Jodie L Babitt

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    Jodie L Babitt
    Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Invest 117:1933-9. 2007
  2. pmc BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice
    Elena Corradini
    Program in Membrane Biology, Nephrology Division, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 139:1721-9. 2010
  3. ncbi request reprint Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    Jodie L Babitt
    Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:531-9. 2006
  4. pmc Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation
    Chia Chi Sun
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Hematol 87:392-400. 2012
  5. pmc Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
    Yin Xia
    Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Blood 111:5195-204. 2008
  6. pmc A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats
    Chia Chi Sun
    Program in Anemia Signaling Research, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nephrol Dial Transplant 28:1733-43. 2013
  7. pmc Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs)
    Qifang Wu
    Program in Anemia Signaling Research, Nephrology Division, Program in Membrane Biology, and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e46307. 2012
  8. pmc BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    Billy Andriopoulos
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nat Genet 41:482-7. 2009
  9. pmc The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease
    Lijian Wang
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, USA
    Inflamm Bowel Dis 18:112-9. 2012
  10. pmc Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis
    Elena Corradini
    Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 137:1489-97. 2009

Research Grants

  1. BMP Signaling in Kidney Epithelial Cells
    JODIE BABITT; Fiscal Year: 2005
  2. BMP Signaling and Iron Metabolism
    JODIE BABITT; Fiscal Year: 2007

Collaborators

Detail Information

Publications26

  1. pmc Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    Jodie L Babitt
    Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Invest 117:1933-9. 2007
    ..These data support a role for modulators of the BMP signaling pathway in treating diseases of iron overload and anemia of chronic disease...
  2. pmc BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice
    Elena Corradini
    Program in Membrane Biology, Nephrology Division, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 139:1721-9. 2010
    ..We then investigated whether excess exogenous BMP6 administration overcomes the BMP6-SMAD signaling impairment and ameliorates hemochromatosis in Hfe(-/-) mice...
  3. ncbi request reprint Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    Jodie L Babitt
    Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:531-9. 2006
    ..Our data suggest a mechanism by which HFE2 mutations cause hemochromatosis: hemojuvelin dysfunction decreases BMP signaling, thereby lowering hepcidin expression...
  4. pmc Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation
    Chia Chi Sun
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Hematol 87:392-400. 2012
    ..In this review, we will summarize the role of hepcidin in iron homeostasis, its contribution to the pathophysiology of ACD, and novel strategies that modulate hepcidin and its target ferroportin for the treatment of ACD...
  5. pmc Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
    Yin Xia
    Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Blood 111:5195-204. 2008
    ..Thus, HJV-mediated BMP signaling and hepcidin regulation occur via a distinct subset of BMP ligands and BMP receptors, independently of neogenin...
  6. pmc A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats
    Chia Chi Sun
    Program in Anemia Signaling Research, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nephrol Dial Transplant 28:1733-43. 2013
    ..Adenine treatment in rats has been proposed as an animal model of anemia of CKD with high hepcidin levels that mirrors the condition in human patients...
  7. pmc Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs)
    Qifang Wu
    Program in Anemia Signaling Research, Nephrology Division, Program in Membrane Biology, and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e46307. 2012
    ..Our data may help explain the mechanism by which BMPs exert cell-context specific effects via a limited number of type I and type II receptors...
  8. pmc BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    Billy Andriopoulos
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nat Genet 41:482-7. 2009
    ..These data support a key role for BMP6 as a ligand for hemojuvelin and an endogenous regulator of hepcidin expression and iron metabolism in vivo...
  9. pmc The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease
    Lijian Wang
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, USA
    Inflamm Bowel Dis 18:112-9. 2012
    ..Here we test the hypothesis that inhibiting hepcidin expression may have beneficial effects in IBD, and also shed light on the mechanism of colitis-induced hepcidin upregulation...
  10. pmc Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis
    Elena Corradini
    Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 137:1489-97. 2009
    ..The bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway is an important endogenous regulator of hepcidin expression. We investigated whether HFE is involved in BMP6-SMAD regulation of hepcidin expression...
  11. doi request reprint The molecular pathogenesis of hereditary hemochromatosis
    Jodie L Babitt
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Semin Liver Dis 31:280-92. 2011
    ..Here, the authors review the current state of knowledge on the molecular pathogenesis of hereditary hemochromatosis...
  12. pmc Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice
    Elena Corradini
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Hepatology 54:273-84. 2011
    ..In contrast to the Smad pathway, the extracellular signal-regulated kinase 1 and 2 (Erk1/2) mitogen-activated protein kinase (Mapk) signaling pathway in the liver is not activated by acute or chronic iron administration in mice...
  13. pmc Regulation of TMPRSS6 by BMP6 and iron in human cells and mice
    Delphine Meynard
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Blood 118:747-56. 2011
    ..Modulation of TMPRSS6 expression could serve as a negative feedback inhibitor to avoid excessive hepcidin increases by iron to help maintain tight homeostatic balance of systemic iron levels...
  14. pmc Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice
    Lijian Wang
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Clin Invest 119:3322-8. 2009
    ..Thus, manipulation of iron homeostasis could represent a new therapeutic approach to controlling inflammation...
  15. pmc Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe
    Elena Corradini
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 141:1907-14. 2011
    ..We examined the effect of dietary iron on regulation of hepcidin expression via the Bmp6/Smad1,5,8 pathway using mice with targeted disruption of Tfr2, Hfe, or both genes...
  16. pmc Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin
    Richard Bouley
    1Nephrology Division, MGH Center for Systems Biology, Program in Membrane Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Renal Physiol 304:F553-64. 2013
    ..It also provides new insights into urine-concentrating defects observed in rat models of hemochromatosis...
  17. pmc Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells
    Yin Xia
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 21:666-77. 2010
    ..Taken together, these results suggest that Dragon may enhance BMP signaling in renal tubular epithelial cells and maintain normal renal physiology...
  18. pmc Inflammation regulates TMPRSS6 expression via STAT5
    Delphine Meynard
    Program in Anemia Signaling Research, Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e82127. 2013
    ..TMPRSS6 inhibition via decreased STAT5 phosphorylation may be an additional mechanism by which inflammation stimulates hepcidin expression to regulate iron homeostasis and immunity. ..
  19. pmc A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum
    Wenjie Chen
    Program in Anemia Signaling Research, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Haematologica 98:296-304. 2013
    ..This assay may provide a useful tool to elucidate the source and physiological role of serum soluble hemojuvelin in hepcidin regulation and iron metabolism using well-established mouse models of iron-related disorders...
  20. pmc The RGM/DRAGON family of BMP co-receptors
    Elena Corradini
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02472, USA
    Cytokine Growth Factor Rev 20:389-98. 2009
    ..This article reviews the current knowledge regarding the structure, regulation, and function of RGMs, focusing on known and potential roles of RGMs in physiology and pathophysiology...
  21. pmc The liver: conductor of systemic iron balance
    Delphine Meynard
    Program in Anemia Signaling Research, Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Blood 123:168-76. 2014
    ..We then review how the liver receives and integrates the many signals that report the body's iron needs to orchestrate hepcidin production and maintain systemic iron homeostasis. ..
  22. ncbi request reprint Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor
    Jodie L Babitt
    Program in Membrane Biology and Division of Nephrology, Department of Medicine, Harvard Medical School, Boston, MA 02129, USA
    J Biol Chem 280:29820-7. 2005
    ..Finally, we demonstrate that BMP signaling occurs in neurons that express RGMa in vivo. These data are consistent with a role for RGMa as a BMP co-receptor...
  23. pmc Mechanisms of anemia in CKD
    Jodie L Babitt
    Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    J Am Soc Nephrol 23:1631-4. 2012
    ..These insights hold promise for the development of new diagnostic tests and therapies that directly target the pathophysiologic processes underlying this form of anemia...
  24. pmc Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD
    Jodie L Babitt
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Kidney Dis 55:726-41. 2010
    ..This article reviews the pathogenesis of anemia in CKD, the role and regulation of hepcidin in systemic iron homeostasis and the anemia of CKD, and the potential diagnostic and therapeutic implications of these findings...
  25. pmc Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    Paul B Yu
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 4:33-41. 2008
    ..These findings suggest an essential physiological role for hepatic BMP signaling in iron-hepcidin homeostasis...
  26. ncbi request reprint In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2
    Elisabetta del Re
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charleston, Massachusetts 02129, USA
    J Biol Chem 279:22765-72. 2004
    ..Our cell-free binding assay system will allow for testing of models of receptor-ligand complexes prior to actual solution of crystal structures...

Research Grants3

  1. BMP Signaling in Kidney Epithelial Cells
    JODIE BABITT; Fiscal Year: 2005
    ..Proposed experiments will also begin to examine the functional significance of Dragon expression in the kidney in relation to ischemic injury and repair. ..
  2. BMP Signaling and Iron Metabolism
    JODIE BABITT; Fiscal Year: 2007
    ..It is hoped that this work will provide clues leading to new treatment strategies for disorders of iron overload such as hemochromatosis and disorders of iron deficiency such as anemia of chronic disease. ..