Antonio C Bianco

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Adaptive activation of thyroid hormone and energy expenditure
    Antonio C Bianco
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, HIM Bldg 643, Massachusetts, Boston, MA 02115, USA
    Biosci Rep 25:191-208. 2005
  2. ncbi An inside job
    Antonio C Bianco
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School Medicine Endocrinology, Diabetes and Hypertension, 77 Avenue Louis Pasteur, Room 643, Boston, Massachusetts 02115, USA
    Endocrinology 148:3077-9. 2007
  3. ncbi Cellular and structural biology of the deiodinases
    Antonio C Bianco
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Thyroid 15:777-86. 2005
  4. ncbi Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects
    Antonio C Bianco
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arq Bras Endocrinol Metabol 48:16-24. 2004
  5. pmc Deiodinases: implications of the local control of thyroid hormone action
    Antonio C Bianco
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 116:2571-9. 2006
  6. ncbi Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue
    Sandra C Souza
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1273-9. 2007
  7. pmc Coordination of hypothalamic and pituitary T3 production regulates TSH expression
    Tatiana L Fonseca
    Division of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Clin Invest 123:1492-500. 2013
  8. pmc The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
    Monica Dentice
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 7:698-705. 2005
  9. pmc Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis
    Jessica A Hall
    Biological and Biomedical Sciences Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 151:4573-82. 2010
  10. pmc The thyroid hormone-inactivating deiodinase functions as a homodimer
    G D Vivek Sagar
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Endocrinol 22:1382-93. 2008

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Detail Information

Publications73

  1. ncbi Adaptive activation of thyroid hormone and energy expenditure
    Antonio C Bianco
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, HIM Bldg 643, Massachusetts, Boston, MA 02115, USA
    Biosci Rep 25:191-208. 2005
    ..This article reviews current biological knowledge about D2 and adaptive T3 production and their roles in energy expenditure...
  2. ncbi An inside job
    Antonio C Bianco
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School Medicine Endocrinology, Diabetes and Hypertension, 77 Avenue Louis Pasteur, Room 643, Boston, Massachusetts 02115, USA
    Endocrinology 148:3077-9. 2007
  3. ncbi Cellular and structural biology of the deiodinases
    Antonio C Bianco
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Thyroid 15:777-86. 2005
    ....
  4. ncbi Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects
    Antonio C Bianco
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arq Bras Endocrinol Metabol 48:16-24. 2004
    ..In addition, D2 interacts with and is a substrate of the pVHL-interacting deubiquitinating enzymes (VDU1 and VDU2); thus deubiquitination regulates the supply of active thyroid hormone in D2-expressing cells...
  5. pmc Deiodinases: implications of the local control of thyroid hormone action
    Antonio C Bianco
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 116:2571-9. 2006
    ..The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination plays a much broader role than once thought, extending into the realms of developmental biology and metabolism...
  6. ncbi Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue
    Sandra C Souza
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1273-9. 2007
    ..0 degrees C) comparable to that in wild-type mice. This observation suggests that one or more NE-dependent mechanism downstream of perilipin phosphorylation is required to initiate and/or sustain the IBAT thermal response...
  7. pmc Coordination of hypothalamic and pituitary T3 production regulates TSH expression
    Tatiana L Fonseca
    Division of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Clin Invest 123:1492-500. 2013
    ..Taken together, these data demonstrated that the hypothalamic-thyroid axis is wired to maintain normal plasma T3 levels, which is achieved through coordination of T4-to-T3 conversion between thyrotrophs and tanycytes...
  8. pmc The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
    Monica Dentice
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 7:698-705. 2005
    ..Thus, ECS(WSB-1) mediates a mechanism by which 'systemic' thyroid hormone can effect local control of the Hedgehog-PTHrP negative feedback loop and thus skeletogenesis...
  9. pmc Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis
    Jessica A Hall
    Biological and Biomedical Sciences Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 151:4573-82. 2010
    ..This discovery highlights the importance of deiodinase-controlled thyroid hormone signaling in BAT development, where it has important metabolic repercussions for energy homeostasis in adulthood...
  10. pmc The thyroid hormone-inactivating deiodinase functions as a homodimer
    G D Vivek Sagar
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Endocrinol 22:1382-93. 2008
    ..In conclusion, the inactivating deiodinase D3 exists as homo- or heterodimer in living intact cells, a feature that is critical for their catalytic activities...
  11. pmc Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity
    G D Vivek Sagar
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:4774-83. 2007
    ..The continuous association of D2 with this regulatory protein complex supports rapid cycles of deiodination, conjugation to ubiquitin, and enzyme reactivation by deubiquitination, allowing tight control of thyroid hormone action...
  12. pmc Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality
    Melany Castillo
    Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Florida, USA
    Diabetes 60:1082-9. 2011
    ..Here we investigate whether the impaired thermogenesis of D2KO mice increases their susceptibility to obesity when placed on a high-fat diet...
  13. pmc Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells
    Beatriz C G Freitas
    Laboratory of Molecular Endocrinology, Division of Endocrinology, Department of Medicine, Federal University of Sao Paulo, Sao Paulo SP, Brazil
    J Clin Invest 120:2206-17. 2010
    ....
  14. pmc The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase
    Ann Marie Zavacki
    Division of Endocrinology, Diabetes and Metabolism, Dominion Towers, Suite 816, 1400 NW 10th Ave, Miami, FL 33136, USA
    Mol Cell Biol 29:5339-47. 2009
    ..We conclude that TEB4 interacts with and mediates loss of D2 activity, indicating that D2 ubiquitination and degradation can be tissue specific, depending on WSB-1 and TEB4 expression levels...
  15. pmc Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation
    Cyntia Curcio-Morelli
    Division of Endocrinology, Brigham and Women s Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Clin Invest 112:189-96. 2003
    ..Thus, deubiquitination regulates the supply of active thyroid hormone to brown adipocytes and other D2-expressing cells...
  16. pmc Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue
    Hye Won Kang
    Department of Medicine, Division of Gastroenterology, Harvard Medical School, Boston, MA, USA
    J Lipid Res 50:2212-21. 2009
    ..Collectively, these findings support a key role for Pctp in limiting mitochondrial oxidation of fatty acids and thus regulating adaptive thermogenesis in BAT...
  17. ncbi The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation
    Wagner S da-Silva
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, HIM Bldg 643, Boston, MA 02115, USA
    Diabetes 56:767-76. 2007
    ..These data document a novel mechanism by which a xenobiotic-activated pathway can regulate metabolically important genes as well as thyroid hormone activation and thus may influence metabolic control in humans...
  18. pmc Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism
    Sungro Jo
    Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Neurosci 32:8491-500. 2012
    ..This adaptation decreases thyroid hormone signaling and may function to reduce ischemia-induced hypoxic brain damage...
  19. pmc Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity
    Melany Castillo
    Division of Endocrinology, Diabetes, and Metabolism, Miller School of Medicine, University of Miami, Florida 33136, USA
    Thyroid 20:545-53. 2010
    ..The use of selective agonists of the thyroid hormone receptor isoform beta (TRbeta) has been linked to metabolic improvement in animal models of diet-induced obesity, nonalcoholic liver disease, and genetic hypercholesterolemia...
  20. pmc The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure
    Wagner S da-Silva
    Division of Endocrinology, Diabetes, and Metabolism, University of Miami Miller School of Medicine, Miami, FL 33143, USA
    FEBS Lett 585:539-44. 2011
    ..Thus, D2 plays a critical role in the metabolic effects of chemical chaperones...
  21. ncbi Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2
    Brian W Kim
    Brigham and Women s Hospital HIM Building, Room 566, 77 Louis Pasteur Avenue, Boston, Massachusetts 02115, USA
    Mol Endocrinol 17:2603-12. 2003
    ..In conclusion, D2 ERAD in human cells proceeds via an association between UBC7 and the carboxyl region of D2, a unique mechanism for the control of thyroid hormone activation...
  22. pmc Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes
    Renata Grozovsky
    Division of Endocrinology, Brighamand Women s Hospital, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Endocrinology 150:1976-83. 2009
    ....
  23. ncbi In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases
    Cyntia Curcio-Morelli
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 144:937-46. 2003
    ....
  24. pmc Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis
    Rafael Arrojo e Drigo
    Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine Miami, Florida 33136, USA
    Mol Endocrinol 25:2065-75. 2011
    ..This explains the lack of D2 activity in primary human airway cells with ER stress resulting from cystic fibrosis...
  25. ncbi Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation
    Sarah Crunkhorn
    Research Division, Joslin Diabetes Center, Division of Endocrinology, Department of Medicine and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 282:15439-50. 2007
    ..These data indicate that obesity and saturated fatty acids decrease PGC-1 and mitochondrial gene expression and function via p38 MAPK-dependent transcriptional pathways...
  26. ncbi Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse
    Ann Marie Zavacki
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, HIM 641, Boston, Massachusetts 02115, USA
    Endocrinology 146:1568-75. 2005
    ....
  27. ncbi Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis
    Vibha Sharma
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, MS 8106, P O Box 6511, Aurora, Colorado 80045, USA
    Endocrinology 147:1438-51. 2006
    ..Rexinoids also stimulate type 1 iodothyronine deiodinase activity in the liver and pituitary...
  28. ncbi Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism
    Marcelo A Christoffolete
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 147:1735-43. 2006
    ..These results resolve the apparent paradox between the homeostatic regulation of D2 and its role in mediating the critical mechanism by which T(4) triggers the TSH-negative feedback...
  29. pmc Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice
    Cintia B Ueta
    Division of Endocrinology, Diabetes, and Metabolism, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Mol Endocrinol 26:809-18. 2012
    ..These findings reveal crucial roles for Dio3 in heart function and remodeling, which may have pathophysiologic implications for human restrictive cardiomyopathy...
  30. pmc Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus
    Edith Sanchez
    Tupper Research Institute and Department of Medicine, Tufts Medical Center, 750 Washington Street, Boston, Massachusetts 02111, USA
    Endocrinology 149:4329-35. 2008
    ..This response may be an important homeostatic mechanism to allow replenishment of depleted energy stores associated with fasting...
  31. ncbi Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations
    Marcelo A Christoffolete
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Endocrinology 148:954-60. 2007
    ..In conclusion, C3H-D2KO mice have notably elevated serum T(4) levels, and this, in conjunction with residual D1 activity, is likely an important role in the maintenance of euthyroid serum T(3) concentrations...
  32. ncbi Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms
    Hideaki Miyoshi
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 281:15837-44. 2006
    ..These results redefine and expand our understanding of how perilipin regulates HSL-mediated lipolysis in adipocytes...
  33. pmc Thyroid hormone-related regulation of gene expression in human fatty liver
    Jussi Pihlajamaki
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 94:3521-9. 2009
    ..Fatty liver is an important complication of obesity; however, regulatory mechanisms mediating altered gene expression patterns have not been identified...
  34. ncbi Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness
    Suzy D Carvalho-Bianco
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Endocrinol 18:1840-9. 2004
    ..These data suggest that cardiac thyrotoxicosis leads to increased beta-adrenergic responsiveness of cardiomyocytes via alterations in the regulatory G-protein elements of the AC membrane complex...
  35. pmc Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment
    Matthew L Rosene
    Division of Endocrinology, Diabetes, and Metabolism, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Endocrinology 151:5961-70. 2010
    ..In conclusion, AMIO and DEA are noncompetitive inhibitors of D2, with DEA being much more potent, and this inhibition at the level of the pituitary gland contributes to the rise in TSH seen in patients taking AMIO...
  36. ncbi Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis
    Marcelo A Christoffolete
    Department of Medicine, Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 53:577-84. 2004
    ..The latter is the preponderant determinant of the impaired adaptive thermogenesis and hypothermia in cold-exposed Dio2(-/-) mice...
  37. pmc Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes
    Monica Dentice
    Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, 80131 Naples, Italy, and Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:14466-71. 2007
    ..This previously unrecognized functional cross-talk between Shh/Gli2 and thyroid hormone in keratinocytes is a pathway by which Shh produces its proliferative effects and offers a potential therapeutic approach to BCC...
  38. pmc Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity
    Cintia B Ueta
    Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Endocrinology 152:3571-81. 2011
    ..In conclusion, hypothyroid mice are metabolically sensitive to environmental temperature, constituting a mechanism that defines resistance to diet-induced obesity and hepatic lipid metabolism...
  39. ncbi Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging
    Akira Nakayama
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    Mol Imaging 2:37-49. 2003
    ..Taken together, BAT perfusion can now be measured noninvasively using NIR fluorescent light, and pharmacological modulators of thermogenesis can be screened at relatively high throughput in living animals...
  40. doi Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism
    Mary Elizabeth Patti
    Harvard Medical School, Harvard University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:1671-7. 2009
    ..57, P = 0.004). Together, our data suggest that altered bile acid levels and composition may contribute to improved glucose and lipid metabolism in patients who have had GB...
  41. ncbi Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase
    Diego Botero
    Thyroid Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Endocrinol 16:1999-2007. 2002
    ..In conclusion, Ubc6p and Ubc7p are required for normal and substrate-induced ubiquitination and proteolysis of D2...
  42. ncbi Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes
    Munira Baqui
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:1206-11. 2003
    ....
  43. ncbi Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus
    Csaba Fekete
    Tupper Research Institute and Department of Medicine, Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    Endocrinology 147:520-9. 2006
    ..We conclude that insulin and glucose only partially replicate the central effects of leptin and may not be essential components of the hypothalamic-pituitary-thyroid regulatory system during fasting...
  44. pmc Cracking the code for thyroid hormone signaling
    Antonio C Bianco
    Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, 1400 NW 10th Avenue, Suite 816, Miami, FL 33136, USA
    Trans Am Clin Climatol Assoc 124:26-35. 2013
    ..On the other hand, induction of D3 in myocardium and brain during ischemia and hypoxia decreases energy expenditure as part of a homeostatic mechanism to slow down cell metabolism in the face of limited O2 supply. ..
  45. pmc The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion
    Mayrin C Medina
    Division of Endocrinology, Diabetes, and Metabolism, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Endocrinology 152:3717-27. 2011
    ..An analogous role is likely in humans, given the similar D3 expression pattern...
  46. doi Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling
    Rafael Arrojo e Drigo
    Division of Endocrinology, Diabetes and Metabolism, University of Miami, Miller School of Medicine, Miami, FL, USA
    Biochim Biophys Acta 1830:3956-64. 2013
    ..Although serum concentration of thyroid hormone is remarkable stable, deiodinases modulate thyroid hormone signaling on a time- and cell-specific fashion by controlling the activation and inactivation of thyroid hormone...
  47. ncbi Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels
    Csaba Fekete
    Tupper Research Institute and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Tufts New England Medical Center, 750 Washington St, Boston, MA 02111, USA
    Brain Res 1056:97-9. 2005
    ..We propose that endotoxin-induced D2 activation in the MBH is independent of circulating levels of thyroid hormone and that this mechanism may contribute to central hypothyroidism associated with infection...
  48. ncbi betaAR signaling required for diet-induced thermogenesis and obesity resistance
    Eric S Bachman
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Science 297:843-5. 2002
    ..These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity...
  49. pmc Minireview: cracking the metabolic code for thyroid hormone signaling
    Antonio C Bianco
    Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, 1400 North West 10th Avenue, Suite 816, Miami, Florida 33136, USA
    Endocrinology 152:3306-11. 2011
    ..On the other hand, induction of D3 in myocardium and brain during ischemia and hypoxia decreases energy expenditure as part of a homeostatic mechanism to slow down cell metabolism in the face of limited O(2) supply...
  50. pmc Reawakened interest in type III iodothyronine deiodinase in critical illness and injury
    Stephen A Huang
    Harvard Medical School, Boston, MA, USA
    Nat Clin Pract Endocrinol Metab 4:148-55. 2008
    ..These studies reveal a novel role of D3 in the tissue response to injury and in the derangement of thyroid hormone homeostasis commonly observed during critical illness...
  51. doi Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features
    Gianluca Iacobellis
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA
    Trends Endocrinol Metab 22:450-7. 2011
    ..Particular emphasis is placed on the paracrine/endocrine properties of epicardial fat and its role in the development and progression of atherosclerosis...
  52. ncbi Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases
    Antonio C Bianco
    Thyroid Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocr Rev 23:38-89. 2002
    ..Finally, we review the new insights from analysis of mice with targeted disruption of the Dio2 gene and overexpression of D2 in the myocardium...
  53. doi Metabolic effects of thyroid hormones-beyond traditional prospects
    Antonio C Bianco
    Thyroid 18:99-100. 2008
  54. ncbi Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis
    Csaba Fekete
    Department of Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 1083, Hungary
    Endocrinology 143:4513-9. 2002
    ..These data confirm the importance of both Y1 and Y5 receptors in the NPY-mediated increase in food consumption and demonstrate that both Y1 and Y5 receptors can mediate the inhibitory effects of NPY on the HPT axis...
  55. ncbi Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study
    Emerson L Olivares
    Departamento de Ciencias Fisiologicas, Instituto de Biologia, Universidade Federal Rural do Rio de Janeiro BR 465, Km 7, 23851 000 Seropédica, Rio de Janeiro, Brazil
    Endocrinology 148:4786-92. 2007
    ..We conclude that the acute decrease in serum T(4) and T(3) after INF is due to increased thyroid hormone catabolism from ectopic D3 expression in the heart...
  56. ncbi Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis
    Csaba Fekete
    Department of Neurobiology C F, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary 1083
    Endocrinology 143:3846-53. 2002
    ....
  57. pmc Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide
    Bruce A Adams
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada
    Endocrinology 149:1571-80. 2008
    ..These results demonstrate that PACAP is not required for the regulation of food intake yet is necessary to maintain normal energy homeostasis, likely playing a role in central cold-sensing mechanisms...
  58. ncbi Adaptive thermogenesis in hummingbirds
    José Eduardo P W Bicudo
    Department of Physiology, Biosciences Institute, University of Sao Paulo, SP, Brazil
    J Exp Biol 205:2267-73. 2002
    ....
  59. ncbi Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    Mitsuhiro Watanabe
    Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch, France
    Nature 439:484-9. 2006
    ..The BA-TGR5-cAMP-D2 signalling pathway is therefore a crucial mechanism for fine-tuning energy homeostasis that can be targeted to improve metabolic control...
  60. ncbi Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization
    Anikó Zeöld
    Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, Budapest H 1083, Hungary
    J Biol Chem 281:31538-43. 2006
    ..Our data also show that the 6 N-terminal amino acids, but not the 12 C-terminal ones, are the ones required for D2 recognition by WSB-1...
  61. pmc Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats
    Warner S Simonides
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Invest 118:975-83. 2008
    ..These results suggest a mechanism of metabolic regulation during hypoxic-ischemic injury in which HIF-1 reduces local thyroid hormone signaling through induction of D3...
  62. ncbi Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats
    Cássio M Villicev
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 2415 Sao Paulo 05508 900, Brazil
    J Endocrinol 193:21-9. 2007
    ..However, the mass of individual skeletal muscles was negatively affected by T3 but only barely by GC-1. These findings highlight the potential use of GC-1 for the treatment of obesity and the metabolic syndrome...
  63. ncbi The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure
    Isabelle Callebaut
    Poôle Bio, Laboratoive de Minéralogie Cristallographie de Paris, CNRS UMR7590, Universities Paris 6 and Paris 7, Paris 75252 Cedex 05, France
    J Biol Chem 278:36887-96. 2003
    ..This model can explain a number of results from previous mutagenesis analyses and permits new verifiable insights into the structural and functional properties of these enzymes...
  64. ncbi Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1
    Fatima R S Freitas
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900, Brazil
    Am J Physiol Endocrinol Metab 285:E1135-41. 2003
    ..In addition, our findings suggest that the development of TR-selective T3 analogs that spare bone mass represents a significant improvement toward long-term TSH-suppressive therapy...
  65. ncbi Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis
    Simone Magagnin Wajner
    Endocrine Division, Thyroid Section, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    J Endocrinol 194:47-54. 2007
    ..Hence, our findings demonstrated that D2 is predominantly expressed in elongated spermatids, suggesting that thyroid hormone might have a direct effect on spermatogenesis in the adult rats...
  66. ncbi Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene
    Anikó Zeöld
    Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Faculty of Information Technology, Peter Pazmany Catholic University, Budapest H 1083, Hungary
    Endocrinology 147:4419-29. 2006
    ....
  67. ncbi [Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-Walker mammary carcinoma]
    Osmar Monte
    Departamento de Ciencias Fisiologicas, Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo
    Arq Bras Endocrinol Metabol 49:253-64. 2005
    ..Thus, in addition to the well known alterations in the extrathyroidal metabolism of thyroid hormones, TSH secretion is decreased in rats with the Walker-256 tumor, indicating a generalized reduction in the thyroid function...
  68. ncbi LXRs regulate the balance between fat storage and oxidation
    Nada Y Kalaany
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Cell Metab 1:231-44. 2005
    ..These studies suggest that, by selectively sensing the cholesterol component of a lipid-rich diet, LXRs govern the balance between storage and oxidation of dietary fat...
  69. ncbi The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus
    Luis Henrique Canani
    Servico de Endocrinologia, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil
    J Clin Endocrinol Metab 90:3472-8. 2005
    ..These findings suggest that the D2-generated T(3) in skeletal muscle plays a role in insulin resistance...
  70. ncbi Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats
    Fatima C Cristovão
    Department of Medicine, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Thyroid 12:13-8. 2002
    ..05). We conclude that (1) severe neonatal hypothyroidism impairs the development and function of the testes and (2) moderate neonatal hypothyroidism stimulates the proliferation of Leydig cells...
  71. ncbi Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation
    Cecilia H A Gouveia
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Endocrinology 146:195-200. 2005
    ..Given the role of D2 in other cell types and processes, it is likely that bone ORD not only plays a role in bone development and adult bone T3 homeostasis but also contributes to extrathyroidal T3 production and maintenance of serum T3...
  72. ncbi Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome
    Csaba Fekete
    Department of Endocrine and Behavioral Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest
    Endocrinology 145:1649-55. 2004
    ....
  73. ncbi Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain
    Csaba Fekete
    Institute of Experimental Medicine, Laboratory of Endocrine Neurobiology, Hungarian Academy of Sciences, Szigony u 43, Budapest H 1083, Hungary
    Endocrinology 148:4865-74. 2007
    ..Furthermore, the data indicate that changes in WSB-1 and USP-33 expression are not part of the brain homeostatic response to hypothyroidism or hyperthyroidism...

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