Genomes and Genes
Abraham L Brass
Affiliation: Massachusetts General Hospital
- The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virusAbraham L Brass
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA
Cell 139:1243-54. 2009..Collectively this work identifies a family of antiviral restriction factors that mediate cellular innate immunity to at least three major human pathogens...
- IFITM3 inhibits influenza A virus infection by preventing cytosolic entryEric M Feeley
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Charlestown, Massachusetts, United States of America
PLoS Pathog 7:e1002337. 2011..Therefore these findings are likely to have significance for the intrinsic immune system's neutralization of a diverse array of threats...
- Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllersMaria J Buzon
Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114
J Virol 85:9646-50. 2011..These data contribute to increasing evidence that intrinsic inhibition of specific HIV-1 replication steps plays an important role in the ability of elite controllers to maintain undetectable viral loads...
- HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcomeDamien Z Soghoian
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard Medical School, Charlestown, MA 02129, USA
Sci Transl Med 4:123ra25. 2012..Moreover, these data suggest that expansion of granzyme A(+) HIV-specific cytolytic CD4 T cell responses early during acute HIV infection contributes substantially to the control of viral replication...