Andrew Chan

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 19:975-80. 2008
  2. pmc Joint effects of colorectal cancer susceptibility loci, circulating 25-hydroxyvitamin D and risk of colorectal cancer
    Linda T Hiraki
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 9:e92212. 2014
  3. pmc Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: a prospective cohort study
    Hamed Khalili
    Gastroenterology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    BMJ 344:e372. 2012
  4. pmc Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses' Health Study cohorts
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    BMJ 347:f6633. 2013
  5. pmc Plasma adiponectin and soluble leptin receptor and risk of colorectal cancer: a prospective study
    Mingyang Song
    Division of Nutrition, Harvard Medical School, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 6:875-85. 2013
  6. pmc Oral contraceptives, reproductive factors and risk of inflammatory bowel disease
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gut 62:1153-9. 2013
  7. pmc Geographical variation and incidence of inflammatory bowel disease among US women
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gut 61:1686-92. 2012
  8. pmc A prospective study of bisphosphonate use and risk of colorectal cancer
    Hamed Khalili
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Oncol 30:3229-33. 2012
  9. doi request reprint An emerging role for anti-inflammatory agents for chemoprevention
    Andrew T Chan
    General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Recent Results Cancer Res 191:1-5. 2013
  10. pmc Aspirin in the chemoprevention of colorectal neoplasia: an overview
    Andrew T Chan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 5:164-78. 2012

Research Grants

  1. Prospective Studies of Colorectal Adenoma
    Andrew Chan; Fiscal Year: 2007
  2. Inflammation and Colorectal Neoplasia
    Andrew T Chan; Fiscal Year: 2010
  3. Inflammation and Colorectal Neoplasia
    Andrew Chan; Fiscal Year: 2009

Detail Information

Publications55

  1. pmc Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 19:975-80. 2008
    ..37-1.08; P for heterogeneity 0.52 for the association in women and men). In summary, the marginal association of the TCF7L2 SNP with CRC might be due to chance, but warrants further laboratory and epidemiological investigation...
  2. pmc Joint effects of colorectal cancer susceptibility loci, circulating 25-hydroxyvitamin D and risk of colorectal cancer
    Linda T Hiraki
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 9:e92212. 2014
    ..Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk...
  3. pmc Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: a prospective cohort study
    Hamed Khalili
    Gastroenterology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    BMJ 344:e372. 2012
    ..To examine the association between chronic use of proton pump inhibitors (PPIs) and risk of hip fracture...
  4. pmc Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses' Health Study cohorts
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    BMJ 347:f6633. 2013
    ..To examine the association between physical activity and risk of ulcerative colitis and Crohn's disease...
  5. pmc Plasma adiponectin and soluble leptin receptor and risk of colorectal cancer: a prospective study
    Mingyang Song
    Division of Nutrition, Harvard Medical School, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 6:875-85. 2013
    ..These findings support a role for adiponectin in colorectal carcinogenesis in men. Further studies are warranted to confirm these associations and elucidate potential underlying mechanisms...
  6. pmc Oral contraceptives, reproductive factors and risk of inflammatory bowel disease
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gut 62:1153-9. 2013
    ..Oral contraceptive use has been associated with risk of Crohn's disease (CD) and ulcerative colitis (UC)...
  7. pmc Geographical variation and incidence of inflammatory bowel disease among US women
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gut 61:1686-92. 2012
    ..However, there are no comparable data in the USA. The incidence of CD and UC in relation to latitude was assessed in a geographically diverse population of women enrolled in two large prospective studies in the USA...
  8. pmc A prospective study of bisphosphonate use and risk of colorectal cancer
    Hamed Khalili
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Oncol 30:3229-33. 2012
    ..A recent case-control study showed an inverse association between bisphosphonate use and colorectal cancer. Data from prospective cohorts are lacking...
  9. doi request reprint An emerging role for anti-inflammatory agents for chemoprevention
    Andrew T Chan
    General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Recent Results Cancer Res 191:1-5. 2013
    ....
  10. pmc Aspirin in the chemoprevention of colorectal neoplasia: an overview
    Andrew T Chan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 5:164-78. 2012
    ..The optimal dose to use for cancer prevention and the precise mechanism underlying aspirin's anticancer effect require further investigation...
  11. pmc Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma
    Takako Kawasaki
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    BMC Cancer 8:33. 2008
    ..Therefore, we hypothesized that COX-2 may play a less important role in the serrated pathway...
  12. pmc Primary prevention of colorectal cancer
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 138:2029-2043.e10. 2010
    ..Taken together, modifications in diet and lifestyle should substantially reduce the risk of colorectal cancer and could complement screening in reducing colorectal cancer incidence...
  13. pmc Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cancer Epidemiol Biomarkers Prev 19:2777-85. 2010
    ..Proteases play a critical role in tumorigenesis and are upregulated in colorectal cancer and neoplastic polyps. In animal models, cathepsin B (CTSB)-activatable imaging agents show high enzyme activity within intestinal tumors...
  14. pmc Aspirin and familial adenomatous polyposis: coming full circle
    Andrew T Chan
    Massachusetts General Hospital, Department of Medicine, Gastrointestinal Unit, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 4:623-7. 2011
    ....
  15. pmc Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenoma
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 136:2127-2136.e1. 2009
    ..We examined the influence of CYP2C9*2 (R144C) and CYP2C9*3 (I359L) variants on dose-related response or toxicity in a randomized trial of celecoxib...
  16. pmc C-reactive protein and risk of colorectal adenoma according to celecoxib treatment
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 4:1172-80. 2011
    ..Patients with low hsCRP may be a subgroup with a favorable risk-benefit profile for celecoxib chemoprevention...
  17. pmc The influence of UGT1A6 variants and aspirin use in a randomized trial of celecoxib for prevention of colorectal adenoma
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 5:61-72. 2012
    ..However, discontinuing celecoxib among aspirin-using individuals who initially developed adenoma despite a UGT1A6 variant genotype resulted in rapid reemergence of disease...
  18. pmc Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 140:799-808, quiz e11. 2011
    ..We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflammatory markers...
  19. ncbi request reprint Aspirin and the risk of colorectal cancer in relation to the expression of COX-2
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 356:2131-42. 2007
    ..Regular use of aspirin reduces the risk of a colorectal neoplasm, but the mechanism by which aspirin affects carcinogenesis in the colon is not well understood...
  20. pmc Statin use and colorectal cancer risk according to molecular subtypes in two large prospective cohort studies
    Jung Eun Lee
    Department of Food and Nutrition, Sookmyung Women s University, Seoul, Korea
    Cancer Prev Res (Phila) 4:1808-15. 2011
    ..Current statin use was not associated with risk of overall colorectal cancer. The possibility that statin use may be associated with lower risk of rectal cancer or KRAS wild-type colorectal cancer requires further confirmation...
  21. ncbi request reprint Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, GRJ 722, Boston, MA 02114, USA
    J Natl Cancer Inst 97:457-60. 2005
    ....
  22. ncbi request reprint Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:917-26. 2005
    ..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women enrolled in the Nurses' Health Study...
  23. pmc Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    JAMA 294:914-23. 2005
    ..However, data on long-term risk of colorectal cancer according to dose, timing, or duration of therapy with aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) remain limited...
  24. ncbi request reprint Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 113:1578-87. 2006
    ..Although randomized trials of cyclooxygenase-2 (COX-2) inhibitors have shown increased cardiovascular risk, studies of nonselective, nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen have been inconsistent...
  25. ncbi request reprint Aspirin, non-steroidal anti-inflammatory drugs and colorectal neoplasia: future challenges in chemoprevention
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 14:413-8. 2003
    ..Hopefully, interpretation of this large body of evidence ultimately will lead to concrete clinical guidelines which will define a role, if any, for these medications as anticancer agents...
  26. ncbi request reprint Can aspirin prevent colorectal cancer?
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02116, USA
    Lancet 369:1577-8. 2007
  27. pmc Aspirin use and survival after diagnosis of colorectal cancer
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, GRJ 722 Boston, MA 02114, USA
    JAMA 302:649-58. 2009
    ..Aspirin reduces risk of colorectal neoplasia in randomized trials and inhibits tumor growth and metastases in animal models. However, the influence of aspirin on survival after diagnosis of colorectal cancer is unknown...
  28. ncbi request reprint A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Clin Gastroenterol Hepatol 2:704-12. 2004
    ..Genetic variation in this enzyme may modulate the influence of aspirin and smoking on adenoma risk...
  29. ncbi request reprint A prospective study of aspirin use and the risk of pancreatic cancer in women
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 96:22-8. 2004
    ....
  30. ncbi request reprint Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
    ..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women...
  31. pmc Aspirin dose and duration of use and risk of colorectal cancer in men
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Gastroenterology 134:21-8. 2008
    ..Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited...
  32. ncbi request reprint A prospective study of aspirin use and the risk for colorectal adenoma
    Andrew T Chan
    Massachusetts General Hospital, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02114, USA
    Ann Intern Med 140:157-66. 2004
    ..However, the effect of dose and duration of use, particularly in an average-risk population, is not well understood...
  33. ncbi request reprint Long-term aspirin use and mortality in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 0214, USA
    Arch Intern Med 167:562-72. 2007
    ..The influence of long-term use of aspirin on total mortality in women remains uncertain...
  34. pmc Cohort study of fatty acid synthase expression and patient survival in colon cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 26:5713-20. 2008
    ..Fatty acid synthase (FASN) is physiologically regulated by energy balance and is often upregulated in colorectal cancer. Nonetheless, the influence of FASN expression on patient outcome is uncertain...
  35. pmc ABO blood group and the risk of pancreatic cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Natl Cancer Inst 101:424-31. 2009
    ..ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies...
  36. ncbi request reprint Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Cancer 115:648-52. 2005
    ..The influence of NAT2 genotype on this association supports a role for heterocyclic amines in mediating the effect of red meat on colorectal carcinogenesis...
  37. pmc Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 27:176-85. 2009
    ..Excess energy balance leads to increased circulating insulin and depressed levels of circulating insulin-like growth factor binding protein (IGFBP) -1, which promote cancer cell growth in preclinical models...
  38. pmc Interaction of molecular markers and physical activity on mortality in patients with colon cancer
    Jeffrey A Meyerhardt
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 15:5931-6. 2009
    ..Physical activity in colon cancer survivors has been associated with lower cancer recurrences and improved survival. Whether molecular features of the tumor portend more or less likelihood for benefit from exercise is unknown...
  39. ncbi request reprint Hormone replacement therapy and survival after colorectal cancer diagnosis
    Jennifer A Chan
    Dana Farber Cancer Institute, Dana 1220, Boston, MA 02115, USA
    J Clin Oncol 24:5680-6. 2006
    ..Postmenopausal estrogen use has been shown to decrease the incidence of colorectal cancer, but there is limited information regarding the effect of estrogen use on survival after diagnosis of colorectal cancer...
  40. ncbi request reprint Physical activity and survival after colorectal cancer diagnosis
    Jeffrey A Meyerhardt
    Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 24:3527-34. 2006
    ..Physically active individuals have a lower risk of developing colorectal cancer but the influence of exercise on cancer survival is unknown...
  41. pmc A prospective study of aspirin use and the risk of gastrointestinal bleeding in men
    Edward S Huang
    Division of Gastroenterology and Hepatology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e15721. 2010
    ..Data regarding the influence of dose and duration of aspirin use on risk of gastrointestinal bleeding are conflicting...
  42. ncbi request reprint Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs
    Chin Hur
    Institute for Technology Assessment, Massachusetts General Hospital Gastrointestinal Unit, Harvard Medical School, Boston, 02114, USA
    Ann Pharmacother 40:1052-63. 2006
    ....
  43. ncbi request reprint Fruit and vegetable consumption and colorectal adenomas in the Nurses' Health Study
    Karin B Michels
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Cancer Res 66:3942-53. 2006
    ..67; 95% CI, 0.51-0.90; P(trend) = 0.005). Frequent consumption of fruit may reduce the risk of colorectal adenomas...
  44. pmc Dietary choline and betaine and the risk of distal colorectal adenoma in women
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 99:1224-31. 2007
    ..No epidemiologic study has examined the association of intake of these nutrients and colorectal adenoma risk...
  45. pmc HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 176:2292-301. 2010
    ..039). In conclusion, HIF1A expression is independently associated with poor prognosis in colorectal cancer, suggesting HIF1A as a biomarker with potentially important therapeutic implications...
  46. pmc A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 100:1734-8. 2008
    ..In conclusion, tumoral LINE-1 hypomethylation is independently associated with shorter survival among colon cancer patients...
  47. pmc PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115 USA
    J Clin Oncol 27:1477-84. 2009
    ..PIK3CA mutation and subsequent activation of the AKT pathway play an important role in colorectal carcinogenesis. However, little is known about the prognostic role of PIK3CA mutation in colon cancer...
  48. pmc A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis
    Shuji Ogino
    Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney St, Room JF 215C, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 104:2047-56. 2009
    ..STMN1 activity is influenced by p53, p27, and the PI3K/AKT pathway. However, its prognostic significance in colon cancer is uncertain...
  49. pmc PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype
    Yoshifumi Baba
    Department of Medical Oncology, Dana FarberCancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 19:822-31. 2010
    ..However, the prognostic significance of PTGER2 expression or its relationship with MSI, CIMP, LINE-1 hypomethylation, or PTGS2 (COX-2) remains uncertain...
  50. pmc Role of vitamin and mineral supplementation and aspirin use in cancer survivors
    Edward Giovannucci
    ScD, Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 28:4081-5. 2010
    ..The potential beneficial or adverse effects of dietary supplements and aspirin in survivors of cancer warrant further study...
  51. pmc Physical activity and male colorectal cancer survival
    Jeffrey A Meyerhardt
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Arch Intern Med 169:2102-8. 2009
    ..Although physically active individuals have a lower risk of developing colorectal cancer, few studies have examined whether exercise benefits colorectal cancer survivors...
  52. pmc ABO blood group and risk of colorectal cancer
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Epidemiol Biomarkers Prev 20:1017-20. 2011
    ..Recent studies have shown an association between non-O blood group and risk of pancreatic cancer. It is unclear whether this association is observed with other gastrointestinal malignancies, including colorectal cancers...
  53. pmc Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Clin Cancer Res 14:8221-7. 2008
    ..However, previous data on the influence of COX-2 expression on patient outcome have been conflicting...
  54. pmc Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 17:2665-72. 2008
    ..008. This study confirms the association between colorectal neoplasia and the 8q24 polymorphisms located between 128.47 and 128.54 Mb and suggests a role for these variants in the formation of multiple adenomas...

Research Grants4

  1. Prospective Studies of Colorectal Adenoma
    Andrew Chan; Fiscal Year: 2007
    ..This overall proposal will ensure that Dr. Chan will become an established independent investigator and a leader in cancer prevention. ..
  2. Inflammation and Colorectal Neoplasia
    Andrew T Chan; Fiscal Year: 2010
    ..S., its optimal use in light of its toxicities remains uncertain. We will investigate the role of inflammation in colorectal carcinogenesis to define predictors of susceptibility for tailored preventative strategies. ..
  3. Inflammation and Colorectal Neoplasia
    Andrew Chan; Fiscal Year: 2009
    ..S., its optimal use in light of its toxicities remains uncertain. We will investigate the role of inflammation in colorectal carcinogenesis to define predictors of susceptibility for tailored preventative strategies. ..