Christine L Chaffer

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 154:61-74. 2013
  2. doi request reprint A perspective on cancer cell metastasis
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 331:1559-64. 2011
  3. pmc Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    Christina Scheel
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 145:926-40. 2011
  4. pmc Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:7950-5. 2011
  5. doi request reprint Cell plasticity and heterogeneity in cancer
    Nemanja D Marjanovic
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Clin Chem 59:168-79. 2013
  6. doi request reprint Cancer stem cells: mirage or reality?
    Piyush B Gupta
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Med 15:1010-2. 2009
  7. pmc How does multistep tumorigenesis really proceed?
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Cancer Discov 5:22-4. 2015
  8. pmc Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
    Pekka Katajisto
    Whitehead Institute for Biomedical Research, Boston, MA 02142, USA Department of Biology, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA Institute of Biotechnology, University of Helsinki, P O Box 00014, Helsinki, Finland
    Science 348:340-3. 2015

Collaborators

Detail Information

Publications8

  1. pmc Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 154:61-74. 2013
    ..Our findings support a dynamic model in which interconversions between low and high tumorigenic states occur frequently, thereby increasing tumorigenic and malignant potential. ..
  2. doi request reprint A perspective on cancer cell metastasis
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 331:1559-64. 2011
    ....
  3. pmc Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    Christina Scheel
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 145:926-40. 2011
    ..Conversely, disruption of autocrine signaling by added inhibitors of these pathways inhibits migration and self-renewal in primary mammary epithelial cells and reduces tumorigenicity and metastasis by their transformed derivatives...
  4. pmc Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:7950-5. 2011
    ..The observed plasticity may allow derivation of patient-specific adult stem cells without genetic manipulation and holds important implications for therapeutic strategies to eradicate cancer...
  5. doi request reprint Cell plasticity and heterogeneity in cancer
    Nemanja D Marjanovic
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Clin Chem 59:168-79. 2013
    ..These factors conspire to create a disease with various phenotypes. There are 2 established models of cancer development and progression to metastatic disease. These are the clonal evolution and cancer stem cell models...
  6. doi request reprint Cancer stem cells: mirage or reality?
    Piyush B Gupta
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Med 15:1010-2. 2009
    ..If present, such plasticity would have major implications for the CSC model and for future therapeutic approaches...
  7. pmc How does multistep tumorigenesis really proceed?
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Cancer Discov 5:22-4. 2015
    ..This model contrasts with the notion that cancer stem cells are the direct products of neoplastically transformed normal tissue stem cells...
  8. pmc Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
    Pekka Katajisto
    Whitehead Institute for Biomedical Research, Boston, MA 02142, USA Department of Biology, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA Institute of Biotechnology, University of Helsinki, P O Box 00014, Helsinki, Finland
    Science 348:340-3. 2015
    ..Hence, mechanisms exist for mammalian stemlike cells to asymmetrically sort aged and young mitochondria, and these are important for maintaining stemness properties. ..