Susan Cheng

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Reproducibility of speckle-tracking-based strain measures of left ventricular function in a community-based study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    J Am Soc Echocardiogr 26:1258-1266.e2. 2013
  2. pmc Differential influence of distinct components of increased blood pressure on cardiovascular outcomes: from the atherosclerosis risk in communities study
    Susan Cheng
    Brigham and Women s Hospital, Cardiovascular Division, 75 Francis St, Boston, MA 02115, USA
    Hypertension 62:492-8. 2013
  3. pmc Blood pressure tracking over the adult life course: patterns and correlates in the Framingham heart study
    Susan Cheng
    Framingham Heart Study, Framingham, MA, USA
    Hypertension 60:1393-9. 2012
  4. doi Superior vena cava syndrome: a contemporary review of a historic disease
    Susan Cheng
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, USA
    Cardiol Rev 17:16-23. 2009
  5. pmc Age- and sex-based reference limits and clinical correlates of myocardial strain and synchrony: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, MA
    Circ Cardiovasc Imaging 6:692-9. 2013
  6. pmc Biomarkers of cardiovascular stress and incident chronic kidney disease
    Jennifer E Ho
    Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine, Framingham, MA
    Clin Chem 59:1613-20. 2013
  7. pmc Relation of QRS width in healthy persons to risk of future permanent pacemaker implantation
    Susan Cheng
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 106:668-72. 2010
  8. pmc Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
    Abigail May Khan
    Cardiology Division, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3242-9. 2011
  9. pmc Association of novel biomarkers of cardiovascular stress with left ventricular hypertrophy and dysfunction: implications for screening
    Vanessa Xanthakis
    Framingham Heart Study, Framingham, MA
    J Am Heart Assoc 2:e000399. 2013
  10. pmc Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study
    Susan Cheng
    The Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:570-8. 2010

Detail Information

Publications51

  1. pmc Reproducibility of speckle-tracking-based strain measures of left ventricular function in a community-based study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    J Am Soc Echocardiogr 26:1258-1266.e2. 2013
    ..The reproducibility of echocardiographic measurements of myocardial strain, performed in a community-based setting, has not been reported previously...
  2. pmc Differential influence of distinct components of increased blood pressure on cardiovascular outcomes: from the atherosclerosis risk in communities study
    Susan Cheng
    Brigham and Women s Hospital, Cardiovascular Division, 75 Francis St, Boston, MA 02115, USA
    Hypertension 62:492-8. 2013
    ..74). With few exceptions, results were similar in analyses stratified by age, sex, and race. Our data indicate that distinct BP components contribute variably to risk for different cardiovascular outcomes...
  3. pmc Blood pressure tracking over the adult life course: patterns and correlates in the Framingham heart study
    Susan Cheng
    Framingham Heart Study, Framingham, MA, USA
    Hypertension 60:1393-9. 2012
    ..We also observed a differential impact of select vascular risk factors on the individual components of BP, underscoring distinct regulation of these measures over the life course...
  4. doi Superior vena cava syndrome: a contemporary review of a historic disease
    Susan Cheng
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, USA
    Cardiol Rev 17:16-23. 2009
    ..Fortunately, both endovascular and open surgical interventions can offer definitive therapy in a majority of cases...
  5. pmc Age- and sex-based reference limits and clinical correlates of myocardial strain and synchrony: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, MA
    Circ Cardiovasc Imaging 6:692-9. 2013
    ..There is rapidly growing interest in applying measures of myocardial strain and synchrony in clinical investigations and in practice; data are limited regarding their reference ranges in healthy individuals...
  6. pmc Biomarkers of cardiovascular stress and incident chronic kidney disease
    Jennifer E Ho
    Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine, Framingham, MA
    Clin Chem 59:1613-20. 2013
    ..We examined whether circulating concentrations are related to the development of kidney disease in the community...
  7. pmc Relation of QRS width in healthy persons to risk of future permanent pacemaker implantation
    Susan Cheng
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 106:668-72. 2010
    ..In conclusion, subjects with prolonged QRS durations, even without bundle branch block, are at increased risk for future pacemaker implantation. Such individuals may warrant monitoring for progressive conduction disease...
  8. pmc Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
    Abigail May Khan
    Cardiology Division, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3242-9. 2011
    ..It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown...
  9. pmc Association of novel biomarkers of cardiovascular stress with left ventricular hypertrophy and dysfunction: implications for screening
    Vanessa Xanthakis
    Framingham Heart Study, Framingham, MA
    J Am Heart Assoc 2:e000399. 2013
    ..It is unknown whether newer biomarkers are associated with LVH and LVSD and can serve as screening tools...
  10. pmc Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study
    Susan Cheng
    The Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:570-8. 2010
    ..The heart progressively remodels over the life course, yet longitudinal data characterizing such remodeling in the community are limited...
  11. pmc Circulating CD31+ leukocyte frequency is associated with cardiovascular risk factors
    Yin Ge
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Atherosclerosis 229:228-33. 2013
    ..Because unfractionated CD31+ blood cells have demonstrated angiogenic properties in vivo, we hypothesized that circulating CD31+ cells would be related to the presence of cardiovascular risk factors in humans...
  12. pmc Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals
    Susan Cheng
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 108:979-84. 2011
    ..These findings suggest that excess visceral adiposity and concomitant hyperinsulinemia may contribute to the natriuretic peptide "deficiency" observed in obesity...
  13. pmc Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors
    Kenneth S Cohen
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Blood 121:e50-6. 2013
    ..CD34(+) frequency is highly heritable. The results of the present study have implications for therapies that use CD34(+) cell populations and support efforts to better understand the genetic mechanisms that underlie CD34(+) frequency...
  14. pmc Circulating angiogenic cell populations, vascular function, and arterial stiffness
    Susan Cheng
    Framingham Heart Study, Framingham, MA 02118, United States
    Atherosclerosis 220:145-50. 2012
    ..We examined the extent to which lower quantities of these circulating angiogenic cell phenotypes may be related to impaired vascular function and greater arterial stiffness...
  15. pmc Reference limits for N-terminal-pro-B-type natriuretic peptide in healthy individuals (from the Framingham Heart Study)
    Michael G Fradley
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 108:1341-5. 2011
    ..In conclusion, the reference limits obtained from this large, healthy, community-based sample may aid in the evaluation of NT-pro-BNP concentrations measured for clinical and research purposes...
  16. pmc Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Clin Invest 121:1402-11. 2011
    ..These studies identify a relationship between lipid acyl chain content and diabetes risk and demonstrate how lipid profiling could aid in clinical risk assessment...
  17. pmc Metabolite profiles during oral glucose challenge
    Jennifer E Ho
    Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, USA
    Diabetes 62:2689-98. 2013
    ..We also identify metabolite responses that distinguish individuals with and without insulin resistance. These findings suggest that unique metabolic phenotypes can be unmasked by OGTT in the prediabetic state. ..
  18. pmc Metabolite profiles and the risk of developing diabetes
    Thomas J Wang
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:448-53. 2011
    ..These findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment...
  19. pmc Metabolite profiling identifies pathways associated with metabolic risk in humans
    Susan Cheng
    Cardiology Division, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 125:2222-31. 2012
    ..Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood...
  20. pmc A genome-wide association study of the human metabolome in a community-based cohort
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 18:130-43. 2013
    ..Thus, our study outlines the relative contributions of inherited and clinical factors on the plasma metabolome and provides a resource for metabolism research. ..
  21. pmc Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study
    Thomas J Wang
    Cardiology Division, GRB 800, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 126:1596-604. 2012
    ..Biomarkers for predicting cardiovascular events in community-based populations have not consistently added information to standard risk factors. A limitation of many previously studied biomarkers is their lack of cardiovascular specificity...
  22. ncbi Rationale and design of a multicenter echocardiographic study to assess the relationship between cardiac structure and function and heart failure risk in a biracial cohort of community-dwelling elderly persons: the Atherosclerosis Risk in Communities stud
    Amil M Shah
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA
    Circ Cardiovasc Imaging 7:173-81. 2014
    ..Limited normative and prognostic data exist on measures of cardiac structure, diastolic function, and novel measures of systolic deformation in older adults living in the community...
  23. pmc Soluble ST2 predicts elevated SBP in the community
    Jennifer E Ho
    Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, USA
    J Hypertens 31:1431-6; discussion 1436. 2013
    ..We sought to investigate the association of sST2 and progression of blood pressure (BP), as well as the development of hypertension...
  24. pmc A combined epidemiologic and metabolomic approach improves CKD prediction
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Soc Nephrol 24:1330-8. 2013
    ..0001). Thus, the addition of metabolite profiling to clinical data may significantly improve the ability to predict whether an individual will develop CKD by identifying predictors of renal risk that are independent of estimated GFR. ..
  25. pmc Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 59:242-8. 2010
    ..Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear...
  26. pmc Genetic and clinical correlates of early-outgrowth colony-forming units
    Stanley Y Shaw
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circ Cardiovasc Genet 4:296-304. 2011
    ..Decreased numbers of circulating angiogenic cell populations have been associated with increased cardiovascular risk. However, few data exist from large, unselected samples, and the genetic determinants of these traits are unclear...
  27. pmc Relation of N-terminal pro-B-type natriuretic peptide with diastolic function in hypertensive heart disease
    Imran Uraizee
    Brigham and Women s Hospital, Cardiovascular Division, Boston, MA
    Am J Hypertens 26:1234-41. 2013
    ..Elevated natriuretic peptide levels in asymptomatic individuals without heart failure are associated with increased risk of adverse cardiovascular outcomes and may reflect subclinical cardiac dysfunction...
  28. pmc Vitamin D status is not related to development of atrial fibrillation in the community
    Michiel Rienstra
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Am Heart J 162:538-41. 2011
    ..Vitamin D is an emerging risk factor in cardiovascular disease, and vitamin D status is modifiable. Thus, we sought to investigate whether vitamin D status predisposed to the development of AF in a community-based sample...
  29. ncbi Clinical and genetic correlates of growth differentiation factor 15 in the community
    Jennifer E Ho
    Framingham Heart Study, Framingham, MA, USA
    Clin Chem 58:1582-91. 2012
    ..We therefore examined the clinical and genetic correlates of circulating GDF15 concentrations, which have not been investigated collectively...
  30. ncbi Secular trends in echocardiographic left ventricular mass in the community: the Framingham Heart Study
    Bernhard M Kaess
    National Heart, Blood and Lung Institute s and Boston University s Framingham Heart Study, Framingham, Massachusetts, USA
    Heart 99:1693-8. 2013
    ..To investigate secular trends in echocardiographically determined left ventricular mass (LVM)...
  31. pmc Association of colony-forming units with coronary artery and abdominal aortic calcification
    Susan Cheng
    Cardiology Division, GRB 800, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Circulation 122:1176-82. 2010
    ..Experimental data suggest that depletion of these angiogenic cell populations may promote atherogenesis, but limited data are available on their relation to subclinical atherosclerotic cardiovascular disease in humans...
  32. ncbi Long-term cardiovascular risks associated with an elevated heart rate: the Framingham Heart Study
    Jennifer E Ho
    Framingham Heart Study of the National Heart, Lung and Blood Institute, Boston University School of Medicine, Framingham, MA
    J Am Heart Assoc 3:e000668. 2014
    ..We sought to examine the association of baseline heart rate with both fatal and nonfatal outcomes during 2 decades of follow-up...
  33. ncbi Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction
    Mauro Gori
    Brigham and Women s Hospital, Boston, MA, USA
    Eur J Heart Fail 16:535-42. 2014
    ..Women are more likely to develop heart failure with preserved ejection fraction (HFpEF) than men. We studied the relationship between sex and cardiovascular structure and function in patients with HFpEF...
  34. pmc Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    JAMA 301:2571-7. 2009
    ..Prolongation of the electrocardiographic PR interval, known as first-degree atrioventricular block when the PR interval exceeds 200 milliseconds, is frequently encountered in clinical practice...
  35. ncbi Age and the effectiveness of anti-hypertensive therapy on improvement in diastolic function
    Susan Cheng
    aBrigham and Women s Hospital, Harvard University, Boston, Massachusetts, USA bNational University Health System, Singapore cNovartis, East Hanover, New Jersey dState University of New York at Buffalo, Buffalo, New York eUniversity of Alabama, Birmingham, Alabama fUniversity of Michigan, Ann Arbor, Michigan, USA
    J Hypertens 32:174-80. 2014
    ..Lowering SBP with antihypertensive therapy has been shown to improve diastolic function, but whether or not age influences this effect is unknown...
  36. pmc Regional cardiac dysfunction and dyssynchrony in a murine model of afterload stress
    Michael Bauer
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS ONE 8:e59915. 2013
    ..Importantly, these findings illustrate the utility of a rapid, non-invasive method for characterizing early cardiac dysfunction, not detectable by conventional echocardiography, following afterload stress...
  37. doi Dyssynchrony, contractile function, and response to cardiac resynchronization therapy
    Dorit Knappe
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Heart Fail 4:433-40. 2011
    ..We hypothesized that a combined assessment of left ventricular (LV) dyssynchrony and contractile function by strain-based imaging would identify patients who would most benefit from CRT...
  38. pmc Influence of sex and hormone status on circulating natriuretic peptides
    Carolyn S P Lam
    Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 58:618-26. 2011
    ..The aim of this study was to assess the relationship between sex hormones and natriuretic peptide levels in community-based adults...
  39. pmc Myocardial tissue tagging with cardiovascular magnetic resonance
    Monda L Shehata
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Cardiovasc Magn Reson 11:55. 2009
    ....
  40. pmc Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community
    Susan Cheng
    The Framingham Heart Study, 73 Mount Wayte Ave, Ste 2, Framingham, MA 01702 5803, USA
    Circulation 122:1470-7. 2010
    ..However, the relation of exhaled CO to metabolic/vascular risk in the community is unknown...
  41. doi Genetic Loci associated with atrial fibrillation: relation to left atrial structure in the Framingham Heart Study
    Jared W Magnani
    National Heart, Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, MA
    J Am Heart Assoc 3:e000616. 2014
    ..We sought to investigate associations between single nucleotide polymorphisms (SNPs) and atrial structure obtained by cardiovascular imaging in the Framingham Heart Study...
  42. pmc Age-related left ventricular remodeling and associated risk for cardiovascular outcomes: the Multi-Ethnic Study of Atherosclerosis
    Susan Cheng
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circ Cardiovasc Imaging 2:191-8. 2009
    ..Age-related alterations of left ventricular (LV) structure and function that may predispose to cardiovascular events are not well understood...
  43. ncbi The relationship between renal impairment and left ventricular structure, function, and ventricular-arterial interaction in hypertension
    Amil M Shah
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02445, USA
    J Hypertens 29:1829-36. 2011
    ..Our objective was to define the relationship between renal dysfunction--both albuminuria and reduced estimated glomerular filtration rate (eGFR)--and cardiac structure and diastolic dysfunction among patients with chronic hypertension...
  44. pmc Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice
    Michael Bauer
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 108:908-16. 2011
    ....
  45. doi Breast cancer therapies and cardiomyopathy
    John Groarke
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Med Clin North Am 96:1001-19. 2012
    ..Imaging strategies that detect cardiac injury before overt left ventricular systolic dysfunction provide an opportunity for early intervention and improved cardiac outcomes...
  46. pmc Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts
    Alexander G Bick
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 91:513-9. 2012
    ..3) in the FHS cohort, suggesting that cardiovascular risk assessment in the general population can benefit from rare variant analysis...
  47. doi Cardiac magnetic resonance imaging for stage B heart failure
    Sara L Partington
    Non invasive Cardiovascular Imaging Program, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Heart Fail Clin 8:179-90. 2012
    ..Thus, in addition to standard metrics of cardiac structure and function, CMR offers a variety of tools for determining cause, severity, and estimating the prognosis associated with an asymptomatic cardiomyopathy...
  48. pmc Cardiovascular complications of radiation therapy for thoracic malignancies: the role for non-invasive imaging for detection of cardiovascular disease
    John D Groarke
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Heart J 35:612-23. 2014
    ..In doing so, we highlight characteristics that can be used to identify individuals at risk for developing post-radiation cardiovascular disease and propose an imaging-based algorithm for their clinical surveillance. ..
  49. doi Cardio-oncology: it takes two to translate
    Javid Moslehi
    Cardio Oncology Program, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 5:187fs20. 2013
    ..Heart-related toxicities from targeted cancer therapies shed light on the biology of cardiovascular disease in humans (Chintalgattu et al., this issue)...
  50. doi Predictors of initial nontherapeutic anticoagulation with unfractionated heparin in ST-segment elevation myocardial infarction
    Susan Cheng
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 119:1195-202. 2009
    ..Although weight-based nomograms have improved the efficacy and safety of dosing unfractionated heparin in ST-segment elevation myocardial infarction, achieving therapeutic anticoagulation in practice remains challenging...
  51. pmc Metabolic signatures of exercise in human plasma
    Gregory D Lewis
    Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 2:33ra37. 2010
    ..Plasma metabolic profiles obtained during exercise provide signatures of exercise performance and cardiovascular disease susceptibility, in addition to highlighting molecular pathways that may modulate the salutary effects of exercise...