Clemens Bergwitz

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Roles of major facilitator superfamily transporters in phosphate response in Drosophila
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e31730. 2012
  2. ncbi request reprint Dietary phosphate modifies lifespan in Drosophila
    Clemens Bergwitz
    Correspondence and offprint requests to Clemens Bergwitz E mail
    Nephrol Dial Transplant 27:3399-406. 2012
  3. pmc SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Hum Genet 78:179-92. 2006
  4. pmc Disorders of phosphate homeostasis and tissue mineralisation
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Endocr Dev 16:133-56. 2009
  5. pmc Defective O-glycosylation due to a novel homozygous S129P mutation is associated with lack of fibroblast growth factor 23 secretion and tumoral calcinosis
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:4267-74. 2009
  6. doi request reprint Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Annu Rev Med 61:91-104. 2010
  7. pmc Phosphate sensing
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Adv Chronic Kidney Dis 18:132-44. 2011
  8. pmc Genetic determinants of phosphate response in Drosophila
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e56753. 2013
  9. pmc Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs
    So Nagai
    Endocrine Unit, Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:1618-26. 2011
  10. doi request reprint FGF23 and syndromes of abnormal renal phosphate handling
    Clemens Bergwitz
    Harvard Medical School, Boston, MA, USA
    Adv Exp Med Biol 728:41-64. 2012

Detail Information

Publications15

  1. pmc Roles of major facilitator superfamily transporters in phosphate response in Drosophila
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e31730. 2012
    ..Finally, while phosphate is essential for Drosophila larval development, loss of MFS13 activity is compatible with viability indicating redundancy at the levels of the transporters...
  2. ncbi request reprint Dietary phosphate modifies lifespan in Drosophila
    Clemens Bergwitz
    Correspondence and offprint requests to Clemens Bergwitz E mail
    Nephrol Dial Transplant 27:3399-406. 2012
    ....
  3. pmc SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Hum Genet 78:179-92. 2006
    ..We conclude that NaP(i)-IIc has a key role in the regulation of phosphate homeostasis...
  4. pmc Disorders of phosphate homeostasis and tissue mineralisation
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Endocr Dev 16:133-56. 2009
    ..This chapter will provide an update on the current knowledge of the pathophysiology, the clinical presentation, diagnostic evaluation and therapy of the disorders of phosphate homeostasis and tissue mineralisation...
  5. pmc Defective O-glycosylation due to a novel homozygous S129P mutation is associated with lack of fibroblast growth factor 23 secretion and tumoral calcinosis
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:4267-74. 2009
    ..However, it remained unclear to date how these mutations lead to loss of biologically active FGF23 in the circulation...
  6. doi request reprint Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Annu Rev Med 61:91-104. 2010
    ..Most insights gained into the regulation of phosphate homeostasis by these factors are derived from human genetic disorders and genetically engineered mice, which are reviewed in this paper...
  7. pmc Phosphate sensing
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Adv Chronic Kidney Dis 18:132-44. 2011
    ..This article will review the bacterial and yeast phosphate sensors, and then discuss what is currently known about the metabolic and endocrine effects of phosphate in multicellular organisms and human beings...
  8. pmc Genetic determinants of phosphate response in Drosophila
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e56753. 2013
    ..We identified a number of candidate genes potentially important for the cellular response to phosphate. Evaluation of 51 genes in live flies revealed some that affect larval development, adult life span and hemolymph phosphate levels...
  9. pmc Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs
    So Nagai
    Endocrine Unit, Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:1618-26. 2011
    ....
  10. doi request reprint FGF23 and syndromes of abnormal renal phosphate handling
    Clemens Bergwitz
    Harvard Medical School, Boston, MA, USA
    Adv Exp Med Biol 728:41-64. 2012
    ..Loss-of-function mutations in these two transporters lead to autosomal recessive Fanconi syndrome or to hereditary hypophosphatemic rickets with hypercalciuria, respectively...
  11. pmc Fanconi-Bickel syndrome and autosomal recessive proximal tubulopathy with hypercalciuria (ARPTH) are allelic variants caused by GLUT2 mutations
    MICHAEL MANNSTADT
    Massachusetts General Hospital, Endocrine Unit, Harvard Medical School, Thier 1051, 55 Fruit Street, Boston Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E1978-86. 2012
    ..Many inherited disorders of calcium and phosphate homeostasis are unexplained at the molecular level...
  12. pmc A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc
    Graciana Jaureguiberry
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Physiol Renal Physiol 295:F371-9. 2008
    ..M137 thus may uncouple sodium-phosphate cotransport, suggesting that this amino acid residue has an important functional role in human NaPi-IIc...
  13. pmc Genetic evidence of serum phosphate-independent functions of FGF-23 on bone
    Despina Sitara
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000154. 2008
    ....
  14. pmc An integrative approach to ortholog prediction for disease-focused and other functional studies
    Yanhui Hu
    Drosophila RNAi Screening Center, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    BMC Bioinformatics 12:357. 2011
    ..Several tools for predicting orthologous gene relationships are available. However, these tools can give different results and identification of predicted orthologs is not always straightforward...
  15. pmc Autoimmune hypocalciuric hypercalcemia unresponsive to glucocorticoid therapy in a patient with blocking autoantibodies against the calcium-sensing receptor
    J Carl Pallais
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:672-80. 2011
    ..Previously, glucocorticoid treatment has been shown to decrease the CaSR autoantibody titers and normalize the hypercalcemia in a patient with autoimmune hypocalciuric hypercalcemia (AHH)...

Research Grants2

  1. Role of the renal sodium-phosphate co-transporter NaPi-IIc in phosphate homeostas
    Clemens Bergwitz; Fiscal Year: 2007
    ..A K08 career development award by the NIH will help me to further explore the importance of NaPi-llc in mammalian biology, and allow me to acquire new skills on my way to becoming an independent scientist. ..