Wonshik Choi

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Extended depth of focus in tomographic phase microscopy using a propagation algorithm
    Wonshik Choi
    GR Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 33:171-3. 2008
  2. pmc Field-based angle-resolved light-scattering study of single live cells
    Wonshik Choi
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 33:1596-8. 2008
  3. pmc Optical diffraction tomography for high resolution live cell imaging
    Yongjin Sung
    GR Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:266-77. 2009
  4. pmc Quantitative DIC microscopy using an off-axis self-interference approach
    Dan Fu
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 35:2370-2. 2010
  5. pmc Single-shot full-field reflection phase microscopy
    Zahid Yaqoob
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 19:7587-95. 2011
  6. pmc Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing
    Zahid Yaqoob
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:10681-7. 2009
  7. pmc Live cell refractometry using Hilbert phase microscopy and confocal reflectance microscopy
    Niyom Lue
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Phys Chem A 113:13327-30. 2009
  8. pmc Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:020506. 2010
  9. pmc Digital optical phase conjugation for delivering two-dimensional images through turbid media
    Timothy R Hillman
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Rep 3:1909. 2013
  10. ncbi request reprint Tomographic phase microscopy
    Wonshik Choi
    G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue 6 014, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Methods 4:717-9. 2007

Collaborators

Detail Information

Publications26

  1. pmc Extended depth of focus in tomographic phase microscopy using a propagation algorithm
    Wonshik Choi
    GR Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 33:171-3. 2008
    ..Diffraction is thus incorporated, extending the depth of focus to more than 10 mum. Tomograms with improved focal depth are demonstrated for single HT29 cells...
  2. pmc Field-based angle-resolved light-scattering study of single live cells
    Wonshik Choi
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 33:1596-8. 2008
    ....
  3. pmc Optical diffraction tomography for high resolution live cell imaging
    Yongjin Sung
    GR Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:266-77. 2009
    ....
  4. pmc Quantitative DIC microscopy using an off-axis self-interference approach
    Dan Fu
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 35:2370-2. 2010
    ..This method is practically simple to implement on any standard microscope without stringent requirements on polarization optics. Optical sectioning can be obtained through enlarged illumination NA...
  5. pmc Single-shot full-field reflection phase microscopy
    Zahid Yaqoob
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 19:7587-95. 2011
    ..We have measured the path-length sensitivity of our instrument to be approximately 21 picometers/Hz that makes it suitable for nanometer-scale full-field measurement of membrane dynamics in live cells...
  6. pmc Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing
    Zahid Yaqoob
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:10681-7. 2009
    ..We present the detection of natural motions of cell surface and two-dimensional surface profiling of a HeLa cell...
  7. pmc Live cell refractometry using Hilbert phase microscopy and confocal reflectance microscopy
    Niyom Lue
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Phys Chem A 113:13327-30. 2009
    ..The accuracy of the axially averaged index measurement is 0.002. This approach can provide novel biological assays of label-free living cells in situ...
  8. pmc Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:020506. 2010
    ..Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering...
  9. pmc Digital optical phase conjugation for delivering two-dimensional images through turbid media
    Timothy R Hillman
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Rep 3:1909. 2013
    ..By measuring the output response to digital distortion of the SLM write pattern, we validate the sub-wavelength sensitivity of the system...
  10. ncbi request reprint Tomographic phase microscopy
    Wonshik Choi
    G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue 6 014, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Methods 4:717-9. 2007
    ..Our results will permit quantitative characterization of specimen-induced aberrations in high-resolution microscopy and have multiple applications in tissue light scattering...
  11. pmc Speckle-field digital holographic microscopy
    Yongkeun Park
    George R Harrison Spectroscopy Laboratory, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Opt Express 17:12285-92. 2009
    ..This technique has great potential in studying biological samples with improved sensitivity, resolution and optical sectioning capability...
  12. pmc Synthetic aperture tomographic phase microscopy for 3D imaging of live cells in translational motion
    Niyom Lue
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 16:16240-6. 2008
    ....
  13. pmc Size homeostasis in adherent cells studied by synthetic phase microscopy
    Yongjin Sung
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139
    Proc Natl Acad Sci U S A 110:16687-92. 2013
    ..In attached epithelial cells, we find that due to the asymmetry in cell division and size-dependent growth rate, there is active regulation of cell size. Thus, like nonadherent cells, size homeostasis requires feedback control. ..
  14. pmc Label-free imaging of membrane potential using membrane electromotility
    Seungeun Oh
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 103:11-8. 2012
    ..We demonstrate wide-field imaging of the propagation of electrical stimuli in gap-junction-coupled cell networks. Membrane electromotility-induced cell deformation may be useful as a reporter of electrical activity...
  15. pmc Video-rate tomographic phase microscopy
    Christopher Fang-Yen
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 16:011005. 2011
    ..We use the instrument to quantitatively monitor rapid changes in refractive index within defined subregions of cells due to exposure to acetic acid or changes in medium osmolarity...
  16. pmc Assessing light scattering of intracellular organelles in single intact living cells
    Maxim Kalashnikov
    GR Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:19674-81. 2009
    ....
  17. pmc Ultraviolet refractometry using field-based light scattering spectroscopy
    Dan Fu
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA
    Opt Express 17:18878-86. 2009
    ..Typical accuracy of the present refractive index technique is <or=0.003. The precision of refractive index measurements is <or=0.002 and that of specific refractive index increment determination is <or=0.01 mL/g...
  18. pmc Confocal diffraction phase microscopy of live cells
    Niyom Lue
    G H Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Lett 33:2074-6. 2008
    ....
  19. pmc Measurement of the time-resolved reflection matrix for enhancing light energy delivery into a scattering medium
    Youngwoon Choi
    Laser Biomedical Research Center, G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA and Department of Physics, Korea University, Seoul 136 701, Korea
    Phys Rev Lett 111:243901. 2013
    ..This leads to enhanced light delivery at the target depth. The proposed method will lay a foundation for efficient phototherapy and deep-tissue in vivo imaging in the near future. ..
  20. pmc Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells
    Yongkeun Park
    George R Harrison Spectroscopy Laboratory, MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Opt Lett 34:3668-70. 2009
    ..The end point of this study is noninvasive monitoring of physiological states of intact living cells...
  21. pmc Imaging red blood cell dynamics by quantitative phase microscopy
    Gabriel Popescu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Blood Cells Mol Dis 41:10-6. 2008
    ..By providing non-invasive methods for imaging mechanics of live cells, these novel techniques provide an opportunity for high-throughput analysis and study of RBC mechanical properties in health and disease...
  22. ncbi request reprint Quantitative phase imaging of live cells using fast Fourier phase microscopy
    Niyom Lue
    Spectroscopy Laboratory, Massachusetts Institute of Technology, MA 02139, USA
    Appl Opt 46:1836-42. 2007
    ....
  23. pmc Stain-free quantification of chromosomes in live cells using regularized tomographic phase microscopy
    Yongjin Sung
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e49502. 2012
    ..In addition, we demonstrate chromosomal imaging using a dual-wavelength RTPM, which shows its potential to determine the molecular composition of cellular organelles in live cells...
  24. pmc Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:13730-5. 2008
    ..These findings offer potential, and sufficiently general, avenues for identifying, through cell membrane dynamics, pathological states that cause or accompany human diseases...
  25. ncbi request reprint Imaging voltage-dependent cell motions with heterodyne Mach-Zehnder phase microscopy
    Christopher Fang-Yen
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 32:1572-4. 2007
    ..We use the microscope to image cultured neurons and measure nanometer-scale voltage-dependent motions in cells expressing the membrane motor protein prestin...
  26. pmc Thickness-radius relationship and spring constants of cholesterol helical ribbons
    Boris Khaykovich
    Nuclear Reactor Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:15663-6. 2009
    ....