Cenk Ayata

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc CADASIL: experimental insights from animal models
    Cenk Ayata
    Neurovascular Research Laboratory, Department of Radiology, and Stroke Service and Neuroscience Intensive Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02129, USA
    Stroke 41:S129-34. 2010
  2. pmc Cortical spreading depression as a target for anti-migraine agents
    Cinzia Costa
    Neurologic Clinic, Department of Public Health and Medical and Surgical Specialties, University of Perugia, Ospedale Santa Maria della Misericordia, Sant Andrea delle Fratte, 06132, Perugia, Italy
    J Headache Pain 14:62. 2013
  3. pmc Hyperlipidemia disrupts cerebrovascular reflexes and worsens ischemic perfusion defect
    Cenk Ayata
    Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, Massachusetts, USA
    J Cereb Blood Flow Metab 33:954-62. 2013
  4. doi Pearls and pitfalls in experimental models of spreading depression
    Cenk Ayata
    Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA
    Cephalalgia 33:604-13. 2013
  5. ncbi Cortical spreading depression confounds concentration-dependent pial arteriolar dilation during N-methyl-D-aspartate superfusion
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Am J Physiol Heart Circ Physiol 290:H1837-41. 2006
  6. ncbi Pronounced hypoperfusion during spreading depression in mouse cortex
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    J Cereb Blood Flow Metab 24:1172-82. 2004
  7. ncbi Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 24:744-55. 2004
  8. ncbi Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Brain 130:2310-9. 2007
  9. pmc Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia
    Phill B Jones
    Massachusetts General Hospital, Harvard Medical School, Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:044007. 2008
  10. pmc Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Stroke 39:1548-55. 2008

Collaborators

Detail Information

Publications54

  1. pmc CADASIL: experimental insights from animal models
    Cenk Ayata
    Neurovascular Research Laboratory, Department of Radiology, and Stroke Service and Neuroscience Intensive Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02129, USA
    Stroke 41:S129-34. 2010
    ..Here, I provide an overview of existing animal models of CADASIL and the pathophysiological insights gained from these models...
  2. pmc Cortical spreading depression as a target for anti-migraine agents
    Cinzia Costa
    Neurologic Clinic, Department of Public Health and Medical and Surgical Specialties, University of Perugia, Ospedale Santa Maria della Misericordia, Sant Andrea delle Fratte, 06132, Perugia, Italy
    J Headache Pain 14:62. 2013
    ..CSD models are useful tools for testing current and novel prophylactic drugs, providing knowledge on mechanisms of action relevant for migraine...
  3. pmc Hyperlipidemia disrupts cerebrovascular reflexes and worsens ischemic perfusion defect
    Cenk Ayata
    Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, Massachusetts, USA
    J Cereb Blood Flow Metab 33:954-62. 2013
    ..These data suggest that hyperlipidemia disrupts cerebral blood flow regulation and diminishes collateral perfusion in acute stroke in the absence of hemodynamically significant atherosclerosis...
  4. doi Pearls and pitfalls in experimental models of spreading depression
    Cenk Ayata
    Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA
    Cephalalgia 33:604-13. 2013
    ..Since its discovery by Leão in 1944, SD has transformed from being viewed as an epiphenomenon into a therapeutic target relevant in the pathophysiology of migraine and brain injury...
  5. ncbi Cortical spreading depression confounds concentration-dependent pial arteriolar dilation during N-methyl-D-aspartate superfusion
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Am J Physiol Heart Circ Physiol 290:H1837-41. 2006
    ..Our data suggest that the responses of pial arterioles to NMDA are caused in part by neurovascular coupling due to cortical spreading depression...
  6. ncbi Pronounced hypoperfusion during spreading depression in mouse cortex
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    J Cereb Blood Flow Metab 24:1172-82. 2004
    ..The differences in CBF response between species may be in part caused by an increased sensitivity of mouse cerebral vessels to elevated extracellular K+...
  7. ncbi Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 24:744-55. 2004
    ..In summary, LSF has distinct advantages over LDF for CBF monitoring because of high spatial resolution...
  8. ncbi Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Brain 130:2310-9. 2007
    ..These responses do not differ from controls when studied non-invasively prior to vascular Abeta deposition, thus challenging the view that elevated soluble Abeta levels are sufficient to cause cerebrovascular dysfunction...
  9. pmc Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia
    Phill B Jones
    Massachusetts General Hospital, Harvard Medical School, Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:044007. 2008
    ....
  10. pmc Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Stroke 39:1548-55. 2008
    ..We, therefore, tested whether pharmacologically induced hypertension improves cerebral blood flow and metabolism and tissue outcome in acute stroke using optical imaging with high spatiotemporal resolution...
  11. pmc Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms
    Hwa Kyoung Shin
    Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 27:998-1009. 2007
    ..Therefore, rapid nontranscriptional upregulation of eNOS activity by small molecule inhibitors of Rho-kinase may be a viable therapeutic approach in acute stroke...
  12. pmc Cortical spreading depression impairs oxygen delivery and metabolism in mice
    Izumi Yuzawa
    Department of Radiology, Neurovascular Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 32:376-86. 2012
    ..Altogether, these data suggest that CSD is associated with long-lasting oxygen supply-demand mismatch linked to severe vasoconstriction in mice...
  13. pmc Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations
    Katharina Eikermann-Haerter
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Circulation 125:335-45. 2012
    ....
  14. pmc Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice
    Katharina Eikermann-Haerter
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 31:5755-63. 2011
    ....
  15. pmc Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1
    Katharina Eikermann-Haerter
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Clin Invest 119:99-109. 2009
    ..These findings demonstrate that genetic and hormonal factors modulate susceptibility to SD and neurological deficits in FHM1 mutant mice, providing a potential mechanism for the phenotypic diversity of human migraine and aura...
  16. pmc Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range
    Inna Sukhotinsky
    Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 30:1168-77. 2010
    ....
  17. pmc Microemboli may link spreading depression, migraine aura, and patent foramen ovale
    Ala Nozari
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Ann Neurol 67:221-9. 2010
    ..The pathophysiological mechanisms that link these conditions are unknown. We aimed to establish a mechanism linking microembolization to migraine aura in an experimental animal model...
  18. pmc Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Brain 130:1631-42. 2007
    ..Our data show that normobaric hyperoxia increases tissue O2 delivery, and that novel mechanisms such as CBF augmentation, and suppression of PIDs may afford neuroprotection during hyperoxia...
  19. pmc Age-related decline in oligodendrogenesis retards white matter repair in mice
    Nobukazu Miyamoto
    Department of Radiology and Neurology, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, MA, USA
    Stroke 44:2573-8. 2013
    ..Here, we ask whether, compared with young brains, white matter regions in older brains may be more vulnerable in part because of decreased rates of compensatory oligodendrogenesis after injury...
  20. pmc Increased glucose availability does not restore prolonged spreading depression durations in hypotensive rats without brain injury
    Ulrike Hoffmann
    Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Exp Neurol 238:130-2. 2012
    ..These data suggest that prolonged CSD durations during reduced cerebral perfusion pressure are independent of tissue energy status, and implicate alternative mechanisms of CSD recovery such as vascular clearance of extracellular K(+)...
  21. pmc Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response
    Edward Baraghis
    Harvard Medical School, Massachusetts General Hospital, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 16:106003. 2011
    ..The general approach of the correction algorithm can be extended to other TPLSM measurements, where changes in the optical properties of the tissue confound physiological measurements, such as the detection of calcium dynamics...
  22. pmc Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations
    Ulrike Hoffmann
    Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 31:1578-82. 2011
    ..However, the frequency and duration of PIDs were not suppressed when recorded for 2  hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression...
  23. pmc Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression
    Sava Sakadzic
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Appl Opt 48:D169-77. 2009
    ..This new instrument will enable further study of neurovascular coupling in normal and diseased brain...
  24. ncbi Hypoxia and hypotension transform the blood flow response to cortical spreading depression from hyperemia into hypoperfusion in the rat
    Inna Sukhotinsky
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 28:1369-76. 2008
    ..e., mimicking ischemic penumbra), the hyperemic response to CSD becomes attenuated resembling the blood flow response during PIDs...
  25. pmc Linking Notch signaling to ischemic stroke
    Joseph F Arboleda-Velasquez
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:4856-61. 2008
    ....
  26. pmc Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering-optical coherence tomography
    Jonghwan Lee
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 33:819-25. 2013
    ..This result supports that the IM measured in this study represent the cellular energy metabolism-related active motion of intracellular organelles rather than free diffusion of intracellular macromolecules...
  27. pmc The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo
    Dmitriy N Atochin
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA
    J Clin Invest 117:1961-7. 2007
    ..They also demonstrate the in vivo relevance of posttranslational modification of eNOS in vascular function...
  28. doi Chronic daily cortical spreading depressions suppress spreading depression susceptibility
    Inna Sukhotinsky
    Harvard Medical School, USA
    Cephalalgia 31:1601-8. 2011
    ..We hypothesized that CSD events during frequent migraine attacks condition the cortex to increase the susceptibility to further attacks...
  29. pmc Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice
    Katharina Eikermann-Haerter
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Ann Neurol 66:564-8. 2009
    ..Chronic testosterone replacement restores CSD susceptibility by an androgen receptor-dependent mechanism. Hence, androgens modulate genetically-enhanced CSD susceptibility and may provide a novel prophylactic target for migraine...
  30. ncbi Recognition memory impairments after subcortical white matter stroke in mice
    Francesco Blasi
    From the Stroke and Neurovascular Research Laboratory, Department of Radiology F B, Y W, M B, C A, M A M, Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology C A, Department of Cell Biology S T, and Department of Radiology, Martinos Center for Biomedical Imaging J B M, Massachusetts General Hospital, Harvard Medical School, Boston and Department of Pharmacology, School of Pharmacy, University College Cork, Cork, Ireland C W
    Stroke 45:1468-73. 2014
    ..Here, we examine tissue and functional outcome after an ischemic lesion within corpus callosum in wild-type (WT) mice and in mice null for a gene, NOTCH3, linked to white matter ischemic injury in patients...
  31. pmc Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury
    Dmitriy N Atochin
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Mass, USA
    Stroke 41:1815-9. 2010
    ..To study the role of sGC in stroke injury, we compared the outcome of cerebral ischemia and reperfusion in mice deficient in the alpha(1) subunit of sGC (sGCalpha(1)(-/-)) with that in wild-type mice...
  32. pmc Cerebrovascular lesions induce transient β-amyloid deposition
    Monica Garcia-Alloza
    Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Brain 134:3697-707. 2011
    ..Additionally, this study indicates that focal ischaemia provides an experimental paradigm in which to study the mechanisms of plaque seeding and growth...
  33. pmc Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome mutations increase susceptibility to spreading depression
    Katharina Eikermann-Haerter
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Ann Neurol 69:413-8. 2011
    ..Our results link vascular smooth muscle Notch 3 mutations to enhanced spreading depression susceptibility, implicating the neurovascular unit in the development of migraine aura...
  34. pmc Gabapentin suppresses cortical spreading depression susceptibility
    Ulrike Hoffmann
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 30:1588-92. 2010
    ..With its favorable safety and tolerability profile, gabapentin may have a role in suppression of injury depolarizations in stroke, intracranial hemorrhage, and traumatic brain injury...
  35. pmc Genetic animal models of cerebral vasculopathies
    Jeong Hyun Lee
    Department of Radiology, Neurovascular Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Prog Mol Biol Transl Sci 105:25-55. 2012
    ..Here, we provide an overview of animal models of CAA and CADASIL and the insight on molecular and physiological mechanisms of disease gained from these models...
  36. pmc The impact of anesthetics and hyperoxia on cortical spreading depression
    Chiho Kudo
    Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Exp Neurol 212:201-6. 2008
    ..Our data show anesthetic modulation of CSD susceptibility in an experimental model of human disease, underscoring the importance of proper study design for hypothesis testing as well as for comparing results between studies...
  37. ncbi Vasoconstrictive neurovascular coupling during focal ischemic depolarizations
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 26:1018-30. 2006
    ..Mitigating the vasoconstrictive neurovascular coupling during intense ischemic depolarizations may provide a novel hemodynamic mechanism of neuroprotection by inhibitors of CSD...
  38. doi Oxcarbazepine does not suppress cortical spreading depression
    Ulrike Hoffmann
    Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Cephalalgia 31:537-42. 2011
    ..Recently, chronic treatment with five migraine prophylactic drugs was shown to suppress cortical spreading depression, implicating spreading depression as a common therapeutic target in migraine prophylaxis...
  39. doi Cortical spreading depression and migraine
    Katharina Eikermann-Haerter
    Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Curr Neurol Neurosci Rep 10:167-73. 2010
    ..Here, we provide an overview of recent advances in our understanding of migraine pathophysiology and treatment...
  40. pmc Optical coherence tomography for the quantitative study of cerebrovascular physiology
    Vivek J Srinivasan
    Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 31:1339-45. 2011
    ..Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range...
  41. pmc Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease
    Joseph F Arboleda-Velasquez
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:E128-35. 2011
    ..We determine that CADASIL pathophysiology is associated with hypomorphic Notch 3 function in vascular smooth muscle cells and implicate the accumulation of clusterin and collagen 18 α1/endostatin in brain vessel pathology...
  42. ncbi Suppression of cortical spreading depression in migraine prophylaxis
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Ann Neurol 59:652-61. 2006
    ..We hypothesized that migraine prophylactic agents suppress CSD as a common mechanism of action...
  43. pmc Glucose modulation of spreading depression susceptibility
    Ulrike Hoffmann
    Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 33:191-5. 2013
    ..These data show that increased cerebral glucose availability makes the tissue resistant to SD...
  44. ncbi Achieving normothermia in patients with febrile subarachnoid hemorrhage: feasibility and safety of a novel intravascular cooling catheter
    Neeraj Badjatia
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurocrit Care 1:145-56. 2004
    ..Fever is common and difficult to control in patients with subarachnoid hemorrhage (SAH). We have previously shown an inverse relationship between fever and outcome in patients with SAH...
  45. doi Calabadion: A new agent to reverse the effects of benzylisoquinoline and steroidal neuromuscular-blocking agents
    Ulrike Hoffmann
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 119:317-25. 2013
    ..To evaluate whether calabadion 1, an acyclic member of the Cucurbit[n]uril family of molecular containers, reverses benzylisoquinoline and steroidal neuromuscular-blocking agent effects...
  46. pmc Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage
    Lei Lu
    Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Brain Res 1555:89-96. 2014
    ..In conclusion, fingolimod exerts protective effects in a mouse model of intracerebral hemorrhage; the mechanisms underlying these neuroprotective effects deserve further study...
  47. pmc Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury
    Ji Hae Seo
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 123:782-6. 2013
    ..Our study reveals that OPCs can rapidly respond to white matter injury and produce MMP9 that disrupts the BBB, indicating that OPCs may mediate injury in white matter under disease conditions...
  48. pmc Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in mice
    Heda R Dapul
    Neuroscience Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Neurotrauma 30:382-91. 2013
    ..Sequential CHI-CCI may model complex injury mechanisms that occur in some patients with TBI and may prove useful for testing putative therapies...
  49. pmc Pharmacological targeting of spreading depression in migraine
    Katharina Eikermann-Haerter
    Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charleston, MA 02129, USA
    Expert Rev Neurother 12:297-306. 2012
    ..Hence, susceptibility to spreading depression can be a useful preclinical model with good positive and negative predictive value for drug screening...
  50. ncbi A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System
    Hakan Ay
    AA Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 38:2979-84. 2007
    ..In this article, we present an automated version of the SSS-TOAST, the Causative Classification System (CCS), to facilitate its utility in multicenter settings...
  51. pmc Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
    Vishal M Gohil
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Biotechnol 28:249-55. 2010
    ..Nutrient-sensitized screening may provide a useful framework for understanding gene function and drug action within the context of energy metabolism...
  52. doi Cortical spreading depression triggers migraine attack: pro
    Cenk Ayata
    Neurovascular Research Laboratory, Department of Radiology, and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Headache 50:725-30. 2010
    ..Here, I will review the accumulated evidence supporting a causal relationship between SD and migraine aura and headache, and discuss the contested notion that SD may also be involved in migraine attacks without a "perceived" aura...
  53. ncbi Ischaemic brain oedema
    Cenk Ayata
    Neurology Service, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    J Clin Neurosci 9:113-24. 2002
    ..Broad guidelines for treatment of stroke oedema can therefore be given at this time...
  54. doi A randomized, double-blind, placebo-controlled pilot study of simvastatin in aneurysmal subarachnoid hemorrhage
    Sherry H Y Chou
    Stroke 39:2891-3. 2008
    ..Studies suggest statins ameliorate aneurysmal subarachnoid hemorrhage (SAH)-induced cerebral vasospasm and ischemic complications. We tested safety and feasibility of simvastatin 80 mg/d for vasospasm prevention in SAH patients...