Genomes and Genes
Julia F Charles
Affiliation: Massachusetts General Hospital
- Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor functionJulia F Charles
Department of Medicine, Division of Rheumatology, UCSF, San Francisco, California, USA
J Clin Invest 122:4592-605. 2012..Therapeutic strategies that prevent the development of OCPs into mature bone-resorbing cells could simultaneously prevent bone resorption and generate an antiinflammatory milieu in the RA joint...
- The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorptionJulia F Charles
Department of Medicine, Division of Rheumatology, Allergy and Immunology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Bone 51:902-12. 2012..These data highlight the need for rigorous validation studies to complement expression profiling results before functional importance can be assigned to highly regulated genes in any biologic process...
- The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12Julia F Charles
Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
Infect Immun 76:2439-47. 2008..Thus, DAP12 is an important regulator of Salmonella-induced ROS production in macrophages, and TREM2 is essential for linking DAP12 to the innate response to serovar Typhimurium...