Ilknur Ay

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Ablation of the sphenopalatine ganglion does not attenuate the infarct reducing effect of vagus nerve stimulation
    Ilknur Ay
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Auton Neurosci 174:31-5. 2013
  2. ncbi Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia: an unlikely role for cerebral blood flow
    Ilknur Ay
    MGH MIT HMS A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA O2129, USA
    Brain Res 1392:110-5. 2011
  3. ncbi Both endothelium and afferent nerve endings play a role in acetylcholine-induced renal vasodilation
    Ilknur Ay
    Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey
    Life Sci 79:877-82. 2006
  4. ncbi VEGF increases blood-brain barrier permeability to Evans blue dye and tetanus toxin fragment C but not adeno-associated virus in ALS mice
    Ilknur Ay
    Day Neuromuscular Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Brain Res 1234:198-205. 2008
  5. ncbi Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia
    Ilknur Ay
    MGH MIT HMS A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA O2129, USA
    Neurosci Lett 459:147-51. 2009
  6. ncbi Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS
    Jianhong Li
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Biochem Biophys Res Commun 390:947-51. 2009
  7. ncbi Recombinant GDNF: tetanus toxin fragment C fusion protein produced from insect cells
    Jianhong Li
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Biochem Biophys Res Commun 385:380-4. 2009
  8. ncbi A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice
    Kristin E Larsen
    Columbia University, Department of Neurology, New York, NY 10032, and Cecil B. Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA
    Brain Res 1120:1-12. 2006
  9. ncbi Mechanism of CGRP-induced vasodilation in the rat isolated perfused kidney
    Ilknur Ay
    Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Pharmacology 71:209-15. 2004
  10. ncbi Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice
    Susanna C Benn
    Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurochem 95:1118-31. 2005

Collaborators

  • Piera Pasinelli
  • Robert H Brown
  • R Blake Pepinsky
  • Peter Caravan
  • Yan Yang
  • Wendy J Broom
  • Jianhong Li
  • Paul S Fishman
  • Samuel A Celia
  • Jonathan W Francis
  • Ritika Uppal
  • Ru Ju Chian
  • Eric Tamrazian
  • Brenda B Kashi
  • Susanna C Benn
  • Katie L Ciesienski
  • Ciprian Catana
  • A Gregory Sorensen
  • Jonathan C Matthews
  • Mary P Remington
  • Kristin E Larsen
  • Ru-Ju Chian
  • Nimet Kabakus
  • Galen S Loving
  • Daniel B Chonde
  • Tyson A Rietz
  • Thomas Benner
  • Young Ro Kim
  • Guangping Dai
  • Roderick T Bronson
  • Anthony Rossomando
  • Kester A Phillips
  • Paul Carmillo
  • Dinah Sah
  • Meiqin Liu
  • Michelle Bejarano
  • David Sulzer
  • Joshua Ross
  • Bulent Celasun
  • Sabiha Aysun
  • Ayhan Ozcan
  • Elena Bastia
  • Figen Soylemezoglu

Detail Information

Publications16

  1. ncbi Ablation of the sphenopalatine ganglion does not attenuate the infarct reducing effect of vagus nerve stimulation
    Ilknur Ay
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Auton Neurosci 174:31-5. 2013
    ..05 vs. corresponding controls for both). Our findings show that VNS can protect the brain against acute ischemic injury, and that this effect is not mediated by SPG projections...
  2. ncbi Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia: an unlikely role for cerebral blood flow
    Ilknur Ay
    MGH MIT HMS A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA O2129, USA
    Brain Res 1392:110-5. 2011
    ....
  3. ncbi Both endothelium and afferent nerve endings play a role in acetylcholine-induced renal vasodilation
    Ilknur Ay
    Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey
    Life Sci 79:877-82. 2006
    ....
  4. ncbi VEGF increases blood-brain barrier permeability to Evans blue dye and tetanus toxin fragment C but not adeno-associated virus in ALS mice
    Ilknur Ay
    Day Neuromuscular Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Brain Res 1234:198-205. 2008
    ..These data demonstrate the potential utility of VEGF for pharmacological modulation of the BBB, and indicate that the increase in BBB permeability mediated by VEGF is limited by the size of the delivered substance...
  5. ncbi Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia
    Ilknur Ay
    MGH MIT HMS A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA O2129, USA
    Neurosci Lett 459:147-51. 2009
    ..The functional score improved by 50% in experimental group 1 and 44% in experimental group 2 (p<0.05 for both groups). Conclusion: VNS appears to offer protection against acute ischemic brain injury...
  6. ncbi Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS
    Jianhong Li
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Biochem Biophys Res Commun 390:947-51. 2009
    ..These studies indicate that insect cell-derived GDNF:TTC retains its bi-functional activity in mammalian CNS in vivo and improves delivery of GDNF to spinal cord following intramuscular- or intrathecal administration...
  7. ncbi Recombinant GDNF: tetanus toxin fragment C fusion protein produced from insect cells
    Jianhong Li
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Biochem Biophys Res Commun 385:380-4. 2009
    ..These results support further testing of recombinant GDNF:TTC as a non-viral vector to improve delivery of GDNF to brain and spinal cord in vivo...
  8. ncbi A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice
    Kristin E Larsen
    Columbia University, Department of Neurology, New York, NY 10032, and Cecil B. Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA
    Brain Res 1120:1-12. 2006
    ..These results indicate that TTC can serve as a non-viral vehicle to substantially improve the delivery of functionally active growth factors to motor neurons in the mammalian CNS...
  9. ncbi Mechanism of CGRP-induced vasodilation in the rat isolated perfused kidney
    Ilknur Ay
    Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Pharmacology 71:209-15. 2004
    ....
  10. ncbi Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice
    Susanna C Benn
    Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurochem 95:1118-31. 2005
    ..These results indicate that TTC may serve as a useful prototype for development as a non-viral vehicle for improving delivery of therapeutic proteins to the CNS...
  11. ncbi IGF-1:tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice
    Ru Ju Chian
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA
    Brain Res 1287:1-19. 2009
    ..IGF-1:TTC may prove to be neuroprotective in other animal models of CNS disease or injury known to be responsive to unmodified IGF-1...
  12. ncbi Bimodal thrombus imaging: simultaneous PET/MR imaging with a fibrin-targeted dual PET/MR probe--feasibility study in rat model
    Ritika Uppal
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA
    Radiology 258:812-20. 2011
    ..To image thrombus by using magnetic resonance (MR) imaging and positron emission tomography (PET) simultaneously in a rat arterial thrombus model with a dual PET/MR probe...
  13. ncbi Inhibition of SOD1 expression by mitomycin C is a non-specific consequence of cellular toxicity
    Wendy J Broom
    Day Neuromuscular Research Laboratory, Massachusetts General Hospital, MGH East, 114 16th Street, Navy Yard, Charlestown, MA 02129, USA
    Neurosci Lett 393:184-8. 2006
    ..Our data indicate the apparent inhibition of SOD1 expression by MC is a non-specific consequence of MC-induced cellular toxicity...
  14. ncbi Fibrin-targeted PET probes for the detection of thrombi
    Katie L Ciesienski
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Suite 2301, Charlestown, Massachusetts 02129, USA
    Mol Pharm 10:1100-10. 2013
    ..FBP1 and FBP2 represent promising new probes for the molecular imaging of thrombi...
  15. ncbi Molecular MRI of intracranial thrombus in a rat ischemic stroke model
    Ritika Uppal
    Department of Radiology, Massachusetts General Hospital East, 149 13th Street, Suite 2301, Charlestown, MA 02129, USA
    Stroke 41:1271-7. 2010
    ..In this study, we examined whether this fibrin-specific MR probe could noninvasively characterize intracranial arterial thrombi...
  16. ncbi Protective effects of valproic acid against hypoxic-ischemic brain injury in neonatal rats
    Nimet Kabakus
    Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Child Neurol 20:582-7. 2005
    ..05). These results suggest that valproic acid can have therapeutic and protective effects in hypoxic-ischemic brain injury...