Genomes and Genes
Affiliation: Massachusetts General Hospital
- Impact of new vitamin D data on future studies and treatmentIshir Bhan
Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Curr Opin Nephrol Hypertens 22:377-82. 2013..This review evaluates recently published data on clinical effects of vitamin D supplementation, focusing on randomized, placebo-controlled trials and nontraditional actions on the cardiovascular and immune systems...
- Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patientsIshir Bhan
Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Kidney Int 82:84-9. 2012..Hence, bioavailable vitamin D levels are better correlated with measures of mineral metabolism than total levels in patients on hemodialysis...
- Isolation of Cardiobacterium hominis from the peritoneal fluid of a patient on continuous ambulatory peritoneal dialysisIshir Bhan
Renal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, CA 02114, USA
Scand J Infect Dis 38:301-3. 2006..We report the isolation of C. hominis from the peritoneal fluid of a patient on continuous ambulatory peritoneal dialysis with a presentation suggestive of peritonitis but no evidence of infective endocarditis...
- Diagnosis and management of mineral metabolism in CKDIshir Bhan
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Gen Intern Med 25:710-6. 2010..Since CKD-related bone loss is often indistinguishable from osteoporosis by standard bone densitometry, many CKD patients may be inappropriately treated with bisphosphonates rather than CKD-specific therapies...
- Clinical measures identify vitamin D deficiency in dialysisIshir Bhan
Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, Suite 750, Boston, MA 02114, USA
Clin J Am Soc Nephrol 5:460-7. 2010..This study was conducted to determine whether routinely measured clinical and demographic parameters could identify dialysis patients who are vitamin D deficient...
- Dietary vitamin D intake in advanced CKD/ESRDIshir Bhan
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Semin Dial 23:407-10. 2010..This article reviews vitamin D metabolism, emerging new roles for vitamin D, and data surrounding the potential importance of nutritional sources of vitamin D in the management of patients with CKD...
- Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trialRavi Thadhani
Division of Nephrology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
JAMA 307:674-84. 2012..Vitamin D is associated with decreased cardiovascular-related morbidity and mortality, possibly by modifying cardiac structure and function, yet firm evidence for either remains lacking...
- Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney diseaseHector Tamez
Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, USA
Am Heart J 164:902-9.e2. 2012..We assessed the effect of an activated vitamin D analog on left atrial volume index (LAVi) in a post hoc analysis of the PRIMO trial (clinicaltrials.gov: NCT00497146)...
- Vitamin D-binding protein modifies the vitamin D-bone mineral density relationshipCamille E Powe
Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Bone Miner Res 26:1609-16. 2011..These findings have important implications for vitamin D supplementation in vitamin D-deficient states. Future studies should continue to explore the relationship between free and bioavailable 25(OH)D and health outcomes...
- Genetic variation in APOL1 associates with younger age at hemodialysis initiationZahra Kanji
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
J Am Soc Nephrol 22:2091-7. 2011..In conclusion, genetic variations in APOL1 identify African Americans that initiate chronic hemodialysis at a younger age. Early interventions to prevent progression of kidney disease may benefit this high-risk population...
- Plasma gelsolin and circulating actin correlate with hemodialysis mortalityPo Shun Lee
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Nephrol 20:1140-8. 2009..9 to 33.5). Worsening renal function correlated with pGSN decline in 53 subjects with CKD not on dialysis. In summary, low pGSN and detectable circulating actin identify chronic hemodialysis patients at highest risk for 1-yr mortality...
- The potential role of plasma gelsolin in dialysis-related protein-energy wastingPo Shun Lee
Brigham and Women s Hospital, Boston, Mass, USA
Blood Purif 29:99-101. 2010..Therefore, pGSN deficiency appears to be a powerful biomarker and a potential therapeutic target in CKD patients...
- N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: prognostic value of baseline and follow-up measurementsORLANDO M GUTIERREZ
Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Clin Chem 54:1339-48. 2008..Previous studies focused on prevalent dialysis patients and examined single measurements of NT-proBNP in time...
- Klotho variants and chronic hemodialysis mortalityDavid J Friedman
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
J Bone Miner Res 24:1847-55. 2009..Our data suggest that a specific Klotho variant (rs577912) is linked to survival in ESRD patients initiating chronic hemodialysis and that therapy with activated vitamin D may modify this risk...
- First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsiaCamille E Powe
Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Hypertension 56:758-63. 2010..These data suggest that first trimester total and free 25(OH)D levels are not independently associated with first trimester blood pressure or subsequent preeclampsia...
- Subclinical hypothyroidism and survival: the effects of heart failure and raceConnie M Rhee
Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 98:2326-36. 2013..Emerging data suggest these associations may depend upon underlying congestive heart failure (CHF) and/or race, but this has not been empirically determined...
- Vitamin D receptor activation and left ventricular hypertrophy in advanced kidney diseaseRavi Thadhani
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, USA
Am J Nephrol 33:139-49. 2011..In chronic kidney disease (CKD), left ventricular hypertrophy (LVH) is prevalent and is associated with increased cardiovascular morbidity and mortality. Vitamin D receptor (VDR) activation attenuates LVH progression in animal models...
- Ergocalciferol and cholecalciferol in CKDSagar U Nigwekar
Division of Nephrology, Massachusetts General Hospital, Boston, USA
Am J Kidney Dis 60:139-56. 2012..Based on the current state of the evidence, we provide suggestions for clinical practice and address areas of uncertainty that need further research...
- Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysisAdrian F Gombart
Department of Medicine, Division of Hematology Oncology, Cedars Sinai Medical Center, David Geffen School of Medicine at Univeristy of California, Los Angeles, USA
Clin Infect Dis 48:418-24. 2009....
- Vascular calcification and ESRD: a hard targetIshir Bhan
Department of Medicine, Massachusetts General Hospital, Bullfinch 127, Boston, MA 02114, USA
Clin J Am Soc Nephrol 4:S102-5. 2009..Reviewed here is the current state of research on the biology and the significance of vascular calcification in ESRD, the role of vitamin D therapy in its development, and options for management...
- Vitamin D therapy for chronic kidney diseaseIshir Bhan
Department of Medicine, Renal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Semin Nephrol 29:85-93. 2009..This article reviews the role of vitamin D therapy in CKD and looks to the answers that future research may bring...
- Design and implementation of an application and associated services to support interdisciplinary medication reconciliation efforts at an integrated healthcare delivery networkEric G Poon
Clinical Informatics Research and Development, Suite 201, 93 Worcester St, Wellesley, MA 02481, USA
J Am Med Inform Assoc 13:581-92. 2006..Results from early pilot testing suggest that this new medication reconciliation process is well accepted by clinicians and has significant potential to prevent medication errors during transitions of care...
- Effect of an electronic medication reconciliation application and process redesign on potential adverse drug events: a cluster-randomized trialJeffrey L Schnipper
Harvard Medical School, Division of General Medicine, Brigham and Women s Hospital, 1620 Tremont St, Boston, MA 02120 1613, USA
Arch Intern Med 169:771-80. 2009..We sought to measure the impact of an information technology-based medication reconciliation intervention on medication discrepancies with potential for harm (potential adverse drug events [PADEs])...
- Hypothyroidism and mortality among dialysis patientsConnie M Rhee
Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin J Am Soc Nephrol 8:593-601. 2013..Hypothyroidism is highly prevalent among ESRD patients, but its clinical significance and the benefits of thyroid hormone replacement in this context remain unclear...
- Classifying and predicting errors of inpatient medication reconciliationJennifer R Pippins
Division of General Medicine, Brigham and Women s Hospital, Boston, MA 02120 1613, USA
J Gen Intern Med 23:1414-22. 2008..Failure to reconcile medications across transitions in care is an important source of potential harm to patients. Little is known about the predictors of unintentional medication discrepancies and how, when, and where they occur...
- Statin use and calcific uremic arteriolopathy: a matched case-control studySagar U Nigwekar
Division of Nephrology, Dermatopathology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Nephrol 37:325-32. 2013..Prior research has shown that statins have anticalcification, antithrombotic and antiinflammatory properties; however, the association between statin use and CUA has not been investigated...
- Dysregulated mineral metabolism in patients with acute kidney injury and risk of adverse outcomesDavid E Leaf
Division of Nephrology, Columbia University Medical Center, New York, NY, USA Division of Renal Medicine, Brigham and Women s Hospital, Boston, MA, USA
Clin Endocrinol (Oxf) 79:491-8. 2013..We evaluated the association between vitamin D metabolites and clinical outcomes among patients with AKI...
- Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidismConnie M Rhee
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 172:153-9. 2012..Despite compelling biological plausibility and clinical implication, the association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism has not been rigorously studied...