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Genomes and Genes | Tanuja ChitnisSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
International Pediatric MS Study Group Clinical Trials Summit: meeting reportTanuja Chitnis
Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, Boston, MA, USA
Neurology 80:1161-8. 2013..The goal of this meeting was to assess areas of consensus regarding clinical trial design and outcome measures among academic experts involved in pediatric MS care and research...
Disease-modifying therapy of pediatric multiple sclerosisTanuja Chitnis
Harvard Medical School, Boston, MA 02115, USA
Neurotherapeutics 10:89-96. 2013....- Consensus statement: evaluation of new and existing therapeutics for pediatric multiple sclerosisT Chitnis
Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, Boston, MA 02114, USA
Mult Scler 18:116-27. 2012..Mechanisms for conducting high-impact, multicenter studies, including long-term follow-up in pediatric MS, are required to ensure that all MS patients, irrespective of age, benefit from advances in MS therapeutics... 
Pediatric multiple sclerosisTanuja Chitnis
Brigham and Women s Hospital, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts 02115, USA
Neurologist 12:299-310. 2006....- Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United StatesT Chitnis
Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children, Boston, MA, USA Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Boston, MA, USA
Mult Scler 15:627-31. 2009..The prevalence of pediatric-onset multiple sclerosis (MS) in the United States is unknown... - Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitisBing Zhu
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 176:3480-9. 2006..In conclusion, PD-L1 and PD-L2 differentially regulate the susceptibility and chronic progression of EAE in a strain-specific manner... - Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosisKatherine A McLaughlin
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 183:4067-76. 2009..7% of patients in the 10- to 18-year age group. B cell autoimmunity to this myelin surface Ag is therefore most common in patients with a very early onset of MS... - Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegenerationTanuja Chitnis
Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Pathol 170:1695-712. 2007..Strategies that up-regulate the expression of CD200 in the CNS or molecules that ligate the CD200R may be relevant as neuroprotective strategies in multiple sclerosis... - Work productivity in relapsing multiple sclerosis: associations with disability, depression, fatigue, anxiety, cognition, and health-related quality of lifeBonnie I Glanz
Department of Neurology, Harvard Medical School, Boston, MA, USA
Value Health 15:1029-35. 2012.... - Accounting for disease modifying therapy in models of clinical progression in multiple sclerosisBrian C Healy
Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Brookline, MA 02115, USA
J Neurol Sci 303:109-13. 2011..DMT modeling choice had a modest impact on the variables classified as predictors of EDSS score change. Importantly, however, interpretation of these predictors is dependent upon modeling choice... - Increased Th17 response to myelin peptides in pediatric MSDavid Vargas-Lowy
Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA, USA
Clin Immunol 146:176-84. 2013..In addition, T cells with a central memory phenotype producing IL-17 were increased in PMS compared to PHC (p<0.05). IL-7 levels in culture supernatants were elevated in PMS compared to PHC and AMS (t test<0.01)... - CD200R1 agonist attenuates mechanisms of chronic disease in a murine model of multiple sclerosisYingru Liu
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 30:2025-38. 2010.... - One year activity on subtraction MRI predicts subsequent 4 year activity and progression in multiple sclerosisMaria Liguori
Department of Radiology, Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurol Neurosurg Psychiatry 82:1125-31. 2011..To compare sensitivity of sMRI and contrast enhanced MRI towards disease activity... - Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitisWassim Elyaman
Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Pathol 173:411-22. 2008..Our data extend the understanding of the pathogenicity of autoreactive memory T cells and have important implications for the development of novel therapies for human autoimmune diseases... - Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosisMark P Gorman
Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Boston, MA, USA
Arch Neurol 66:54-9. 2009..To investigate whether or not the disparity in disease progression in those with pediatric-onset compared with adult-onset multiple sclerosis (MS) is due to differences in relapse rates... - Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatmentsRobert Gross
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, United States
J Neuroimmunol 233:168-74. 2011..The HLA DRB1 1501 allele explained some of this variation in event-free survival while on GA, and we found suggestive evidence that an IRF8 polymorphism influences event-free survival in IFN β treated subjects... - The impact of a recent relapse on patient-reported outcomes in subjects with multiple sclerosisBrian C Healy
Partners Multiple Sclerosis Center, Brigham and Women s Hospital, 6th Floor, 1 Brookline Place, Brookline, MA 02445, USA
Qual Life Res 21:1677-84. 2012..In this study, we estimate the impact of a recent relapse on physical and mental health in subjects with relapsing-remitting multiple sclerosis (RRMS) using validated patient-reported outcome (PRO) measures... - Cognitive deterioration in patients with early multiple sclerosis: a 5-year studyBonnie I Glanz
Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Neurol Neurosurg Psychiatry 83:38-43. 2012..Methodological issues associated with longitudinal cognitive research such as practice effects and drop-outs were also examined... - Effect of gender on late-onset multiple sclerosisRiley M Bove
Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Boston, USA
Mult Scler 18:1472-9. 2012.... - Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal studyJennifer Moodie
Department of Neurology, University of Massachusetts, Boston, MA, USA
J Neurol Sci 315:49-54. 2012..We previously described a composite MRI scale combining T1-lesions, T2-lesions and whole brain atrophy in multiple sclerosis (MS): the magnetic resonance disease severity scale (MRDSS)... - Gestational vitamin D and the risk of multiple sclerosis in offspringFariba Mirzaei
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Ann Neurol 70:30-40. 2011..Vitamin D may have a protective role in the etiology of multiple sclerosis (MS), but the effect of gestational vitamin D on adult onset MS has not been studied... - Improving power to detect disease progression in multiple sclerosis through alternative analysis strategiesBrian Healy
Partners MS Center, Brigham and Women s Hospital, Brookline, MA 02445, USA
J Neurol 258:1812-9. 2011..Sustained progression on the EDSS is a less powerful outcome measure for clinical progression than approaches based on the actual EDSS values... - A method for evaluating treatment switching criteria in multiple sclerosisBrian C Healy
Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
Mult Scler 16:1483-9. 2010..We investigated a method to evaluate a treatment switching approach, namely treatment change after one multiple sclerosis (MS) relapse... - Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivoTanuja Chitnis
Center for Neurologic Diseases, Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
J Immunol 172:4260-5. 2004..These data have implications for the treatment of immune-mediated diseases by immunomodulatory agents that alter the cytokine milieu in vivo... - Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in miceJaime Imitola
Brigham and Women s Hospital, Center for Neurologic Diseases, Partner Multiple Sclerosis Center, Harvard Medical School, Department of Neurology, Boston, Massachusetts 02115, USA
J Biomed Opt 16:021109. 2011.... - The role of CD4 T cells in the pathogenesis of multiple sclerosisTanuja Chitnis
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Int Rev Neurobiol 79:43-72. 2007..Here, we outline basic concepts in CD4+ T-cell immunology and summarize the current understanding of the role of CD4+ T cells in the pathogenesis of MS... - Pathogenesis of pediatric multiple sclerosisDavid Vargas-Lowy
Center for Neurological Diseases, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02114, USA
J Child Neurol 27:1394-407. 2012.... - Dietary intake of vitamin D during adolescence and risk of multiple sclerosisKassandra L Munger
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg 2, 3rd Fl, Boston, MA 02115, USA
J Neurol 258:479-85. 2011..11), whereas intake of whole milk, an important source of dietary vitamin D, was associated with an increased risk. The possibility of opposite effects of vitamin D and milk intake on MS risk should be considered in future studies... - Daclizumab use in patients with pediatric multiple sclerosisMark P Gorman
Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, ACC 708, 55 Fruit St, Boston, MA 02114, USA
Arch Neurol 69:78-81. 2012.... - Body size and risk of MS in two cohorts of US womenKassandra L Munger
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Neurology 73:1543-50. 2009..To examine whether obesity during childhood, adolescence, or adulthood is associated with an increased risk of multiple sclerosis (MS)... - Cytokines in multiple sclerosis: from bench to bedsideJaime Imitola
Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Rm 710, Boston, MA 02115, USA
Pharmacol Ther 106:163-77. 2005..In this review, we will summarize the current knowledge on the role of cytokine pathways in MS and what we learned from investigation of its animal model: experimental autoimmune encephalomyelitis (EAE)... - Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured proteinKevin C O'Connor
Center for Neurologic Diseases, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Med 13:211-7. 2007..MOG-specific autoantibodies were identified in a subset of ADEM but only rarely in adult-onset MS cases, indicating that MOG is a more prominent target antigen in ADEM than MS... - Insights into the molecular pathogenesis of progression in multiple sclerosis: potential implications for future therapiesJaime Imitola
Center for Neurologic Diseases and Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Arch Neurol 63:25-33. 2006..The molecular pathways leading to structural and functional neurodegeneration and those that prevent regeneration need to be identified in order to design new therapeutic strategies that can halt or even reverse disease progression... - Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis modelsShinjiro Kaneko
Division of Neuroscience, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 26:9794-804. 2006..Finally, we demonstrate that delayed NAm treatment is also beneficial to EAE models, pointing to the therapeutic potential of NAm as a protective agent for EAE and perhaps MS patients... - Pediatric multiple sclerosisTanuja Chitnis
Harvard Medical School, Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children, 55 Fruit Street, Boston, MA 02114, USA
Neurol Clin 29:481-505. 2011..However, there remain several key areas that require further exploration. This article summarizes the current state of knowledge on pediatric MS and discusses future avenues of investigation... - Evaluation of an online platform for multiple sclerosis research: patient description, validation of severity scale, and exploration of BMI effects on disease courseRiley Bove
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Institute for the Neurosciences, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 8:e59707. 2013..com (PLM), for research in multiple sclerosis (MS). An investigation of the role of body mass index (BMI) on MS disease course was conducted to illustrate the utility of the platform... - Regulation of postsurgical fibrosis by the programmed death-1 inhibitory pathwayMatthew A Holsti
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 172:5774-81. 2004.... - Assessment of definitions of sustained disease progression in relapsing-remitting multiple sclerosisBrian C Healy
Partners MS Center, Harvard Medical School, Brigham and Women s Hospital, 1 Brookline Place, Brookline, MA 02445, USA Biostatistics Center, Massachusetts General Hospital, Boston, MA 02114, USA
Mult Scler Int 2013:189624. 2013..Relapses or changes in provider did not explain the poor performance of the measures. Short-term changes in the EDSS or FS scores may not be an accurate marker of irreversible change in RRMS... - A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosisZongqi Xia
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 5:e14169. 2010..We used a candidate gene approach to address whether genetic variants implicated in susceptibility to late onset Alzheimer's Disease (AD) influence brain volume and cognition in MS patients... - Prenatal and perinatal factors and risk of multiple sclerosisHannah Gardener
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Epidemiology 20:611-8. 2009..A potential role of prenatal and perinatal exposures in autoimmunity has been hypothesized, but few studies have examined the relation between various prenatal and perinatal factors and the risk of multiple sclerosis (MS)... - Cytokine shifts and tolerance in experimental autoimmune encephalomyelitisTanuja Chitnis
Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA
Immunol Res 28:223-39. 2003..In addition, we will discuss modulation of EAE by altered expression of members of the cytokineregulated Jak/STAT intracellular signaling pathway... - Smoking and disease progression in multiple sclerosisBrian C Healy
Department of Neurology, Partners MS Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arch Neurol 66:858-64. 2009..Although cigarette smokers are at increased risk of developing multiple sclerosis (MS), the effect of smoking on the progression of MS remains uncertain... - Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitisTanuja Chitnis
Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA
J Allergy Clin Immunol 112:837-49; quiz 850. 2003.... - Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactionsTanuja Chitnis
Laboratory of Molecular Immunology, Harvard Medical School, Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Institutes of Medicine, Rm. 780, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
J Neuroimmunol 136:140-8. 2003..These results indicate that the humoral response in patients with MS does not include moderate- or high-affinity autoantibodies to MBP... - Demographic and clinical characteristics of malignant multiple sclerosisT Gholipour
Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02445, USA
Neurology 76:1996-2001. 2011..Malignant status can be transient (TM) or sustained until year 5 (SM). We studied the incidence, predictors, and demographic and clinical characteristics of malignant MS... - Challenges in the classification of pediatric multiple sclerosis and future directionsAnita L Belman
State University of New York at Stony Brook, Stony Brook, NY 11794
Neurology 68:S70-4. 2007.... - Acute disseminated encephalomyelitisSilvia Tenembaum
Department of Pediatric Neurology, National Pediatric Hospital Dr J P Garrahan, Buenos Aires, Argentina
Neurology 68:S23-36. 2007..An overview of ADEM treatment in children is provided. Finally, the controversies surrounding pediatric MS and ADEM are addressed...