Ken Arai

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells
    Ken Arai
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Neurosci 29:4351-5. 2009
  2. pmc Mechanisms of neurovascular dysfunction in acute ischemic brain
    Y Terasaki
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, USA
    Curr Med Chem 21:2035-42. 2014
  3. pmc Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases
    Takakuni Maki
    Neuroprotection Research Laboratory, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    CNS Neurol Disord Drug Targets 12:302-15. 2013
  4. pmc Experimental models for analysis of oligodendrocyte pathophysiology in stroke
    Ken Arai
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Exp Transl Stroke Med 1:6. 2009
  5. pmc Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling
    Ken Arai
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neurosci Res 88:758-63. 2010
  6. pmc Cellular mechanisms of neurovascular damage and repair after stroke
    Ken Arai
    The Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    J Child Neurol 26:1193-8. 2011
  7. pmc Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke
    Ken Arai
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    FEBS J 276:4644-52. 2009
  8. pmc Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia
    Guang Jin
    Massachusetts General Hospital, Neuroprotection Research Laboratory, 149 13th Street, R 2401, Charlestown, MA 02129, USA
    Stroke 39:2538-43. 2008
  9. pmc Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 31:10666-70. 2011
  10. pmc Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro
    Brian J Lee
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Brain Res 1307:22-7. 2010

Collaborators

Detail Information

Publications51

  1. pmc An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells
    Ken Arai
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Neurosci 29:4351-5. 2009
    ..These data suggest that a novel oligovascular niche may be important for sustaining oligodendrocyte renewal and homeostasis in mammalian brain...
  2. pmc Mechanisms of neurovascular dysfunction in acute ischemic brain
    Y Terasaki
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, USA
    Curr Med Chem 21:2035-42. 2014
    ....
  3. pmc Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases
    Takakuni Maki
    Neuroprotection Research Laboratory, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    CNS Neurol Disord Drug Targets 12:302-15. 2013
    ....
  4. pmc Experimental models for analysis of oligodendrocyte pathophysiology in stroke
    Ken Arai
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Exp Transl Stroke Med 1:6. 2009
    ..A systematic utilization of these cell, tissue and whole-animal platforms may eventually lead us to discover new targets for treating white matter injury in stroke and other CNS disorders...
  5. pmc Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling
    Ken Arai
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neurosci Res 88:758-63. 2010
    ..Taken together, these data suggest that astrocytes are an important source for oligodendrocyte-supportive factors. Coupling between these two major glial components in brain may be vital for sustaining white matter homeostasis...
  6. pmc Cellular mechanisms of neurovascular damage and repair after stroke
    Ken Arai
    The Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    J Child Neurol 26:1193-8. 2011
    ..Because plasticity is a signature feature of the young and developing brain, these concepts may have special relevance to how the pediatric brain responds after stroke...
  7. pmc Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke
    Ken Arai
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    FEBS J 276:4644-52. 2009
    ..Understanding how neurovascular signals and substrates make the transition from initial injury to angiogenic recovery will be important if we are to find new therapeutic approaches for stroke...
  8. pmc Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia
    Guang Jin
    Massachusetts General Hospital, Neuroprotection Research Laboratory, 149 13th Street, R 2401, Charlestown, MA 02129, USA
    Stroke 39:2538-43. 2008
    ..The current study was designed to investigate 12/15-LOX involvement in vascular injury in the ischemic brain...
  9. pmc Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 31:10666-70. 2011
    ..Our findings demonstrate that VEGF-A can induce OPC migration via an ROS- and FAK-dependent mechanism, and suggest a novel role for VEGF-A in white-matter maintenance and homeostasis...
  10. pmc Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro
    Brian J Lee
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Brain Res 1307:22-7. 2010
    ..Edaravone significantly ameliorated this response. These data suggest that free radical scavengers are effective in all cell types of the neurovascular unit, and should still be considered as a potential therapeutic approach for stroke...
  11. pmc Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice
    Nobukazu Miyamoto
    From the Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA N M, T M, L D D P, K H, J H S, E T M, E H L, K A Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA J B M and NeuroVascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences J H S, K W K and Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology K W K, Seoul National University, Seoul, Korea
    Stroke 44:3516-21. 2013
    ..Here, we test the hypothesis that oxidative stress interferes with endogenous white matter repair by disrupting renewal processes mediated by oligodendrocyte precursor cells (OPCs)...
  12. pmc Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neurosci Lett 513:42-6. 2012
    ..This phenomenon may be important for white matter homeostasis...
  13. pmc Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury
    Loc Duyen D Pham
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Glia 60:875-81. 2012
    ..In gray matter, a neurovascular niche promotes cortical recovery after brain injury. Our study suggests that an analogous oligovascular niche may mediate recovery in white matter...
  14. pmc Crosstalk between cerebral endothelium and oligodendrocyte
    Nobukazu Miyamoto
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, MGH East 149 2401, Charlestown, MA, 02129, USA
    Cell Mol Life Sci 71:1055-66. 2014
    ..Therefore, a deeper understanding of the mechanisms of endothelial-oligodendrocyte trophic coupling may lead to new therapeutic approaches for white matter-related diseases, such as stroke or vascular dementia. ..
  15. pmc Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury
    Ji Hae Seo
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 123:782-6. 2013
    ..Our study reveals that OPCs can rapidly respond to white matter injury and produce MMP9 that disrupts the BBB, indicating that OPCs may mediate injury in white matter under disease conditions...
  16. pmc Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 109:7505-10. 2012
    ....
  17. pmc Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1
    Emiri Tejima
    Program in Neuroscience, Harvard Medical School, Charlestown, Massachusetts, USA
    J Neurotrauma 26:1935-41. 2009
    ..Taken together, these cell culture and in vivo data provide initial proof-of-principle that TIMP-1 is neuroprotective against traumatic and ischemic brain injury in mice...
  18. pmc Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway
    Stefanie Pallast
    Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 30:1157-67. 2010
    ..0%+/-2.7%), suggesting cell death through organelle damage. Taken together, these findings show that 12/15-LOX and AIF are sequential actors in a common cell death pathway that may contribute to stroke-induced brain damage...
  19. pmc Novel lipoxygenase inhibitors as neuroprotective reagents
    Klaus van Leyen
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci Res 86:904-9. 2008
    ..Future studies of these novel neuroprotective inhibitors of 12/15-LOX may provide new therapeutic opportunities to combat stroke and other neurodegenerative diseases...
  20. ncbi request reprint Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia
    Kiyoshi Tsuji
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Stroke 36:1954-9. 2005
    ..Here, we used a combination of pharmacological and genetic approaches to show that tPA promotes MMP-9 levels in stroke in vivo...
  21. pmc Injury and repair in the neurovascular unit
    Changhong Xing
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Boston, USA
    Neurol Res 34:325-30. 2012
    ....
  22. pmc A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death
    Eizo Marutani
    Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 287:32124-35. 2012
    ..These results suggest that an H(2)S-releasing NMDAR antagonist derivative S-memantine prevents ischemic neuronal death, providing a novel therapeutic strategy for ischemic brain injury...
  23. pmc Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia
    Yoshihiro Murata
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 32:8112-5. 2012
    ..Our data provide initial proof-of-concept that the neuronal death target JNK may also participate in endogenous processes of neurovascular remodeling and recovery after cerebral ischemia...
  24. pmc Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes
    Shuzhen Guo
    Department of Radiology and Neurology, Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Stroke 40:652-5. 2009
    ..We tested the hypothesis that lithium can promote the expression of growth factors in brain endothelial cells and astrocytes...
  25. pmc Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro
    Anna Rosell
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 29:933-43. 2009
    ..Further studies are warranted to assess how interactions between proinflammatory environments and EPC responses may be leveraged to enhance therapeutic angiogenesis...
  26. pmc Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells
    Changhong Xing
    Neuroprotection Research Laboratory, Department of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, MGH East, 149 2401, 13th St, Charlestown, MA 02129, USA
    Neurochem Res 35:1092-7. 2010
    ..No changes were detected in pericytes. These findings may provide a potential mechanism for CD47-induced changes in blood-brain barrier homeostasis, and further suggest that CD47 may be a relevant neurovascular target in stroke...
  27. pmc Experimental model of warfarin-associated intracerebral hemorrhage
    Christian Foerch
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Masschusetts 02129, USA
    Stroke 39:3397-404. 2008
    ..This study describes the development of a mouse model of W-ICH in which hematoma growth and outcomes can be correlated with anticoagulation parameters...
  28. pmc 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress
    Stefanie Pallast
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Neurochem 111:882-9. 2009
    ..These findings position 12/15-LOX as the central executioner in an oxidative stress-related neuronal death program...
  29. pmc Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Glia 58:1007-15. 2010
    ..These data suggest a novel pathway by which inflammatory cytokines may enhance the ability of reactive astrocytes to release prorecovery mediators after stroke...
  30. pmc Age-related decline in oligodendrogenesis retards white matter repair in mice
    Nobukazu Miyamoto
    Department of Radiology and Neurology, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, MA, USA
    Stroke 44:2573-8. 2013
    ..Here, we ask whether, compared with young brains, white matter regions in older brains may be more vulnerable in part because of decreased rates of compensatory oligodendrogenesis after injury...
  31. ncbi request reprint Baicalein and 12/15-lipoxygenase in the ischemic brain
    Klaus van Leyen
    Stroke and Neurovascular Research Group, Department of Radiology, Massachusetts General Hospital, 149 13th St, R 2401, Charlestown, MA 02129, USA
    Stroke 37:3014-8. 2006
    ..The current study was designed to test if the neuroprotective properties of baicalein are related to its lipoxygenase inhibition...
  32. pmc High-mobility group box 1: an amplifier of stem and progenitor cell activity after stroke
    Kazuhide Hayakawa
    Harvard Medical School, MA, USA
    Acta Neurochir Suppl 118:31-8. 2013
    ..These emerging findings support the hypothesis that HMGB1 might be an important molecule for regulating stem and progenitor cell therapies in stroke patients...
  33. pmc Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke
    Norio Fujiwara
    Neuroprotection Research Laboratory, Departments of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    BMC Neurosci 10:79. 2009
    ..NBO was maintained for 3 hours. Infarct volume, brain swelling and hemorrhagic transformation were quantified at 24 hours. Outcome assessments were blinded to therapy...
  34. doi request reprint Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage
    Norio Fujiwara
    ACC 729 C, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Stroke 42:1469-72. 2011
    ..Normobaric oxygen (NBO) therapy may be neuroprotective in acute ischemic stroke. However, how NBO may affect intracerebral hemorrhage is unclear. We tested NBO in a rat model of striatal intracerebral hemorrhage...
  35. pmc Pathophysiologic cascades in ischemic stroke
    Changhong Xing
    Department of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Int J Stroke 7:378-85. 2012
    ..An integrative approach that encompasses the multimodal and multicell signaling phenomenon of stroke will be required to move forward...
  36. pmc Oligovascular signaling in white matter stroke
    Ken Arai
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Biol Pharm Bull 32:1639-44. 2009
    ..A deeper understanding of the mechanisms of oligovascular signaling in normal and pathologic conditions may lead us to new therapeutic targets for stroke and other neurodegenerative diseases...
  37. pmc Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice
    Christian Foerch
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e54203. 2013
    ..However, due to potential species differences and the inability of models to fully capture the dynamics of human ICH, caution is warranted when considering the implications of these findings for human therapy...
  38. pmc Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model
    Francisco Campos
    Stroke Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Stroke 44:505-11. 2013
    ..Based on these observations, we hypothesized that combination of fingolimod with tissue plasminogen activator (tPA) would reduce the risk of hemorrhagic transformation associated with delayed administration of tPA...
  39. ncbi request reprint Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells
    Ken Arai
    Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurochem 89:232-9. 2004
    ..These data indicate that ERK may contribute to non-caspase-dependent pathways of injury after ER stress...
  40. doi request reprint Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury
    Daniel J Macaya
    Tissue Engineering, VA Boston Healthcare System, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02130, USA
    Biomaterials 34:3591-602. 2013
    ..Overall, injectable collagen-genipin hydrogels containing FGF-2-containing LMTs are a promising candidate for the treatment for SCI through the attraction of astrocytes into the graft...
  41. pmc Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage
    Christian Foerch
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 29:1015-21. 2009
    ..Future studies are needed to assess the therapeutic potential emerging from our finding for human W-ICH...
  42. ncbi request reprint Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes
    Ken Arai
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Glia 43:254-64. 2003
    ..Taken together, these results suggest that the ERK MAP kinase is essential for MMP-9 upregulation via PKC and cytokine pathways in astrocytes...
  43. pmc A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion
    Nobukazu Miyamoto
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, USA
    Neurosci Lett 573:40-5. 2014
    ..Taken together, our proof-of-concept study demonstrates that radical scavengers may provide a potential therapeutic approach for white matter injury by suppressing BBB damage. ..
  44. pmc Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, Charlestown, MA, USA Harvard Medical School, USA Electronic address
    Stem Cell Res 12:531-8. 2014
    ..Further investigation of this phenomenon may lead to a better understanding of cell-cell interactions required for neurovascular recovery after stroke. ..
  45. pmc Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage
    Sherry H Y Chou
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02114, USA
    Stroke 42:3624-7. 2011
    ..How these 2 phenomena are related remains unclear. We hypothesize that matrix metalloproteinases (MMPs) mediate the depletion of anti-inflammatory plasma-type gelsolin (pGSN)...
  46. pmc Mechanisms and targets for angiogenic therapy after stroke
    Deepti Navaratna
    Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Cell Adh Migr 3:216-23. 2009
    ..A better understanding of the molecular interplay between all these complex pathways may lead to novel therapeutic avenues for tackling this difficult disease...
  47. pmc Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue
    Sava Sakadzic
    Photon Migration Imaging Laboratory, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Nat Methods 7:755-9. 2010
    ..The properties of the probe allowed for direct high-resolution measurement of cortical extravascular (tissue) pO(2), opening many possibilities for functional metabolic brain studies...
  48. pmc Studying extracellular signaling utilizing a glycoproteomic approach: lectin blot surveys, a first and important step
    Jing Cao
    Neuroprotection Research Laboratory, Massachussetts General Hospital and Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 1013:227-33. 2013
    ..Here, we will use patient plasma samples post hypothermic therapy-an extremely complex medium-as a tool to describe in detail the technique of lectin blotting for proteomic analysis...
  49. ncbi request reprint Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator
    Xiaoying Wang
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, Charlestown, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 9:1313-7. 2003
    ..Targeting the tPA-LRP signaling pathway in brain may offer new approaches for decreasing neurotoxicity and improving stroke therapy...
  50. pmc White matter hyperintensity volume correlates with matrix metalloproteinase-2 in acute ischemic stroke
    Zachary A Corbin
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
    J Stroke Cerebrovasc Dis 23:1300-6. 2014
    ..We sought to determine whether WMH severity is associated with plasma levels of MMPs and oxidative stress (F2-isoprostane) in subjects with acute ischemic stroke (AIS)...