Richelle C Charles

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Cellular and Cytokine Responses to Salmonella enterica Serotype Typhi Proteins in Patients with Typhoid Fever in Bangladesh
    Saruar Bhuiyan
    Division of Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, ICDDR, B, Dhaka, Bangladesh Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts Department of Medicine, Harvard Medical School, Boston, Massachusetts Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts Virginia G Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    Am J Trop Med Hyg 90:1024-30. 2014
  2. pmc Identification of immunogenic Salmonella enterica serotype Typhi antigens expressed in chronic biliary carriers of S. Typhi in Kathmandu, Nepal
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS Negl Trop Dis 7:e2335. 2013
  3. pmc Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 4:e6994. 2009
  4. pmc Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Clin Vaccine Immunol 17:1188-95. 2010
  5. pmc Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh
    Daniel T Leung
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Clin Vaccine Immunol 20:780-8. 2013
  6. pmc Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera
    Taher Uddin
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh NIDDK, LBC, National Institutes of Health, Bethesda, Maryland Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts Departments of Medicine and Pediatrics, Harvard Medical School, Boston, Massachusetts Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    Am J Trop Med Hyg 90:873-81. 2014
  7. pmc Identification of in vivo-induced bacterial proteins during human infection with Salmonella enterica serotype Paratyphi A
    Mohammad Murshid Alam
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 20:712-9. 2013
  8. pmc In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh
    Alaullah Sheikh
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    PLoS Negl Trop Dis 5:e1419. 2011
  9. pmc Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera
    Russell A Johnson
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:1712-21. 2012
  10. pmc Evaluation of a typhoid/paratyphoid diagnostic assay (TPTest) detecting anti-Salmonella IgA in secretions of peripheral blood lymphocytes in patients in Dhaka, Bangladesh
    Farhana Khanam
    International Centre for Diarrhoeal Disease Research ICDDR, B, Bangladesh, Dhaka, Bangladesh
    PLoS Negl Trop Dis 7:e2316. 2013

Collaborators

Detail Information

Publications17

  1. pmc Cellular and Cytokine Responses to Salmonella enterica Serotype Typhi Proteins in Patients with Typhoid Fever in Bangladesh
    Saruar Bhuiyan
    Division of Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, ICDDR, B, Dhaka, Bangladesh Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts Department of Medicine, Harvard Medical School, Boston, Massachusetts Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts Virginia G Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    Am J Trop Med Hyg 90:1024-30. 2014
    ..These results suggest that S. Typhi antigens induce a predominantly Th1 response, but that elevations in other cytokines may be modulatory. ..
  2. pmc Identification of immunogenic Salmonella enterica serotype Typhi antigens expressed in chronic biliary carriers of S. Typhi in Kathmandu, Nepal
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS Negl Trop Dis 7:e2335. 2013
    ..Little is known about the interaction between the host and pathogen in the biliary tract of chronic carriers, and there is currently no reliable diagnostic assay to identify asymptomatic S. Typhi carriage...
  3. pmc Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 4:e6994. 2009
    ..The PhoP regulon is a well studied two component (PhoP/Q) coordinately regulated network of genes whose expression is required for intracellular survival of S. enterica...
  4. pmc Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Clin Vaccine Immunol 17:1188-95. 2010
    ..Typhi-infected patients and detected anti-HlyE responses at the time of clinical presentation in patients but not in controls. These findings could assist in the development of improved diagnostic assays...
  5. pmc Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh
    Daniel T Leung
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Clin Vaccine Immunol 20:780-8. 2013
    ....
  6. pmc Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera
    Taher Uddin
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh NIDDK, LBC, National Institutes of Health, Bethesda, Maryland Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts Departments of Medicine and Pediatrics, Harvard Medical School, Boston, Massachusetts Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    Am J Trop Med Hyg 90:873-81. 2014
    ..The markedly lower ASC and MBC responses to OSP and LPS observed among vaccinees might explain, in part, the lower protection of an OCV compared with natural infection...
  7. pmc Identification of in vivo-induced bacterial proteins during human infection with Salmonella enterica serotype Paratyphi A
    Mohammad Murshid Alam
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 20:712-9. 2013
    ..S. Paratyphi A antigens identified by IVIAT warrant further evaluation for their contributions to pathogenesis and might have diagnostic, therapeutic, or preventive relevance...
  8. pmc In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh
    Alaullah Sheikh
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    PLoS Negl Trop Dis 5:e1419. 2011
    ..Salmonella enterica serotype Typhi is the cause of typhoid fever. It is a human-restricted pathogen, and few data exist on S. Typhi gene expression in humans...
  9. pmc Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera
    Russell A Johnson
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:1712-21. 2012
    ..Induction of anti-OSP responses may be associated with protection against cholera, and our results may support the development of a vaccine targeting V. cholerae OSP...
  10. pmc Evaluation of a typhoid/paratyphoid diagnostic assay (TPTest) detecting anti-Salmonella IgA in secretions of peripheral blood lymphocytes in patients in Dhaka, Bangladesh
    Farhana Khanam
    International Centre for Diarrhoeal Disease Research ICDDR, B, Bangladesh, Dhaka, Bangladesh
    PLoS Negl Trop Dis 7:e2316. 2013
    ..We report the characterization of novel approach utilizing lymphocyte secretions, for diagnosing patients with enteric fever by the TPTest procedure...
  11. pmc Interferon-γ and proliferation responses to Salmonella enterica Serotype Typhi proteins in patients with S. Typhi Bacteremia in Dhaka, Bangladesh
    Alaullah Sheikh
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    PLoS Negl Trop Dis 5:e1193. 2011
    ..Cellular immune responses are required to control and clear Salmonella infection. Despite this, there are limited data on cellular immune responses in humans infected with wild type S. Typhi...
  12. pmc Frequency of reexposure to Vibrio cholerae O1 evaluated by subsequent vibriocidal titer rise after an episode of severe cholera in a highly endemic area in Bangladesh
    Ana A Weil
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Am J Trop Med Hyg 87:921-6. 2012
    ..Repeated exposures to V. cholerae in endemic areas may be a necessary component for long-lasting protection against severe disease...
  13. pmc Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera
    Mohammad Arifuzzaman
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:1304-11. 2012
    ..These findings may explain the lower efficacy and shorter duration of protection afforded by OCV in young children...
  14. pmc Analysis of Salmonella enterica serotype paratyphi A gene expression in the blood of bacteremic patients in Bangladesh
    Alaullah Sheikh
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    PLoS Negl Trop Dis 4:e908. 2010
    ..Salmonella enterica serotype Paratyphi A is a human-restricted cause of paratyphoid fever, accounting for up to a fifth of all cases of enteric fever in Asia...
  15. pmc Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide
    Mohammad Murshid Alam
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America International Centre for Diarrheal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    PLoS Negl Trop Dis 8:e2683. 2014
    ..Serogroup specificity in Vibrio cholerae is determined by the O-specific polysaccharide (OSP) of lipopolysaccharide (LPS). Generally, polysaccharides are poorly immunogenic, especially in young children...
  16. pmc Immunoproteomic analysis of antibody in lymphocyte supernatant in patients with typhoid fever in Bangladesh
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Vaccine Immunol 21:280-5. 2014
    ..These observations suggest that purified antigens could be used with ALS and corresponding acute-phase activated B lymphocytes in diagnostic platforms to identify acutely infected patients, even in areas where enteric fever is endemic. ..
  17. pmc Immunogenicity of a killed bivalent (o1 and o139) whole cell oral cholera vaccine, shanchol, in haiti
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Negl Trop Dis 8:e2828. 2014
    ..There is a need to assess the immunogenicity of the vaccine in Haiti and other populations without historical exposure to Vibrio cholerae...