Affiliation: Massachusetts General Hospital
Ayata C. CADASIL: experimental insights from animal models. Stroke. 2010;41:S129-34 pubmed publisher
..Here, I provide an overview of existing animal models of CADASIL and the pathophysiological insights gained from these models. ..
Mawet J, Kurth T, Ayata C. Migraine and stroke: in search of shared mechanisms. Cephalalgia. 2015;35:165-81 pubmed publisher
..However, evidence from prospective clinical trials is required before modifying the practice in this patient population. ..
Shin H, Oka F, Kim J, Atochin D, Huang P, Ayata C. Endothelial dysfunction abrogates the efficacy of normobaric hyperoxia in stroke. J Neurosci. 2014;34:15200-7 pubmed publisher
..Therefore, vascular risk factors associated with endothelial dysfunction may predict normobaric hyperoxia nonresponders in ischemic stroke. These data may have implications for myocardial and systemic circulation as well. ..
Dilekoz E, Houben T, Eikermann Haerter K, Balkaya M, Lenselink A, Whalen M, et al
. Migraine mutations impair hippocampal learning despite enhanced long-term potentiation. J Neurosci. 2015;35:3397-402 pubmed publisher
..Data suggest that abnormally enhanced plasticity can be as detrimental to efficient learning as reduced plasticity and highlight how genetically enhanced neuronal excitability may impact cognitive function. ..
von BornstÃ¤dt D, Houben T, Seidel J, Zheng Y, Dilekoz E, Qin T, et al
. Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations. Neuron. 2015;85:1117-31 pubmed publisher
..Based on the data, we propose that minimizing sensory stimulation and hypoxic or hypotensive transients in stroke and brain injury would reduce PID incidence and their adverse impact on outcome. ..
Eikermann Haerter K, Lee J, Yalcin N, Yu E, Daneshmand A, Wei Y, et al
. Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice. Stroke. 2015;46:229-36 pubmed publisher
Xie H, Yu K, Zhou N, Shen X, Tian S, Zhang B, et al
. Enriched Environment Elicits Proangiogenic Mechanisms After Focal Cerebral Ischemia. Transl Stroke Res. 2018;: pubmed publisher
..Together, our data suggest that exposure to EE promotes angiogenesis in the ischemic brain that may in part be mediated by blood-borne factors. ..
Ayata C, Moskowitz M. Cortical spreading depression confounds concentration-dependent pial arteriolar dilation during N-methyl-D-aspartate superfusion. Am J Physiol Heart Circ Physiol. 2006;290:H1837-41 pubmed
..Our data suggest that the responses of pial arterioles to NMDA are caused in part by neurovascular coupling due to cortical spreading depression. ..
Ayata C, Shin H, Dilekoz E, Atochin D, Kashiwagi S, Eikermann Haerter K, et al
. Hyperlipidemia disrupts cerebrovascular reflexes and worsens ischemic perfusion defect. J Cereb Blood Flow Metab. 2013;33:954-62 pubmed publisher
..These data suggest that hyperlipidemia disrupts cerebral blood flow regulation and diminishes collateral perfusion in acute stroke in the absence of hemodynamically significant atherosclerosis...