Research Topics
| Claudia ChaeSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Vitamin E supplementation and the risk of heart failure in womenClaudia U Chae
Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
Circ Heart Fail 5:176-82. 2012..No large clinical trials have addressed the role of antioxidant therapy in the primary prevention of HF...- Aging syndrome genes and premature coronary artery diseaseAdrian F Low
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
BMC Med Genet 6:38. 2005..We evaluated whether common variants at the LMNA or KLOTHO genes are associated with rigorously defined premature CAD... 
The menopausal transition and cardiovascular riskClaudia U Chae
Department of Medicine, Harvard Medical School, Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Obstet Gynecol Clin North Am 38:477-88. 2011..Whether these changes are due to aging or to menopause itself, increased attention to risk factor modification in the pre- and perimenopausal years will help reduce future cardiovascular disease risk among women...
Blood pressure and inflammation in apparently healthy menC U Chae
Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Hypertension 38:399-403. 2001..These data suggest that increased blood pressure may be a stimulus for inflammation and that this is a possible mechanism underlying the well-established role of hypertension as a risk factor for atherosclerotic disease...- Mild renal insufficiency and risk of congestive heart failure in men and women > or =70 years of ageClaudia U Chae
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
Am J Cardiol 92:682-6. 2003..43, 95% CI 1.17 to 1.74). Thus, mild renal insufficiency was a strong independent predictor of CHF in this cohort, suggesting that serum creatinine may offer a readily accessible tool to identify elderly patients at risk for CHF... - Renal function, congestive heart failure, and amino-terminal pro-brain natriuretic peptide measurement: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) StudySaif Anwaruddin
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 47:91-7. 2006..73 m2 (hazard ratio 1.61; 95% confidence interval 1.14 to 2.26; p = 0.006). CONCLUSIONS: The use of NT-proBNP testing is valuable for the evaluation of the dyspneic patient with suspected CHF, irrespective of renal function... - Prospective study of sudden cardiac death among women in the United StatesChristine M Albert
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, Mass 02215 1204, USA
Circulation 107:2096-101. 2003..Nonetheless, existing data, although sparse, suggest possible gender differences in risk factors for SCD... - Ethnic differences in C-reactive protein concentrationsAlyson Kelley-Hedgepeth
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA
Clin Chem 54:1027-37. 2008..We hypothesized that known CVD risk factors, including anthropometric characteristics, would explain much of the observed ethnic variation in CRP... - Measurement of the interleukin family member ST2 in patients with acute dyspnea: results from the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) studyJames L Januzzi
Department of Medicine and Laboratory Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 50:607-13. 2007..The aim of this study was to examine the value of measurement of the interleukin-1 receptor family member ST2 in patients with dyspnea... - Dietary intakes of flavonols and flavones and coronary heart disease in US womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Am J Epidemiol 165:1305-13. 2007..93; p for trend = 0.04). The lower risk associated with kaempferol intake was probably attributable to broccoli consumption. These prospective data do not support an inverse association between flavonol or flavone intake and CHD risk... - Association of atrial fibrillation and amino-terminal pro-brain natriuretic peptide concentrations in dyspneic subjects with and without acute heart failure: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) studyAngela Morello
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Am Heart J 153:90-7. 2007..Atrial fibrillation (AF) may cause dyspnea in the absence of acute HF and may also affect plasma levels of NT-proBNP... - Coronary multidetector computed tomography in the assessment of patients with acute chest painUdo Hoffmann
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 165 Charles River Plaza, Ste 400, Boston, MA 02114, USA
Circulation 114:2251-60. 2006.... - MDCT in early triage of patients with acute chest painUdo Hoffmann
Department of Radiology, Massachusetts General Hospital Cardiac MR CT PET Program and Harvard Medical School, 100 CPZ 400, Boston, MA 02114, USA
AJR Am J Roentgenol 187:1240-7. 2006..We sought to determine whether contrast-enhanced MDCT-based detection of stenosis is feasible and improves early and accurate triage of patients with acute chest pain... - Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular eventsAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Circulation 113:1578-87. 2006..Although randomized trials of cyclooxygenase-2 (COX-2) inhibitors have shown increased cardiovascular risk, studies of nonselective, nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen have been inconsistent... - Utility of amino-terminal pro-brain natriuretic peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency departmentJames L Januzzi
Department of Internal Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Arch Intern Med 166:315-20. 2006..Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful for diagnosis and triage of patients with dyspnea, but its role for predicting outcomes in such patients remains undefined... - Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart diseaseChristine M Albert
Center for Arrhythmia Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
Circulation 112:3232-8. 2005..Alpha-linolenic acid, an intermediate-chain n-3 fatty acid found primarily in plants, may decrease the risk of fatal coronary heart disease (CHD) through a reduction in fatal ventricular arrhythmias and sudden cardiac death (SCD)... - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-2004. A 75-year-old woman with acute onset of chest pain followed by feverAdolf W Karchmer
Division of Infectious Diseases, Beth Israel Deaconess Medical Center. Boston, USA
N Engl J Med 351:1240-8. 2004 - Ethnic variation in hypertension among premenopausal and perimenopausal women: Study of Women's Health Across the NationDonald M Lloyd-Jones
Division of Cardiology, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Hypertension 46:689-95. 2005..Treatment and control rates vary considerably across ethnicities. Greater efforts must be made to improve hypertension awareness, treatment, and control in all middle-aged women, particularly those in ethnic minority groups... - Effect of body mass index on natriuretic peptide levels in patients with acute congestive heart failure: a ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) substudyDaniel G Krauser
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Am Heart J 149:744-50. 2005..NT-proBNP fell below the diagnostic cutoff for CHF less often than BNP in overweight and obese individuals; however, when used as a diagnostic tool to identify CHF in such patients, both markers may have reduced sensitivity... - The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) studyJames L Januzzi
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Cardiol 95:948-54. 2005..NT-proBNP measurement is a valuable addition to standard clinical assessment for the identification and exclusion of acute CHF in the emergency department setting... - Phobic anxiety and risk of coronary heart disease and sudden cardiac death among womenChristine M Albert
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215 1204, USA
Circulation 111:480-7. 2005..To the best of our knowledge, no studies have looked at this association among women. Anxiety may influence CHD mortality by increasing the risk of ventricular arrhythmia and SCD... - Physical exertion, exercise, and sudden cardiac death in womenWilliam Whang
Cardiovascular Division, Massachusetts General Hospital, Boston, USA
JAMA 295:1399-403. 2006..Regular exercise may significantly minimize this small transient risk and may lower the overall long-term risk of sudden cardiac death... - Relation of lower hematocrit to progression from asymptomatic left ventricular dysfunction to symptomatic heart failure (from the Studies of Left Ventricular Dysfunction Prevention trial)Sandeep R Das
Donald W Reynolds Cardiovascular Clinical Research Center, Dallas, Texas, USA
Am J Cardiol 96:827-31. 2005..37 to 2.34), first HF hospitalization (HR 2.35, 95% CI 1.52 to 3.62), and death or the development of HF symptoms (HR 1.60, 95% CI 1.28 to 1.99) compared with patients in the highest hematocrit quartile (hematocrit > 46%)...
Research Grants
- RISK FACTORS FOR CONGESTIVE HEART FAILURE IN WOMENClaudia Chae; Fiscal Year: 2003The purpose of this award is to prepare the candidate, Dr. Claudia Chae, for a career as an independent clinical scientist in cardiovascular epidemiology, with particular expertise in the prevention and treatment of congestive heart ..