Sydney S Cash

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model
    Inna Sukhotinsky
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e62013. 2013
  2. pmc Status epilepticus as a system disturbance: is status epilepticus due to synchronization or desynchronization?
    Sydney S Cash
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, U S A
    Epilepsia 54:37-9. 2013
  3. pmc The human K-complex represents an isolated cortical down-state
    Sydney S Cash
    Department of Neurology, Epilepsy Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Science 324:1084-7. 2009
  4. pmc Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex
    Corey J Keller
    Department of Neurology, 30 Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Brain 133:1668-81. 2010
  5. pmc Human seizures self-terminate across spatial scales via a critical transition
    Mark A Kramer
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 109:21116-21. 2012
  6. pmc Emergence of stable functional networks in long-term human electroencephalography
    Catherine J Chu
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci 32:2703-13. 2012
  7. pmc Single-neuron dynamics in human focal epilepsy
    Wilson Truccolo
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 14:635-41. 2011
  8. pmc Intracranial cortical responses during visual-tactile integration in humans
    Brian T Quinn
    Department of Neurology, Comprehensive Epilepsy Center, New York University, New York, New York 10016, Center for Neural Science, New York University, New York, New York 10003, Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California 92093, Massachusetts General Hospital, Harvard University Medical School, Boston, Massachusetts 02114, Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom, and Department of Radiology, New York University, New York, New York 10016
    J Neurosci 34:171-81. 2014
  9. pmc Emergence of persistent networks in long-term intracranial EEG recordings
    Mark A Kramer
    Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 31:15757-67. 2011
  10. pmc Inferring seizure frequency from brief EEG recordings
    M Brandon Westover
    MGH Epilepsy Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    J Clin Neurophysiol 30:174-7. 2013

Detail Information

Publications30

  1. pmc Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model
    Inna Sukhotinsky
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e62013. 2013
    ..This early success in controlling seizures also suggests future therapeutic avenues...
  2. pmc Status epilepticus as a system disturbance: is status epilepticus due to synchronization or desynchronization?
    Sydney S Cash
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, U S A
    Epilepsia 54:37-9. 2013
    ..Finally, we will explore implications for these hypotheses in the treatment of patients with epilepsy and in status epilepticus. ..
  3. pmc The human K-complex represents an isolated cortical down-state
    Sydney S Cash
    Department of Neurology, Epilepsy Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Science 324:1084-7. 2009
    ..This correspondence is compatible with proposed contributions of the KC to sleep preservation and memory consolidation...
  4. pmc Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex
    Corey J Keller
    Department of Neurology, 30 Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Brain 133:1668-81. 2010
    ....
  5. pmc Human seizures self-terminate across spatial scales via a critical transition
    Mark A Kramer
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 109:21116-21. 2012
    ..This description constrains the specific biophysical mechanisms underlying seizure termination, suggests a dynamical understanding of status epilepticus, and demonstrates an accessible system for studying critical transitions in nature...
  6. pmc Emergence of stable functional networks in long-term human electroencephalography
    Catherine J Chu
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci 32:2703-13. 2012
    ....
  7. pmc Single-neuron dynamics in human focal epilepsy
    Wilson Truccolo
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 14:635-41. 2011
    ..These findings suggest a revision of current thinking about seizure mechanisms and point to the possibility of seizure prevention based on spiking activity in neocortical neurons...
  8. pmc Intracranial cortical responses during visual-tactile integration in humans
    Brian T Quinn
    Department of Neurology, Comprehensive Epilepsy Center, New York University, New York, New York 10016, Center for Neural Science, New York University, New York, New York 10003, Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, California 92093, Massachusetts General Hospital, Harvard University Medical School, Boston, Massachusetts 02114, Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom, and Department of Radiology, New York University, New York, New York 10016
    J Neurosci 34:171-81. 2014
    ..These results tend to support earlier concepts of multisensory integration as relatively late and centered in tertiary multimodal association cortices. ..
  9. pmc Emergence of persistent networks in long-term intracranial EEG recordings
    Mark A Kramer
    Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 31:15757-67. 2011
    ..These results suggest that a metastable, frequency-band-dependent scaffold of brain connectivity exists from which transient activity emerges and recedes...
  10. pmc Inferring seizure frequency from brief EEG recordings
    M Brandon Westover
    MGH Epilepsy Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    J Clin Neurophysiol 30:174-7. 2013
    ..This framework should aid the clinician in applying a more principled approach toward decision making in the setting of a single seizure on a routine EEG...
  11. pmc Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex
    Corey J Keller
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci Methods 179:208-18. 2009
    ..This device can provide a new and robust means for obtaining detailed, quantitative data for defining neurovascular coupling in awake humans...
  12. pmc Epilepsy as a disorder of cortical network organization
    Mark A Kramer
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Neuroscientist 18:360-72. 2012
    ..Although the characteristics of functional networks that support the epileptic seizure remain an area of active research, the prevailing trends point to a complex set of network dynamics between, before, and during seizures...
  13. pmc Coalescence and fragmentation of cortical networks during focal seizures
    Mark A Kramer
    Department of Mathematics and Statistics, Boston University, 111 Cummington Street, Boston, MA 02215, USA
    J Neurosci 30:10076-85. 2010
    ..These results suggest that, at the macroscopic spatial scale, epilepsy is not so much a manifestation of hypersynchrony but instead of network reorganization...
  14. doi request reprint Probabilistic sleep architecture models in patients with and without sleep apnea
    Matt T Bianchi
    Neurology Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Sleep Res 21:330-41. 2012
    ..Markov sleep models may prove important for quantifying sleep disruption to provide objective metrics to correlate with endpoints ranging from sleepiness to cardiovascular morbidity...
  15. ncbi request reprint Advances in the application of technology to epilepsy: the CIMIT/NIO Epilepsy Innovation Summit
    Steven C Schachter
    Center for Integration of Medicine and Innovative Technology, Boston, MA, USA
    Epilepsy Behav 16:3-46. 2009
    ..This article summarizes the discussions and demonstrates that cross-disciplinary interactions can catalyze collaborations between physicians and engineers to address and solve many of the pressing unmet needs in epilepsy...
  16. pmc Absence of early epileptiform abnormalities predicts lack of seizures on continuous EEG
    Mouhsin M Shafi
    Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurology 79:1796-801. 2012
    ..To determine whether the absence of early epileptiform abnormalities predicts absence of later seizures on continuous EEG monitoring of hospitalized patients...
  17. pmc Emergence of synchronous EEG spindles from asynchronous MEG spindles
    Nima Dehghani
    Multimodal Imaging Laboratory, Department of Radiology, University of California, San Diego, California, USA
    Hum Brain Mapp 32:2217-27. 2011
    ....
  18. pmc Network analysis: applications for the developing brain
    Catherine J Chu-Shore
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Child Neurol 26:488-500. 2011
    ....
  19. ncbi request reprint Spectrogram screening of adult EEGs is sensitive and efficient
    Lidia M V R Moura
    From the Department of Neurology L M V R M, M N, S P, S S C, A J C, D B H, E S R, M B W, Epilepsy Service, Massachusetts General Hospital, Boston and Department of Neurology M M S, Division of Epilepsy, Beth Israel Deaconess Medical Center, Boston, MA
    Neurology 83:56-64. 2014
    ..Quantitatively evaluate whether screening with compressed spectral arrays (CSAs) is a practical and time-effective protocol for assisting expert review of continuous EEG (cEEG) studies in hospitalized adults...
  20. pmc A candidate mechanism underlying the variance of interictal spike propagation
    Helen R Sabolek
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 32:3009-21. 2012
    ..These data support the hypothesis that the paths by which synchronous activity spreads through an epileptic network change with each activation, based on the recent history of localized activity that has been successfully inhibited...
  21. pmc Revising the "Rule of Three" for inferring seizure freedom
    M Brandon Westover
    Neurology Department, Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 53:368-76. 2012
    ..Therefore, we set out to determine whether an alternative approach to the Rule of Three might be possible, and under what conditions the rule may be expected to hold or would need to be extended...
  22. pmc Real-time segmentation of burst suppression patterns in critical care EEG monitoring
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci Methods 219:131-41. 2013
    ..Develop a real-time algorithm to automatically discriminate suppressions from non-suppressions (bursts) in electroencephalograms of critically ill adult patients...
  23. pmc Calculating the risk benefit equation for aggressive treatment of non-convulsive status epilepticus
    Matthew Ferguson
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurocrit Care 18:216-27. 2013
    ..To address the question: does non-convulsive status epilepticus warrant the same aggressive treatment as convulsive status epilepticus?..
  24. pmc Intravenous levetiracetam in the rat pilocarpine-induced status epilepticus model: behavioral, physiological and histological studies
    Yi Zheng
    Epilepsy Research Laboratory, Epilepsy Service and Neurology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropharmacology 58:793-8. 2010
    ..We sought to determine the effect of LEV administered intravenously in a chemoconvulsant model of status epilepticus...
  25. pmc Information theoretic quantification of diagnostic uncertainty
    M Brandon Westover
    Neurology Department, Massachusetts General Hospital, Wang 720, Boston, MA 02114, USA
    Open Med Inform J 6:36-50. 2012
    ..Finally, we illustrate how, in information theoretic terms, one can understand the effect on diagnostic uncertainty of considering ranges instead of simple point estimates of pre-test probability...
  26. pmc A transition in brain state during propofol-induced unconsciousness
    Eran A Mukamel
    Swartz Program for Theoretical Neuroscience, Harvard University, Cambridge, Massachusetts 02138, Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, California 92093 and Computational Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, California 92037, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Harvard Medical School, Boston, Massachusetts 02115, Division of Health Science and Technology, Harvard Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
    J Neurosci 34:839-45. 2014
    ..These results provide objective electrophysiological landmarks of distinct unconscious brain states, and could be used to help improve EEG-based monitoring for general anesthesia. ..
  27. pmc Modulation of EEG functional connectivity networks in subjects undergoing repetitive transcranial magnetic stimulation
    Mouhsin M Shafi
    Berenson Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA
    Brain Topogr 27:172-91. 2014
    ..cTBS produces widespread alterations in cortical functional connectivity, with resulting shifts in cortical network topology. ..
  28. pmc Parallel versus serial processing dependencies in the perisylvian speech network: a Granger analysis of intracranial EEG data
    David W Gow
    Department of Neurology, Cognitive Behavioral Neurology Group, Massachusetts General Hospital, 175 Cambridge Street, Suite S340, Boston, MA 02114, United States
    Brain Lang 110:43-8. 2009
    ..Implications of these results for understanding the functional architecture of spoken language processing and interpreting the role of the posterior superior temporal gyrus in speech perception are discussed...
  29. ncbi request reprint Network inference with confidence from multivariate time series
    Mark A Kramer
    Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 79:061916. 2009
    ..We demonstrate that the procedure is accurate and robust in both the determination of edges and the reporting of uncertainty associated with that determination...
  30. pmc Obstructive sleep apnea alters sleep stage transition dynamics
    Matt T Bianchi
    Neurology Department, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11356. 2010
    ..One approach involves using stage transition analysis to characterize sleep continuity...