Research Topics
| Lino BecerraSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
| Collaborators
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Detail Information
Publications
A key role of the basal ganglia in pain and analgesia--insights gained through human functional imagingDavid Borsook
PAIN Group, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Mol Pain 6:27. 2010..These include the integration of motor, emotional, autonomic and cognitive responses to pain...- Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux)David Borsook
Pain Analgesia Imaging Neuroscience P A I N Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 1064, USA
Mol Pain 3:34. 2007..Spontaneous tics showed increased activation in classic aversion circuitry that may contribute to increased levels of anxiety. We believe that this is the first report of functional imaging of brain changes in tic-doloureaux... - Diffuse optical tomography activation in the somatosensory cortex: specific activation by painful vs. non-painful thermal stimuliLino Becerra
Pain and Analgesia Imaging Neuroscience Group, McLean Hospital, Belmont, Massachusetts, United States of America
PLoS ONE 4:e8016. 2009..Here we further our findings by studying the response to thermal innocuous and noxious stimuli... - Imaging drugs with and without clinical analgesic efficacyJaymin Upadhyay
Imaging Consortium for Drug Development, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
Neuropsychopharmacology 36:2659-73. 2011..This investigation demonstrates how CNS-acting drugs can be compared, and how the phMRI/fMRI methodology may be used with conventional measures to better evaluate candidate analgesics in small subject cohorts... 
Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphineJaymin Upadhyay
Imaging Consortium for Drug Development, PAIN Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neuroimage 59:3762-73. 2012..Such methods may be useful during early clinical phase evaluation of potential analgesics in drug development...- Segmentally arranged somatotopy within the face representation of human primary somatosensory cortexEric A Moulton
PAIN Group, Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
Hum Brain Mapp 30:757-65. 2009..Based on activation foci, somatotopic activation in the post-central gyrus was detected for brush, consistent with the segmental face representation model... - A statistical framework for optimal design matrix generation with application to fMRIGautam V Pendse
Imaging and Analysis Group IMAG, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
IEEE Trans Med Imaging 29:1573-611. 2010..Although developed with motivation from fMRI, our framework is quite general and has potentially wide applicability to a variety of disciplines... - Interictal dysfunction of a brainstem descending modulatory center in migraine patientsEric A Moulton
PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, United States of America
PLoS ONE 3:e3799. 2008..To determine whether a brainstem dysfunction could play a role in facilitating migraine attacks, we measured brainstem function in migraineurs when they were not having an attack (i.e. the interictal phase)... - Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI studyEric A Moulton
P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neuroimage 35:1586-600. 2007..The involvement of these emotion-related regions suggests that they may be highly sensitive to context, such as prior experience (application of capsaicin) and the specific pain mechanism (hyperalgesic vs. normal skin)... - Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant imagesEric A Moulton
Pain Analgesia Imaging Neuroscience Group and Clinical Psychopathology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
J Neurosci 31:3795-804. 2011..The separate cortical networks suggest that noxious heat-evoked responses in the cerebellum can be divided into sensorimotor and emotional networks... - Robust, unbiased general linear model estimation of phMRI signal amplitude in the presence of variation in the temporal response profileGautam V Pendse
P A I N Group, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
J Magn Reson Imaging 31:1445-57. 2010..If not properly accounted for, this variation can result in inaccurate and unevenly biased signal amplitude estimates when modeled within a general linear model (GLM) framework... - A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot studySteven Scrivani
P A I N Group, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
Pain Med 11:920-41. 2010.... 
Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imagingDavid Borsook
P A I N Group, Massachusetts General Hospital, McLean Hospital, and Children s Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
Discov Med 11:209-19. 2011..An important area for future research is to image clinical ongoing pain to further our knowledge of brain function in different pain states and the effects of treatment...- Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobiaNasim Maleki
PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Hum Brain Mapp 33:75-88. 2012..Consistent with physiological and anatomical studies in rats, the data provide an anatomical substrate for exacerbation of migraine headache by light in the human... - Yohimbine-induced amygdala activation in pathological gamblers: a pilot studyIgor Elman
Bedford Veterans Administration Medical Center and Department of Psychiatry, Cambridge Health Alliance, Harvard Medical School, Somerville, Massachusetts, United States of America
PLoS ONE 7:e31118. 2012..In this pilot functional magnetic resonance imaging (fMRI) study we assessed whether a prototype behavioral addiction, pathological gambling (PG), is likewise associated with an enhanced response to stress... - Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutionsDavid Borsook
P A I N Group, Massachusetts General Hospital, McLean Hospital, and Children s Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
Discov Med 11:197-207. 2011..The fit-for-purpose, scientific validation, and clinical qualification of novel CNS biomarkers for chronic pain could dramatically change the current outlook for treatment of chronic pain and research into its etiology... - A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #2: protocol optimization and best practicesAdam J Schwarz
Imaging Consortium for Drug Development, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Drug Discov Today 16:671-82. 2011.... - A simple and objective method for reproducible resting state network (RSN) detection in fMRIGautam V Pendse
PAIN Group, Imaging and Analysis Group, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, United States of America
PLoS ONE 6:e27594. 2011..org). Our reproducibility analyses indicated that many of the published RSNs in rsfMRI literature are highly reproducible. However, we found several other RSNs that are highly reproducible but not frequently listed in the literature... - Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuliLino Becerra
Pain and Analgesia Imaging and Neuroscience Group, Department of Psychiatry, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:10646-57. 2006..Thus, sensory processing in patients with trigeminal neuropathic pain is associated with distinct activation patterns consistent with sensitization within and outside of the primary sensory pathway... - Functional imaging of the trigeminal system: applications to migraine pathophysiologyDavid Borsook
P.A.I.N. Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478-9106, USA
Headache 46:S32-8. 2006.... - Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinicDavid Borsook
P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Curr Pain Headache Rep 11:201-7. 2007..It is possible that fMRI may become clinically useful... - Noninvasive mapping of human trigeminal brainstem pathwaysJaymin Upadhyay
PAIN Group, Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
Magn Reson Med 60:1037-46. 2008..Application of DTI to map pain and somatosensory pathways in conjunction with a characterization of function properties of pain and somatosensory processing would further define the systematic changes that occur in trigeminal pathology... - Alterations in brain structure and functional connectivity in prescription opioid-dependent patientsJaymin Upadhyay
P A I N Group, Harvard Medical School, c o Brain Imaging Centre, McLean Hospital, Department of Psychiatry, 115 Mill Street, Belmont, MA 02478 9106, USA
Brain 133:2098-114. 2010..These results may have important clinical implications for uncovering the effects of long-term prescription opioid use on brain structure and function... - Excitatory neurotransmitters in brain regions in interictal migraine patientsAndrew Prescot
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
Mol Pain 5:34. 2009..We hypothesized that there may be differences in levels of excitatory amino acid neurotransmitters and/or their derivatives in migraine group based on their increased sensitivity to pain... - Robust reproducible resting state networks in the awake rodent brainLino Becerra
Pain and Analgesia Imaging Neuroscience Group, A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e25701. 2011..This analysis indicates that 7 networks are robust and reproducible in the rat and their putative role is discussed... - Evaluation of novel drugs using fMRI in early-phase clinical trials: safety monitoringEdward George
Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Drug Discov Today 15:684-9. 2010..This could lead to the adoption of standards. Some of these issues are unique to the application of the technology in early-phase trials... - Neuroimaging of the periaqueductal gray: state of the fieldClas Linnman
Pain and Analgesia Imaging Neuroscience Group, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Neuroimage 60:505-22. 2012.... - An approach to localizing corneal pain representation in human primary somatosensory cortexEric A Moulton
P A I N Group, Center for Pain and the Brain, Children s Hospital Boston, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 7:e44643. 2012..This finding opens future avenues of research to evaluate the relationship between corneal pain and central brain mechanisms relating to the development of chronic pain conditions, such as dry eye-like symptoms... - Enhanced false discovery rate using Gaussian mixture models for thresholding fMRI statistical mapsGautam Pendse
Pain and Analgesia Imaging and Neuroscience Group, McLean Hospital, Belmont, MA, USA
Neuroimage 47:231-61. 2009..Our results indicate that it is very important to account for the form and fraction of the "null" hypothesis adaptively from the data in order to obtain valid inference... - Emotional pain without sensory pain--dream on?David Borsook
Pain and Analgesia Imaging Neuroscience Group, Brain Imaging Center, McLean Hospital, Belmont, MA 02476, USA
Neuron 61:153-5. 2009..As such, it provides insights into the brain's ability to evaluate others' feeling to observed pain without having a specific sensory experience of pain itself... - Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteersLino Becerra
P.A.I.N. Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
Anesth Analg 103:208-16, table of contents. 2006..Activation patterns were opposite to those previously observed for the mu antagonist, naloxone... - Functional imaging of pain and analgesia--a valid diagnostic tool?David Borsook
Brain Imaging Centre, Department of Psychiatry, P A I N Group, McLean Hospital, Belmont, MA, USA
Pain 117:247-50. 2005 - Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and diseaseDavid Borsook
P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478 9106, USA
J Neurobiol 61:107-25. 2004..These advances are likely to contribute greatly to the diagnosis and treatment of clinical pain conditions affecting the trigeminal system (e.g., neuropathic pain, migraine)... - How close are we in utilizing functional neuroimaging in routine clinical diagnosis of neuropathic pain?David Borsook
Center for Pain and the Brain, c o Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Curr Pain Headache Rep 15:223-9. 2011..The routine application of brain imaging as a clinical marker of disease state or therapeutic (drug) efficacy would significantly enhance the clinical process by providing objective measures for clinicians and patients...