Christine L Chaffer

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi A perspective on cancer cell metastasis
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 331:1559-64. 2011
  2. ncbi Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    Christina Scheel
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 145:926-40. 2011
  3. ncbi Cancer stem cells: mirage or reality?
    Piyush B Gupta
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Med 15:1010-2. 2009
  4. ncbi Cell plasticity and heterogeneity in cancer
    Nemanja D Marjanovic
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Clin Chem 59:168-79. 2013
  5. ncbi Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:7950-5. 2011

Detail Information

Publications5

  1. ncbi A perspective on cancer cell metastasis
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 331:1559-64. 2011
    ....
  2. ncbi Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    Christina Scheel
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 145:926-40. 2011
    ..Conversely, disruption of autocrine signaling by added inhibitors of these pathways inhibits migration and self-renewal in primary mammary epithelial cells and reduces tumorigenicity and metastasis by their transformed derivatives...
  3. ncbi Cancer stem cells: mirage or reality?
    Piyush B Gupta
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Med 15:1010-2. 2009
    ..If present, such plasticity would have major implications for the CSC model and for future therapeutic approaches...
  4. ncbi Cell plasticity and heterogeneity in cancer
    Nemanja D Marjanovic
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Clin Chem 59:168-79. 2013
    ..These factors conspire to create a disease with various phenotypes. There are 2 established models of cancer development and progression to metastatic disease. These are the clonal evolution and cancer stem cell models...
  5. ncbi Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:7950-5. 2011
    ..The observed plasticity may allow derivation of patient-specific adult stem cells without genetic manipulation and holds important implications for therapeutic strategies to eradicate cancer...