Anna Liisa Brownell

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model
    Anna Liisa Brownell
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroimage 20:1064-75. 2003
  2. ncbi request reprint 3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy
    Anna Liisa Brownell
    Department of Radiology, Bartlett Hall 504R, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neurochem 89:1206-14. 2004
  3. ncbi request reprint Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease
    Xukui Wang
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Neurol Sci 231:57-66. 2005
  4. pmc Mapping dopamine function in primates using pharmacologic magnetic resonance imaging
    Bruce G Jenkins
    Massachusetts General Hospital MGH Nuclear Magnetic Resonance Center, Athinoula A Martinos Center for Biomedical Imaging, Boston, Massachusetts 02129, USA
    J Neurosci 24:9553-60. 2004
  5. ncbi request reprint Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats
    Daniela Pellegrino
    Experimental PET Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nucl Med 48:1147-53. 2007
  6. ncbi request reprint Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors
    Meixiang Yu
    Experimental PET Laboratory, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Nucl Med Biol 32:631-40. 2005
  7. ncbi request reprint Radiolabeling and biodistribution of methyl 2-(methoxycarbonyl)-2-(methylamino) bicyclo[2.1.1] -hexane -5-carboxylate, a potential neuroprotective drug
    Meixiang Yu
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Bartlett Hall 511R, Boston, MA 02114, USA
    Life Sci 73:1577-85. 2003
  8. pmc Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu4)
    Kun Eek Kil
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, United States
    Bioorg Med Chem 21:5955-62. 2013
  9. ncbi request reprint Positron emission tomography of herpes simplex virus 1 oncolysis
    Darshini Kuruppu
    Division of Surgical Oncology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 67:3295-300. 2007
  10. pmc Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo
    Ji Quan Wang
    Athinoula A Martinos Biomedical Imaging Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 2129, USA
    Bioorg Med Chem Lett 22:1958-62. 2012

Research Grants

  1. Development of NET-Selective Piperidine-Based PET Ligand
    Anna Liisa Brownell; Fiscal Year: 2006
  2. MICROPET FOR ANIMAL STUDIES
    Anna Liisa Brownell; Fiscal Year: 2001
  3. Olfaction as a Biomarker for Parkinson's Disease
    Anna Liisa Brownell; Fiscal Year: 2007
  4. F-18 Synthesizer
    Anna Liisa Brownell; Fiscal Year: 2007
  5. Novel Approaches for in vivo of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2006
  6. Novel Approaches for in vivo of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2005
  7. Novel Approaches for in vivo of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2004
  8. Novel Approaches for in vivo imaging of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2003
  9. Targeting Glial mGluR5 in Schizophrenia
    Francesca Cicchetti; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model
    Anna Liisa Brownell
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroimage 20:1064-75. 2003
    ..These experimental results obtained in primate studies of striato-thalamo-cortico circuitry show a similar trend as hypothetized in Parkinson's disease-type degeneration...
  2. ncbi request reprint 3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy
    Anna Liisa Brownell
    Department of Radiology, Bartlett Hall 504R, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neurochem 89:1206-14. 2004
    ..Animals that did not develop lesions showed reversible enhancement in cortical glucose utilization and no change in striatal glucose utilization or neurochemicals or locomotor activity...
  3. ncbi request reprint Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease
    Xukui Wang
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Neurol Sci 231:57-66. 2005
    ..Cerebral imaging and histological evidence support the use of cystamine as a neuroprotective agent for Huntington's disease (HD) pathology...
  4. pmc Mapping dopamine function in primates using pharmacologic magnetic resonance imaging
    Bruce G Jenkins
    Massachusetts General Hospital MGH Nuclear Magnetic Resonance Center, Athinoula A Martinos Center for Biomedical Imaging, Boston, Massachusetts 02129, USA
    J Neurosci 24:9553-60. 2004
    ..These data indicate that phMRI is a powerful tool for assessment of dynamic changes associated with normal and dysfunctional DA brain circuitry in primates...
  5. ncbi request reprint Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats
    Daniela Pellegrino
    Experimental PET Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nucl Med 48:1147-53. 2007
    ..To further address this issue, we investigated the imaging profile and expression of dopamine D(2) receptors and mGluRs in a classic parkinsonian rodent model induced by the toxin 6-hydroxydopamine...
  6. ncbi request reprint Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors
    Meixiang Yu
    Experimental PET Laboratory, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Nucl Med Biol 32:631-40. 2005
    ..The feasibility of synthesizing high-affinity and high-selectivity ligands for mGluR5 receptors and their suitability as PET imaging ligands for mGluR5 receptors in vivo are demonstrated...
  7. ncbi request reprint Radiolabeling and biodistribution of methyl 2-(methoxycarbonyl)-2-(methylamino) bicyclo[2.1.1] -hexane -5-carboxylate, a potential neuroprotective drug
    Meixiang Yu
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Bartlett Hall 511R, Boston, MA 02114, USA
    Life Sci 73:1577-85. 2003
    ..During 20-40 min, 2.9+/-0.4% of the total activity stayed in the brain. These results showed that MMMHC could be labeled with C-11 with high yield, and it passed the brain-blood barrier and accumulated in several brain regions...
  8. pmc Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu4)
    Kun Eek Kil
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, United States
    Bioorg Med Chem 21:5955-62. 2013
    ..Biodistribution studies and blood analyses support fast metabolism. Altogether this is the first PET imaging ligand for mGlu4, in which the labeled ML128 was used for imaging its in vivo distribution and pharmacokinetics in brain. ..
  9. ncbi request reprint Positron emission tomography of herpes simplex virus 1 oncolysis
    Darshini Kuruppu
    Division of Surgical Oncology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 67:3295-300. 2007
    ..These observations have important consequences with regard to strategies to use [(18)F]FHBG PET for monitoring sites of HSV-TK expression during viral oncolysis...
  10. pmc Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo
    Ji Quan Wang
    Athinoula A Martinos Biomedical Imaging Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 2129, USA
    Bioorg Med Chem Lett 22:1958-62. 2012
    ..5±3.2%. The results show [(11)C]CMGDE is the first PET tracer that is brain penetrating and can be used to image group II mGluRs in vivo...
  11. doi request reprint Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging
    Y Iris Chen
    A Martino s Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Obesity (Silver Spring) 20:1519-26. 2012
    ..In conclusion, we demonstrate the feasibility of measuring BAT volume and function in vivo using routine MRI sequences. The MRI measurement of BAT volume is consistent with quantitative measurement of the tissue ex vivo...
  12. pmc Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease
    Yolanda D Black
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurosci Lett 486:161-5. 2010
    ..Our findings substantiate the key role of mGluR5 receptors in animal models of PD, strengthening the rationale for the development of mGluR5 antagonists for their neuroprotective, as well as symptomatic, benefit...
  13. doi request reprint Evaluation of (4-[18F]Fluorophenyl)triphenylphosphonium ion. A potential myocardial blood flow agent for PET
    Timothy M Shoup
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Imaging Biol 13:511-7. 2011
    ..The lipophilic cationic compound, (4-[¹⁸F]fluorophenyl)triphenylphosphonium ion (¹⁸F-FTPP) was synthesized and evaluated as a potential positron emission tomography (PET) myocardial perfusion agent...
  14. ncbi request reprint Evaluation of four pyridine analogs to characterize 6-OHDA-induced modulation of mGluR5 function in rat brain using microPET studies
    Aijun Zhu
    Department of Radiology, Experimental PET Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Cereb Blood Flow Metab 27:1623-31. 2007
    ..These studies showed that glutamatergic neurotransmission might have a complementary role in dopaminergic degeneration, which can be evaluated by in vivo PET imaging...
  15. pmc A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload
    Michael J Raher
    Cardiac Ultrasound Laboratory, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Heart Circ Physiol 295:H2495-502. 2008
    ..These metabolic changes are accompanied by increased LV remodeling and dysfunction after TAC, highlighting the impact of insulin resistance in the development of pressure-overload-induced heart failure...
  16. ncbi request reprint Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5
    Ji Quan Wang
    Experimental PET Laboratory, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Synapse 61:951-61. 2007
    ..18)F]FPEB was prepared conveniently and showed high specificity and selectivity toward mGluR5. It possesses the potential to be used in human studies to evaluate mGluR5 functions in various neurological disorders...
  17. ncbi request reprint Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
    Kevin St P McNaught
    Department of Neurology, Neuropathology Division, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 56:149-62. 2004
    ..This animal model induced by proteasome inhibitors closely recapitulates key features of PD and may be valuable in studying etiopathogenic mechanisms and putative neuroprotective therapies for the illness...
  18. ncbi request reprint Dual-modality in vivo monitoring of subventricular zone stem cell migration and metabolism
    Francesca Cicchetti
    Centre de Recherche en Neurosciences, CHUL, RC 9800, 2705 Boulevard Laurier, Quebec, Canada G1V 4G2
    Contrast Media Mol Imaging 2:130-8. 2007
    ..Thus, combining MRI and PET enables monitoring of cell migration and metabolism non-invasively in vivo for extended periods of time...
  19. ncbi request reprint Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging
    Rosario Sanchez-Pernaute
    McLean Hospital Harvard University, Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Toxicol Appl Pharmacol 207:251-6. 2005
    ..Functional imaging techniques are instrumental to our understanding and modeling of disease mechanisms, which should in turn lead to development of new therapies for Parkinson's disease and other neurodegenerative disorders...
  20. pmc Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002
    ..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease...

Research Grants10

  1. Development of NET-Selective Piperidine-Based PET Ligand
    Anna Liisa Brownell; Fiscal Year: 2006
    ..4. Promising PET imaging agents will be studied in cell toxicity and animal models during the second year. ..
  2. MICROPET FOR ANIMAL STUDIES
    Anna Liisa Brownell; Fiscal Year: 2001
    ..Our previous experience in developing and operating PET systems will be of great benefit in the expansion of the facility. ..
  3. Olfaction as a Biomarker for Parkinson's Disease
    Anna Liisa Brownell; Fiscal Year: 2007
    ..To investigate olfaction and its relation to PD-like progressive degeneration we will conduct longitudinal in vivo imaging studies combined with in vitro analysis of endpoint measures in a MPTP mouse model of PD. ..
  4. F-18 Synthesizer
    Anna Liisa Brownell; Fiscal Year: 2007
    ..The synthesizer must balance a number of factors in the design to fulfill requirements for performance, accessibility and fitness to the research environment. ..
  5. Novel Approaches for in vivo of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2006
    ..abstract_text> ..
  6. Novel Approaches for in vivo of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2005
    ..abstract_text> ..
  7. Novel Approaches for in vivo of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2004
    ..abstract_text> ..
  8. Novel Approaches for in vivo imaging of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2003
    ..abstract_text> ..
  9. Targeting Glial mGluR5 in Schizophrenia
    Francesca Cicchetti; Fiscal Year: 2010
    ..In this project, we will investigate if metabotropic glutamate receptor function shows inflammation dependent modulation, which contributes to the development of schizophrenia and which would serve as a new therapeutic target site. ..