Gary J Brenner

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Curriculum and cases for pain medicine crisis resource management education
    Gary J Brenner
    Massachusetts General Hospital Center for Pain Medicine, WAC 330, 15 Parkman St, Boston, MA 02114, USA
    Anesth Analg 116:107-10. 2013
  2. ncbi request reprint Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons
    Gary J Brenner
    Neural Plasticity Research Group, Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02110, USA
    Eur J Neurosci 20:375-84. 2004
  3. ncbi request reprint Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:8310-21. 2004
  4. ncbi request reprint Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity
    Robert S Griffin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 27:8699-708. 2007
  5. pmc Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity
    Tatsuro Kohno
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:4533-40. 2008
  6. ncbi request reprint ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 22:478-85. 2002
  7. ncbi request reprint Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission
    Haibin Wang
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 25:7986-92. 2005
  8. ncbi request reprint Bradykinin and peripheral sensitization
    Haibin Wang
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Biol Chem 387:11-4. 2006
  9. pmc Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
    Nitin Agarwal
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld, Heidelberg, 69120 Germany
    Nat Neurosci 10:870-9. 2007

Research Grants

Collaborators

Detail Information

Publications9

  1. doi request reprint Curriculum and cases for pain medicine crisis resource management education
    Gary J Brenner
    Massachusetts General Hospital Center for Pain Medicine, WAC 330, 15 Parkman St, Boston, MA 02114, USA
    Anesth Analg 116:107-10. 2013
    ..Here, we present an educational curriculum in pain medicine crisis resource management for both pain medicine fellows and attending physicians as well as the results of a successful pilot program...
  2. ncbi request reprint Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons
    Gary J Brenner
    Neural Plasticity Research Group, Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02110, USA
    Eur J Neurosci 20:375-84. 2004
    ..These data provide evidence for an activity-dependent NMDAR phosphorylation at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons initiated by peripheral noxious stimuli...
  3. ncbi request reprint Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:8310-21. 2004
    ....
  4. ncbi request reprint Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity
    Robert S Griffin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 27:8699-708. 2007
    ..We conclude that induction of the complement cascade in spinal cord microglia after peripheral nerve injury contributes to neuropathic pain through the release and action of the C5a anaphylatoxin peptide...
  5. pmc Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity
    Tatsuro Kohno
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:4533-40. 2008
    ..We conclude that bradykinin, by activating multiple kinases in dorsal horn neurons, potentiates glutamatergic synaptic transmission to produce pain hypersensitivity...
  6. ncbi request reprint ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 22:478-85. 2002
    ..Activation of the ERK pathway in a subset of nociceptive spinal neurons contributes, therefore, to persistent pain hypersensitivity, possibly via transcriptional regulation of genes, such as prodynorphin and NK-1...
  7. ncbi request reprint Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission
    Haibin Wang
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 25:7986-92. 2005
    ..We conclude that bradykinin is released in the spinal cord in response to nociceptor inputs and acts as a synaptic neuromodulator, potentiating glutamatergic synaptic transmission to produce pain hypersensitivity...
  8. ncbi request reprint Bradykinin and peripheral sensitization
    Haibin Wang
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Biol Chem 387:11-4. 2006
    ....
  9. pmc Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
    Nitin Agarwal
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld, Heidelberg, 69120 Germany
    Nat Neurosci 10:870-9. 2007
    ....

Research Grants1

  1. NMDA Receptor Phosphorylation and Trafficking after Pain
    Gary Brenner; Fiscal Year: 2006
    ..Both phosphorylation and trafficking, from intracellular stores to the postsynaptic site, of NMDA receptors in dorsal horn neurons will be investigated as they relate to central pain hypersensitivity . ..