Research Topics
Genomes and Genes
| Nabeel BardeesySummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouseNabeel Bardeesy
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:5947-52. 2006....- Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasiaNabeel Bardeesy
Department of Adult Oncology, Dana Farber Cancer Institute, National Cancer Institute, Bethesda, Maryland, USA
Mol Cell Biol 22:635-43. 2002..This genetically defined model provides insights into the molecular pathogenesis of SCA and serves as a platform for dissection of cell-specific programs of epithelial tumor suppression... - Genetics and biology of pancreatic ductal adenocarcinomaAram F Hezel
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Genes Dev 20:1218-49. 2006..This confluence of developments offers the opportunity for accelerated discovery and the future promise of improved treatment... - Modeling INK4/ARF tumor suppression in the mouseJustin H Berger
Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
Curr Mol Med 7:63-75. 2007.... - A mouse plasma peptide atlas as a resource for disease proteomicsQing Zhang
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Genome Biol 9:R93. 2008..A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis... - Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancerNabeel Bardeesy
Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 20:3130-46. 2006.... - RAS unplugged: negative feedback and oncogene-induced senescenceNabeel Bardeesy
Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer Cell 10:451-3. 2006.... - Role of epidermal growth factor receptor signaling in RAS-driven melanomaNabeel Bardeesy
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Mol Cell Biol 25:4176-88. 2005..Thus, this inducible tumor model system permits the identification and validation of alternative points of therapeutic intervention without neutralization of the primary genetic lesion... - Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasmsAram F Hezel
MGH Cancer Center, Simches Research Building, CPZN 4216, 185 Cambridge St, Boston, MA 02114, USA
Mol Cell Biol 28:2414-25. 2008..These genetic studies provide in vivo evidence of a key role for LKB1 in the establishment of epithelial cell polarity that is vital for pancreatic acinar cell function and viability and for the suppression of neoplasia... - LKB1 modulates lung cancer differentiation and metastasisHongbin Ji
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nature 448:807-10. 2007..These studies establish LKB1 as a critical barrier to pulmonary tumorigenesis, controlling initiation, differentiation and metastasis... - The LKB1 tumor suppressor negatively regulates mTOR signalingReuben J Shaw
Department of Systems Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
Cancer Cell 6:91-9. 2004..These findings position aberrant mTOR activation at the nexus of these germline neoplastic conditions and suggest the use of mTOR inhibitors in the treatment of Peutz-Jeghers syndrome... - Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancerSamanthi A Perera
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Carcinogenesis 29:747-53. 2008..Furthermore, these findings clearly demonstrate (in an in vivo model system) the dual nature of telomere shortening as both a tumor-suppressive and tumor-promoting mechanism in lung cancer, dependent on p53 status... - Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinomaAndrew J Aguirre
Department of Medical Oncology, Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Genes Dev 17:3112-26. 2003..This faithful mouse model may permit the systematic analysis of genetic lesions implicated in the human disease and serve as a platform for the identification of early disease markers and for the efficient testing of novel therapies... - Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformationNabeel Bardeesy
Department of Adult Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 419:162-7. 2002..Together, our data rationalize several features of PJS polyposis--notably its peculiar histopathological presentation and limited malignant potential--and place Lkb1 in a distinct class of tumour suppressors... - Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumorsJulian Carretero
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115 USA
Cancer Cell 17:547-59. 2010..These studies demonstrate that integrated genomic and proteomic analyses can be used to identify signaling pathways that may be targeted for treatment... - The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metforminReuben J Shaw
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
Science 310:1642-6. 2005..Finally, we show that metformin, one of the most widely prescribed type 2 diabetes therapeutics, requires LKB1 in the liver to lower blood glucose levels... - STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesisRyan B Corcoran
Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
Cancer Res 71:5020-9. 2011..Moreover, our work suggests that gp130 and phospho-STAT3 expression may be effective biomarkers for predicting response to JAK2 inhibitors... - Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogeneDawang Zhou
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Cancer Cell 16:425-38. 2009..Approximately 30% of human HCCs show low Yap1(Ser127) phosphorylation and a majority exhibit loss of cleaved, activated Mst1. Mst1/2 inhibition of Yap1 is an important pathway for tumor suppression in liver relevant to human HCC... - The Lkb1 metabolic sensor maintains haematopoietic stem cell survivalSushma Gurumurthy
Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 468:659-63. 2010..Instead, these data define a central role for Lkb1 in restricting HSC entry into cell cycle and in broadly maintaining energy homeostasis in haematopoietic cells through a novel metabolic checkpoint... - SMAD4-dependent barrier constrains prostate cancer growth and metastatic progressionZhihu Ding
Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nature 470:269-73. 2011..This model-informed progression analysis, together with genetic, functional and translational studies, establishes SMAD4 as a key regulator of PCA progression in mice and humans... - Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cellsAlexandros Tzatsos
Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 286:33061-9. 2011.... - LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesisSushma Gurumurthy
Massachusetts General Hospital, Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer Res 68:55-63. 2008..Our data indicate that Lkb1 is a potent suppressor of carcinogen-induced skin and lung cancers and that downstream targets beyond the AMPK-mTOR pathway are likely mediators of Lkb1-dependent tumor suppression... - A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic responseZhao Chen
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 483:613-7. 2012.... - Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancersDavid T Ting
Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
Science 331:593-6. 2011..The overexpression of satellite transcripts in cancer may reflect global alterations in heterochromatin silencing and could potentially be useful as a biomarker for cancer detection... - The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressReuben J Shaw
Department of Systems Biology, Harvard Medical School, and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 101:3329-35. 2004..The role of LKB1/AMPK in the survival of a subset of genetically defined tumor cells may provide opportunities for cancer therapeutics... - YAP oncogene overexpression supercharges colon cancer proliferationJoseph Avruch
Department of Molecular Biology Massachusetts General Hospital Boston, MA USA Diabetes Unit Massachusetts General Hospital Boston, MA USA Department of Medicine Harvard Medical School Boston, MA USA
Cell Cycle 11:1090-6. 2012..This interplay between overexpressed YAP and β-catenin also drives proliferation of colon cancer cells. The dispensability of YAP in normal intestine makes YAP's expression or outputs attractive targets for cancer therapy... - Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinomaRuben Plentz
Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
Gastroenterology 136:1741-9.e6. 2009..We investigated the role of this pathway in PDAC progression... - High-resolution characterization of the pancreatic adenocarcinoma genomeAndrew J Aguirre
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:9067-72. 2004..Thus, the integration of DNA and RNA profiles provides a highly productive entry point for the discovery of genes involved in the pathogenesis of pancreatic adenocarcinoma... - RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasisMin Yu
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 487:510-3. 2012..Thus, molecular analysis of CTCs may identify candidate therapeutic targets to prevent the distal spread of cancer... - Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell agingAlexandros Tzatsos
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA
Cell Stem Cell 3:469-70. 2008.... - Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failureYoji Andrew Minamishima
Department of Medical Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Blood 111:3236-44. 2008..The latter is likely the result of hyperviscosity syndrome and volume overload, although a direct effect of chronic, high-level HIF stimulation on cardiac myocytes cannot be excluded... - Pancreatic cancer biology and geneticsNabeel Bardeesy
Department of Adult Oncology, Dana Farber Cancer Institute and Departments of Medicine and Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Cancer 2:897-909. 2002.... - TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progressionAram F Hezel
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer Res 72:4840-5. 2012..Therefore, our findings indicate that αvβ6 and TGF-β act in a common tumor suppressor pathway whose pharmacologic inactivation promotes pancreatic cancer progression... - PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine networkHaoqiang Ying
Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02215, USA
Cancer Discov 1:158-69. 2011..Thus, PTEN/phosphoinositide 3-kinase (PI3K) pathway alteration is a common event in PDAC development and functions in part to strongly activate the NF-κB network, which may serve to shape the PDAC tumor microenvironment... - Pancreatic cancers require autophagy for tumor growthShenghong Yang
Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 25:717-29. 2011.... - The WTX tumor suppressor regulates mesenchymal progenitor cell fate specificationAnnie Moisan
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA
Dev Cell 20:583-96. 2011..Furthermore, the constellation of anomalies in Wtx null mice suggests that this tumor suppressor broadly regulates MPCs in multiple tissues... - Mutational profiling reveals PIK3CA mutations in gallbladder carcinomaVikram Deshpande
Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
BMC Cancer 11:60. 2011..The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined... - Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGFβ type II receptor independent mannerYingqi Teng
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Biochem Biophys Res Commun 407:633-9. 2011..Our results emphasize the importance of BMP signaling pathways in the maturation and function of certain lineages of chondrocytes and offer an insight into the heterogeneity of the chondrocyte population in the body... - LKB1 (XEEK1) regulates Wnt signalling in vertebrate developmentOlga Ossipova
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Nat Cell Biol 5:889-94. 2003..These studies show that LKB1/XEEK1 is required for Wnt-beta-catenin signalling in frogs and mammals and provides novel insights into its role in vertebrate developmental patterning and carcinogenesis... - Rassf family of tumor suppressor polypeptidesJoseph Avruch
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA
J Biol Chem 284:11001-5. 2009..Herein, we review the binding of the Rassf polypeptides to Ras-like GTPases and the Mst1/2 kinases and their role in Rassf function... - Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinomaKimberly A Kelly
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
PLoS Med 5:e85. 2008..Here we sought to identify novel molecular markers and to test their potential as targeted imaging agents... - Protein kinases of the Hippo pathway: Regulation and substratesJoseph Avruch
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA Department of Medicine, Harvard Medical School, Boston, MA 02115, USA Electronic address
Semin Cell Dev Biol 23:770-84. 2012.... - Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinomaMichael R O'Dell
James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, New York 14642, USA
Cancer Res 72:1557-67. 2012..These findings establish a new genetically and histopathologically faithful model of IHCC and lend experimental support to the hypothesis that IPBN and VMC are precursors to invasive cancers... - Telomere induced senescence: end game signalingAram F Hezel
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Curr Mol Med 5:145-52. 2005..In addition, we discuss how the telomere-induced pathways intersect with the DNA damage response and document how the failure in either process results in unrestrained chromosomal instability... - In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobeKen Young Lin
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Transl Oncol 1:84-94. 2008..This clinically approved fiber-optic system, together with the fractal-based image analysis, can potentially be applied to characterize other tumors in vivo and may be a valuable tool to facilitate their clinical evaluation... - Pten constrains centroacinar cell expansion and malignant transformation in the pancreasBen Z Stanger
Howard Hughes Medical Institute and the Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Cancer Cell 8:185-95. 2005.... - Loss of Lkb1 provokes highly invasive endometrial adenocarcinomasCristina M Contreras
Department of Pathology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
Cancer Res 68:759-66. 2008..This study shows that Lkb1 plays an important role in the malignant transformation of endometrium and that Lkb1 loss promotes a highly invasive phenotype... - LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposisPekka Katajisto
Genome Scale Biology Program and Institute of Biomedicine, Biomedicum Helsinki, 00014 University of Helsinki, Finland
Nat Genet 40:455-9. 2008..We also noted TGFbeta signaling defects in polyps of individuals with PJS, suggesting that the identified stromal-derived mechanism of tumor suppression is also relevant in PJS... - A mouse to human search for plasma proteome changes associated with pancreatic tumor developmentVitor M Faca
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Med 5:e123. 2008....
Research Grants
- Mouse Model of Pancreatic Cancer Progression-MaintenanceNabeel Bardeesy; Fiscal Year: 2007..An important component of my program will be my continued participation in a multidisciplinary consortium of pancreatic cancer researchers currently in the process of addressing a series of programmatic initiatives. ..