Benjamin K Chen

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi Efficient assembly of an HIV-1/MLV Gag-chimeric virus in murine cells
    B K Chen
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 98:15239-44. 2001
  2. ncbi CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef
    B K Chen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Virol 70:6044-53. 1996
  3. ncbi The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    G B Cohen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Immunity 10:661-71. 1999
  4. ncbi Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity
    I Rousso
    Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 97:13523-5. 2000

Collaborators

  • P S Kim
  • I Rousso
  • G B Cohen
  • M B Mixon
  • R T Gandhi
  • D Baltimore
  • O Mandelboim
  • J L Strominger
  • D M Davis

Detail Information

Publications4

  1. ncbi Efficient assembly of an HIV-1/MLV Gag-chimeric virus in murine cells
    B K Chen
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 98:15239-44. 2001
    ..With further adaptation, this chimeric MHIV approach may provide the basis for creating an infectious mouse model for HIV/AIDS...
  2. ncbi CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef
    B K Chen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Virol 70:6044-53. 1996
    ..HIV therefore has three genes that are able to independently down-modulate CD4; together, they can eliminate the bulk of cell surface CD4...
  3. ncbi The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    G B Cohen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Immunity 10:661-71. 1999
    ..These results suggest that subpopulations of CTL and NK cells may be uniquely suited for combating HIV...
  4. ncbi Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity
    I Rousso
    Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 97:13523-5. 2000
    ..Our results strongly support the suggestion that HIV-1 buds from lipid rafts and point to a role for rafts as a viral assembly hub...