Genomes and Genes
Julia F Charles
Affiliation: Massachusetts General Hospital
- Bone and the innate immune systemJulia F Charles
Department of Medicine, Division of Rheumatology, Allergy and Immunology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA
Curr Osteoporos Rep 12:1-8. 2014..Innate immune signals are critical for removal of damaged and apoptotic cells and to stimulate normal tissue repair and regeneration. In this review we focus on the innate immune mechanisms that function to regulate bone homeostasis. ..
- Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor functionJulia F Charles
Department of Medicine, Division of Rheumatology, UCSF, San Francisco, California, USA
J Clin Invest 122:4592-605. 2012..Therapeutic strategies that prevent the development of OCPs into mature bone-resorbing cells could simultaneously prevent bone resorption and generate an antiinflammatory milieu in the RA joint...
- The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorptionJulia F Charles
Department of Medicine, Division of Rheumatology, Allergy and Immunology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Bone 51:902-12. 2012..These data highlight the need for rigorous validation studies to complement expression profiling results before functional importance can be assigned to highly regulated genes in any biologic process...
- The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12Julia F Charles
Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
Infect Immun 76:2439-47. 2008..Thus, DAP12 is an important regulator of Salmonella-induced ROS production in macrophages, and TREM2 is essential for linking DAP12 to the innate response to serovar Typhimurium...