Ishir Bhan

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Impact of new vitamin D data on future studies and treatment
    Ishir Bhan
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Nephrol Hypertens 22:377-82. 2013
  2. pmc Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients
    Ishir Bhan
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 82:84-9. 2012
  3. ncbi request reprint Isolation of Cardiobacterium hominis from the peritoneal fluid of a patient on continuous ambulatory peritoneal dialysis
    Ishir Bhan
    Renal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, CA 02114, USA
    Scand J Infect Dis 38:301-3. 2006
  4. pmc Diagnosis and management of mineral metabolism in CKD
    Ishir Bhan
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Gen Intern Med 25:710-6. 2010
  5. doi request reprint Dietary vitamin D intake in advanced CKD/ESRD
    Ishir Bhan
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Semin Dial 23:407-10. 2010
  6. pmc Clinical measures identify vitamin D deficiency in dialysis
    Ishir Bhan
    Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, Suite 750, Boston, MA 02114, USA
    Clin J Am Soc Nephrol 5:460-7. 2010
  7. doi request reprint Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial
    Ravi Thadhani
    Division of Nephrology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    JAMA 307:674-84. 2012
  8. pmc Vitamin D-binding protein and vitamin D status of black Americans and white Americans
    Camille E Powe
    From the Department of Medicine, Brigham and Women s Hospital C E P, Division of Nephrology, Massachusetts General Hospital J W, H T, I B, R T, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School A H B, Division of Nephrology, Beth Israel Deaconess Medical Center D Z, S A K, and Howard Hughes Medical Institute D Z, S A K all in Boston the Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore M K E, A B Z the Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD M N and the Department of Medicine, San Francisco General Hospital and University of California, San Francisco, San Francisco N R P
    N Engl J Med 369:1991-2000. 2013
  9. doi request reprint Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease
    Hector Tamez
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, USA
    Am Heart J 164:902-9.e2. 2012
  10. pmc Hypothyroidism and mortality among dialysis patients
    Connie M Rhee
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 8:593-601. 2013

Collaborators

Detail Information

Publications32

  1. pmc Impact of new vitamin D data on future studies and treatment
    Ishir Bhan
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Nephrol Hypertens 22:377-82. 2013
    ..This review evaluates recently published data on clinical effects of vitamin D supplementation, focusing on randomized, placebo-controlled trials and nontraditional actions on the cardiovascular and immune systems...
  2. pmc Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients
    Ishir Bhan
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 82:84-9. 2012
    ..Hence, bioavailable vitamin D levels are better correlated with measures of mineral metabolism than total levels in patients on hemodialysis...
  3. ncbi request reprint Isolation of Cardiobacterium hominis from the peritoneal fluid of a patient on continuous ambulatory peritoneal dialysis
    Ishir Bhan
    Renal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, CA 02114, USA
    Scand J Infect Dis 38:301-3. 2006
    ..We report the isolation of C. hominis from the peritoneal fluid of a patient on continuous ambulatory peritoneal dialysis with a presentation suggestive of peritonitis but no evidence of infective endocarditis...
  4. pmc Diagnosis and management of mineral metabolism in CKD
    Ishir Bhan
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Gen Intern Med 25:710-6. 2010
    ..Since CKD-related bone loss is often indistinguishable from osteoporosis by standard bone densitometry, many CKD patients may be inappropriately treated with bisphosphonates rather than CKD-specific therapies...
  5. doi request reprint Dietary vitamin D intake in advanced CKD/ESRD
    Ishir Bhan
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Semin Dial 23:407-10. 2010
    ..This article reviews vitamin D metabolism, emerging new roles for vitamin D, and data surrounding the potential importance of nutritional sources of vitamin D in the management of patients with CKD...
  6. pmc Clinical measures identify vitamin D deficiency in dialysis
    Ishir Bhan
    Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, Suite 750, Boston, MA 02114, USA
    Clin J Am Soc Nephrol 5:460-7. 2010
    ..This study was conducted to determine whether routinely measured clinical and demographic parameters could identify dialysis patients who are vitamin D deficient...
  7. doi request reprint Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial
    Ravi Thadhani
    Division of Nephrology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    JAMA 307:674-84. 2012
    ..Vitamin D is associated with decreased cardiovascular-related morbidity and mortality, possibly by modifying cardiac structure and function, yet firm evidence for either remains lacking...
  8. pmc Vitamin D-binding protein and vitamin D status of black Americans and white Americans
    Camille E Powe
    From the Department of Medicine, Brigham and Women s Hospital C E P, Division of Nephrology, Massachusetts General Hospital J W, H T, I B, R T, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School A H B, Division of Nephrology, Beth Israel Deaconess Medical Center D Z, S A K, and Howard Hughes Medical Institute D Z, S A K all in Boston the Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore M K E, A B Z the Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD M N and the Department of Medicine, San Francisco General Hospital and University of California, San Francisco, San Francisco N R P
    N Engl J Med 369:1991-2000. 2013
    ..Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency...
  9. doi request reprint Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease
    Hector Tamez
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, USA
    Am Heart J 164:902-9.e2. 2012
    ..We assessed the effect of an activated vitamin D analog on left atrial volume index (LAVi) in a post hoc analysis of the PRIMO trial (clinicaltrials.gov: NCT00497146)...
  10. pmc Hypothyroidism and mortality among dialysis patients
    Connie M Rhee
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 8:593-601. 2013
    ..Hypothyroidism is highly prevalent among ESRD patients, but its clinical significance and the benefits of thyroid hormone replacement in this context remain unclear...
  11. pmc Genetic variation in APOL1 associates with younger age at hemodialysis initiation
    Zahra Kanji
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Soc Nephrol 22:2091-7. 2011
    ..In conclusion, genetic variations in APOL1 identify African Americans that initiate chronic hemodialysis at a younger age. Early interventions to prevent progression of kidney disease may benefit this high-risk population...
  12. pmc Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship
    Camille E Powe
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Bone Miner Res 26:1609-16. 2011
    ..These findings have important implications for vitamin D supplementation in vitamin D-deficient states. Future studies should continue to explore the relationship between free and bioavailable 25(OH)D and health outcomes...
  13. pmc Plasma gelsolin and circulating actin correlate with hemodialysis mortality
    Po Shun Lee
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:1140-8. 2009
    ..9 to 33.5). Worsening renal function correlated with pGSN decline in 53 subjects with CKD not on dialysis. In summary, low pGSN and detectable circulating actin identify chronic hemodialysis patients at highest risk for 1-yr mortality...
  14. ncbi request reprint The potential role of plasma gelsolin in dialysis-related protein-energy wasting
    Po Shun Lee
    Brigham and Women s Hospital, Boston, Mass, USA
    Blood Purif 29:99-101. 2010
    ..Therefore, pGSN deficiency appears to be a powerful biomarker and a potential therapeutic target in CKD patients...
  15. pmc Dysregulated mineral metabolism in patients with acute kidney injury and risk of adverse outcomes
    David E Leaf
    Division of Nephrology, Columbia University Medical Center, New York, NY, USA
    Clin Endocrinol (Oxf) 79:491-8. 2013
    ..We evaluated the association between vitamin D metabolites and clinical outcomes among patients with AKI...
  16. ncbi request reprint N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: prognostic value of baseline and follow-up measurements
    ORLANDO M GUTIERREZ
    Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 54:1339-48. 2008
    ..Previous studies focused on prevalent dialysis patients and examined single measurements of NT-proBNP in time...
  17. pmc Klotho variants and chronic hemodialysis mortality
    David J Friedman
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Bone Miner Res 24:1847-55. 2009
    ..Our data suggest that a specific Klotho variant (rs577912) is linked to survival in ESRD patients initiating chronic hemodialysis and that therapy with activated vitamin D may modify this risk...
  18. pmc First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia
    Camille E Powe
    Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Hypertension 56:758-63. 2010
    ..These data suggest that first trimester total and free 25(OH)D levels are not independently associated with first trimester blood pressure or subsequent preeclampsia...
  19. pmc Hyponatremia, mineral metabolism, and mortality in incident maintenance hemodialysis patients: a cohort study
    Sagar U Nigwekar
    Division of Nephrology, Massachusetts General Hospital, Boston, MA Scholars in Clinical Science Program, Harvard Medical School, Boston, MA Electronic address
    Am J Kidney Dis 62:755-62. 2013
    ..Recent animal studies also implicate hyponatremia in bone abnormalities. However, associations between hyponatremia, mineral bone abnormalities, and mortality in incident hemodialysis patients are unknown...
  20. pmc Subclinical hypothyroidism and survival: the effects of heart failure and race
    Connie M Rhee
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 98:2326-36. 2013
    ..Emerging data suggest these associations may depend upon underlying congestive heart failure (CHF) and/or race, but this has not been empirically determined...
  21. doi request reprint Vitamin D receptor activation and left ventricular hypertrophy in advanced kidney disease
    Ravi Thadhani
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Am J Nephrol 33:139-49. 2011
    ..In chronic kidney disease (CKD), left ventricular hypertrophy (LVH) is prevalent and is associated with increased cardiovascular morbidity and mortality. Vitamin D receptor (VDR) activation attenuates LVH progression in animal models...
  22. doi request reprint Ergocalciferol and cholecalciferol in CKD
    Sagar U Nigwekar
    Division of Nephrology, Massachusetts General Hospital, Boston, USA
    Am J Kidney Dis 60:139-56. 2012
    ..Based on the current state of the evidence, we provide suggestions for clinical practice and address areas of uncertainty that need further research...
  23. doi request reprint Vascular calcification and ESRD: a hard target
    Ishir Bhan
    Department of Medicine, Massachusetts General Hospital, Bullfinch 127, Boston, MA 02114, USA
    Clin J Am Soc Nephrol 4:S102-5. 2009
    ..Reviewed here is the current state of research on the biology and the significance of vascular calcification in ESRD, the role of vitamin D therapy in its development, and options for management...
  24. doi request reprint Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis
    Adrian F Gombart
    Department of Medicine, Division of Hematology Oncology, Cedars Sinai Medical Center, David Geffen School of Medicine at Univeristy of California, Los Angeles, USA
    Clin Infect Dis 48:418-24. 2009
    ....
  25. pmc Prospective study of vitamin D status at initiation of care in critically ill surgical patients and risk of 90-day mortality
    Sadeq A Quraishi
    1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 2Department of Anaesthesia, Harvard Medical School, Boston, MA 3Department of Medicine, Massachusetts General Hospital, Boston, MA 4Department of Medicine, Harvard Medical School, Boston, MA 5Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 6Department of Epidemiology, Harvard School of Public Health, Boston, MA
    Crit Care Med 42:1365-71. 2014
    ....
  26. doi request reprint Vitamin D therapy for chronic kidney disease
    Ishir Bhan
    Department of Medicine, Renal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Semin Nephrol 29:85-93. 2009
    ..This article reviews the role of vitamin D therapy in CKD and looks to the answers that future research may bring...
  27. doi request reprint Effect of an electronic medication reconciliation application and process redesign on potential adverse drug events: a cluster-randomized trial
    Jeffrey L Schnipper
    Harvard Medical School, Division of General Medicine, Brigham and Women s Hospital, 1620 Tremont St, Boston, MA 02120 1613, USA
    Arch Intern Med 169:771-80. 2009
    ..We sought to measure the impact of an information technology-based medication reconciliation intervention on medication discrepancies with potential for harm (potential adverse drug events [PADEs])...
  28. pmc Design and implementation of an application and associated services to support interdisciplinary medication reconciliation efforts at an integrated healthcare delivery network
    Eric G Poon
    Clinical Informatics Research and Development, Suite 201, 93 Worcester St, Wellesley, MA 02481, USA
    J Am Med Inform Assoc 13:581-92. 2006
    ..Results from early pilot testing suggest that this new medication reconciliation process is well accepted by clinicians and has significant potential to prevent medication errors during transitions of care...
  29. pmc Classifying and predicting errors of inpatient medication reconciliation
    Jennifer R Pippins
    Division of General Medicine, Brigham and Women s Hospital, Boston, MA 02120 1613, USA
    J Gen Intern Med 23:1414-22. 2008
    ..Failure to reconcile medications across transitions in care is an important source of potential harm to patients. Little is known about the predictors of unintentional medication discrepancies and how, when, and where they occur...
  30. pmc VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system
    Juan Kong
    Laboratory of Metabolic Disease Research and Drug Development and Shengjing Hospital, China Medical University, Shenyang, 110000, China Ravi Thadhani, M P H, Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 E mail and Yan Chun Li, Department of Medicine, The University of Chicago, 900 East 57th Street, KCBD 9110, Chicago, Illinois 60637 E mail
    Mol Endocrinol 27:2116-25. 2013
    ..Taken together, these observations provide evidence that the vitamin D-VDR signaling prevents lung injury by blocking the Ang-2-Tie-2-MLC kinase cascade and the renin-angiotensin system. ..
  31. ncbi request reprint Statin use and calcific uremic arteriolopathy: a matched case-control study
    Sagar U Nigwekar
    Division of Nephrology, Dermatopathology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Nephrol 37:325-32. 2013
    ..Prior research has shown that statins have anticalcification, antithrombotic and antiinflammatory properties; however, the association between statin use and CUA has not been investigated...
  32. ncbi request reprint Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism
    Connie M Rhee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 172:153-9. 2012
    ..Despite compelling biological plausibility and clinical implication, the association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism has not been rigorously studied...