Research Topics
Genomes and Genes
| Jodie L BabittSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balanceJodie L Babitt
Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Invest 117:1933-9. 2007..These data support a role for modulators of the BMP signaling pathway in treating diseases of iron overload and anemia of chronic disease...- BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout miceElena Corradini
Program in Membrane Biology, Nephrology Division, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Gastroenterology 139:1721-9. 2010..We then investigated whether excess exogenous BMP6 administration overcomes the BMP6-SMAD signaling impairment and ameliorates hemochromatosis in Hfe(-/-) mice... 
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expressionJodie L Babitt
Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 38:531-9. 2006..Our data suggest a mechanism by which HFE2 mutations cause hemochromatosis: hemojuvelin dysfunction decreases BMP signaling, thereby lowering hepcidin expression...
Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammationChia Chi Sun
Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Hematol 87:392-400. 2012..In this review, we will summarize the role of hepcidin in iron homeostasis, its contribution to the pathophysiology of ACD, and novel strategies that modulate hepcidin and its target ferroportin for the treatment of ACD...- Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogeninYin Xia
Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Blood 111:5195-204. 2008..Thus, HJV-mediated BMP signaling and hepcidin regulation occur via a distinct subset of BMP ligands and BMP receptors, independently of neogenin... - Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs)Qifang Wu
Program in Anemia Signaling Research, Nephrology Division, Program in Membrane Biology, and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 7:e46307. 2012..Our data may help explain the mechanism by which BMPs exert cell-context specific effects via a limited number of type I and type II receptors... - BMP6 is a key endogenous regulator of hepcidin expression and iron metabolismBilly Andriopoulos
Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Nat Genet 41:482-7. 2009..These data support a key role for BMP6 as a ligand for hemojuvelin and an endogenous regulator of hepcidin expression and iron metabolism in vivo... - The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel diseaseLijian Wang
Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, USA
Inflamm Bowel Dis 18:112-9. 2012..Here we test the hypothesis that inhibiting hepcidin expression may have beneficial effects in IBD, and also shed light on the mechanism of colitis-induced hepcidin upregulation... - Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosisElena Corradini
Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Gastroenterology 137:1489-97. 2009..The bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway is an important endogenous regulator of hepcidin expression. We investigated whether HFE is involved in BMP6-SMAD regulation of hepcidin expression... - The molecular pathogenesis of hereditary hemochromatosisJodie L Babitt
Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Semin Liver Dis 31:280-92. 2011..Here, the authors review the current state of knowledge on the molecular pathogenesis of hereditary hemochromatosis... - Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in miceLijian Wang
Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts, USA
J Clin Invest 119:3322-8. 2009..Thus, manipulation of iron homeostasis could represent a new therapeutic approach to controlling inflammation... - Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in miceElena Corradini
Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Hepatology 54:273-84. 2011.... - Regulation of TMPRSS6 by BMP6 and iron in human cells and miceDelphine Meynard
Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Blood 118:747-56. 2011..Modulation of TMPRSS6 expression could serve as a negative feedback inhibitor to avoid excessive hepcidin increases by iron to help maintain tight homeostatic balance of systemic iron levels... - Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or HfeElena Corradini
Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 141:1907-14. 2011..We examined the effect of dietary iron on regulation of hepcidin expression via the Bmp6/Smad1,5,8 pathway using mice with targeted disruption of Tfr2, Hfe, or both genes... - Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cellsYin Xia
Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Nephrol 21:666-77. 2010..Taken together, these results suggest that Dragon may enhance BMP signaling in renal tubular epithelial cells and maintain normal renal physiology... - The RGM/DRAGON family of BMP co-receptorsElena Corradini
Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02472, USA
Cytokine Growth Factor Rev 20:389-98. 2009..This article reviews the current knowledge regarding the structure, regulation, and function of RGMs, focusing on known and potential roles of RGMs in physiology and pathophysiology... - Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptorJodie L Babitt
Program in Membrane Biology and Division of Nephrology, Department of Medicine, Harvard Medical School, Boston, MA 02129, USA
J Biol Chem 280:29820-7. 2005..Finally, we demonstrate that BMP signaling occurs in neurons that express RGMa in vivo. These data are consistent with a role for RGMa as a BMP co-receptor... - A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serumWenjie Chen
Haematologica 98:296-304. 2013..This assay may provide a useful tool to elucidate the source and physiological role of serum soluble hemojuvelin in hepcidin regulation and iron metabolism using well-established mouse models of iron-related disorders... - Mechanisms of anemia in CKDJodie L Babitt
Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
J Am Soc Nephrol 23:1631-4. 2012..These insights hold promise for the development of new diagnostic tests and therapies that directly target the pathophysiologic processes underlying this form of anemia... - Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolismPaul B Yu
Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
Nat Chem Biol 4:33-41. 2008..These findings suggest an essential physiological role for hepatic BMP signaling in iron-hepcidin homeostasis... - Molecular mechanisms of hepcidin regulation: implications for the anemia of CKDJodie L Babitt
Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Kidney Dis 55:726-41. 2010..This article reviews the pathogenesis of anemia in CKD, the role and regulation of hepcidin in systemic iron homeostasis and the anemia of CKD, and the potential diagnostic and therapeutic implications of these findings... - Heterologous downregulation of vasopressin type 2 receptor is induced by transferrinRichard Bouley
1Nephrology Division, MGH Center for Systems Biology, Program in Membrane Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Renal Physiol 304:F553-64. 2013..It also provides new insights into urine-concentrating defects observed in rat models of hemochromatosis... - In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2Elisabetta del Re
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charleston, Massachusetts 02129, USA
J Biol Chem 279:22765-72. 2004..Our cell-free binding assay system will allow for testing of models of receptor-ligand complexes prior to actual solution of crystal structures...
Research Grants
- BMP Signaling in Kidney Epithelial CellsJODIE BABITT; Fiscal Year: 2005..Proposed experiments will also begin to examine the functional significance of Dragon expression in the kidney in relation to ischemic injury and repair. ..
- BMP Signaling and Iron MetabolismJODIE BABITT; Fiscal Year: 2007..It is hoped that this work will provide clues leading to new treatment strategies for disorders of iron overload such as hemochromatosis and disorders of iron deficiency such as anemia of chronic disease. ..