Mike Boxem

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi A protein domain-based interactome network for C. elegans early embryogenesis
    Mike Boxem
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 134:534-45. 2008
  2. ncbi Cyclin-dependent kinases in C. elegans
    Mike Boxem
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Cell Div 1:6. 2006
  3. ncbi Towards a proteome-scale map of the human protein-protein interaction network
    Jean François Rual
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 437:1173-8. 2005
  4. ncbi Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network
    Nicolas Simonis
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Nat Methods 6:47-54. 2009
  5. ncbi Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network
    Muneesh Tewari
    Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Cell 13:469-82. 2004
  6. ncbi 'Edgetic' perturbation of a C. elegans BCL2 ortholog
    Matija Dreze
    Center for Cancer Systems Biology CCSB and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Methods 6:843-9. 2009
  7. ncbi Increasing specificity in high-throughput yeast two-hybrid experiments
    Pierre-Olivier Vidalain
    Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Methods 32:363-70. 2004
  8. ncbi A first version of the Caenorhabditis elegans Promoterome
    Denis Dupuy
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genome Res 14:2169-75. 2004
  9. ncbi The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation
    Mike Boxem
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    FEBS Lett 576:245-50. 2004
  10. ncbi A map of the interactome network of the metazoan C. elegans
    Siming Li
    Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 303:540-3. 2004

Research Grants

  1. Generation of a domain interaction map of C. elegans early embryogenesis
    Mike Boxem; Fiscal Year: 2007

Collaborators

Detail Information

Publications13

  1. ncbi A protein domain-based interactome network for C. elegans early embryogenesis
    Mike Boxem
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 134:534-45. 2008
    ..This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms...
  2. ncbi Cyclin-dependent kinases in C. elegans
    Mike Boxem
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Cell Div 1:6. 2006
    ..This review focuses on the in vivo roles of cyclin-dependent kinases in C. elegans, and highlights novel findings implicating CDKs in coupling development to cell-cycle progression...
  3. ncbi Towards a proteome-scale map of the human protein-protein interaction network
    Jean François Rual
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 437:1173-8. 2005
    ..This work represents an important step towards a systematic and comprehensive human interactome project...
  4. ncbi Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network
    Nicolas Simonis
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Nat Methods 6:47-54. 2009
    ..Comparison with other types of functional genomic data shows the complementarity of distinct experimental approaches in predicting different functional relationships between genes or proteins..
  5. ncbi Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network
    Muneesh Tewari
    Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Cell 13:469-82. 2004
    ..Integrating interactome maps with systematic genetic perturbations may be useful for developing a systems biology approach to this and other signaling modules...
  6. ncbi 'Edgetic' perturbation of a C. elegans BCL2 ortholog
    Matija Dreze
    Center for Cancer Systems Biology CCSB and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Methods 6:843-9. 2009
    ..This approach is amenable to higher throughput and is particularly applicable to interactome network analysis in organisms for which transgenesis is straightforward...
  7. ncbi Increasing specificity in high-throughput yeast two-hybrid experiments
    Pierre-Olivier Vidalain
    Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Methods 32:363-70. 2004
    ..Contaminating plasmids are eliminated by extended culture of yeast cells under positive selection for the interaction, allowing the identification of the true interaction partner...
  8. ncbi A first version of the Caenorhabditis elegans Promoterome
    Denis Dupuy
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genome Res 14:2169-75. 2004
    ....
  9. ncbi The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation
    Mike Boxem
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    FEBS Lett 576:245-50. 2004
    ..These observations suggest that MAP-2 is essential for germ cell development in C. elegans and that this ubiquitous enzyme may play important roles in a tissue specific manner...
  10. ncbi A map of the interactome network of the metazoan C. elegans
    Siming Li
    Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 303:540-3. 2004
    ..Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses...
  11. ncbi Distinct requirements for CD1d intracellular transport for development of V(alpha)14 iNKT cells
    Fenna C M Sillé
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:1780-8. 2009
    ....
  12. ncbi C. elegans class B synthetic multivulva genes act in G(1) regulation
    Mike Boxem
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Curr Biol 12:906-11. 2002
    ..In contrast, lin-15B appeared to act in parallel to lin-35. Our results demonstrate the potential for genetic identification of novel G(1) regulators in C. elegans...
  13. ncbi OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development
    Hidetoshi Komatsu
    Massachusetts General Hospital, Center for Cancer Research, Charlestown, Massachusetts, United States of America
    PLoS Biol 6:e196. 2008
    ..We hypothesize that C. elegans OSM-11 and homologous proteins act as coactivators for Notch receptors, allowing precise regulation of Notch receptor signaling in developmental programs in both vertebrates and invertebrates...

Research Grants1

  1. Generation of a domain interaction map of C. elegans early embryogenesis
    Mike Boxem; Fiscal Year: 2007
    ..The integrated interaction network generated will therefore be very valuable to both C. elegans researchers and others studying animal development. ..