intern Med 26:287-92. 2011
    ..These new sources of knowledge, support, and engagement have become important for patients living with chronic disease, yet the quality and content of the information provided in these digital arenas are poorly understood...
  83. pmc Early angiography in patients with chronic kidney disease: a collaborative systematic review
    David M Charytan
    Renal Division and Clinical Biometrics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 4:1032-43. 2009
    ....
  84. doi request reprint Cardiac resynchronization in patients with atrial fibrillation: a meta-analysis of prospective cohort studies
    Gaurav A Upadhyay
    Department of Medicine and the Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 52:1239-46. 2008
    ..This study is a meta-analysis of prospective cohort studies comparing the impact of cardiac resynchronization therapy (CRT) for patients in atrial fibrillation (AF) and sinus rhythm (SR)...
  85. ncbi request reprint How should patients with unstable angina and non-ST-segment elevation myocardial infarction be managed? A meta-analysis of randomized trials
    Niteesh K Choudhry
    Harvard Medical School and Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Am J Med 118:465-74. 2005
    ..Patients with unstable angina or non-ST-segment elevation myocardial infarction (MI) may be managed with either an "invasive" or "conservative" strategy. It is unclear which of these strategies is superior...
  86. ncbi request reprint A perspective on US drug reimportation
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02120, USA
    JAMA 293:358-62. 2005
  87. ncbi request reprint Does this patient with a pericardial effusion have cardiac tamponade?
    Christopher L Roy
    Division of General Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    JAMA 297:1810-8. 2007
    ..The clinical examination may assist in the decision to perform pericardiocentesis in patients with cardiac tamponade diagnosed by echocardiography...
  88. ncbi request reprint CPR for patients labeled DNR: the role of the limited aggressive therapy order
    Niteesh K Choudhry
    Harvard University, Cambridge, Massachusetts, USA
    Ann Intern Med 138:65-8. 2003
    ..This new level of resuscitation could be called a "limited aggressive therapy" order...
  89. ncbi request reprint A perspective on U.S. drug reimportation
    Niteesh K Choudhry
    Brigham and Women s Hospital
    Minn Med 88:46-51. 2005
  90. ncbi request reprint Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomized controlled trials
    Paaladinesh Thavendiranathan
    Department of Medicine, University of Toronto, Toronto, Ontario
    Arch Intern Med 166:2307-13. 2006
    ..To clarify the role of statins for patients without CV disease, we performed a meta-analysis of randomized controlled trials (RCTs)...
  91. ncbi request reprint Patterns and predictors of statin use after coronary artery bypass graft surgery
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    J Thorac Cardiovasc Surg 134:932-8. 2007
    ..The purposes of this study were to assess statin prescription rates in patients who have undergone coronary artery bypass graft surgery and to identify the determinants of postoperative statin administration...
  92. pmc Medication adherence after myocardial infarction: a long way left to go
    Niteesh K Choudhry
    J Gen Intern Med 23:216-8. 2008
  93. ncbi request reprint Physician responses to the malpractice crisis: from defense to offense
    Allen Kachalia
    Division of General Medicine, Brigham and Women s Hospital, USA
    J Law Med Ethics 33:416-28. 2005
  94. doi request reprint Using computer-based decision support to close the "know do" gap in lipid-lowering therapy
    Jerry Avorn
    Circulation 117:336-7. 2008
  95. ncbi request reprint Ventricular arrhythmias and cerebrovascular events in the elderly using conventional and atypical antipsychotic medications
    Philip S Wang
    J Clin Psychopharmacol 27:707-10. 2007
  96. pmc Do blood tests cause anemia in hospitalized patients? The effect of diagnostic phlebotomy on hemoglobin and hematocrit levels
    Paaladinesh Thavendiranathan
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Gen Intern Med 20:520-4. 2005
    ..To determine whether phlebotomy contributes to changes in hemoglobin and hematocrit levels in hospitalized general internal medicine patients...