Joseph Biederman

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Psychopathology in females with attention-deficit/hyperactivity disorder: a controlled, five-year prospective study
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, 32 Fruit Street, Boston, MA 02114, USA
    Biol Psychiatry 60:1098-105. 2006
  2. ncbi Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
  3. ncbi Sex differences in the functional neuroanatomy of working memory in adults with ADHD
    Eve M Valera
    Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Psychiatry 167:86-94. 2010
  4. ncbi Is oppositional defiant disorder a meaningful diagnosis in adults? Results from a large sample of adults with ADHD
    Theresa Harpold
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:601-5. 2007
  5. ncbi Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
  6. ncbi Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St, Boston, MA 02114, USA
    J Affect Disord 82:209-16. 2004
  7. ncbi Developmental trajectories of anxiety disorders in offspring at high risk for panic disorder and major depression
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    Psychiatry Res 153:245-52. 2007
  8. ncbi A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorder
    Gagan Joshi
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 20:7-14. 2010
  9. ncbi An open-label study of the tolerability of mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and treated primary essential hypertension
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 67:696-702. 2006
  10. ncbi Child behavior checklist clinical scales discriminate referred youth with autism spectrum disorder: a preliminary study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Dev Behav Pediatr 31:485-90. 2010

Detail Information

Publications132 found, 100 shown here

  1. ncbi Psychopathology in females with attention-deficit/hyperactivity disorder: a controlled, five-year prospective study
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, 32 Fruit Street, Boston, MA 02114, USA
    Biol Psychiatry 60:1098-105. 2006
    ..This study estimated the lifetime burden of comorbid psychopathology in a large sample of girls with and without ADHD followed up over five years...
  2. ncbi Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
    ..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD...
  3. ncbi Sex differences in the functional neuroanatomy of working memory in adults with ADHD
    Eve M Valera
    Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Psychiatry 167:86-94. 2010
    ..The authors examined sex differences in the neural functioning of adults with ADHD during performance of a verbal working memory task...
  4. ncbi Is oppositional defiant disorder a meaningful diagnosis in adults? Results from a large sample of adults with ADHD
    Theresa Harpold
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:601-5. 2007
    ..A better understanding of the course, phenomenology, and clinical significance of ODD in adults is needed to better understand therapeutic approaches for this disorder...
  5. ncbi Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
    ..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies...
  6. ncbi Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St, Boston, MA 02114, USA
    J Affect Disord 82:209-16. 2004
    ..This study evaluated whether these patterns of transmission between parents and high-risk offspring are moderated by referral bias...
  7. ncbi Developmental trajectories of anxiety disorders in offspring at high risk for panic disorder and major depression
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    Psychiatry Res 153:245-52. 2007
    ....
  8. ncbi A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorder
    Gagan Joshi
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 20:7-14. 2010
    ..The aim of this study was to evaluate the safety and efficacy of extended release carbamazepine (CBZ-ER) monotherapy in the treatment of pediatric bipolar disorder (BD)...
  9. ncbi An open-label study of the tolerability of mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and treated primary essential hypertension
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 67:696-702. 2006
    ....
  10. ncbi Child behavior checklist clinical scales discriminate referred youth with autism spectrum disorder: a preliminary study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Dev Behav Pediatr 31:485-90. 2010
    ....
  11. ncbi Antecedents to panic disorder in nonreferred adults
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:1179-86. 2006
    ..The current study examined both childhood and adult comorbid disorders as potential antecedent disorders to panic disorder in a large sample of nonreferred adults...
  12. ncbi Executive functioning in offspring at risk for depression and anxiety
    Jamie A Micco
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 85 Alewife Brook Parkway, Suite 2000, Cambridge, MA 02138, USA
    Depress Anxiety 26:780-90. 2009
    ..Studies of at-risk offspring can shed light on this question by examining whether EFDs characterize children at high risk for depression and anxiety who are not yet symptomatic...
  13. ncbi The child behavior checklist broad-band scales predict subsequent psychopathology: A 5-year follow-up
    Carter R Petty
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Warren 705, 15 Parkman Street, Boston, MA 02114, USA
    J Anxiety Disord 22:532-9. 2008
    ..To evaluate the utility of the Child Behavior Check list (CBCL) for identifying children of parents with panic disorder or major depression at high-risk for future psychopathology...
  14. ncbi Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorder
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, 32 Fruit St, Boston, 02114, USA
    Am J Psychiatry 163:1730-8. 2006
    ..The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD)...
  15. ncbi The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Biol Psychiatry 57:1485-92. 2005
    ..To evaluate this further, we genotyped additional families for this marker and a panel of markers encompassing the CRH locus...
  16. ncbi A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD
    Michael C Monuteaux
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008
    ..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology...
  17. ncbi Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: a pilot study
    Nikos Makris
    Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Atten Disord 13:407-13. 2010
    ..Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD...
  18. ncbi A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 36:1141-52. 2006
    ..To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence...
  19. ncbi Adult psychiatric outcomes of girls with attention deficit hyperactivity disorder: 11-year follow-up in a longitudinal case-control study
    Joseph Biederman
    Clinical and Research Programs in Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 167:409-17. 2010
    ..Few follow-up studies have been conducted of girls with ADHD, and none have followed girls into adulthood. The authors sought to estimate the prevalence of psychopathology in girls with and without ADHD followed into young adulthood...
  20. ncbi Relationship of DAT1 and adult ADHD to task-positive and task-negative working memory networks
    Ariel Beth Brown
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
    Psychiatry Res 193:7-16. 2011
    ..Further, we show that DMN suppression is likely linked to DAT1 and to severity of inattention in ADHD. DMN may therefore be a target of DAT1 effects, and lie on the path between the gene and inattention in ADHD...
  21. ncbi Does ADHD predict substance-use disorders? A 10-year follow-up study of young adults with ADHD
    Timothy E Wilens
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 50:543-53. 2011
    ..The main aims of this study were to identify clinically meaningful characteristics of children that predicted the future development of SUDs and to see whether the role of these characteristics varied by sex...
  22. ncbi Childhood antecedents to panic disorder in referred and nonreferred adults
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 15:549-61. 2005
    ..We used a recursive partitioning method to examine antecedent childhood anxiety disorders in large samples of referred and nonreferred subjects with and without panic disorder...
  23. ncbi Parsing the familiality of oppositional defiant disorder from that of conduct disorder: a familial risk analysis
    Carter R Petty
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Psychiatr Res 43:345-52. 2009
    ..Family risk analysis can provide an improved understanding of the association between attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD), attending to the comorbidity with conduct disorder (CD)...
  24. ncbi Effect of prior stimulant treatment for attention-deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescents
    Timothy E Wilens
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Pediatr Adolesc Med 162:916-21. 2008
    ..To examine the effects of early stimulant treatment on subsequent risk for cigarette smoking and substance use disorders (SUDs) in adolescents with attention-deficit/hyperactivity disorder (ADHD)...
  25. ncbi Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 59:460-7. 2006
    ..Association with a single nucleotide polymorphism (SNP; G861C) has been observed, but more extensive linkage disequilibrium analyses have not been reported...
  26. ncbi Effects of parental anxiety disorders in children at high risk for panic disorder: a controlled study
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Research, Boston, MA 02114, United States
    J Affect Disord 94:191-7. 2006
    ..To examine the association between anxiety disorders in parents and offspring in a sample of children at risk for panic disorder. We hypothesized that individual anxiety disorders will breed true in offspring...
  27. ncbi Characterizing non-OCD anxiety disorders in psychiatrically referred children and adolescents
    Paul Hammerness
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02138, United States
    J Affect Disord 105:213-9. 2008
    ..To characterize childhood and adolescent anxiety disorders in a psychiatric clinic...
  28. ncbi Predictors, clinical characteristics, and outcome of conduct disorder in girls with attention-deficit/hyperactivity disorder: a longitudinal study
    Michael C Monuteaux
    The Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychol Med 37:1731-41. 2007
    ..However, it is unclear how these results extend to females. Our aim was to examine the predictors, clinical characteristics, and functional outcome of CD in a sample of female youth with and without ADHD...
  29. ncbi An open study of adjunct OROS-methylphenidate in children who are atomoxetine partial responders: II. Tolerability and pharmacokinetics
    Paul Hammerness
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA
    J Child Adolesc Psychopharmacol 19:493-9. 2009
    ..The aim of this study was to evaluate the tolerability of adding OROS methylphenidate (MPH) to children who are partial responders to atomoxetine (ATMX) in the treatment of attention-deficit/hyperactivity disorder (ADHD)...
  30. ncbi The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: a longitudinal study
    Michael C Monuteaux
    Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Child Psychol Psychiatry 51:233-41. 2010
    ..The purpose of this study was to examine the effect of sex on the course and psychiatric correlates of ADHD from childhood into adolescence...
  31. ncbi Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot study
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA
    Psychiatry Res 145:155-67. 2006
    ..Results support the hypotheses of elevated behavior, anxiety, and mood disorders among offspring at risk for bipolar disorder, and suggest that this psychopathology is already evident in early childhood...
  32. ncbi Atomoxetine and adult attention-deficit/hyperactivity disorder: the effects of comorbidity
    Thomas J Spencer
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 67:415-20. 2006
    ....
  33. ncbi Can self-reported behavioral scales assess executive function deficits? A controlled study of adults with ADHD
    Joseph Biederman
    Pediatric Psychopharmacology and Adult ADHD Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:240-6. 2007
    ..Scores on the CBS above the 50th percentile identify adults with ADHD at significantly higher risk for functional morbidity beyond that conferred by the diagnosis of ADHD alone...
  34. ncbi Association of bipolar and substance use disorders in parents of adolescents with bipolar disorder
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 62:129-34. 2007
    ..We have previously shown that juvenile bipolar disorder (BPD) is a risk for substance use disorders (SUD). Here we examine the expression of both disorders in families of youth with BPD to evaluate the familial risk mechanism...
  35. ncbi Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task
    George Bush
    Departments of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 65:102-14. 2008
    ..Stimulant medications are effective treatments for ADHD, but their neural effects have not been fully characterized...
  36. ncbi Working memory network alterations and associated symptoms in adults with ADHD and Bipolar Disorder
    Ariel Brown
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Psychiatr Res 46:476-83. 2012
    ..We conclude that comorbid ADHD + BPD is associated with alterations across anterior and posterior nodes of the working memory network, and symptoms of each disorder are related to anatomically and functionally distinct brain regions...
  37. ncbi Familial risk analyses of attention deficit hyperactivity disorder and substance use disorders
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit St, Warren 705, Boston, MA 02114, USA
    Am J Psychiatry 165:107-15. 2008
    ..A robust and bidirectional comorbidity between attention deficit hyperactivity disorder (ADHD) and psychoactive substance use disorder (alcohol or drug abuse or dependence) has been consistently reported in the extant literature...
  38. ncbi Clinical outcomes of laboratory-observed preschool behavioral disinhibition at five-year follow-up
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Cambridge, MA 02138, USA
    Biol Psychiatry 62:565-72. 2007
    ..In the present study, our objective was to examine the diagnostic outcome in middle childhood of behavioral disinhibition assessed at preschool age among offspring at risk for anxiety and mood disorders...
  39. ncbi How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlates
    Janet Wozniak
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 58:583-8. 2005
    ..The main goal of this study was to test whether the hypothesized cardinal symptom of euphoria results in differences in clinical correlates in bipolar youth ascertained with no a priori assumptions about cardinal symptoms...
  40. ncbi A comparison of once-daily and divided doses of modafinil in children with attention-deficit/hyperactivity disorder: a randomized, double-blind, and placebo-controlled study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 67:727-35. 2006
    ....
  41. ncbi New developments in the treatment of ADHD
    Joseph Biederman
    Dept. of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 67:148-59. 2006
  42. ncbi Moderating effects of major depression on patterns of comorbidity in patients with panic disorder
    Joseph Biederman
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, WACC 725, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatry Res 126:143-9. 2004
    ..Overanxious disorder was associated with both panic disorder and major depression. Major depression has important moderating effects on patterns of comorbidity of panic disorder in referred adults...
  43. ncbi Parental predictors of pediatric panic disorder/agoraphobia: a controlled study in high-risk offspring
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, 02114, USA
    Depress Anxiety 22:114-20. 2005
    ..These findings suggest that psychiatric comorbidity with other anxiety disorders and with bipolar disorder in parents with PD and their spouses confer a particularly high risk in their offspring to develop PD/AG in childhood...
  44. ncbi The Child Behavior Checklist-Pediatric Bipolar Disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: a longitudinal analysis
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Yawkey Center, Suite 6A, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 70:732-40. 2009
    ..To examine the predictive utility of the Child Behavior Checklist-Pediatric Bipolar Disorder (CBCL-PBD) profile to help identify children at risk for bipolar disorder...
  45. ncbi Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptoms
    Michael C Monuteaux
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 48:757-64. 2009
    ..The aim of this study was to examine the role of the COMT and SLC6A4 genes in the risk for CD and its symptomatic subtypes in the context of ADHD...
  46. ncbi Does conduct disorder mediate the development of substance use disorders in adolescents with bipolar disorder? A case-control family study
    Timothy E Wilens
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    J Clin Psychiatry 70:259-65. 2009
    ..However, because bipolar disorder and CD are frequently comorbid in the young, the impact of CD in mediating SUD in bipolar disorder youth remains unclear...
  47. ncbi The longitudinal course of comorbid oppositional defiant disorder in girls with attention-deficit/hyperactivity disorder: findings from a controlled 5-year prospective longitudinal follow-up study
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Dev Behav Pediatr 29:501-7. 2008
    ..However, most of the available information on the subject derives from predominantly male samples. This study evaluated the longitudinal course and impact of comorbid ODD in a large sample of girls with ADHD...
  48. ncbi Are cognitive deficits in attention deficit/hyperactivity disorder related to the course of the disorder? A prospective controlled follow-up study of grown up boys with persistent and remitting course
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology, Boston, MA, USA
    Psychiatry Res 170:177-82. 2009
    ..More work is needed to help define the implications of these deficits in individuals with a remitting course of ADHD...
  49. ncbi Adaptive phase I study of OROS methylphenidate treatment of attention deficit hyperactivity disorder with epilepsy
    Joseph Gonzalez-Heydrich
    Department of Psychiatry, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Epilepsy Behav 18:229-37. 2010
    ..The goal of this study was to pilot a randomized controlled trial of OROS methylphenidate (OROS-MPH) to treat attention deficit hyperactivity disorder (ADHD) plus epilepsy...
  50. ncbi Stability of executive function deficits in girls with ADHD: a prospective longitudinal followup study into adolescence
    Joseph Biederman
    Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Dev Neuropsychol 33:44-61. 2008
    ..These findings document the stability of EFDs in girls with ADHD from childhood into adolescence...
  51. ncbi Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 66:253-9. 2005
    ..To evaluate the effects of medications used in the treatment of adults with attention-deficit/hyperactivity disorder (ADHD) on blood pressure and pulse...
  52. ncbi A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder
    Thomas Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Biol Psychiatry 57:456-63. 2005
    ..A previous, pilot study by our group suggested that these results were due to inadequate dosing...
  53. ncbi Representativeness of participants in a clinical trial for attention-deficit/hyperactivity disorder? Comparison with adults from a large observational study
    Craig B H Surman
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Ste 2000, 185 Alewife Brook Pkwy, Cambridge, MA 02138, USA
    J Clin Psychiatry 71:1612-6. 2010
    ..In particular, exclusion criteria may frequently exclude individuals with comorbid mental health conditions, which are common in the adult ADHD population...
  54. ncbi New insights into the comorbidity between ADHD and major depression in adolescent and young adult females
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:426-34. 2008
    ..The main aim of this study was to evaluate the association between attention-deficit/hyperactivity disorder (ADHD) and major depression (MD) in adolescent and young adult females...
  55. ncbi Impact of executive function deficits in youth with bipolar I disorder: a controlled study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 186:58-64. 2011
    ..Youth with BP-I disorder and EFDs are at high risk for significant impairments in academic functioning...
  56. ncbi Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycle
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, 55 Fruit St, YAW 6A 6900, Boston, MA 02114, USA
    J Clin Psychiatry 72:11-6. 2011
    ....
  57. ncbi Examination of concordance between maternal and youth reports in the diagnosis of pediatric bipolar disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit Street, Warren 705, Boston, MA 02114, USA
    Bipolar Disord 11:298-306. 2009
    ..To this end we compared discordant (mother positive and youth negative) and concordant (mother and youth positive) cases...
  58. ncbi Severity of the aggression/anxiety-depression/attention child behavior checklist profile discriminates between different levels of deficits in emotional regulation in youth with attention-deficit hyperactivity disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, Boston, MA, USA
    J Dev Behav Pediatr 33:236-43. 2012
    ....
  59. ncbi Association between attention-deficit/hyperactivity disorder and sleep impairment in adulthood: evidence from a large controlled study
    Craig B H Surman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Cambridge, MA 02138, USA
    J Clin Psychiatry 70:1523-9. 2009
    ..To examine whether sleep impairment is associated with attention-deficit/hyperactivity disorder (ADHD) in adults...
  60. ncbi Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorder
    Ariel B Brown
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010
    ..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples...
  61. ncbi Lack of association between behavioral inhibition and psychosocial adversity factors in children at risk for anxiety disorders
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Cambridge, MA 02138, USA
    Am J Psychiatry 161:547-55. 2004
    ..To explore whether this association was mediated by environmental factors, the authors examined associations between psychosocial adversity variables and behavioral inhibition in this group of children...
  62. ncbi Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: a controlled study
    Timothy E Wilens
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    Drug Alcohol Depend 95:188-98. 2008
    ..Clinicians should carefully screen adolescents with bipolar disorder for substance and cigarette use...
  63. ncbi Patterns and predictors of attention-deficit/hyperactivity disorder persistence into adulthood: results from the national comorbidity survey replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Psychiatry 57:1442-51. 2005
    ..Despite growing interest in adult attention-deficit/hyperactivity disorder (ADHD), little is known about predictors of persistence of childhood cases into adulthood...
  64. ncbi Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?
    Larry J Seidman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Dev Neuropsychol 27:79-105. 2005
    ..These findings suggest that executive dysfunctions are correlates of ADHD regardless of gender and age, at least through the late teen years...
  65. ncbi Differential effect of environmental adversity by gender: Rutter's index of adversity in a group of boys and girls with and without ADHD
    Joseph Biederman
    Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Am J Psychiatry 159:1556-62. 2002
    ..This study examined the effect of gender in mediating the association between environmental adversity and the risk of attention deficit hyperactivity disorder (ADHD) and associated impairments...
  66. ncbi Gender effects on attention-deficit/hyperactivity disorder in adults, revisited
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:692-700. 2004
    ..These results bear striking similarities to findings reported in pediatric samples, supporting the validity of ADHD and stressing the importance of identifying and treating the disorder in adulthood...
  67. ncbi Modafinil improves symptoms of attention-deficit/hyperactivity disorder across subtypes in children and adolescents
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA, USA
    J Pediatr 152:394-9. 2008
    ..This secondary analysis evaluated the efficacy of modafinil in children and adolescents by subtype of attention-deficit/hyperactivity disorder (ADHD) using pooled data from 3 double-blind, placebo-controlled studies...
  68. ncbi Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 159:36-42. 2002
    ..In this study the authors systematically examined the impact of gender on the clinical features of ADHD in a group of children referred to a clinic...
  69. ncbi Phenomenology of childhood psychosis: findings from a large sample of psychiatrically referred youth
    Joseph Biederman
    Clinical Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, USA
    J Nerv Ment Dis 192:607-14. 2004
    ..In conclusion, childhood-onset psychosis in referred youth is common and highly morbid. It remains an important topic of research deserving full clinical and scientific attention...
  70. ncbi A preliminary meta-analysis of the child behavior checklist in pediatric bipolar disorder
    Eric Mick
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:1021-7. 2003
    ..CONCLUSIONS: While there was a significant heterogeneity in estimates between studies, a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression was identified...
  71. ncbi Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research Program
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 53:952-60. 2003
    ..Our data suggest that when BPD and CD co-occur in children, both are correctly diagnosed. In these comorbid cases, CD symptoms should not be viewed as secondary to BPD, and manic symptoms should not be viewed as secondary to CD...
  72. ncbi Novel treatments for attention-deficit/hyperactivity disorder in children
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 63:16-22. 2002
    ....
  73. ncbi Temperamental correlates of disruptive behavior disorders in young children: preliminary findings
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Building 149, 13th Street, Boston, MA 02129, USA
    Biol Psychiatry 51:563-74. 2002
    ..Longitudinal studies using behavioral assessments of behavioral disinhibition are needed to confirm these findings...
  74. ncbi Association between attention-deficit/hyperactivity disorder and bulimia nervosa: analysis of 4 case-control studies
    Craig B H Surman
    Clinical and Research Program in Pediatric Psychopharmacology at Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 67:351-4. 2006
    ..If confirmed, this association between bulimia nervosa and ADHD could have important clinical and therapeutic implications...
  75. ncbi Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 54:1376-81. 2003
    ..Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype...
  76. ncbi Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onset
    Eric Mick
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Child Adolesc Psychopharmacol 13:453-62. 2003
    ..This pattern of correlates is consistent with findings documented in children with pediatric bipolar disorder and supports the hypothesis that child-onset bipolar disorder may represent a developmental subtype of the disorder...
  77. ncbi Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder
    Joseph Biederman
    Massachusetts General Hospital, ACC 725, Boston, MA 02114, USA
    Int J Neuropsychopharmacol 7:77-97. 2004
    ..Further, more research is needed on the efficacy of treatment for comorbid ADHD, use of combined medications, and the combination of medication and psychosocial treatment...
  78. ncbi Psychiatric comorbidity, family dysfunction, and social impairment in referred youth with oppositional defiant disorder
    Ross W Greene
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, ACC 725, Boston, MA 02114, USA
    Am J Psychiatry 159:1214-24. 2002
    ..The authors sought to achieve an improved understanding of the diagnosis of oppositional defiant disorder independent of its association with conduct disorder...
  79. ncbi Effect of comorbid symptoms of oppositional defiant disorder on responses to atomoxetine in children with ADHD: a meta-analysis of controlled clinical trial data
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital Harvard Medical School, Yawkey Center for Outpatient Care 6A, Boston, MA 02114, USA
    Psychopharmacology (Berl) 190:31-41. 2007
    ....
  80. ncbi Pharmacotherapy for attention-deficit/hyperactivity disorder (ADHD) decreases the risk for substance abuse: findings from a longitudinal follow-up of youths with and without ADHD
    Joseph Biederman
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 64:3-8. 2003
    ..Findings included confirmation that, in fact, stimulant therapy protected medicated ADHD patients against substance use disorder, which occurred at rates that were 3 to 4 times greater among people with untreated ADHD...
  81. ncbi Diagnostic threshold for conduct disorder in girls and boys
    Alysa E Doyle
    Clinical and Research Program in Pediatric Psychopharmacology, Child Psychiatry Service, Massachusetts General Hospital, ACC-725, 15 Parkman Street, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 191:379-86. 2003
    ..The current results support the possibility that differential rates of CD reflect actual differences in rates of antisocial behavior across gender...
  82. ncbi Behavioral inhibition and disinhibition as hypothesized precursors to psychopathology: implications for pediatric bipolar disorder
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Cambridge, Massacusetts 02138, USA
    Biol Psychiatry 53:985-99. 2003
    ....
  83. ncbi Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Psychiatry 9:2. 2009
    ..In this report we test for association with genes coding brain-derived neurotrophic factor (BDNF), the serotonin transporter (SLC6A4), and catechol-O-methyltransferase (COMT)...
  84. ncbi Parsing the associations between prenatal exposure to nicotine and offspring psychopathology in a nonreferred sample
    Joseph Biederman
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Adolesc Health 45:142-8. 2009
    ..The main aim of this study was to disentangle the association between maternal smoking during pregnancy with psychopathological outcomes, adjusting for possible confounders...
  85. ncbi A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder
    Thomas Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Gen Psychiatry 59:649-56. 2002
    ..CONCLUSIONS: Treatment with desipramine was well tolerated and was associated with robust clinically significant reductions in tic and ADHD symptoms in children and adolescents with chronic tic disorders and ADHD diagnoses...
  86. ncbi Neuropsychological functioning in youth with bipolar disorder
    Alysa E Doyle
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 58:540-8. 2005
    ..We compared neuropsychological and academic functioning of youth with and without DSM-IV BPD, controlling for effects of comorbid ADHD...
  87. ncbi Convergence between structured diagnostic interviews and clinical assessment on the diagnosis of pediatric-onset mania
    Janet Wozniak
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:938-44. 2003
    ..CONCLUSIONS: In children referred for evaluation of suspected bipolar disorder, a structured interview diagnosis of mania is very likely to be corroborated by a clinical interview...
  88. ncbi The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 163:716-23. 2006
    ..Despite growing interest in adult attention deficit hyperactivity disorder (ADHD), little is known about its prevalence or correlates...
  89. ncbi Impact of obsessive-compulsive disorder on the antimanic response to olanzapine therapy in youth with bipolar disorder
    Gagan Joshi
    Pediatric Psychopharmacology Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Bipolar Disord 12:196-204. 2010
    ..To compare antimanic response to olanzapine therapy in youth with bipolar disorder (BPD) based on the status of comorbidity with obsessive-compulsive disorder (OCD)...
  90. ncbi Clinical characteristics of comorbid obsessive-compulsive disorder and bipolar disorder in children and adolescents
    Gagan Joshi
    Pediatric Psychopharmacology Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Bipolar Disord 12:185-95. 2010
    ....
  91. ncbi Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pediatrics 111:179-85. 2003
    ..We investigated all long-term studies in which pharmacologically treated and untreated youths with ADHD were examined for later SUD outcomes...
  92. ncbi Overview and neurobiology of attention-deficit/hyperactivity disorder
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 63:3-9. 2002
    ..Therefore, the treatment characteristics of newer, more selective treatments such as atomoxetine should continue to be explored in ADHD...
  93. ncbi Family based association analysis of statistically derived quantitative traits for drug use in ADHD and the dopamine transporter gene
    Jessica Lasky-Su
    Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, and Pediatric psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    Addict Behav 31:1088-99. 2006
    ..A sliding window of analysis of 3 SNPs also resulted in only nominal associations. CONCLUSIONS: SNPs in DAT do not appear to be associated with the phenotypes generated from drug frequency variables among individuals with ADHD...
  94. ncbi An open trial of bupropion for the treatment of adults with attention-deficit/hyperactivity disorder and bipolar disorder
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 54:9-16. 2003
    ..Further controlled trials are warranted...
  95. ncbi A systematic chart review of the nature of psychiatric adverse events in children and adolescents treated with selective serotonin reuptake inhibitors
    Timothy E Wilens
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 13:143-52. 2003
    ..To this end we completed a retrospective analysis of medical charts to determine the incidence, nature, and clinical correlates of treatment emergent adverse effects in the behavioral, cognitive, and emotional domains...
  96. ncbi Psychiatric comorbidity and functioning in clinically referred preschool children and school-age youths with ADHD
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Am Acad Child Adolesc Psychiatry 41:262-8. 2002
    ..We evaluated the clinical characteristics, psychiatric comorbidity, and functioning of preschool children and school-age youths with ADHD referred to a pediatric psychiatric clinic for evaluation...
  97. ncbi Case-control genome-wide association study of attention-deficit/hyperactivity disorder
    Benjamin M Neale
    Center for Human Genetic Research, Massachusettes General Hospital, Boston, MA, USA
    J Am Acad Child Adolesc Psychiatry 49:906-20. 2010
    ..Thus additional genomewide association studies (GWAS) are needed...
  98. ncbi Effects of once-daily osmotic-release methylphenidate on blood pressure and heart rate in children with attention-deficit/hyperactivity disorder: results from a one-year follow-up study
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:36-41. 2004
    ..We evaluated the longer-term effects on vital signs of once-daily osmotic-release methylphenidate (MPH, Concerta) in children with ADHD...
  99. ncbi Efficacy of Adderall and methylphenidate in attention deficit hyperactivity disorder: a drug-placebo and drug-drug response curve analysis of a naturalistic study
    Stephen V Faraone
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Neuropsychopharmacol 5:121-9. 2002
    ..The analyses also highlight an important subgroup of placebo responders, which suggests that future research should focus on how to predict robust placebo response in ADHD patients...
  100. ncbi Temporal association between childhood psychopathology and substance use disorders: findings from a sample of adults with opioid or alcohol dependency
    Amy L Hahesy
    Pediatric and Adult Psychopharmacology Clinic, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 15 Parkman Street, ACC 725, Boston, MA 02114, USA
    Psychiatry Res 109:245-53. 2002
    ..These findings further highlight the importance of targeting antecedent disorders for preventive and early intervention programs aimed at reducing the risk for SUD...
  101. ncbi Impact of comorbidity in adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 65:3-7. 2004
    ..More studies are needed on the outcomes of adults with this disorder, especially cost-of-illness studies...