Research Topics
| Aaron L BaggishSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Combined use of amino terminal-pro-brain natriuretic peptide levels and QRS duration to predict left ventricular systolic dysfunction in patients with dyspneaRahul Sakhuja
Cardiology Division, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Cardiol 96:263-6. 2005..This strategy can be used to predict depressed function and target more formal evaluation with echocardiography in patients with dyspnea...
Long-term anabolic-androgenic steroid use is associated with left ventricular dysfunctionAaron L Baggish
Division of Cardiology, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, Mass 02114, USA
Circ Heart Fail 3:472-6. 2010..We compared cardiac parameters in weightlifters reporting long-term AAS use to those in otherwise similar weightlifters without prior AAS exposure...- Intracranial abscess from embolic Serratia marcescens endocarditisAaron L Baggish
Department of Cardiology, Massachusetts General Hospital, Boston, MA, USA
Lancet Infect Dis 7:630. 2007 - Training-specific changes in cardiac structure and function: a prospective and longitudinal assessment of competitive athletesAaron L Baggish
Div of Cardiology, Dept of Medicine, Massachusetts General Hospital, Yawkey 5, 55 Fruit St, Boston, MA 02114, USA
J Appl Physiol 104:1121-8. 2008..EA develop biventricular dilation with enhanced diastolic function, while SA develop isolated, concentric left ventricular hypertrophy with diminished diastolic relaxation... 
Impact of family hypertension history on exercise-induced cardiac remodelingAaron L Baggish
Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA
Am J Cardiol 104:101-6. 2009..In conclusion, these findings suggest that patterns of exercise-induced LV remodeling are strongly associated with FH history status...- The impact of endurance exercise training on left ventricular systolic mechanicsAaron L Baggish
Division of Cardiology, Massachusetts General Hospital, Yawkey Suite 5B, 55 Fruit St, Boston, MA 02114, USA
Am J Physiol Heart Circ Physiol 295:H1109-H1116. 2008..001). EET leads to significant changes in LV systolic function with regional heterogeneity that may be secondary to concomitant RV adaptation. These changes are not detected by conventional measurements such as ejection fraction... - Differences in cardiac parameters among elite rowers and subelite rowersAaron L Baggish
Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA
Med Sci Sports Exerc 42:1215-20. 2010..Factors associated with this variability remain incompletely understood. To date, the relationship between the competition level at which athletes participate and their underlying cardiac parameters has not been explored... - Cardiovascular screening in college athletes with and without electrocardiography: A cross-sectional studyAaron L Baggish
Massachusetts General Hospital, Boston, 02114, USA
Ann Intern Med 152:269-75. 2010..To date, no prospective data that compare screening with and without ECG have been available... - The impact of moderate-altitude staging on pulmonary arterial hemodynamics after ascent to high altitudeAaron L Baggish
Massachusetts General Hospital, Boston, 02114, USA
High Alt Med Biol 11:139-45. 2010..SA significantly attenuated the PAP increase associated with continuous direct ascent to high altitude and appeared to uncouple PAP from both alveolar hypoxia and arterial hypoxemia... - New York Heart Association class versus amino-terminal pro-B type natriuretic peptide for acute heart failure prognosisAaron L Baggish
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Biomarkers 15:307-14. 2010..The prognostic value of the New York Heart Association classification (NYHAC) in acutely decompensated heart failure (ADHF) is unknown... - Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise trainingAaron L Baggish
Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
J Physiol 589:3983-94. 2011..73; P = 0.02). Although future work is required, these results suggest the potential value of c-miRNAs as exercise biomarkers and their possible roles as physiological mediators of exercise-induced cardiovascular adaptation... - Clopidogrel use in coronary artery diseaseAaron L Baggish
Department of Cardiology, Massachusetts General Hospital, Boston, MA, USA
Expert Rev Cardiovasc Ther 4:7-15. 2006..This review outlines the pharmacology of clopidogrel, highlights the results of clopidogrel trials in the setting of acute coronary syndromes, and presents areas of uncertainty and potential future work... - Utility of amino-terminal pro-brain natriuretic peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency departmentJames L Januzzi
Department of Internal Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Arch Intern Med 166:315-20. 2006..Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful for diagnosis and triage of patients with dyspnea, but its role for predicting outcomes in such patients remains undefined... - Effect of body mass index on natriuretic peptide levels in patients with acute congestive heart failure: a ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) substudyDaniel G Krauser
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Am Heart J 149:744-50. 2005..NT-proBNP fell below the diagnostic cutoff for CHF less often than BNP in overweight and obese individuals; however, when used as a diagnostic tool to identify CHF in such patients, both markers may have reduced sensitivity... - The effects of ejection fraction on N-terminal ProBNP and BNP levels in patients with acute CHF: analysis from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) studyAnnabel Chen
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Card Fail 11:S9-14. 2005..NT-proBNP appears superior to BNP for the evaluation of suspected acute CHF in patients with preserved LVEF... - NT-proBNP levels, echocardiographic findings, and outcomes in breathless patients: results from the ProBNP Investigation of Dyspnoea in the Emergency Department (PRIDE) echocardiographic substudyAnnabel A Chen
Division of Cardiology, Cardiac Ultrasound Laboratory, and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
Eur Heart J 27:839-45. 2006..Routine NT-proBNP testing may thus be useful to triage patients to more timely or deferred echocardiographic evaluation... - Usefulness of aminoterminal pro-brain natriuretic peptide testing for the diagnostic and prognostic evaluation of dyspneic patients with diabetes mellitus seen in the emergency department (from the PRIDE Study)Michelle O'Donoghue
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Am J Cardiol 100:1336-40. 2007..09 to 10.7, p <0.001). In conclusion, NT-pro-BNP testing offers valuable diagnostic and prognostic information in the evaluation of dyspneic patients with DM in the ED, using identical cutpoints as the population as whole... - A validated clinical and biochemical score for the diagnosis of acute heart failure: the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Acute Heart Failure ScoreAaron L Baggish
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am Heart J 151:48-54. 2006..CONCLUSION: We report a simple and accurate scoring system combining NT-proBNP testing and clinical assessment for the diagnosis or exclusion of acute HF in patients with dyspnea... - Early repolarization pattern in competitive athletes: clinical correlates and the effects of exercise trainingPeter A Noseworthy
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
Circ Arrhythm Electrophysiol 4:432-40. 2011..Although ERP is common among athletes, prevalence, ECG lead distribution, clinical characteristics, and effects of physical training remain uncertain. We sought to examine the nonanterior ERP in competitive athletes... - Measurement of the interleukin family member ST2 in patients with acute dyspnea: results from the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) studyJames L Januzzi
Department of Medicine and Laboratory Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 50:607-13. 2007..The aim of this study was to examine the value of measurement of the interleukin-1 receptor family member ST2 in patients with dyspnea... - Neither race nor gender influences the usefulness of amino-terminal pro-brain natriuretic peptide testing in dyspneic subjects: a ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) substudyDaniel G Krauser
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Card Fail 12:452-7. 2006..CONCLUSION: NT-proBNP is useful for the diagnosis and exclusion of acute HF in dyspneic subjects, irrespective of race or gender... - Performance of the 2010 European Society of Cardiology criteria for ECG interpretation in athletesRory B Weiner
Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA
Heart 97:1573-7. 2011..The European Society of Cardiology (ESC) recently published revised criteria for ECG interpretation in the athlete... - Heart failure outcomes and benefits of NT-proBNP-guided management in the elderly: results from the prospective, randomized ProBNP outpatient tailored chronic heart failure therapy (PROTECT) studyHanna K Gaggin
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
J Card Fail 18:626-34. 2012..Elderly patients with heart failure (HF) have a worse prognosis than younger patients. We wished to study whether elders benefit from natriuretic peptide-guided HF care in this single-center study... - The feasibility, diagnostic yield, and learning curve of portable echocardiography for out-of-hospital cardiovascular disease screeningRory B Weiner
Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Soc Echocardiogr 25:568-75. 2012..Data documenting the feasibility, yield, and logistical considerations of out-of-hospital TTE for preparticipation evaluation of athletes are sparse... - Significance of electrocardiographic right bundle branch block in trained athletesJonathan H Kim
Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
Am J Cardiol 107:1083-9. 2011.... - Hemoglobin and N-terminal pro-brain natriuretic peptide: Independent and synergistic predictors of mortality in patients with acute heart failure Results from the International Collaborative of NT-proBNP (ICON) StudyAaron L Baggish
PRIDE Study Group, and Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
Clin Chim Acta 381:145-50. 2007..Hemoglobin and amino-terminal pro-brain natriuretic peptide (NT-proBNP) are both independent predictors of mortality in patients with chronic HF. Their combined predictive power for mortality in the setting of acute HF is uncertain... - Soluble ST2 plasma concentrations predict 1-year mortality in acutely dyspneic emergency department patients with pulmonary diseaseAbelardo Martinez-Rumayor
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
Am J Clin Pathol 130:578-84. 2008..20 ng/mL or more diverged early and rose progressively in 1 year (P < .001). ST2 concentrations are frequently elevated in acute pulmonary diseases and are markedly prognostic for death by 1 year... - Association of atrial fibrillation and amino-terminal pro-brain natriuretic peptide concentrations in dyspneic subjects with and without acute heart failure: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) studyAngela Morello
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Am Heart J 153:90-7. 2007..Atrial fibrillation (AF) may cause dyspnea in the absence of acute HF and may also affect plasma levels of NT-proBNP... - Preload dependency of left ventricular torsion: the impact of normal saline infusionRory B Weiner
Division of Cardiology, Massachusetts General Hospital, Boston, Mass, USA
Circ Cardiovasc Imaging 3:672-8. 2010..The net difference between systolic apical counterclockwise rotation and basal clockwise rotation is left ventricular torsion (LVT). Although LVT is altered in various cardiac diseases, determinants of LVT are incompletely understood... - Improvement in structural and functional echocardiographic parameters during chronic heart failure therapy guided by natriuretic peptides: mechanistic insights from the ProBNP Outpatient Tailored Chronic Heart Failure (PROTECT) studyRory B Weiner
Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA
Eur J Heart Fail 15:342-51. 2013.... - The impact of endurance exercise training on left ventricular torsionRory B Weiner
Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
JACC Cardiovasc Imaging 3:1001-9. 2010..We sought to examine the effect of endurance exercise training (EET) on peak systolic left ventricular torsion (LVT) and peak early diastolic untwisting rate (UTR)... - Pulmonary artery acceleration time provides an accurate estimate of systolic pulmonary arterial pressure during transthoracic echocardiographyKibar Yared
Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Am Soc Echocardiogr 24:687-92. 2011..To date, in the absence of TR, no noninvasive method of deriving EPSPAP has been developed... - The differential diagnosis of an elevated amino-terminal pro-B-type natriuretic peptide levelAaron L Baggish
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Cardiol 101:43-8. 2008..Future studies will be necessary to further understand the utility of NT-proBNP testing in states other than cardiovascular disease... - Amino-terminal pro-B-type natriuretic peptide testing and prognosis in patients with acute dyspnea, including those with acute heart failureAaron L Baggish
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Cardiol 101:49-55. 2008.... - The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) studyJames L Januzzi
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Cardiol 95:948-54. 2005..NT-proBNP measurement is a valuable addition to standard clinical assessment for the identification and exclusion of acute CHF in the emergency department setting... - Multimodality imaging of pericardial diseasesKibar Yared
Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
JACC Cardiovasc Imaging 3:650-60. 2010..This report reviews the imaging modalities most useful in the assessment of patients with pericardial disease, with an emphasis on the complementary value of multimodality cardiac imaging... - Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunctionJames L Januzzi
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 58:1881-9. 2011..The aim of this study was to evaluate whether chronic heart failure (HF) therapy guided by concentrations of amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is superior to standard of care (SOC) management... - Clinical uncertainty, diagnostic accuracy, and outcomes in emergency department patients presenting with dyspneaSandy M Green
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Yawkey 5984, 55 Fruit St, Boston, MA 02114, USA
Arch Intern Med 168:741-8. 2008..We hypothesized that diagnostic uncertainty in this setting is associated with adverse outcomes, and amino-terminal pro-B-type natriuretic peptide (NT-proBNP) testing would improve diagnostic accuracy and reduce diagnostic uncertainty... - The impact of isometric handgrip testing on left ventricular twist mechanicsRory B Weiner
Cardiovascular Performance Program, Massachusetts General Hospital, Yawkey Suite 5B, 55 Fruit Street, Boston, MA 02114, USA
J Physiol 590:5141-50. 2012..71). Peak systolic apical rotation and LVT decrease during IHGT in healthy humans. This impairment of LV twist mechanics may in part underlie the LV dysfunction that can occur in the clinical context of acute increase in afterload... - Exercise-induced cardiac remodelingRory B Weiner
Cardiovascular Performance Program, Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA
Prog Cardiovasc Dis 54:380-6. 2012..The increasing popularity of recreational exercise and competitive athletics has led to a growing number of individuals exhibiting these findings in routine clinical practice. This review will provide an overview of EICR in athletes... - Effect of weight loss after weight loss surgery on plasma N-terminal pro-B-type natriuretic peptide levelsAnnabel Chen-Tournoux
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 106:1450-5. 2010..These findings suggest a direct, reversible relation between obesity and reduced natriuretic peptide levels... - Ischemia-modified albumin improves the usefulness of standard cardiac biomarkers for the diagnosis of myocardial ischemia in the emergency department settingSaif Anwaruddin
Department of Internal Medicine, Massachusetts General Hospital, Boston 02114, USA
Am J Clin Pathol 123:140-5. 2005..IMA is highly sensitive and has a high negative predictive value, which might improve the usefulness of standard biomarkers of myocardial ischemia... - Cost effectiveness of natriuretic peptide measurement in the primary care setting: have we found the gatekeeper for the evaluation of dyspneic outpatients?Aaron L Baggish
Cardiology Division and PRIDE Study Group, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Congest Heart Fail 12:108-9. 2006 - Effect of statins on creatine kinase levels before and after a marathon runBeth A Parker
Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Connecticut, USA
Am J Cardiol 109:282-7. 2012..02 and r(2) = 0.00, respectively; p >0.42), suggesting that susceptibility to exercise-induced muscle injury with statins increases with age. In conclusion, our results show that statins increase exercise-related muscle injury... - Design and methods of the Pro-B Type Natriuretic Peptide Outpatient Tailored Chronic Heart Failure Therapy (PROTECT) StudyAnju Bhardwaj
Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
Am Heart J 159:532-538.e1. 2010..Changes in NT-proBNP concentrations parallel prognosis; however, it remains unclear whether HF care with a goal to maximize medical therapy and also lower NT-proBNP concentrations is superior to standard HF care alone... - The electrocardiographic early repolarization pattern in athletes: normal variant or sudden death risk factor?Varsha Keelara Tanguturi
Department of Medicine, Brigham and Womens Hospital, Boston, MA, USA
Sports Med 42:359-66. 2012..This review will describe the evolving understanding of the ERP and will explore the relevance of the ERP for the care of athletes... - Cardiac arrest during long-distance running racesJonathan H Kim
Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
N Engl J Med 366:130-40. 2012..Approximately 2 million people participate in long-distance running races in the United States annually. Reports of race-related cardiac arrests have generated concern about the safety of this activity... - Postoperative troponin-T predicts prolonged intensive care unit length of stay following cardiac surgeryAaron L Baggish
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
Crit Care Med 32:1866-71. 2004..0 ng/mL increase in cTnT measured at 18-24 hrs postprocedure. CONCLUSIONS: Elevated postoperative cTnT concentrations can prospectively identify patients requiring prolonged intensive care unit length of stay after cardiac surgery... - The Athlete's Heart 2007: diseases of the coronary circulationAaron L Baggish
Department of Cardiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Cardiol Clin 25:431-40, vi. 2007..This article discusses diseases of the coronary circulation relevant to athletes... - Management strategy in 249 consecutive patients with obstructive hypertrophic cardiomyopathy referred to a dedicated programRichard D Rothman
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, USA
Am J Cardiol 110:1169-74. 2012..7-year follow-up, obviating SRT in these patients. Clinicians in programs offering SRT should optimize conservative therapy before recommending SRT... - Ultrasound for high altitude researchPeter J Fagenholz
Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Ultrasound Med Biol 38:1-12. 2012.... - Radiopharmaceutical agents for myocardial perfusion imagingAaron L Baggish
Division of Cardiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
Circulation 118:1668-74. 2008 - Amino-terminal pro-brain natriuretic Peptide, renal function, and outcomes in acute heart failure: redefining the cardiorenal interaction?Roland R J van Kimmenade
Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands
J Am Coll Cardiol 48:1621-7. 2006..We sought to study the individual and integrative role of amino-terminal pro-brain natriuretic peptide (NT-proBNP) and parameters of renal function for prognosis in heart failure...