MIRIAM BREDELLA

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Effects of growth hormone administration for 6months on bone turnover and bone marrow fat in obese premenopausal women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA 02114, USA Electronic address
    Bone 62:29-35. 2014
  2. pmc Positive effects of brown adipose tissue on femoral bone structure
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA Electronic address
    Bone 58:55-8. 2014
  3. pmc Effects of GH on body composition and cardiovascular risk markers in young men with abdominal obesity
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 98:3864-72. 2013
  4. pmc IGFBP-2 is a negative predictor of cold-induced brown fat and bone mineral density in young non-obese women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 53:336-9. 2013
  5. doi request reprint Femoroacetabular impingement
    Miriam A Bredella
    Division of Musculoskeletal Radiology and Interventions, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Magn Reson Imaging Clin N Am 21:45-64. 2013
  6. pmc Determinants of bone microarchitecture and mechanical properties in obese men
    Miriam A Bredella
    Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:4115-22. 2012
  7. pmc Effects of GH in women with abdominal adiposity: a 6-month randomized, double-blind, placebo-controlled trial
    Miriam A Bredella
    Department of Radiology, Neuroendocrine Unit Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Eur J Endocrinol 166:601-11. 2012
  8. pmc Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E584-90. 2012
  9. pmc Comparison of DXA and CT in the assessment of body composition in premenopausal women with obesity and anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:2227-33. 2010
  10. pmc Peak growth hormone-releasing hormone-arginine-stimulated growth hormone is inversely associated with intramyocellular and intrahepatic lipid content in premenopausal women with obesity
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:3995-4002. 2009

Research Grants

Detail Information

Publications42

  1. doi request reprint Effects of growth hormone administration for 6months on bone turnover and bone marrow fat in obese premenopausal women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA 02114, USA Electronic address
    Bone 62:29-35. 2014
    ..The purpose of our study was to determine the effects of a short course of GH on markers of bone turnover and bone marrow fat in premenopausal women with abdominal adiposity...
  2. pmc Positive effects of brown adipose tissue on femoral bone structure
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA Electronic address
    Bone 58:55-8. 2014
    ..Recent studies suggest a link between brown adipose tissue (BAT) and bone. The purpose of our study was to investigate the effects of BAT on femoral bone structure...
  3. pmc Effects of GH on body composition and cardiovascular risk markers in young men with abdominal obesity
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 98:3864-72. 2013
    ..Visceral adiposity is associated with increased cardiometabolic risk and decreased GH secretion...
  4. pmc IGFBP-2 is a negative predictor of cold-induced brown fat and bone mineral density in young non-obese women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 53:336-9. 2013
    ..We show for the first time that IGFBP-2 is a negative predictor of cold-induced BAT and BMD in young non-obese women, suggesting that IGFBP-2 may serve as a regulator of BAT-mediated osteoblastogenesis...
  5. doi request reprint Femoroacetabular impingement
    Miriam A Bredella
    Division of Musculoskeletal Radiology and Interventions, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Magn Reson Imaging Clin N Am 21:45-64. 2013
    ....
  6. pmc Determinants of bone microarchitecture and mechanical properties in obese men
    Miriam A Bredella
    Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:4115-22. 2012
    ..Recent studies have suggested that obesity in men is associated with increased fracture risk. Obesity in men is also associated with dysregulation of the GH/IGF-I and gonadal steroid axes, important regulators of bone homeostasis...
  7. pmc Effects of GH in women with abdominal adiposity: a 6-month randomized, double-blind, placebo-controlled trial
    Miriam A Bredella
    Department of Radiology, Neuroendocrine Unit Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Eur J Endocrinol 166:601-11. 2012
    ..Abdominal adiposity is associated with increased cardiovascular risk and decreased GH secretion. The objective of our study was to determine the effects of GH on body composition and cardiovascular risk markers in abdominally obese women...
  8. pmc Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E584-90. 2012
    ..Brown adipose tissue (BAT) is lower in obese individuals and decreases during aging. Recent studies have suggested a link between BAT and bone metabolism...
  9. pmc Comparison of DXA and CT in the assessment of body composition in premenopausal women with obesity and anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:2227-33. 2010
    ..The level of hydration does not significantly affect most DXA body composition measurements, with the exceptions of thigh fat...
  10. pmc Peak growth hormone-releasing hormone-arginine-stimulated growth hormone is inversely associated with intramyocellular and intrahepatic lipid content in premenopausal women with obesity
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:3995-4002. 2009
    ..Little is known about the role of decreased endogenous GH secretion in the pathogenesis of insulin resistance in obesity...
  11. pmc Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 19:49-53. 2011
    ..This suggests that the detrimental effect of visceral fat on bone health may be mediated in part by IGF-1 as an important regulator of the fat and bone lineage...
  12. pmc Breath-hold 1H-magnetic resonance spectroscopy for intrahepatic lipid quantification at 3 Tesla
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Comput Assist Tomogr 34:372-6. 2010
    ..To compare breath-hold 1H-magnetic resonance spectroscopy (1H-MRS) with respiratory-gated 1H-MRS and computed tomography (CT) for quantification of hepatic lipid content...
  13. pmc Comparison of 3.0 T proton magnetic resonance spectroscopy short and long echo-time measures of intramyocellular lipids in obese and normal-weight women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Magn Reson Imaging 32:388-93. 2010
    ..To compare correlations of intramyocellular lipids (IMCL) measured by short and long echo-time proton magnetic resonance spectroscopy (1H-MRS) with indices of body composition and insulin resistance in obese and normal-weight women...
  14. pmc Adiponectin is inversely associated with intramyocellular and intrahepatic lipids in obese premenopausal women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 19:911-6. 2011
    ....
  15. pmc Determinants of bone mineral density in obese premenopausal women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA 02114, USA
    Bone 48:748-54. 2011
    ..Moreover, our findings suggest that IGF-1 may be a mediator of the deleterious effects of VAT on bone health through effects on bone formation...
  16. pmc Increased bone marrow fat in anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2129-36. 2009
    ..Recent data suggest that marrow fat measured by 1H-magnetic resonance spectroscopy (MRS) in combination with bone mineral density (BMD) may be more valuable than either parameter alone in detecting bone weakness...
  17. pmc Anthropometry, CT, and DXA as predictors of GH deficiency in premenopausal women: ROC curve analysis
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospita, Boston, MA 02114, USA
    J Appl Physiol (1985) 106:418-22. 2009
    ..It can be used to identify women in whom GH deficiency is likely and therefore in whom formal GH stimulation testing might be indicated...
  18. ncbi request reprint MRI of the sacroiliac joints in patients with moderate to severe ankylosing spondylitis
    Miriam A Bredella
    Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
    AJR Am J Roentgenol 187:1420-6. 2006
    ....
  19. pmc Use of FDG-PET in differentiating benign from malignant compression fractures
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, MA 02114, USA
    Skeletal Radiol 37:405-13. 2008
    ..The objective was to evaluate the use of fluorodeoxyglucose positron emission tomography (FDG-PET) in differentiating benign from malignant compression fractures...
  20. pmc Distal radius in adolescent girls with anorexia nervosa: trabecular structure analysis with high-resolution flat-panel volume CT
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Yawkey 6E, Boston, MA 02114, USA
    Radiology 249:938-46. 2008
    ....
  21. ncbi request reprint MR imaging of femoroacetabular impingement
    Miriam A Bredella
    Division of Musculoskeletal Radiology, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Magn Reson Imaging Clin N Am 13:653-64. 2005
    ..In addition, MR imaging is able to detect underlying subtle anatomic variations of the femoral head-neck junction and acetabulum associated with FAI...
  22. ncbi request reprint Value of PET in the assessment of patients with neurofibromatosis type 1
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Yawkey 6E, Boston, MA 02114, USA
    AJR Am J Roentgenol 189:928-35. 2007
    ..The objective of our study was to investigate the use of PET in the detection of malignant peripheral nerve sheath tumors (MPNSTs) in patients with neurofibromatosis type 1 (NF1)...
  23. ncbi request reprint Spectrum of shoulder injuries in the baseball pitcher
    Hugue Ouellette
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Skeletal Radiol 37:491-8. 2008
    ..An understanding of the lesions involved in overhead throwing is crucial in baseball pitchers, as long-term disability can result from these injuries, sometimes with severe financial consequences to the player...
  24. pmc Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 46:458-63. 2010
    ..We concluded that bone microarchitecture is abnormal in women with AN. Endogenous IGF-I, leptin, and androgen levels predict bone microarchitecture independent of BMI...
  25. doi request reprint Medial patellar ossification after patellar instability: a radiographic finding indicative of prior patella subluxation/dislocation
    Seth A Jerabek
    Harvard Combined Orthopaedic Surgery Residency Program, Boston, MA 02114, USA
    Skeletal Radiol 38:785-90. 2009
    ..To describe the correlation between medial patellar ossification and prior patella subluxation and/or dislocation...
  26. pmc Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls
    Madhusmita Misra
    Neuroendocrine Unit and Pediatric Endocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 295:E385-92. 2008
    ..Our data indicate that lower peak GH and higher UFC in overweight girls are associated with visceral adiposity, insulin resistance, and lipids...
  27. pmc Intramyocellular lipid quantification: comparison between 3.0- and 1.5-T (1)H-MRS
    Martin Torriani
    Division of Musculoskeletal Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Magn Reson Imaging 25:1105-11. 2007
    ..This study aimed to prospectively compare measurement precision of calf intramyocellular lipid (IMCL) quantification at 3.0 and 1.5 T using (1)H magnetic resonance spectroscopy ((1)H-MRS)...
  28. doi request reprint Throwing elbow in adults
    Hugue A Ouellette
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Semin Musculoskelet Radiol 14:412-8. 2010
    ..MR imaging is useful for assessment of the throwing elbow in adults...
  29. ncbi request reprint MR imaging of the elbow in baseball pitchers
    Hugue Ouellette
    Division of Musculoskeletal Radiology, Massachusetts General Hospital, 55 Fruit Street, Yawkey 6046, Boston, MA 02114, USA
    Skeletal Radiol 37:115-21. 2008
    ..Typical injuries are secondary to medial joint distraction, lateral joint compression, and rotatory forces at the olecranon. MR imaging is useful for evaluation of the elbow in baseball pitchers...
  30. pmc Preadipocyte factor-1 is associated with marrow adiposity and bone mineral density in women with anorexia nervosa
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:407-13. 2010
    ..Adipocytes and osteoblasts differentiate from a common progenitor cell, the human mesenchymal stem cell. Therefore, understanding factors that regulate this differentiation process may provide insight into bone loss in AN...
  31. pmc Waist to hip ratio and trunk to extremity fat (DXA) are better surrogates for IMCL and for visceral fat respectively than for subcutaneous fat in adolescent girls
    Eray Savgan-Gurol
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA
    Nutr Metab (Lond) 7:86. 2010
    ..abstract:..
  32. ncbi request reprint Value of FDG PET in the assessment of patients with multiple myeloma
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, 15 Parkman St, WACC 515, Boston, MA 02114, USA
    AJR Am J Roentgenol 184:1199-204. 2005
    ..Our objective was to evaluate if whole-body PET with FDG is able to detect bone marrow involvement in patients with multiple myeloma and to assess its appearance and distribution pattern...
  33. ncbi request reprint Value of FDG positron emission tomography in conjunction with MR imaging for evaluating therapy response in patients with musculoskeletal sarcomas
    Miriam A Bredella
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    AJR Am J Roentgenol 179:1145-50. 2002
    ....
  34. ncbi request reprint Metastatic myxoid liposarcomas: imaging and histopathologic findings
    Kenneth Sheah
    Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, YAW 6E, Boston, MA 02114, USA
    Skeletal Radiol 37:251-8. 2008
    ..The objective was to describe the imaging and histopathologic characteristics of metastatic myxoid liposarcomas...
  35. doi request reprint Ischiofemoral impingement syndrome: an entity with hip pain and abnormalities of the quadratus femoris muscle
    Martin Torriani
    Division of Musculoskeletal Radiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, YAW 6048, Boston, MA 02114, USA
    AJR Am J Roentgenol 193:186-90. 2009
    ..The purpose of this study was to describe the MRI findings of an entity in which patients present with hip pain, abnormal MR signal intensity of the quadratus femoris muscle, and narrowing of the ischiofemoral space...
  36. doi request reprint Transverse thickening along the articular surface of the rotator cuff consistent with the rotator cable: identification with MR arthrography and relevance in rotator cuff evaluation
    Kenneth Sheah
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, YAW 6030, Boston, MA 02114, USA
    AJR Am J Roentgenol 193:679-86. 2009
    ....
  37. doi request reprint Musculoskeletal applications of flat-panel volume CT
    Benjamin Reichardt
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, FND 216, Boston, MA 02114, USA
    Skeletal Radiol 37:1069-76. 2008
    ..We further discuss high-resolution CT and omni-scanning (combines fluoroscopic and tomographic imaging)...
  38. doi request reprint MRI of metatarsal head subchondral fractures in patients with forefoot pain
    Martin Torriani
    Musculoskeletal Radiology, Massachusetts General Hospital, 55 Fruit St, YAW 6E, Boston, MA 02114, USA
    AJR Am J Roentgenol 190:570-5. 2008
    ..The purpose of our study was to determine the MRI features of metatarsal head subchondral fractures in symptomatic adults...
  39. doi request reprint Reproducibility of trabecular structure analysis using flat-panel volume computed tomography
    Arnold C Cheung
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Skeletal Radiol 38:1003-8. 2009
    ..To determine inter-scan, inter-reader and intra-reader variability of trabecular structure analysis using flat-panel volume computed tomography (fp-VCT) in cadaver knee specimens...
  40. doi request reprint Tumor burden in patients with neurofibromatosis types 1 and 2 and schwannomatosis: determination on whole-body MR images
    Wenli Cai
    Department of Radiology, Massachusetts General Hospital, 25 New Chardon St, 400C, Boston, MA 02114, USA
    Radiology 250:665-73. 2009
    ....
  41. doi request reprint Impingement of lesser trochanter on ischium as a potential cause for hip pain
    Jay W Patti
    Division of Musculoskeletal Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, YAW 6048, Boston, MA 02114, USA
    Skeletal Radiol 37:939-41. 2008
    ..While the prevalence and etiology of this finding is unclear, it may represent a cause for hip pain...
  42. ncbi request reprint MR imaging of post-traumatic articular cartilage injuries confined to the femoral trochlea. Arthroscopic correlation and clinical significance
    Rolf W Huegli
    Department of Radiology, University Hospital of Basel, Petersgraben 4, Basel 4031, Switzerland
    Eur J Radiol 53:90-5. 2005
    ..To assess and describe post-traumatic articular cartilage injuries isolated to the trochlear groove and provide insight into potential mechanism of injury...

Research Grants2

  1. EFFECTS OF GROWTH HORMONE ON INTRAMYOCELLULAR LIPIDS
    MIRIAM BREDELLA; Fiscal Year: 2007
    ..Ultimately, these data may reveal strategies to increase safety and efficacy of GH therapy. ..