Al Charest

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development
    Jacinthe Sirois
    McGill Cancer Center and Biochemistry Department, McGill University, 3655 Sir William Osler Promenade, Montreal, Que, Canada H3G 1Y6
    Mech Dev 123:869-80. 2006
  2. ncbi request reprint Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6
    A Charest
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 276:29456-65. 2001
  3. pmc Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma
    Alan Charest
    Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:916-21. 2003
  4. ncbi request reprint Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)
    Alain Charest
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Chromosomes Cancer 37:58-71. 2003
  5. ncbi request reprint ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice
    Al Charest
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cancer Res 66:7473-81. 2006
  6. pmc Genome complexity reduction for SNP genotyping analysis
    Barbara Jordan
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:2942-7. 2002
  7. ncbi request reprint Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
    Development 132:165-76. 2005

Collaborators

  • Richard Hynes
  • Tyler E Jacks
  • Michael Yaffe
  • Jurgen Roes
  • John E Landers
  • Jacinthe Sirois
  • Joseph H McCarty
  • Barbara Jordan
  • Jean Francois Cote
  • Michel L Tremblay
  • Stephen A Duncan
  • Eugene Daniels
  • Annie Bourdeau
  • Noriko Uetani
  • John Savill
  • David Housman
  • Roderick T Bronson
  • Denise Crowley
  • Adam Lacy-Hulbert
  • John F Dowd
  • Justin P Blumenstiel
  • David E Housman
  • Asiah Osman
  • Ru fang Yeh Rf

Detail Information

Publications7

  1. ncbi request reprint Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development
    Jacinthe Sirois
    McGill Cancer Center and Biochemistry Department, McGill University, 3655 Sir William Osler Promenade, Montreal, Que, Canada H3G 1Y6
    Mech Dev 123:869-80. 2006
    ....
  2. ncbi request reprint Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6
    A Charest
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 276:29456-65. 2001
    ..Our results broaden the scope of PDZ domain-mediated functions...
  3. pmc Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma
    Alan Charest
    Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:916-21. 2003
    ..Thus we have found a RTK fusion protein whose subcellular location leads to constitutive kinase activation and results in oncogenic transformation...
  4. ncbi request reprint Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)
    Alain Charest
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Chromosomes Cancer 37:58-71. 2003
    ..This is the first example of a fusion RTK protein that results from an intra-chromosomal deletion, and it represents the first fusion RTK protein isolated from a human astrocytoma...
  5. ncbi request reprint ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice
    Al Charest
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cancer Res 66:7473-81. 2006
    ..These findings provide novel and important insights into the role of ROS and SHP-2 function in solid tumor biology and set the stage for preclinical testing of targeted therapeutic approaches...
  6. pmc Genome complexity reduction for SNP genotyping analysis
    Barbara Jordan
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:2942-7. 2002
    ..Finally, we describe an in silico approach that can effectively predict the SNP loci amplified in a given DOP-PCR, permitting the design of an efficient set of reactions for large-scale, genome-wide SNP studies...
  7. ncbi request reprint Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
    Development 132:165-76. 2005
    ....