Abraham L Brass

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
    Abraham L Brass
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA
    Cell 139:1243-54. 2009
  2. pmc IFITM3 inhibits influenza A virus infection by preventing cytosolic entry
    Eric M Feeley
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Charlestown, Massachusetts, United States of America
    PLoS Pathog 7:e1002337. 2011
  3. pmc Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus
    I Chueh Huang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
    PLoS Pathog 7:e1001258. 2011
  4. pmc The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication
    Sinu P John
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 87:7837-52. 2013
  5. doi request reprint A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication
    Xiaofei E
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 88:2279-90. 2014
  6. pmc Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllers
    Maria J Buzon
    Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114
    J Virol 85:9646-50. 2011
  7. doi request reprint HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome
    Damien Z Soghoian
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard Medical School, Charlestown, MA 02129, USA
    Sci Transl Med 4:123ra25. 2012

Collaborators

  • I Chueh Huang
  • Erol Fikrig
  • Shan Lu
  • Jens H Kuhn
  • Paul Kellam
  • Hendrik Streeck
  • David J Adams
  • Jenna Rychert
  • Jason M Brenchley
  • Eric S Rosenberg
  • Christopher R Chin
  • Sinu P John
  • Thomas Pertel
  • Eric M Feeley
  • Xiaofei E
  • George Savidis
  • Damien Z Soghoian
  • Stephen J Elledge
  • Maria J Buzon
  • Timothy F Kowalik
  • Shixia Wang
  • Jill M Perreira
  • Mehul Vora
  • Aaron M Aker
  • Andrew E H Elia
  • Aaron R Everitt
  • Sarah E Smith
  • Heiko Jessen
  • Alicja Piechocka-Trocha
  • Kailan Sierra-Davidson
  • Sam Cutler
  • Madelene Lindqvist
  • Kimberly Lane
  • Isaiah Davis
  • Srinika Ranasinghe
  • Michael Flanders
  • Bruce D Walker
  • Gaurav D Gaiha
  • Jennifer S Sims
  • Xu G Yu
  • Mathias Lichterfeld
  • Florencia Pereyra
  • Bethany J Ryan
  • Ruben O Donis
  • Li Mei Chen
  • Katherine Seiss
  • Robert Weiss

Detail Information

Publications7

  1. pmc The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
    Abraham L Brass
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA
    Cell 139:1243-54. 2009
    ..Collectively this work identifies a family of antiviral restriction factors that mediate cellular innate immunity to at least three major human pathogens...
  2. pmc IFITM3 inhibits influenza A virus infection by preventing cytosolic entry
    Eric M Feeley
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Charlestown, Massachusetts, United States of America
    PLoS Pathog 7:e1002337. 2011
    ..Therefore these findings are likely to have significance for the intrinsic immune system's neutralization of a diverse array of threats...
  3. pmc Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus
    I Chueh Huang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
    PLoS Pathog 7:e1001258. 2011
    ..They further show that IFITM proteins differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression...
  4. pmc The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication
    Sinu P John
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 87:7837-52. 2013
    ..On the basis of this and other data, we propose a model for IFITM3-mediated restriction. ..
  5. doi request reprint A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication
    Xiaofei E
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 88:2279-90. 2014
    ..Together, these results demonstrate that DDB2 and a DDB2-ATM feedback loop influence HCMV replication. ..
  6. pmc Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllers
    Maria J Buzon
    Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114
    J Virol 85:9646-50. 2011
    ..These data contribute to increasing evidence that intrinsic inhibition of specific HIV-1 replication steps plays an important role in the ability of elite controllers to maintain undetectable viral loads...
  7. doi request reprint HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome
    Damien Z Soghoian
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard Medical School, Charlestown, MA 02129, USA
    Sci Transl Med 4:123ra25. 2012
    ..Moreover, these data suggest that expansion of granzyme A(+) HIV-specific cytolytic CD4 T cell responses early during acute HIV infection contributes substantially to the control of viral replication...