Research Topics
Genomes and GenesSpecies | Andrew ChanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Association of the TCF7L2 polymorphism with colorectal cancer and adenoma riskAditi Hazra
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Causes Control 19:975-80. 2008..37-1.08; P for heterogeneity 0.52 for the association in women and men). In summary, the marginal association of the TCF7L2 SNP with CRC might be due to chance, but warrants further laboratory and epidemiological investigation...- Geographical variation and incidence of inflammatory bowel disease among US womenHamed Khalili
Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Gut 61:1686-92. 2012..However, there are no comparable data in the USA. The incidence of CD and UC in relation to latitude was assessed in a geographically diverse population of women enrolled in two large prospective studies in the USA... - A prospective study of bisphosphonate use and risk of colorectal cancerHamed Khalili
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Oncol 30:3229-33. 2012..A recent case-control study showed an inverse association between bisphosphonate use and colorectal cancer. Data from prospective cohorts are lacking... 
An emerging role for anti-inflammatory agents for chemopreventionAndrew T Chan
General Hospital, Harvard Medical School, Boston, MA 02114, USA
Recent Results Cancer Res 191:1-5. 2013....- Aspirin in the chemoprevention of colorectal neoplasia: an overviewAndrew T Chan
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
Cancer Prev Res (Phila) 5:164-78. 2012..The optimal dose to use for cancer prevention and the precise mechanism underlying aspirin's anticancer effect require further investigation... - Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenomaTakako Kawasaki
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
BMC Cancer 8:33. 2008..Therefore, we hypothesized that COX-2 may play a less important role in the serrated pathway... - Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasiaAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cancer Epidemiol Biomarkers Prev 19:2777-85. 2010..Proteases play a critical role in tumorigenesis and are upregulated in colorectal cancer and neoplastic polyps. In animal models, cathepsin B (CTSB)-activatable imaging agents show high enzyme activity within intestinal tumors... 
Can aspirin prevent colorectal cancer?Andrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02116, USA
Lancet 369:1577-8. 2007- Aspirin and the risk of colorectal cancer in relation to the expression of COX-2Andrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 356:2131-42. 2007..Regular use of aspirin reduces the risk of a colorectal neoplasm, but the mechanism by which aspirin affects carcinogenesis in the colon is not well understood... - Aspirin use and survival after diagnosis of colorectal cancerAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, GRJ 722 Boston, MA 02114, USA
JAMA 302:649-58. 2009..Aspirin reduces risk of colorectal neoplasia in randomized trials and inhibits tumor growth and metastases in animal models. However, the influence of aspirin on survival after diagnosis of colorectal cancer is unknown... - Aspirin, non-steroidal anti-inflammatory drugs and colorectal neoplasia: future challenges in chemopreventionAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Cancer Causes Control 14:413-8. 2003..Hopefully, interpretation of this large body of evidence ultimately will lead to concrete clinical guidelines which will define a role, if any, for these medications as anticancer agents... - Primary prevention of colorectal cancerAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 138:2029-2043.e10. 2010..Taken together, modifications in diet and lifestyle should substantially reduce the risk of colorectal cancer and could complement screening in reducing colorectal cancer incidence... - Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenomaAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Gastroenterology 136:2127-2136.e1. 2009..We examined the influence of CYP2C9*2 (R144C) and CYP2C9*3 (I359L) variants on dose-related response or toxicity in a randomized trial of celecoxib... - Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugsAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Gastroenterology 140:799-808, quiz e11. 2011..We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflammatory markers... - Aspirin and familial adenomatous polyposis: coming full circleAndrew T Chan
Massachusetts General Hospital, Department of Medicine, Gastrointestinal Unit, Boston, MA 02114, USA
Cancer Prev Res (Phila) 4:623-7. 2011.... - Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenomaAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, GRJ 722, Boston, MA 02114, USA
J Natl Cancer Inst 97:457-60. 2005.... - Statin use and colorectal cancer risk according to molecular subtypes in two large prospective cohort studiesJung Eun Lee
Department of Food and Nutrition, Sookmyung Women s University, Seoul, Korea
Cancer Prev Res (Phila) 4:1808-15. 2011..Current statin use was not associated with risk of overall colorectal cancer. The possibility that statin use may be associated with lower risk of rectal cancer or KRAS wild-type colorectal cancer requires further confirmation... - Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in womenAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Natl Cancer Inst 97:917-26. 2005..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women enrolled in the Nurses' Health Study... - Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancerAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
JAMA 294:914-23. 2005..However, data on long-term risk of colorectal cancer according to dose, timing, or duration of therapy with aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) remain limited... - Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular eventsAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Circulation 113:1578-87. 2006..Although randomized trials of cyclooxygenase-2 (COX-2) inhibitors have shown increased cardiovascular risk, studies of nonselective, nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen have been inconsistent... - The influence of UGT1A6 variants and aspirin use in a randomized trial of celecoxib for prevention of colorectal adenomaAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Cancer Prev Res (Phila) 5:61-72. 2012..However, discontinuing celecoxib among aspirin-using individuals who initially developed adenoma despite a UGT1A6 variant genotype resulted in rapid reemergence of disease... - C-reactive protein and risk of colorectal adenoma according to celecoxib treatmentAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Cancer Prev Res (Phila) 4:1172-80. 2011..Patients with low hsCRP may be a subgroup with a favorable risk-benefit profile for celecoxib chemoprevention... - A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenomaAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Clin Gastroenterol Hepatol 2:704-12. 2004..Genetic variation in this enzyme may modulate the influence of aspirin and smoking on adenoma risk... - Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health StudyGregory J Tranah
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Mol Carcinog 44:21-30. 2005..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women... - A prospective study of aspirin use and the risk of pancreatic cancer in womenEva S Schernhammer
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Natl Cancer Inst 96:22-8. 2004.... - Aspirin dose and duration of use and risk of colorectal cancer in menAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Gastroenterology 134:21-8. 2008..Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited... - Cohort study of fatty acid synthase expression and patient survival in colon cancerShuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 26:5713-20. 2008..Fatty acid synthase (FASN) is physiologically regulated by energy balance and is often upregulated in colorectal cancer. Nonetheless, the influence of FASN expression on patient outcome is uncertain... - A prospective study of aspirin use and the risk for colorectal adenomaAndrew T Chan
Massachusetts General Hospital, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02114, USA
Ann Intern Med 140:157-66. 2004..Before aspirin can be recommended for chemoprevention in the general adult population, these results suggest the need for a more thorough evaluation of the risks and benefits of routine aspirin use at doses not previously considered... - Long-term aspirin use and mortality in womenAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 0214, USA
Arch Intern Med 167:562-72. 2007..The influence of long-term use of aspirin on total mortality in women remains uncertain... - Hormone replacement therapy and survival after colorectal cancer diagnosisJennifer A Chan
Dana Farber Cancer Institute, Dana 1220, Boston, MA 02115, USA
J Clin Oncol 24:5680-6. 2006..Postmenopausal estrogen use has been shown to decrease the incidence of colorectal cancer, but there is limited information regarding the effect of estrogen use on survival after diagnosis of colorectal cancer... - Physical activity and survival after colorectal cancer diagnosisJeffrey A Meyerhardt
Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Clin Oncol 24:3527-34. 2006..Physically active individuals have a lower risk of developing colorectal cancer but the influence of exercise on cancer survival is unknown... - Interaction of molecular markers and physical activity on mortality in patients with colon cancerJeffrey A Meyerhardt
Dana Farber Cancer Institute, Boston, MA 02115, USA
Clin Cancer Res 15:5931-6. 2009..Physical activity in colon cancer survivors has been associated with lower cancer recurrences and improved survival. Whether molecular features of the tumor portend more or less likelihood for benefit from exercise is unknown... - Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancerBrian M Wolpin
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 27:176-85. 2009..Excess energy balance leads to increased circulating insulin and depressed levels of circulating insulin-like growth factor binding protein (IGFBP) -1, which promote cancer cell growth in preclinical models... - ABO blood group and the risk of pancreatic cancerBrian M Wolpin
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Natl Cancer Inst 101:424-31. 2009..ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies... - Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancerAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Int J Cancer 115:648-52. 2005..The influence of NAT2 genotype on this association supports a role for heterocyclic amines in mediating the effect of red meat on colorectal carcinogenesis... - A prospective study of aspirin use and the risk of gastrointestinal bleeding in menEdward S Huang
Division of Gastroenterology and Hepatology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 5:e15721. 2010..Data regarding the influence of dose and duration of aspirin use on risk of gastrointestinal bleeding are conflicting... - Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costsChin Hur
Institute for Technology Assessment, Massachusetts General Hospital Gastrointestinal Unit, Harvard Medical School, Boston, 02114, USA
Ann Pharmacother 40:1052-63. 2006.... - Fruit and vegetable consumption and colorectal adenomas in the Nurses' Health StudyKarin B Michels
Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Cancer Res 66:3942-53. 2006..67; 95% CI, 0.51-0.90; P(trend) = 0.005). Frequent consumption of fruit may reduce the risk of colorectal adenomas... - A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancerShuji Ogino
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Natl Cancer Inst 100:1734-8. 2008..In conclusion, tumoral LINE-1 hypomethylation is independently associated with shorter survival among colon cancer patients... - Dietary choline and betaine and the risk of distal colorectal adenoma in womenEunyoung Cho
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
J Natl Cancer Inst 99:1224-31. 2007..No epidemiologic study has examined the association of intake of these nutrients and colorectal adenoma risk... - HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancersYoshifumi Baba
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Am J Pathol 176:2292-301. 2010..039). In conclusion, HIF1A expression is independently associated with poor prognosis in colorectal cancer, suggesting HIF1A as a biomarker with potentially important therapeutic implications... - PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancerShuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115 USA
J Clin Oncol 27:1477-84. 2009..PIK3CA mutation and subsequent activation of the AKT pathway play an important role in colorectal carcinogenesis. However, little is known about the prognostic role of PIK3CA mutation in colon cancer... - A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosisShuji Ogino
Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney St, Room JF 215C, Boston, Massachusetts 02115, USA
Am J Gastroenterol 104:2047-56. 2009..STMN1 activity is influenced by p53, p27, and the PI3K/AKT pathway. However, its prognostic significance in colon cancer is uncertain... - Physical activity and male colorectal cancer survivalJeffrey A Meyerhardt
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
Arch Intern Med 169:2102-8. 2009..Although physically active individuals have a lower risk of developing colorectal cancer, few studies have examined whether exercise benefits colorectal cancer survivors... - PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotypeYoshifumi Baba
Department of Medical Oncology, Dana FarberCancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 19:822-31. 2010..However, the prognostic significance of PTGER2 expression or its relationship with MSI, CIMP, LINE-1 hypomethylation, or PTGS2 (COX-2) remains uncertain... - Role of vitamin and mineral supplementation and aspirin use in cancer survivorsEdward Giovannucci
ScD, Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
J Clin Oncol 28:4081-5. 2010..The potential beneficial or adverse effects of dietary supplements and aspirin in survivors of cancer warrant further study... - ABO blood group and risk of colorectal cancerHamed Khalili
Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
Cancer Epidemiol Biomarkers Prev 20:1017-20. 2011..Recent studies have shown an association between non-O blood group and risk of pancreatic cancer. It is unclear whether this association is observed with other gastrointestinal malignancies, including colorectal cancers... - Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancerShuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Clin Cancer Res 14:8221-7. 2008..However, previous data on the influence of COX-2 expression on patient outcome have been conflicting... - Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia riskSonja I Berndt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Hum Mol Genet 17:2665-72. 2008..008. This study confirms the association between colorectal neoplasia and the 8q24 polymorphisms located between 128.47 and 128.54 Mb and suggests a role for these variants in the formation of multiple adenomas...
Research Grants
- Prospective Studies of Colorectal AdenomaAndrew Chan; Fiscal Year: 2007..This overall proposal will ensure that Dr. Chan will become an established independent investigator and a leader in cancer prevention. ..
- Inflammation and Colorectal NeoplasiaAndrew T Chan; Fiscal Year: 2010..S., its optimal use in light of its toxicities remains uncertain. We will investigate the role of inflammation in colorectal carcinogenesis to define predictors of susceptibility for tailored preventative strategies. ..
- Inflammation and Colorectal NeoplasiaAndrew Chan; Fiscal Year: 2009..S., its optimal use in light of its toxicities remains uncertain. We will investigate the role of inflammation in colorectal carcinogenesis to define predictors of susceptibility for tailored preventative strategies. ..