Research Topics
Genomes and GenesSpecies | David BartelSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
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Publications
Vertebrate microRNA genesLee P Lim
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 299:1540. 2003
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAsKatsutomo Okamura
Sloan Kettering Institute, Department of Developmental Biology, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA
Nature 453:803-6. 2008..These novel regulatory RNAs reveal unexpected complexity in the sorting of small RNAs, and open a window onto the biological usage of endogenous RNA interference in Drosophila...- Constructing an RNA worldD P Bartel
Whitehead Institute for Biomedical Research and Dept of Biology, MIT, 9 Cambridge Center, Cambridge, MA 02142, USA
Trends Cell Biol 9:M9-M13. 1999..Filling these gaps would place the hypothesis on much firmer ground and provide components for building minimal forms of RNA-based cellular life... - Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAsDavid P Bartel
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Rev Genet 5:396-400. 2004 - MicroRNAs: genomics, biogenesis, mechanism, and functionDavid P Bartel
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 116:281-97. 2004..Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes... 
MicroRNAs: target recognition and regulatory functionsDavid P Bartel
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 136:215-33. 2009..This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes...- Small RNAs correspond to centromere heterochromatic repeatsBrenda J Reinhart
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Science 297:1831. 2002 - The microRNAs of Caenorhabditis elegansLee P Lim
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Genes Dev 17:991-1008. 2003..Our census of the worm miRNAs and their expression patterns helps define this class of noncoding RNAs, lays the groundwork for functional studies, and provides the tools for more comprehensive analyses of miRNA genes in other species... - Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identificationUwe Ohler
Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
RNA 10:1309-22. 2004..The improved analysis supports our previous assertion that miRNA gene identification is nearing completion in C. elegans with apparently no more than 20 miRNA genes now remaining to be identified... - A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strandsAlexander Stark
Broad Institute of Massachussetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02141, USA
Genes Dev 22:8-13. 2008..We also report sense/antisense miRNAs in mouse and find antisense transcripts close to many miRNAs in both flies and mammals, suggesting that additional sense/antisense pairs exist... - Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegansJ Graham Ruby
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 127:1193-207. 2006..The motif is conserved in other nematodes, presumably because of its importance for producing these diverse, autonomously expressed, small RNAs (dasRNAs)... - MicroRNAs in plantsBrenda J Reinhart
Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Genes Dev 16:1616-26. 2002..The previously described roles of CARPEL FACTORY in the development of Arabidopsis embryos, leaves, and floral meristems suggest that the miRNAs could play regulatory roles in the development of plants as well as animals... - Prediction of plant microRNA targetsMatthew W Rhoades
Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142, USA
Cell 110:513-20. 2002..The targeting of developmental transcription factors suggests that many plant miRNAs function during cellular differentiation to clear key regulatory transcripts from daughter cell lineages... - Discovery of functional elements in 12 Drosophila genomes using evolutionary signaturesAlexander Stark
The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02140, USA
Nature 450:219-32. 2007..We also study how discovery power scales with the divergence and number of species compared, and we provide general guidelines for comparative studies... - Mammalian microRNAs predominantly act to decrease target mRNA levelsHuili Guo
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Nature 466:835-40. 2010..These results show that changes in mRNA levels closely reflect the impact of miRNAs on gene expression and indicate that destabilization of target mRNAs is the predominant reason for reduced protein output... - Computational identification of plant microRNAs and their targets, including a stress-induced miRNAMatthew W Jones-Rhoades
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
Mol Cell 14:787-99. 2004..The expression of miR395, the sulfurylase-targeting miRNA, increases upon sulfate starvation, showing that miRNAs can be induced by environmental stress... - Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAsJ Graham Ruby
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genome Res 17:1850-64. 2007.... - A two-hit trigger for siRNA biogenesis in plantsMichael J Axtell
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
Cell 127:565-77. 2006..Therefore, two "hits,"--often, but not always, two cleavage events--constitute a conserved trigger for siRNA biogenesis, a finding with implications for recognition and silencing of aberrant RNA... - The widespread impact of mammalian MicroRNAs on mRNA repression and evolutionKyle Kai-How Farh
Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 310:1817-21. 2005.... - A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thalianaRamya Rajagopalan
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genes Dev 20:3407-25. 2006.... - Most Caenorhabditis elegans microRNAs are individually not essential for development or viabilityEric A Miska
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
PLoS Genet 3:e215. 2007..This study represents the first comprehensive genetic analysis of miRNA function in any organism and provides a unique, permanent resource for the systematic study of miRNAs... - The impact of microRNAs on protein outputDaehyun Baek
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 455:64-71. 2008..The impact of microRNAs on the proteome indicated that for most interactions microRNAs act as rheostats to make fine-scale adjustments to protein output... - Early origins and evolution of microRNAs and Piwi-interacting RNAs in animalsAndrew Grimson
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 455:1193-7. 2008..Nonetheless, miRNAs and piRNAs have been available as classes of riboregulators to shape gene expression throughout the evolution and radiation of animal phyla... - Allelic imbalance sequencing reveals that single-nucleotide polymorphisms frequently alter microRNA-directed repressionJinkuk Kim
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
Nat Biotechnol 27:472-7. 2009..Extrapolating these results to the other broadly conserved miRNAs suggests that when comparing two mouse strains (or two human individuals), polymorphic miRNA sites cause expression of many genes (often hundreds) to differ... - Mammalian microRNAs: experimental evaluation of novel and previously annotated genesH Rosaria Chiang
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genes Dev 24:992-1009. 2010.... - Control of developmental regulators by Polycomb in human embryonic stem cellsTong Ihn Lee
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 125:301-13. 2006..These results indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed to maintain pluripotency and that are poised for activation during ES cell differentiation... - RNAi in budding yeastInes A Drinnenberg
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 326:544-50. 2009..These results identify a previously unknown class of Dicer proteins, bring the tool of RNAi to the study of budding yeasts, and bring the tools of budding yeast to the study of RNAi... - Coherent but overlapping expression of microRNAs and their targets during vertebrate developmentAlena Shkumatava
Whitehead Institute of Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 01142, USA
Genes Dev 23:466-81. 2009..However, for most targets expression was lower in miRNA-expressing cells than in the rest of the embryo, indicating that miRNAs usually operate in concert with the other regulatory machinery of the cell... - MicroRNAs prevent precocious gene expression and enable pattern formation during plant embryogenesisMichael D Nodine
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genes Dev 24:2678-92. 2010..We propose that, by preventing precocious expression of differentiation-promoting transcription factors, miRNAs enable proper embryonic patterning... - miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurelyBeiyan Zhou
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 104:7080-5. 2007..Our results indicate that miR-150 most likely down-regulates mRNAs that are important for pre- and pro-B cell formation or function, and its ectopic expression in these cells blocks further development of B cells... - Intronic microRNA precursors that bypass Drosha processingJ Graham Ruby
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 448:83-6. 2007..This suggests that other lineages with many similarly sized introns probably also have mirtrons, and that the mirtron pathway could have provided an early avenue for the emergence of miRNAs before the advent of Drosha... - MicroRNA targeting specificity in mammals: determinants beyond seed pairingAndrew Grimson
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Cell 27:91-105. 2007..Because it predicts site efficacy without recourse to evolutionary conservation, the model also identifies effective nonconserved sites and siRNA off-targets... - MicroRNAs in the Hox network: an apparent link to posterior prevalenceSoraya Yekta
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Nat Rev Genet 9:789-96. 2008..In this way, miRNA-mediated regulation seems to recapitulate interactions at other levels of gene expression, some more ancestral, within a network under stabilizing selection... - Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cellsAlexander Marson
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 134:521-33. 2008..These data reveal how key ES cell transcription factors promote the ES cell miRNA expression program and integrate miRNAs into the regulatory circuitry controlling ES cell identity... - Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationChristine Mayr
Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 315:1576-9. 2007..Thus, losing miRNA-directed repression of an oncogene provides a mechanism for tumorigenesis, and disrupting a single miRNA-target interaction can produce an observable phenotype in mammalian cells... - Prediction of mammalian microRNA targetsBenjamin P Lewis
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 115:787-98. 2003..The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions... - MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' regionAllison C Mallory
Whitehead Institute for Biomedical Research, Cambridge, MA 02142 1479, USA
EMBO J 23:3356-64. 2004.... - MicroRNA regulation of NAC-domain targets is required for proper formation and separation of adjacent embryonic, vegetative, and floral organsAllison C Mallory
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142 USA
Curr Biol 14:1035-46. 2004.... - Censors of the genomeNelson C Lau
Massachusetts Institute of Technology, USA
Sci Am 289:34-41. 2003 - MicroRNA-directed cleavage of HOXB8 mRNASoraya Yekta
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Science 304:594-6. 2004.... - Processivity of ribozyme-catalyzed RNA polymerizationMichael S Lawrence
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Biochemistry 42:8748-55. 2003..This finding contributes to the understanding of one of the more sophisticated activities yet to be generated de novo in the laboratory and sheds light on the parameters to be targeted for further optimization... - Expanding the microRNA targeting code: functional sites with centered pairingChanseok Shin
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Mol Cell 38:789-802. 2010..This expanded repertoire of cleavage targets and the identification of the centered site type help explain why central regions of many miRNAs are evolutionarily conserved... - A ribozyme that ligates RNA to proteinScott Baskerville
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 99:9154-9. 2002.... - A class I ligase ribozyme with reduced Mg2+ dependence: Selection, sequence analysis, and identification of functional tertiary interactionsSarah C Bagby
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
RNA 15:2129-46. 2009.... - Improved polymerase ribozyme efficiency on hydrophobic assembliesULRICH F MULLER
Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
RNA 14:552-62. 2008..We discuss how, during the origin of life, micellar ribozyme aggregates could have acted as precursors to membrane-encapsulated life forms... - The three-dimensional architecture of the class I ligase ribozymeNicholas H Bergman
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
RNA 10:176-84. 2004..The predictive value of the model was tested and supported by a photo-cross-linking experiment... - MicroRNAs modulate hematopoietic lineage differentiationChang Zheng Chen
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Science 303:83-6. 2004..Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development... - Crystal structure of the catalytic core of an RNA-polymerase ribozymeDavid M Shechner
Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 326:1271-5. 2009..A cytosine nucleobase and two backbone phosphates abut the ligation junction; their location suggests a model for catalysis resembling that of proteinaceous polymerases... - Most mammalian mRNAs are conserved targets of microRNAsRobin C Friedman
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Genome Res 19:92-105. 2009..Our expanded set of target predictions (including conserved 3'-compensatory sites), are available at the TargetScan website, which displays the P(CT) for each site and each predicted target... - Metal ion requirements for structure and catalysis of an RNA ligase ribozymeMargaret E Glasner
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
Biochemistry 41:8103-12. 2002..Ligation rates of the prefolded ribozyme were directly measured and proceed at 800 min(-1) at pH 9.0... - Compact and ordered collapse of randomly generated RNA sequencesErik A Schultes
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Struct Mol Biol 12:1130-6. 2005..Thus, for RNAs the size of small ribozymes, natural selection seems necessary to achieve uniquely folding sequences, but not to account for the well-ordered secondary structures and overall compactness observed in nature... - Antiquity of microRNAs and their targets in land plantsMichael J Axtell
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Plant Cell 17:1658-73. 2005..Therefore, several individual miRNA regulatory circuits have ancient origins and have remained intact throughout the evolution and diversification of plants... - New ligase-derived RNA polymerase ribozymesMichael S Lawrence
Whitehead Institute for Biomedical Research/Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
RNA 11:1173-80. 2005..Because each of them is a new potential starting point for further in vitro evolution and engineering, together they substantially enrich the set of candidates from which an RNA replicase ribozyme might eventually emerge... - Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genesScott Baskerville
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
RNA 11:241-7. 2005.... - MicroRNAS and their regulatory roles in plantsMatthew W Jones-Rhoades
Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, Cambridge, Massachusetts 02142, USA
Annu Rev Plant Biol 57:19-53. 2006.... - MicroRNA-directed regulation of Arabidopsis AUXIN RESPONSE FACTOR17 is essential for proper development and modulates expression of early auxin response genesAllison C Mallory
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Plant Cell 17:1360-75. 2005.... - The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb developmentEran Hornstein
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 438:671-4. 2005.... - A biochemical framework for RNA silencing in plantsGuiliang Tang
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 17:49-63. 2003..Thus, endonuclease complexes guided by small RNAs are a common feature of RNA silencing in both animals and plants... - MicroRNAs: at the root of plant development?Bonnie Bartel
Department Biochemistry, Rice University, Houston, Texas 77005, USA
Plant Physiol 132:709-17. 2003 - PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegansPedro J Batista
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Cell 31:67-78. 2008..Our findings demonstrate that 21U-RNAs are the piRNAs of C. elegans and link this class of small RNAs and their associated Piwi Argonaute to the maintenance of temperature-dependent fertility... - Characterization of the piRNA complex from rat testesNelson C Lau
Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
Science 313:363-7. 2006..Piwi has been genetically linked to TGS in flies, and slicer activity cofractionates with the purified complex. These results are consistent with a gene-silencing role for piRC in mammals... - The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegansAllison L Abbott
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Dev Cell 9:403-14. 2005..These results indicate that let-7 family microRNAs function in combination to affect both early and late developmental timing decisions... - Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexesChristian Matranga
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Cell 123:607-20. 2005..For siRNAs, virtually all RISC is assembled through this cleavage-assisted mechanism. In contrast, passenger-strand cleavage is not important for the incorporation of miRNAs that derive from mismatched duplexes... - MicroRNAs regulate brain morphogenesis in zebrafishAntonio J Giraldez
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Science 308:833-8. 2005..Injection of miR-430 miRNAs rescues the brain defects in MZdicer mutants, revealing essential roles for miRNAs during morphogenesis... - Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defectsMing Li
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
Dev Cell 9:415-22. 2005..These results suggest that lin-58 alleles disrupt a repressor binding site that restricts the time of miR-48 action in wild-type animals... - Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAsVirginie Gasciolli
Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
Curr Biol 15:1494-500. 2005.... - A uniform system for microRNA annotationVictor Ambros
Dartmouth Medical School Department of Genetics, Hanover, New Hampshire 03755, USA
RNA 9:277-9. 2003..Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families... - AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1Herve Vaucheret
Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, 78026 Versailles Cedex, France
Mol Cell 22:129-36. 2006..We suggest that miR168 stabilization occurs at the level of silencing-complex assembly and that modulating the efficiency of assembling miRNA-programmed silencing complexes will also be important in other contexts... - Combinatorial minimization and secondary structure determination of a nucleotide synthase ribozymeKelly E Chapple
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
RNA 9:1208-20. 2003.... - TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathwayMarc Buhler
Department of Cell Biology, 240 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115 USA
Nat Struct Mol Biol 15:1015-23. 2008..Thus, Cid14 prevents certain abundant RNAs from becoming substrates for the RNAi machinery, thereby freeing the RNAi machinery to act on its proper targets... - Common functions for diverse small RNAs of land plantsMichael J Axtell
Department of Biology and Huck Institutes of the Life Sciences, Pensylvania State University, University Park, PA 16802, USA
Plant Cell 19:1750-69. 2007..Diverse, lineage-specific, small RNAs can therefore perform common biological functions in plants... - Endogenous siRNA and miRNA targets identified by sequencing of the Arabidopsis degradomeCharles Addo-Quaye
Department of Computer Science and Engineering, Pennsylvania State University, University Park, PA 16802, USA
Curr Biol 18:758-62. 2008..This empirical method is broadly applicable to the discovery and quantification of cleaved targets of small RNAs without a priori predictions... - The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant developmentHerve Vaucheret
Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, 78026 Versailles Cedex, France
Genes Dev 18:1187-97. 2004.... - Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAsFranck Vazquez
, UPRES-EA3569, IFR118, EPT1016, , , , 59650 Villeneuve d'Ascq Cedex, France
Mol Cell 16:69-79. 2004..The identification of this silencing pathway provides yet another dimension to posttranscriptional mRNA regulation in plants... - Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAsLee P Lim
Rosetta Inpharmatics, Merck and Co, 401 Terry Avenue N, Seattle, Washington 98109, USA
Nature 433:769-73. 2005..Moreover, miR-1 and miR-124, and presumably other tissue-specific miRNAs, seem to downregulate a far greater number of targets than previously appreciated, thereby helping to define tissue-specific gene expression in humans... - Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsBenjamin P Lewis
Cell 120:15-20. 2005..Targeting was also detected in open reading frames. In sum, well over one third of human genes appear to be conserved miRNA targets...
Research Grants
- RNA CONFORMATION AND CATALYSISDavid Bartel; Fiscal Year: 2007....
- The Roles of MicroRNAs in Plant DevelopmentDavid Bartel; Fiscal Year: 2007....
- MicroRNA genes and their functionsDavid Bartel; Fiscal Year: 2005..abstract_text> ..
- RNA CONFORMATION AND CATALYSISDavid Bartel; Fiscal Year: 2003..abstract_text> ..
- MicroRNA genes and their functionsDavid P Bartel; Fiscal Year: 2010..Achieving these goals will shed light on why microRNAs are needed for normal growth and development, and how their dysfunction can contribute to human diseases. ..