J Michael Andresen

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds
    J M Andresen
    Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Med Genet 44:44-50. 2007
  2. ncbi request reprint The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset
    J Michael Andresen
    Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Ann Hum Genet 71:295-301. 2007
  3. ncbi request reprint The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
    J Borrow
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nat Genet 14:33-41. 1996
  4. pmc Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
    Nancy S Wexler
    Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:3498-503. 2004
  5. ncbi request reprint RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice
    Heliane G Serra
    Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Cell 127:697-708. 2006
  6. doi request reprint Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds
    Javier Gayan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Genet Epidemiol 32:445-53. 2008
  7. ncbi request reprint Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1
    Nathan D Jorgensen
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurochem 102:2040-8. 2007

Collaborators

  • J Gayan
  • Lon R Cardon
  • L Djousse
  • Anne B Young
  • Huda Zoghbi
  • H T Orr
  • Richard Myers
  • Nathan D Jorgensen
  • Heliane G Serra
  • Nancy S Wexler
  • Melissa A Swenson
  • Jason E Pitt
  • Lisa Duvick
  • Alana Lysholm
  • H Brent Clark
  • Eric Burright
  • Tao Zu
  • Nathan Jorgensen
  • Kerri Carlson
  • Sam Stevens
  • Ira Shoulson
  • David E Housman
  • Leticia Acosta
  • Andrew Feigin
  • James Gusella
  • Jang Ho Cha
  • Carol Moskowitz
  • Leslie M Thompson
  • Adam Brickman
  • Norman Arnheim
  • Shelley Peery
  • Denise Brocklebank
  • S Robert Snodgrass
  • Simone A Roberts
  • Judith Lorimer
  • Margot Mieja De Young
  • Fidela Gomez
  • Sandra Wiktorski
  • Americo Negrette
  • Michael Irizarry
  • Karen Marder
  • Penelope Hogarth
  • Kenneth Fischbeck
  • Theresa Stillings
  • Bernhard Landwehrmeyer
  • Leon Dure
  • Frederick Marshall
  • Julie Porter
  • Jacqueline Bickham
  • Maria A Ramos-Arroyo
  • Maria Dolores Martinez-Jaurrieta
  • Jacqueline Gray
  • Stacey S Cherny
  • Denise Krch
  • Steven Hersch
  • Zane Hollingsworth
  • Graciela Penchaszadeh
  • Edith Shackell
  • Marcy MacDonald
  • Amarilis Acevedo-Cruz
  • Ernesto Bonilla
  • Jane Paulsen
  • Christopher J O'Brien
  • Donald S Higgins
  • P Michael Conneally
  • Jack B Penney
  • Stephen R Dlouhy
  • Gustavo J Rey
  • Marion E Hodes
  • Juan Sanchez Ramos
  • Diana Rosas
  • Jose Alvir
  • J Borrow
  • F Mitelman
  • C I Civin
  • R Becher
  • V P Stanton
  • D E Housman
  • D Horsman
  • A E Watmore
  • S Volinia
  • A M Frischauf
  • C Disteche
  • R S Chaganti
  • F G Behm
  • I Dube

Detail Information

Publications7

  1. pmc Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds
    J M Andresen
    Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Med Genet 44:44-50. 2007
    ..Many genetic polymorphisms have previously shown evidence of association with age of onset of Huntington's disease in several different populations...
  2. ncbi request reprint The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset
    J Michael Andresen
    Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Ann Hum Genet 71:295-301. 2007
    ..27, P= 2 x 10(-16)]. In both populations, the influence of each CAG repeat on age of onset appears to be stronger in the adult-onset range of CAG repeats than in the juvenile-onset range...
  3. ncbi request reprint The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
    J Borrow
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nat Genet 14:33-41. 1996
    ..We suggest that MOZ may represent a chromatin-associated acetyltransferase, and raise the possibility that a dominant MOZ-CBP fusion protein could mediate leukaemogenesis via aberrant chromatin acetylation...
  4. pmc Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
    Nancy S Wexler
    Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:3498-503. 2004
    ..37), shared environment (0.22), and nonshared environment (0.41) variances, confirming that approximately 40% of the variance remaining in onset age is attributable to genes other than the HD gene and 60% is environmental...
  5. ncbi request reprint RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice
    Heliane G Serra
    Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Cell 127:697-708. 2006
    ..These studies indicate RORalpha and Tip60 have a role in SCA1 and suggest a mechanism by which compromising cerebellar development contributes to severity of neurodegeneration in an adult...
  6. doi request reprint Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds
    Javier Gayan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Genet Epidemiol 32:445-53. 2008
    ..14 at 5q32). All these regions harbor candidate genes that are potential HD modifier genes. Finding these modifier genes can reveal accessible and promising new therapeutic pathways and targets to ameliorate and cure HD...
  7. ncbi request reprint Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1
    Nathan D Jorgensen
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurochem 102:2040-8. 2007
    ..However, Akt targeted to the cytoplasm failed to destabilize ATXN1 if Hsp70/Hsc70 was present. Thus, Hsp70/Hsc70 can regulate ATXN1 levels in concert with phosphorylation of ATXN1 at S776...