Yee Ming Chan

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Horm Res Paediatr 73:312-9. 2010
  2. doi Effects of kisspeptin on hormone secretion in humans
    Yee Ming Chan
    Department of Medicine, Boston Children s Hospital, Boston, MA, USA
    Adv Exp Med Biol 784:89-112. 2013
  3. pmc Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E1458-67. 2012
  4. pmc A needle in a haystack: mutations in GNRH1 as a rare cause of isolated GnRH deficiency
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, United States
    Mol Cell Endocrinol 346:51-6. 2011
  5. pmc Kisspeptin/Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice
    Y M Chan
    Reproductive Endocrine Unit and Harvard Reproductive Sciences Center, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neuroendocrinol 21:1015-23. 2009
  6. pmc Kisspeptin resets the hypothalamic GnRH clock in men
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, BHX 5, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:E908-15. 2011
  7. ncbi Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice
    Risto Lapatto
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Endocrinology 148:4927-36. 2007
  8. pmc Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men
    Jasmine J Yang
    Harvard Reproductive Sciences Center, Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Endocrinology 153:1498-508. 2012
  9. pmc GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1
    Yee Ming Chan
    Harvard Center for Reproductive Sciences and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:E1771-81. 2011
  10. pmc Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men
    Yee Ming Chan
    Reproductive Endocrine Unit and Harvard Reproductive Sciences Center, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Peptides 30:42-8. 2009

Collaborators

Detail Information

Publications14

  1. pmc Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Horm Res Paediatr 73:312-9. 2010
    ..We sought to determine whether hamartomas that cause CPP could be distinguished by anatomic features, expression of these molecules, or expression of KISS1, whose products signal through the receptor GPR54 to stimulate GnRH release...
  2. doi Effects of kisspeptin on hormone secretion in humans
    Yee Ming Chan
    Department of Medicine, Boston Children s Hospital, Boston, MA, USA
    Adv Exp Med Biol 784:89-112. 2013
    ..These findings pave the way for future studies using kisspeptin as a physiologic, diagnostic, and therapeutic tool in both healthy adults and in patients with reproductive disorders...
  3. pmc Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E1458-67. 2012
    ..However, the effects of kisspeptin are just being explored, and the dynamics of kisspeptin responsiveness across the menstrual cycle are incompletely understood...
  4. pmc A needle in a haystack: mutations in GNRH1 as a rare cause of isolated GnRH deficiency
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, United States
    Mol Cell Endocrinol 346:51-6. 2011
    ..Thus, mutations in GNRH1 have been associated with both mild and severe forms of GnRH deficiency, and may work in combination with other gene mutations to produce GnRH-deficient phenotypes...
  5. pmc Kisspeptin/Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice
    Y M Chan
    Reproductive Endocrine Unit and Harvard Reproductive Sciences Center, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neuroendocrinol 21:1015-23. 2009
    ..This GnRH activity is sufficient to produce significant effects on vaginal cytology and uterine weights in female mice and on spermatogenesis and testicular weights in male mice...
  6. pmc Kisspeptin resets the hypothalamic GnRH clock in men
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, BHX 5, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:E908-15. 2011
    ..The neuropeptide kisspeptin potently and selectively stimulates the secretion of GnRH. Although this property of kisspeptin is well described, the effects of kisspeptin on endogenous GnRH pulse generation remain largely unexplored...
  7. ncbi Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice
    Risto Lapatto
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Endocrinology 148:4927-36. 2007
    ..Kiss1 knockout females demonstrate a bimodal phenotypic variability, with some animals having higher gonadal weight, larger vaginal opening, and persistent vaginal cornification...
  8. pmc Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men
    Jasmine J Yang
    Harvard Reproductive Sciences Center, Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Endocrinology 153:1498-508. 2012
    ..Tacr3 mice are a useful model to examine the mechanisms by which neurokinin B signaling modulates GnRH release...
  9. pmc GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1
    Yee Ming Chan
    Harvard Center for Reproductive Sciences and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:E1771-81. 2011
    ..KISS1 is a candidate gene for GnRH deficiency...
  10. pmc Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men
    Yee Ming Chan
    Reproductive Endocrine Unit and Harvard Reproductive Sciences Center, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Peptides 30:42-8. 2009
    ..Collectively, these findings suggest that kisspeptin and Gpr54 serve as an essential conduit for relaying developmental information to the GnRH neuron...
  11. pmc Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications
    Hilana M Lewkowitz-Shpuntoff
    Harvard Reproductive Endocrine Sciences Center, Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Bartlett Hall Extension, 5th Floor, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E136-44. 2012
    ..However, the true prevalence of intermediary olfactory phenotypes (hyposmia) in IHH patients has not yet been assessed, and systematic correlations with anatomical and genetic abnormalities have not been reported...
  12. pmc Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination
    David H Margolin
    Department of Neurology, Massachusetts General Hospital, Boston 02115, USA
    N Engl J Med 368:1992-2003. 2013
    ..The combination of ataxia and hypogonadism was first described more than a century ago, but its genetic basis has remained elusive...
  13. pmc GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 106:11703-8. 2009
    ..Our results establish mutations in GNRH1 as a genetic cause of nIHH...
  14. ncbi Transition from insulin to glyburide in a 4-month-old girl with neonatal diabetes mellitus caused by a mutation in KCNJ11
    Yee Ming Chan
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Boston, MA, USA
    Pediatr Diabetes 8:235-8. 2007
    ..Dosing of glyburide three times daily was critical for her successful transition...