Adelaide M Carothers

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility
    Adelaide M Carothers
    Department of Surgery, Carrie Hall, Room 116, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Exp Cell Res 312:387-400. 2006
  2. ncbi Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice
    Amy E Moran
    Department of Surgery, Weill College of Medicine of Cornell University, and Strang Cancer Prevention Center, New York, New York 10021, USA
    J Biol Chem 279:43261-72. 2004
  3. ncbi Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min/+ (Min/+) mouse
    Amy E Moran
    Department of Surgery, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, NY, USA
    Cancer Res 65:1097-104. 2005
  4. pmc Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis
    Adelaide M Carothers
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer Res 70:4433-42. 2010
  5. ncbi Estrogen receptors alpha and beta are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice
    Nancy L Cho
    Departments of Surgery and Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Res 67:2366-72. 2007
  6. ncbi Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer
    Sara H Javid
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Carcinogenesis 26:587-95. 2005
  7. pmc Chronic cyclooxygenase-2 inhibition promotes myofibroblast-associated intestinal fibrosis
    Jennifer S Davids
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 3:348-58. 2010
  8. ncbi Changes in antitumor response in C57BL/6J-Min/+ mice during long-term administration of a selective cyclooxygenase-2 inhibitor
    Adelaide M Carothers
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 66:6432-8. 2006
  9. doi Aberrant crypt foci in the adenoma prevention with celecoxib trial
    Nancy L Cho
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 1:21-31. 2008
  10. doi Immunohistochemical and molecular analysis of tyrosine kinase activity in desmoid tumors
    Nancy L Cho
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Surg Res 173:320-6. 2012

Collaborators

Detail Information

Publications14

  1. ncbi Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility
    Adelaide M Carothers
    Department of Surgery, Carrie Hall, Room 116, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Exp Cell Res 312:387-400. 2006
    ..Thus, the positive regulation of E-cadherin adhesion provided by Apc+ in vivo allows proper negative regulation of Egfr, Src, Pyk2, and MAPK, as well as RhoA activities...
  2. ncbi Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice
    Amy E Moran
    Department of Surgery, Weill College of Medicine of Cornell University, and Strang Cancer Prevention Center, New York, New York 10021, USA
    J Biol Chem 279:43261-72. 2004
    ....
  3. ncbi Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min/+ (Min/+) mouse
    Amy E Moran
    Department of Surgery, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, NY, USA
    Cancer Res 65:1097-104. 2005
    ..Moreover, these data suggest that carnosol prevents Apc-associated intestinal tumorigenesis, potentially via its ability to enhance E-cadherin-mediated adhesion and suppress beta-catenin tyrosine phosphorylation...
  4. pmc Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis
    Adelaide M Carothers
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer Res 70:4433-42. 2010
    ..Our findings argue that celecoxib resistance is an acquired adaptation to changes in the crypt microenvironment that is associated with chronic intestinal inflammation and impaired acute wound-healing responsiveness...
  5. ncbi Estrogen receptors alpha and beta are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice
    Nancy L Cho
    Departments of Surgery and Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Res 67:2366-72. 2007
    ..Our results indicate that ERalpha and ERbeta are inhibitory modifiers of Apc-dependent colon tumorigenesis. As a result, loss of E(2) and ER signaling in postmenopausal women may contribute to colorectal cancer development...
  6. ncbi Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer
    Sara H Javid
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Carcinogenesis 26:587-95. 2005
    ..In conclusion, both coumestrol and E(2) prevent intestinal tumorigenesis and ameliorate enterocyte migration and intercellular adhesion in the Apc(Min/+) mouse model of CRC...
  7. pmc Chronic cyclooxygenase-2 inhibition promotes myofibroblast-associated intestinal fibrosis
    Jennifer S Davids
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 3:348-58. 2010
    ..We conclude that chronic COX-2 inhibition alters TGFbeta signaling in the intestinal mucosa, producing conditions consistent with chronic inflammation...
  8. ncbi Changes in antitumor response in C57BL/6J-Min/+ mice during long-term administration of a selective cyclooxygenase-2 inhibitor
    Adelaide M Carothers
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 66:6432-8. 2006
    ..Chronic uninterrupted celecoxib treatment, however, induces untoward effects that enhance early progression events in intestinal tumorigenesis and may contribute to treatment toxicity...
  9. doi Aberrant crypt foci in the adenoma prevention with celecoxib trial
    Nancy L Cho
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 1:21-31. 2008
    ..Our overall results indicated that nondysplastic ACF were not accurate surrogate endpoint biomarkers of recurrent colorectal adenomas in the APC trial...
  10. doi Immunohistochemical and molecular analysis of tyrosine kinase activity in desmoid tumors
    Nancy L Cho
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Surg Res 173:320-6. 2012
    ..Partial response to tyrosine kinase inhibitors (TKI) has previously been described. Here, we examined the role of the tyrosine kinases c-Src and c-Kit in driving desmoid tumorigenesis...
  11. ncbi Adenomatous polyposis coli truncation alters cytoskeletal structure and microtubule stability in early intestinal tumorigenesis
    Sara A Hughes
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Gastrointest Surg 6:868-74; discussion 875. 2002
    ..These changes are consistent with the defects in enterocyte migration and junctional complex formation observed in the Min/+ model of early APC-associated colorectal tumorigenesis...
  12. pmc Mesenchymal stromal cell mutations and wound healing contribute to the etiology of desmoid tumors
    Adelaide M Carothers
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts MA 02115, USA
    Cancer Res 72:346-55. 2012
    ..The differentiation potential of these MSCs combined with expression of BMI-1, a transcriptional repressor downstream of Hedgehog and Notch signaling, suggests that desmoid tumors may respond to therapies targeting these pathways...
  13. doi Sulindac reverses aberrant expression and localization of beta-catenin in papillary thyroid cancer cells with the BRAFV600E mutation
    Nancy L Cho
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Thyroid 20:615-22. 2010
    ..In this study, we tested the hypothesis that the nonsteroidal antiinflammatory drug sulindac would reverse aberrant beta-catenin activity in thyroid cancer cells...
  14. ncbi Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea
    Jihyeung Ju
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Cancer Res 65:10623-31. 2005
    ....