Zabrina L Brumme

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins
    Zabrina L Brumme
    Ragon Institute of MGH, MIT and Harvard, Charlestown, MA, USA
    PLoS ONE 4:e6687. 2009
  2. pmc Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection
    Zabrina L Brumme
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:9216-27. 2008
  3. pmc Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study
    Santiago Avila-Ríos
    Center for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico
    Retrovirology 6:72. 2009
  4. pmc Impaired replication capacity of acute/early viruses in persons who become HIV controllers
    Toshiyuki Miura
    Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA
    J Virol 84:7581-91. 2010
  5. pmc HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:140-9. 2009
  6. pmc HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers
    Toshiyuki Miura
    Ragon Institute formerly Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 83:3407-12. 2009
  7. doi Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection
    Zabrina L Brumme
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, Harvard Medical School, Massachusetts 02129, USA
    AIDS 22:1277-86. 2008
  8. pmc HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition
    Toshiyuki Miura
    Ragon Institute, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:2743-55. 2009
  9. pmc Characteristics and outcomes of initial virologic suppressors during analytic treatment interruption in a therapeutic HIV-1 gag vaccine trial
    Jonathan Z Li
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e34134. 2012
  10. pmc Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 82:8422-30. 2008

Collaborators

Detail Information

Publications20

  1. pmc HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins
    Zabrina L Brumme
    Ragon Institute of MGH, MIT and Harvard, Charlestown, MA, USA
    PLoS ONE 4:e6687. 2009
    ..Results are organized into protein-wide escape maps illustrating the sites and pathways of HLA-driven viral evolution...
  2. pmc Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection
    Zabrina L Brumme
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:9216-27. 2008
    ..Dramatic differences in escape and reversion rates across codons, genes, and HLA restrictions are observed, highlighting the complexity of viral adaptation to the host immune response...
  3. pmc Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study
    Santiago Avila-Ríos
    Center for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico
    Retrovirology 6:72. 2009
    ..However, it is not known whether characteristic HLA frequency distributions in different populations have resulted in additional unique footprints...
  4. pmc Impaired replication capacity of acute/early viruses in persons who become HIV controllers
    Toshiyuki Miura
    Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA
    J Virol 84:7581-91. 2010
    ..These data suggest that viral dynamics during acute infection have a major impact on HIV disease outcome...
  5. pmc HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:140-9. 2009
    ....
  6. pmc HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers
    Toshiyuki Miura
    Ragon Institute formerly Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 83:3407-12. 2009
    ..These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HIV-1 infection...
  7. doi Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection
    Zabrina L Brumme
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, Harvard Medical School, Massachusetts 02129, USA
    AIDS 22:1277-86. 2008
    ..Here we undertake a population-based identification of HLA-associated polymorphisms in Gag and investigate their relationship with plasma viral load...
  8. pmc HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition
    Toshiyuki Miura
    Ragon Institute, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:2743-55. 2009
    ..These data suggest a dual mechanism for durable control of HIV replication, consisting of viral fitness loss resulting from CTL escape mutations together with strong CD8 T-cell immune responses to the arising variant epitopes...
  9. pmc Characteristics and outcomes of initial virologic suppressors during analytic treatment interruption in a therapeutic HIV-1 gag vaccine trial
    Jonathan Z Li
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e34134. 2012
    ..In the placebo-controlled trial ACTG A5197, a trend favoring viral suppression was seen in the HIV-1-infected subjects who received a recombinant Ad5 HIV-1 gag vaccine...
  10. pmc Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 82:8422-30. 2008
    ..These results indicate that the spontaneous control of HIV replication is not attributable to shared viral genetic defects or shared viral polymorphisms...
  11. pmc Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences
    Christoph T Berger
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, Boston, MA 02129, USA
    J Exp Med 207:61-75. 2010
    ..These data indicate that responses to ARF-encoded HIV epitopes are induced during natural infection, can contribute to viral control in vivo, and drive viral evolution on a population level...
  12. pmc Frequent and variable cytotoxic-T-lymphocyte escape-associated fitness costs in the human immunodeficiency virus type 1 subtype B Gag proteins
    Christian L Boutwell
    Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA
    J Virol 87:3952-65. 2013
    ....
  13. pmc TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection
    Huabiao Chen
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, USA
    Nat Immunol 13:691-700. 2012
    ..Thus, the efficacy of such so-called 'protective alleles' is modulated by specific TCR clonotypes selected during natural infection, which provides a functional explanation for divergent HIV-1 outcomes...
  14. pmc Transmission and long-term stability of compensated CD8 escape mutations
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
    J Virol 83:3993-7. 2009
    ..Herein, we illustrate the long-term stability of stereotypic escape mutations in the immunodominant HLA-B27-restricted epitope KK10 in p24/Gag following transmission when accompanied by a specific compensatory mutation...
  15. pmc Factors associated with viral rebound in HIV-1-infected individuals enrolled in a therapeutic HIV-1 gag vaccine trial
    Jonathan Z Li
    Section of Retroviral Therapeutics, Brigham and Women s Hospital, Boston, Massachusetts 02139, USA
    J Infect Dis 203:976-83. 2011
    ..Human immunodeficiency virus type 1 (HIV-1) vaccines directed to the cell-mediated immune system could have a role in lowering the plasma HIV-1 RNA set point, which may reduce infectivity and delay disease progression...
  16. pmc Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1
    Zabrina L Brumme
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 3:e94. 2007
    ..The design of preventative and therapeutic CTL-based vaccine approaches could incorporate information on predictable escape pathways...
  17. pmc Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification
    Zabrina L Brumme
    Ragon Institute of MGH, MIT and Harvard, Charlestown MA 02129, USA
    J Exp Med 206:1215-8. 2009
    ..Studies using single-genome amplification now reveal new details about the kinetics and specificity of the CD8(+) T cell response and the evolution of the virus during early HIV infection...
  18. pmc Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
    Hendrik Streeck
    Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 5:e100. 2008
    ....
  19. pmc Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals
    Shao Chong Zhang
    Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 188:5924-34. 2012
    ..These results underscore an important and widespread role of Ag processing mutations in HIV immune escape and identify molecular mechanisms underlying impaired epitope presentation...
  20. pmc Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection
    Matthew R Henn
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    PLoS Pathog 8:e1002529. 2012
    ....