Yu Chen

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo
    Yu Chen
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 12:034008. 2007
  2. ncbi Development of high-sensitivity near-infrared fluorescence imaging device for early cancer detection
    Yu Chen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
    Biomed Instrum Technol 39:75-85. 2005
  3. ncbi Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues
    Yu Chen
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Express 16:2469-85. 2008
  4. ncbi Correlation between near-infrared spectroscopy and magnetic resonance imaging of rat brain oxygenation modulation
    Yu Chen
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Phys Med Biol 48:417-27. 2003
  5. ncbi In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green
    Xavier Intes
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Med Phys 30:1039-47. 2003
  6. pmc Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 79:897-905. 2012
  7. ncbi Benign and malignant lesions in the human breast depicted with ultrahigh resolution and three-dimensional optical coherence tomography
    Pei Lin Hsiung
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02215, USA
    Radiology 244:865-74. 2007
  8. pmc Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy
    Aaron D Aguirre
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:016025. 2010
  9. ncbi High-resolution line-scanning optical coherence microscopy
    Yu Chen
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 32:1971-3. 2007
  10. ncbi Adaptive calibration for object localization in turbid media with interfering diffuse photon density waves
    Yu Chen
    Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Appl Opt 41:7325-33. 2002

Detail Information

Publications60

  1. ncbi High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo
    Yu Chen
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 12:034008. 2007
    ..The foregoing observations suggest that OCT can be a useful non-excisional, real-time modality for imaging pathological changes in donor kidney morphology prior to transplantation...
  2. ncbi Development of high-sensitivity near-infrared fluorescence imaging device for early cancer detection
    Yu Chen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
    Biomed Instrum Technol 39:75-85. 2005
    ..Also, this portable device would be complementary to x-ray mammography and provide add-on information on early diagnosis and localization of breast tumor...
  3. ncbi Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues
    Yu Chen
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Express 16:2469-85. 2008
    ..Enhanced classification of image features using UHR-OCT promises to help in the computer-aided diagnosis of GI diseases...
  4. ncbi Correlation between near-infrared spectroscopy and magnetic resonance imaging of rat brain oxygenation modulation
    Yu Chen
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Phys Med Biol 48:417-27. 2003
    ..A linear relationship with high correlation coefficient between the relative changes in the BOLD MRI signal and the NIRS signal is observed...
  5. ncbi In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green
    Xavier Intes
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Med Phys 30:1039-47. 2003
    ..These results provide further evidence that in vivo pharmacokinetics of ICG in breast tumors may be a useful diagnostic tool for differentiation of benign and malignant pathologies...
  6. pmc Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 79:897-905. 2012
    ..Here we aim to determine plasma biomarkers associated with AD in 2 independent cohorts and validate the findings in the multicenter Alzheimer's Disease Neuroimaging Initiative (ADNI)...
  7. ncbi Benign and malignant lesions in the human breast depicted with ultrahigh resolution and three-dimensional optical coherence tomography
    Pei Lin Hsiung
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02215, USA
    Radiology 244:865-74. 2007
    ..OCT is potentially useful for visualization of breast lesions at a resolution greater than that of currently available clinical imaging methods...
  8. pmc Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy
    Aaron D Aguirre
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:016025. 2010
    ..OCT provided complementary information through assessment of tissue architectural features over a larger field of view. OCM may provide a complementary imaging modality to standard OCT approaches for endoscopic microscopy...
  9. ncbi High-resolution line-scanning optical coherence microscopy
    Yu Chen
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 32:1971-3. 2007
    ..The sensitivity of the system is 93 dB with averaging over 30 line scans. En face real time, cellular-level imaging of biological tissues is demonstrated at approximately 2 frames/s...
  10. ncbi Adaptive calibration for object localization in turbid media with interfering diffuse photon density waves
    Yu Chen
    Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Appl Opt 41:7325-33. 2002
    ..Experimental data on human breast phantoms demonstrate that localization accuracy within several millimeters has been accomplished through this method...
  11. ncbi Analysis on performance and optimization of frequency-domain near-infrared instruments
    Tao Tu
    University of Pennsylvania, Department of Electrical Engineering, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 7:643-9. 2002
    ..This kind of method can be used to design suitable instruments for various applications. We also analyze the selection of the instrument parameters to achieve optimal performance at an efficient cost using this analytical model...
  12. ncbi Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines
    Pei Lin Hsiung
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Gastrointest Endosc 62:561-74. 2005
    ..This study investigates ultrahigh-resolution and three-dimensional OCT for ex vivo imaging of the large and small intestines and correlates images with histology...
  13. pmc Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation
    Yu Chen
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Neurosci Methods 178:162-73. 2009
    ..OCT is a promising a new technology which provides complementary information to OISI for functional neuroimaging...
  14. ncbi Detection limit enhancement of fluorescent heterogeneities in turbid media by dual-interfering excitation
    Xavier Intes
    Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia 19104, USA
    Appl Opt 41:3999-4007. 2002
    ..To detect the same inhomogeneity, less concentration and lifetime contrast is required with dual-interfering sources...
  15. ncbi Probing rat brain oxygenation with near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI)
    Yu Chen
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 510:199-204. 2003
  16. ncbi Importance of chirality and reduced flexibility of protein side chains: a study with square and tetrahedral lattice models
    Jinfeng Zhang
    Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Chem Phys 121:592-603. 2004
    ..Our results suggest that side chain entropy may be an important factor contributing to the formation of alpha helices for compact conformations...
  17. pmc Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
    William T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 119:669-78. 2010
    ..In summary, our targeted proteomic screen revealed novel CSF biomarkers that can improve the distinction between AD and non-AD cases by established biomarkers alone...
  18. doi High-resolution optical coherence tomography imaging of the living kidney
    Peter M Andrews
    Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Lab Invest 88:441-9. 2008
    ..We conclude that OCT represents an exciting new approach to visualize, in real-time, pathological changes in the living kidney in a non-invasive fashion. Possible clinical applications are discussed...
  19. pmc Simultaneous isolation of DNA and RNA from the same cell population obtained by laser capture microdissection for genome and transcriptome profiling
    Chang Xu
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA, USA
    J Mol Diagn 10:129-34. 2008
    ..Thus, we developed a method to obtain both DNA and RNA material from a single population of LCM-harvested cells and herein discuss the strengths and limitations of this methodology...
  20. ncbi Fold recognition via a tree
    Yu Chen
    Bioinformatics Program, University of Michigan, Ann Arbor, Michigan 48109 1065, USA
    J Comput Biol 13:1565-73. 2006
    ..These tests are approximately comparable to fold recognition tests on superfamily level. Results show that fold recognition via a fold tree can be faster and better at detecting distant homologues than classic fold recognition methods...
  21. ncbi Cellular prion protein promotes proliferation and G1/S transition of human gastric cancer cells SGC7901 and AGS
    Jie Liang
    State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, 15 West Chang Le Rd, Xi an, Shaanxi Province, China
    FASEB J 21:2247-56. 2007
    ....
  22. ncbi Carbon nanotube-based functional materials for optical limiting
    Yu Chen
    Department of Chemistry, Lab for Advanced Materials, East China University of Science and Technology, Shanghai 200237, People s Republic of China
    J Nanosci Nanotechnol 7:1268-83. 2007
    ..It would be very desirable, from the practical application point of view, if one can design broadband optical limiting chromophores that would function in a multimechanistic fashion...
  23. pmc Generation of functional hemangioblasts from human embryonic stem cells
    Shi Jiang Lu
    Advanced Cell Technology, Worcester, Massachusetts 01605, USA
    Nat Methods 4:501-9. 2007
    ..Our data suggest that hES-derived blast cells (hES-BCs) could be important in vascular repair...
  24. ncbi Silicon-based microfilters for whole blood cell separation
    Hong Miao Ji
    Institute of Microelectronics, Singapore, Singapore
    Biomed Microdevices 10:251-7. 2008
    ..Based on the experimental results, the crossflow microfilter is superior and can be integrated with downstream components for on-chip genomic analysis...
  25. ncbi Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption
    Timo Rieg
    Department of Medicine, University of California San Diego, San Diego, CA 92161, USA
    FASEB J 21:3717-26. 2007
    ..Based on these findings in knockout mice, we propose that a blunting in P2Y2 receptor expression or activity is a new mechanism for salt-resistant arterial hypertension...
  26. doi A new evolutionary algorithm for solving many-objective optimization problems
    Xiufen Zou
    School of Mathematics and Statistics, Wuhan University, Wuhan 430072, China
    IEEE Trans Syst Man Cybern B Cybern 38:1402-12. 2008
    ..We can conclude that our new algorithm is suitable to tackle many-objective problems...
  27. doi Assessment of skin dose for breast chest wall radiotherapy as a function of bolus material
    Shu Hui Hsu
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
    Phys Med Biol 53:2593-606. 2008
    ..The dosimetric effect of different Aquaplast materials has been quantified in this work. These materials can be used to create a custom bolus with potentially better reproducibility of placement...
  28. ncbi Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge
    Jia ping Zhang
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burns, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Burns 34:220-7. 2008
    ....
  29. pmc An algorithm for finding functional modules and protein complexes in protein-protein interaction networks
    Guangyu Cui
    School of Computer Science and Engineering, Inha University, Incheon 402 751, South Korea
    J Biomed Biotechnol 2008:860270. 2008
    ....
  30. doi Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project
    Yu Chen
    Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 29:766-71. 2008
    ..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...
  31. ncbi A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk
    Kathryn E Talbott
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
    Breast Cancer Res Treat 111:481-7. 2008
    ..The finding supports the potential role of variation in estrogen biosynthesis genes in premenopausal breast cancer risk...
  32. ncbi Application of Lattice Boltzmann Method to image segmentation
    Yu Chen
    School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China
    Conf Proc IEEE Eng Med Biol Soc 2007:6562-5. 2007
    ..The algorithm was evaluated with the clinical images of CT, DSA, and MRI. The experimental results show the LBM-based image segmentation algorithm is effective...
  33. doi Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer
    Xiaoxuan Ning
    Department of Geriatrics, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Mol Cancer Res 5:1254-62. 2007
    ....
  34. ncbi Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer
    Heather Greenlee
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, 7th Floor, New York, NY 10032, USA
    Breast Cancer Res Treat 102:111-7. 2007
    ....
  35. ncbi An iterative refinement algorithm for consistency based multiple structural alignment methods
    Yu Chen
    Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 22:2087-93. 2006
    ..Correcting errors after making errors is not as good as avoiding errors from the beginning. Hence it is important to refine the pairwise library to reduce the number of conflicts before any consistency-based assembly...
  36. ncbi Homing of intravenously infused embryonic stem cell-derived cells to injured hearts after myocardial infarction
    Jiang Yong Min
    Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
    J Thorac Cardiovasc Surg 131:889-97. 2006
    ..The present study was designed to test whether intravenously infused embryonic stem cell-derived cells could translocate to injured myocardium after myocardial infarction and improve cardiac function...
  37. ncbi A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Breast Cancer Res Treat 85:121-31. 2004
    ....
  38. ncbi Osmotic regulation of cell function and possible clinical applications
    Alok Shukla
    Department of Surgery Trauma, University of California San Diego, San Diego, California 92103, USA
    Shock 21:391-400. 2004
    ..Knowledge of how osmotic cues regulate immune cell function will enable us to fully exploit the clinical potential of hypertonic resuscitation to reduce inflammatory and anergic complications in trauma patients...
  39. ncbi Single kidney eliciting a search for associated genital tract anomaly
    Tzung Hai Yen
    Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Nephrol Dial Transplant 19:731-2. 2004
  40. ncbi Electrophysiologic properties of lidocaine, cocaine, and n-3 fatty-acids block of cardiac Na+ channels
    Yong Fu Xiao
    Department of Medicine, Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Eur J Pharmacol 485:31-41. 2004
    ....
  41. ncbi Retroperitoneal neurofibrosarcoma in a patient with neurofibromatosis. 2: A case report and review of the literature
    Yu Chen
    Department of Pathology, Long Island Jewish Medical Center, 270 05 76th Avenue, New Hyde Park, NY 11040, USA
    Pediatr Pathol Mol Med 22:375-81. 2003
    ..In this case report, the authors document a retroperitoneal neurogenic sarcoma occurring in a 20-year-old woman with NF2 (bilateral acoustic schwannomas, meningioma, and multiple intraspinal tumors)...
  42. ncbi [Inhibition of tongue cancer development in nude mice transfected with adenovirus carrying human endostatin gene]
    Xue Qiang Ding
    Department of Stomatology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Ai Zheng 22:1152-7. 2003
    ....
  43. ncbi Carcinoembryonic antigen-producing cell-specific oncolytic adenovirus, OV798, for colorectal cancer therapy
    Yuanhao Li
    Cell Genesys, Inc, South San Francisco, CA 94080, USA
    Mol Cancer Ther 2:1003-9. 2003
    ..In vitro and in vivo characterization indicate that OV798 could be used as a therapy for human colon cancer...
  44. ncbi Identification of human uroplakin II promoter and its use in the construction of CG8840, a urothelium-specific adenovirus variant that eliminates established bladder tumors in combination with docetaxel
    Jane Zhang
    Cell Genesys, Inc, Foster City, California 94404, USA
    Cancer Res 62:3743-50. 2002
    ..These results demonstrate the utility of the UPII promoter in the generation of urothelium-specific adenoviral vectors and provide a potential foundation for the development of bladder tumor-specific oncolytic viral therapies...
  45. ncbi Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cells
    Jiang Yong Min
    Stem Cell Research Laboratory, The Charles A Dana Research Institute and The Harvard Thorndike Laboratory, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Thorac Cardiovasc Surg 125:361-9. 2003
    ..This study was designed to investigate the feasibility of and potential functional improvement with embryonic stem cell transplantation in rats 32 weeks after myocardial infarction...
  46. ncbi Intramolecular quenching of tryptophan fluorescence by the peptide bond in cyclic hexapeptides
    Paul D Adams
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    J Am Chem Soc 124:9278-86. 2002
    ....
  47. ncbi [Clinical and pathological characterization of antineutrophil cytoplasmic antibody associated small vasculitis in children]
    Jian Hua Zhou
    Department of Pediatrics, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, China
    Zhonghua Er Ke Za Zhi 42:408-11. 2004
    ....
  48. ncbi Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation
    Pankaj V Paranjpe
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    J Control Release 100:275-92. 2004
    ..This bioconjugate represents the 'first-in-series' of targeted bioconjugates and serves as prototype for improving tumor cell concentration and efficacy...
  49. pmc Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Breast Cancer Res 7:R71-81. 2005
    ....
  50. ncbi Magnetic confinement of electron and photon radiotherapy dose: a Monte Carlo simulation with a nonuniform longitudinal magnetic field
    Yu Chen
    Department of Physics, Randall Laboratory, University of Michigan, Ann Arbor, Michigan 48109 1120, USA
    Med Phys 32:3810-8. 2005
    ..The simulations also show that the electron dose profile can be manipulated by the appropriate control of the beam energy together with the strength and displacement of the longitudinal magnetic field...
  51. ncbi Evaluation of a bioartificial liver based on a nonwoven fabric bioreactor with porcine hepatocytes in pigs
    Lan Juan Li
    Key Laboratory of Infectious Diseases, Ministry of Public Health, Department of Infectious Diseases, The 1st Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
    J Hepatol 44:317-24. 2006
    ..We developed a bioartificial liver (BAL) based on a direct hemoperfusion typed nonwoven fabric bioreactor containing porcine hepatocytes. In this study, the efficacy of our BAL was evaluated with a pig fulminant hepatic failure (FHF) model...
  52. ncbi Malignant hypertension in patients with idiopathic IgA nephropathy
    Yu Chen
    Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, P R China
    Kidney Blood Press Res 28:251-8. 2005
    ..But little information has been available about malignant hypertension secondary to IgA nephropathy (IgANMHT). The purpose of this study is to evaluate the clinico-pathological features and outcomes of IgANMHT patients...
  53. pmc A novel approach to structural alignment using realistic structural and environmental information
    Yu Chen
    College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 1065, USA
    Protein Sci 14:2935-46. 2005
    ..The overall performance is also evaluated on a large scale by comparisons to current structural classification databases as well as to other alignment methods...
  54. pmc LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
    Jin Wu Tsai
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cell Biol 170:935-45. 2005
    ..Finally, axonal growth also ceased. These results identify multiple distinct and novel roles for LIS1 in nucleokinesis and process dynamics and suggest that nuclear position controls neural progenitor cell division...
  55. ncbi [Antitumor effects of ring-closed and ring-opened hydroxycamptothecin on oral squamous carcinoma cell line Tca8113]
    An Xun Wang
    Department of Stomatology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, P R China
    Ai Zheng 24:970-4. 2005
    ..This study was to compare the antitumor effects of C-HCPT and O-HCPT on oral squamous carcinoma cell line Tca8113, and explore the mechanisms...
  56. ncbi Effects of Salvia miltiorrhiza on intestinal microflora in rats with ischemia/reperfusion liver injury
    Hui Chun Xing
    Department of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 4:274-80. 2005
    ..The aim of the present study was to determine the effects of Salvia miltiorrhiza on intestinal microflora, endotoxemia, and bacterial translocation in rats with hepatic I/R injury...
  57. ncbi [Killing effect of Ad.TERT-TRAIL on tumor cell lines and its mechanism]
    Yun xia Tang
    Xin Yuan Institute of Medincine and Biotechnology, School of Life Science, Zhejiang Sci Tech University, Hangzhou, Zhejiang, 310018, P R China
    Ai Zheng 24:536-42. 2005
    ..In vitro and in vivo experiments confirmed that Ad.TERT has antitumor effect. This study was to construct Ad.TERT-TRAIL through inserting apoptosis gene trail into Ad.TERT, and explore its antitumor effect and mechanism...
  58. ncbi Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk
    Virginia G Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, 676 North St Clair Street, Chicago, IL 60611, USA
    Cancer Res 65:3454-61. 2005
    ..25-3.87). This is the first study assessing the TGF-beta signaling pathway through two common and functionally relevant TGFBR1 and TGFB1 variants. This approach may predict breast cancer risk in a large subset of the population...
  59. ncbi Synthesis of the axially substituted titanium Pc-C60 dyad with a convenient method
    Yu Chen
    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, CREST, JST, Katahira 2 1 1, Sendai 980 8577, Japan
    Org Lett 7:1613-6. 2005
    ..The intramolecular photoinduced process between phthalocyanine donor and fullerene acceptor was preliminarily studied...
  60. ncbi Effect of prolonged uremia on insulin-like growth factor-I receptor autophosphorylation and tyrosine kinase activity in kidney and muscle
    Tanny Tsao
    Research Service Veterans Affairs Palo Alto Health Care System, Calif 94304, USA
    Exp Nephrol 10:285-92. 2002
    ..Taking all these findings together it appears that IGF-I resistance in uremia cannot be attributed to a receptor defect. This in turn argues against altered receptor function as a cause of the failure of IGF-I to modify clinical ARF...