Gil Blander

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi The Sir2 family of protein deacetylases
    Gil Blander
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biochem 73:417-35. 2004
  2. ncbi SIRT1 deacetylates and positively regulates the nuclear receptor LXR
    Xiaoling Li
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mol Cell 28:91-106. 2007
  3. ncbi SIRT1 shows no substrate specificity in vitro
    Gil Blander
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 280:9780-5. 2005
  4. ncbi SIRT1 promotes differentiation of normal human keratinocytes
    Gil Blander
    Genstruct Inc, One Alewife Center, Cambridge, Massachusetts 2140, USA
    J Invest Dermatol 129:41-9. 2009
  5. ncbi SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
    Marcia C Haigis
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
    Cell 126:941-54. 2006
  6. ncbi Superoxide dismutase 1 knock-down induces senescence in human fibroblasts
    Gil Blander
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:38966-9. 2003
  7. ncbi The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
    Ron Firestein
    Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2020. 2008

Collaborators

Detail Information

Publications7

  1. ncbi The Sir2 family of protein deacetylases
    Gil Blander
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biochem 73:417-35. 2004
    ..We summarize the current knowledge of the Sir2 homologs from different organisms, and finally we discuss the role of Sir2 in caloric restriction and aging...
  2. ncbi SIRT1 deacetylates and positively regulates the nuclear receptor LXR
    Xiaoling Li
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mol Cell 28:91-106. 2007
    ..Our findings suggest that deacetylation of LXRs by SIRT1 may be a mechanism that affects atherosclerosis and other aging-associated diseases...
  3. ncbi SIRT1 shows no substrate specificity in vitro
    Gil Blander
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 280:9780-5. 2005
    ..This result brings us one step closer to understanding how SIRT1 and possibly other protein deacetylases chose their substrate...
  4. ncbi SIRT1 promotes differentiation of normal human keratinocytes
    Gil Blander
    Genstruct Inc, One Alewife Center, Cambridge, Massachusetts 2140, USA
    J Invest Dermatol 129:41-9. 2009
    ..We conclude that SIRT1 functions in normal human keratinocytes to inhibit proliferation and to promote differentiation...
  5. ncbi SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
    Marcia C Haigis
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
    Cell 126:941-54. 2006
    ..These results indicate that SIRT4 functions in beta cell mitochondria to repress the activity of GDH by ADP-ribosylation, thereby downregulating insulin secretion in response to amino acids, effects that are alleviated during CR...
  6. ncbi Superoxide dismutase 1 knock-down induces senescence in human fibroblasts
    Gil Blander
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:38966-9. 2003
    ..Together, these findings support the notion that in normal human cells the SOD1 protein may play a role in the regulation of cellular lifespan by p53 and may also regulate the death signals in cancer cells...
  7. ncbi The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
    Ron Firestein
    Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2020. 2008
    ..Taken together, these observations show that SIRT1 suppresses intestinal tumor formation in vivo and raise the prospect that therapies targeting SIRT1 may be of clinical use in beta-catenin-driven malignancies...