Ashwin N Ananthakrishnan

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Clostridium difficile infection: epidemiology, risk factors and management
    Ashwin N Ananthakrishnan
    Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA
    Nat Rev Gastroenterol Hepatol 8:17-26. 2011
  2. ncbi request reprint Association between reduced plasma 25-hydroxy vitamin D and increased risk of cancer in patients with inflammatory bowel diseases
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts Electronic address
    Clin Gastroenterol Hepatol 12:821-7. 2014
  3. pmc A prospective study of long-term intake of dietary fiber and risk of Crohn's disease and ulcerative colitis
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Electronic address
    Gastroenterology 145:970-7. 2013
  4. pmc Genetic risk factors for Clostridium difficile infection in ulcerative colitis
    A N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Aliment Pharmacol Ther 38:522-30. 2013
  5. pmc Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Inflamm Bowel Dis 19:1921-7. 2013
  6. pmc How does genotype influence disease phenotype in inflammatory bowel disease?
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Inflamm Bowel Dis 19:2021-30. 2013
  7. pmc Cyclic Vomiting Syndrome (CVS): is there a difference based on onset of symptoms--pediatric versus adult?
    Nilay Kumar
    Department of Gastroenterology and Hepatology, Medical College of Wisconsin, 4th Floor, Froedtert East Building, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    BMC Gastroenterol 12:52. 2012
  8. doi request reprint Personalizing therapy for inflammatory bowel diseases
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA
    Expert Rev Gastroenterol Hepatol 7:549-58. 2013
  9. pmc Sleep disturbance and risk of active disease in patients with Crohn's disease and ulcerative colitis
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 11:965-71. 2013
  10. pmc Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach
    Ashwin N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Inflamm Bowel Dis 19:1411-20. 2013

Detail Information

Publications78

  1. doi request reprint Clostridium difficile infection: epidemiology, risk factors and management
    Ashwin N Ananthakrishnan
    Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA
    Nat Rev Gastroenterol Hepatol 8:17-26. 2011
    ..Infection control measures are key to prevent horizontal transmission of infection. Ongoing research into effective treatment protocols and prevention is essential...
  2. ncbi request reprint Association between reduced plasma 25-hydroxy vitamin D and increased risk of cancer in patients with inflammatory bowel diseases
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts Electronic address
    Clin Gastroenterol Hepatol 12:821-7. 2014
    ..The effects of low plasma 25-hydroxy vitamin D (25[OH]D) on outcomes other than bone health are understudied in patients with IBD. We examined the association between plasma level of 25(OH)D and risk of cancers in patients with IBD...
  3. pmc A prospective study of long-term intake of dietary fiber and risk of Crohn's disease and ulcerative colitis
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Electronic address
    Gastroenterology 145:970-7. 2013
    ..However, few prospective studies have examined associations between long-term intake of dietary fiber and risk of incident CD or UC...
  4. pmc Genetic risk factors for Clostridium difficile infection in ulcerative colitis
    A N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Aliment Pharmacol Ther 38:522-30. 2013
    ..Whether genetic polymorphisms associated with susceptibility to IBD are also associated with risk of CDI is unknown...
  5. pmc Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Inflamm Bowel Dis 19:1921-7. 2013
    ..Vitamin D may have an immunologic role in Crohn's disease (CD) and ulcerative colitis (UC). Retrospective studies suggested a weak association between vitamin D status and disease activity but have significant limitations...
  6. pmc How does genotype influence disease phenotype in inflammatory bowel disease?
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Inflamm Bowel Dis 19:2021-30. 2013
    ..g., diet) and internal (microbiome) environment to allow us to progress toward personalized and precision medicine in the management of these complex diseases...
  7. pmc Cyclic Vomiting Syndrome (CVS): is there a difference based on onset of symptoms--pediatric versus adult?
    Nilay Kumar
    Department of Gastroenterology and Hepatology, Medical College of Wisconsin, 4th Floor, Froedtert East Building, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    BMC Gastroenterol 12:52. 2012
    ..Genetic differences in pediatric-onset (presentation before age 18) and adult-onset CVS have been reported recently but their clinical features and possible differences in response to therapy have not been well studied...
  8. doi request reprint Personalizing therapy for inflammatory bowel diseases
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA
    Expert Rev Gastroenterol Hepatol 7:549-58. 2013
    ....
  9. pmc Sleep disturbance and risk of active disease in patients with Crohn's disease and ulcerative colitis
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 11:965-71. 2013
    ..Sleep impairment can activate inflammatory pathways. Few prospective studies have examined the role of sleep disturbance on risk of relapse in IBD...
  10. pmc Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach
    Ashwin N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Inflamm Bowel Dis 19:1411-20. 2013
    ....
  11. pmc Treatment of intra-abdominal abscesses in Crohn's disease: a nationwide analysis of patterns and outcomes of care
    Ashwin N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital Crohn s and Colitis Center, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA
    Dig Dis Sci 58:2013-8. 2013
    ..There have been no nationally representative studies comparing different treatment modalities for abdominal abscesses...
  12. pmc Weekend hospitalisations and post-operative complications following urgent surgery for ulcerative colitis and Crohn's disease
    A N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Aliment Pharmacol Ther 37:895-904. 2013
    ..There is increasing complexity in the management of patients with acute severe exacerbation of inflammatory bowel disease [IBD; Crohn's disease (CD), ulcerative colitis (UC)] with frequent requirement for urgent surgery...
  13. pmc Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis
    Ashwin N Ananthakrishnan
    Crohn s and Colitis Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Gastroenterol 108:594-601. 2013
    ..The objective of this study is to examine whether there is a difference in the risk of psychiatric comorbidity following surgery in CD and UC...
  14. doi request reprint Can mucosal healing be a cost-effective endpoint for biologic therapy in Crohn's disease? A decision analysis
    Ashwin N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Inflamm Bowel Dis 19:37-44. 2013
    ..Whether treatment to achieve MH is a cost-effective endpoint has not been established previously...
  15. pmc Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease
    A N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
    Aliment Pharmacol Ther 37:445-54. 2013
    ..Prior studies examining this may be confounded by the co-existence of functional bowel symptoms. Limited data exist examining an association between depression or anxiety and disease-specific endpoints such as bowel surgery...
  16. doi request reprint Infection-related hospitalizations are associated with increased mortality in patients with inflammatory bowel diseases
    Ashwin N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA
    J Crohns Colitis 7:107-12. 2013
    ..There have been no nationally representative studies examining the spectrum of infection related hospitalizations in patients with IBD...
  17. pmc Association between depressive symptoms and incidence of Crohn's disease and ulcerative colitis: results from the Nurses' Health Study
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Gastroenterol Hepatol 11:57-62. 2013
    ..Although many mechanisms have been proposed to link these disorders, few prospective studies have examined the relationship between depressed mood and incidence of CD or UC...
  18. pmc Environmental triggers for inflammatory bowel disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA
    Curr Gastroenterol Rep 15:302. 2013
    ..The effect of diet on established disease remains poorly studied. There is need for routine measurement of a spectrum of environmental exposures in prospective studies to further our understanding...
  19. doi request reprint Strategies for the prevention of postoperative recurrence in Crohn's disease: results of a decision analysis
    Ashwin N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Gastroenterol 106:2009-17. 2011
    ..Several options exist for the prevention of postoperative recurrence in CD, but the comparative cost effectiveness of these competing strategies has not been previously analyzed...
  20. doi request reprint Detecting and treating Clostridium difficile infections in patients with inflammatory bowel disease
    Ashwin N Ananthakrishnan
    Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA
    Gastroenterol Clin North Am 41:339-53. 2012
    ..Several gaps in research exist; prospective multicenter cohorts of CDI-IBD are essential to improve our understanding of the impact of CDI on IBD patients and define appropriate therapeutic regimens to improve patient outcomes...
  21. pmc Predictors of severe outcomes associated with Clostridium difficile infection in patients with inflammatory bowel disease
    A N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, USA
    Aliment Pharmacol Ther 35:789-95. 2012
    ..However, most studies have focused on demonstrating that CDI is associated with adverse outcomes in IBD patients. Few have attempted to identify predictors of severe outcomes associated with CDI among IBD patients...
  22. doi request reprint Certolizumab pegol compared to natalizumab in patients with moderate to severe Crohn's disease: results of a decision analysis
    Ashwin N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital Crohn s and Colitis Center, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA
    Dig Dis Sci 57:472-80. 2012
    ..In patients failing two anti-TNF agents, a choice exists between using a third-anti-TNF therapy or natalizumab (NAT), an α-4 integrin inhibitor. A cost-effectiveness analysis comparing these competing strategies has not been performed...
  23. doi request reprint Ambient air pollution correlates with hospitalizations for inflammatory bowel disease: an ecologic analysis
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 02114, USA
    Inflamm Bowel Dis 17:1138-45. 2011
    ..The association between ambient air pollution and IBD hospitalizations has not been previously studied...
  24. doi request reprint A nationwide analysis of changes in severity and outcomes of inflammatory bowel disease hospitalizations
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Gastrointest Surg 15:267-76. 2011
    ..The impact of this on IBD hospitalization outcomes is unknown...
  25. doi request reprint Fracture-associated hospitalizations in patients with inflammatory bowel disease
    Ashwin N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA
    Dig Dis Sci 56:176-82. 2011
    ..Maintenance of bone health is an important concern in patients with inflammatory bowel disease (IBD). They may frequently have impaired bone density resulting in greater incidence of fractures...
  26. doi request reprint Temporal trends in disease outcomes related to Clostridium difficile infection in patients with inflammatory bowel disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 02114, USA
    Inflamm Bowel Dis 17:976-83. 2011
    ..No studies have examined the temporal change in severity of C. difficile infection (CDI) complicating IBD...
  27. doi request reprint Length of office visits for gastrointestinal disease: impact of physician specialty
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Gastroenterol 105:1719-25. 2010
    ..Physician-visit length is an important determinant of patient satisfaction and outcomes. Our objective was to compare visit length for gastrointestinal disorders between gastroenterologists and primary-care providers (PCPs)...
  28. pmc Higher physician density is associated with lower incidence of late-stage colorectal cancer
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Department of Pediatrics, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Gen Intern Med 25:1164-71. 2010
    ..Routine screening decreases incidence and mortality; however rates of screening remain low. Physician recommendation is a key determinant of screening rates; thus, physician availability may also influence CRC incidence and mortality...
  29. doi request reprint Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life
    Alex Ulitsky
    Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    JPEN J Parenter Enteral Nutr 35:308-16. 2011
    ..It was hypothesized that vitamin D deficiency is associated with increased disease activity and lower health-related quality of life (HRQOL)...
  30. pmc Higher predicted vitamin D status is associated with reduced risk of Crohn's disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02214, USA
    Gastroenterology 142:482-9. 2012
    ..Vitamin D influences innate immunity, which is believed to be involved in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). However, data examining vitamin D status in relation to risk of CD and UC are lacking...
  31. doi request reprint Does primary sclerosing cholangitis impact quality of life in patients with inflammatory bowel disease?
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI 53227, USA
    Inflamm Bowel Dis 16:494-500. 2010
    ..Between 2%-10% of patients with IBD have primary sclerosing cholangitis (PSC). There has been limited examination of the disease-specific HRQoL in this population compared to non-PSC IBD controls...
  32. ncbi request reprint Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses' Health Study cohorts
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    BMJ 347:f6633. 2013
    ..To examine the association between physical activity and risk of ulcerative colitis and Crohn's disease...
  33. ncbi request reprint Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gut 63:776-84. 2014
    ..Dietary fats influence intestinal inflammation and regulate mucosal immunity. Data on the association between dietary fat and risk of Crohn's disease (CD) and ulcerative colitis (UC) are limited and conflicting...
  34. pmc Geographical variation and incidence of inflammatory bowel disease among US women
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gut 61:1686-92. 2012
    ..However, there are no comparable data in the USA. The incidence of CD and UC in relation to latitude was assessed in a geographically diverse population of women enrolled in two large prospective studies in the USA...
  35. doi request reprint Clostridium difficile and inflammatory bowel disease
    Mazen Issa
    Inflammatory Bowel Disease Center, Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 14:1432-42. 2008
    ..In this review we summarize the present knowledge regarding C. difficile infection in the setting of IBD, including unique clinical scenarios facing IBD patients, diagnostic algorithms, and treatment approaches...
  36. doi request reprint Differential effect of genetic burden on disease phenotypes in Crohn's disease and ulcerative colitis: analysis of a North American cohort
    Ashwin N Ananthakrishnan
    1 Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Harvard Medical School, Boston, Massachusetts, USA
    Am J Gastroenterol 109:395-400. 2014
    ..There is considerable heterogeneity in disease course and accurate prediction of natural history has been challenging. The phenotypic implication of increasing genetic predisposition to CD or UC is unknown...
  37. pmc Impact of coexistent celiac disease on phenotype and natural history of inflammatory bowel diseases
    Emily C Oxford
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
    Am J Gastroenterol 108:1123-9. 2013
    ..We conducted this study to determine whether patients with coexisting celiac disease present a unique phenotype of IBD and to examine the frequency of co-occurrence of celiac disease and IBD in comparison with other autoimmune disorders...
  38. pmc Oral contraceptives, reproductive factors and risk of inflammatory bowel disease
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gut 62:1153-9. 2013
    ..Oral contraceptive use has been associated with risk of Crohn's disease (CD) and ulcerative colitis (UC)...
  39. doi request reprint Higher hospital volume is associated with lower mortality in acute nonvariceal upper-GI hemorrhage
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Gastrointest Endosc 70:422-32. 2009
    ..Acute nonvariceal upper-GI hemorrhage (NVUGIH) is associated with significant morbidity and mortality...
  40. pmc Hormone therapy increases risk of ulcerative colitis but not Crohn's disease
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 143:1199-206. 2012
    ..The role of postmenopausal hormone therapy on risk of Crohn's disease (CD) and ulcerative colitis (UC) is unclear...
  41. doi request reprint Impact of autonomic dysfunction on inflammatory bowel disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    J Clin Gastroenterol 44:272-9. 2010
    ..The autonomic nervous system has been proposed to be involved in the pathogenesis of IBD. Autonomic dysfunction (AD) is associated with systemic manifestations and altered gut motility that may contributed to functional symptoms...
  42. doi request reprint A novel risk score to stratify severity of Crohn's disease hospitalizations
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 105:1799-807. 2010
    ..General comorbidity indices were developed to predict mortality, which is rare in this population. There are limited tools to stratify these hospitalizations by severity...
  43. ncbi request reprint Impact of prior irregular infliximab dosing on performance of long-term infliximab maintenance therapy in Crohn's disease
    Daniel J Stein
    Medical College of Wisconsin Division of Gastroenterology, Milwaukee, Wisconsin, USA
    Inflamm Bowel Dis 16:1173-9. 2010
    ..There are limited data regarding performance of infliximab in patients who require reinitiation of maintenance dosing following previous irregular exposure...
  44. pmc Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study
    Ashwin N Ananthakrishnan
    Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Ann Intern Med 156:350-9. 2012
    ..Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are anti-inflammatory but have been linked in some studies to Crohn disease (CD) and ulcerative colitis (UC)...
  45. doi request reprint Does it matter where you are hospitalized for inflammatory bowel disease? A nationwide analysis of hospital volume
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 103:2789-98. 2008
    ..To examine if a high hospital volume was associated with superior outcomes in inflammatory bowel disease (IBD) patients requiring hospitalization...
  46. pmc Clostridium difficile infection in hospitalized liver transplant patients: a nationwide analysis
    Muhammad Ali
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Liver Transpl 18:972-8. 2012
    ..70, 95% CI = 1.29-2.25). In conclusion, the prevalence of CDI is higher for LT patients versus non-LT patients (2.7% versus 0.9%). CDI is an independent risk factor for mortality in the LT population...
  47. doi request reprint History of medical hospitalization predicts future need for colectomy in patients with ulcerative colitis
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Inflamm Bowel Dis 15:176-81. 2009
    ..These patients may be more likely to require future colectomy. There are limited data examining whether medical hospitalization is predictive of subsequent colectomy...
  48. doi request reprint Durability of infliximab in Crohn's disease: a single-center experience
    Jason E Gonzaga
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Inflamm Bowel Dis 15:1837-43. 2009
    ..Durability of infliximab maintenance therapy over multiple years has not been defined...
  49. doi request reprint Simple score to identify colectomy risk in ulcerative colitis hospitalizations
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 16:1532-40. 2010
    ..Despite growing interest in research using administrative data in inflammatory bowel disease, there is no available tool in such research to stratify disease severity or identify patients at high risk for colectomy...
  50. doi request reprint QuantiFERON TB gold testing for tuberculosis screening in an inflammatory bowel disease cohort in the United States
    Bashar J Qumseya
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Inflamm Bowel Dis 17:77-83. 2011
    ..We evaluated the performance of the QuantiFERON TB Gold test (QFT-G) for TB screening in a cohort of inflammatory bowel disease (IBD) patients in the United States...
  51. pmc Early life factors and risk of inflammatory bowel disease in adulthood
    Hamed Khalili
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Inflamm Bowel Dis 19:542-7. 2013
    ..Early life factors have been postulated to play a role in development of immune tolerance and intestinal microbiome, which in turn may influence the risk of inflammatory bowel disease...
  52. doi request reprint Older age is associated with higher rate of discontinuation of anti-TNF therapy in patients with inflammatory bowel disease
    Amit Desai
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Inflamm Bowel Dis 19:309-15. 2013
    ..However, few studies to date have investigated the safety and durability of anti-tumor necrosis factor (TNF) therapy in this subgroup...
  53. doi request reprint Deep vein thrombosis and pulmonary embolism in hospitalized patients with cirrhosis: a nationwide analysis
    Muhammad Ali
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA
    Dig Dis Sci 56:2152-9. 2011
    ..Our aim was to determine burden and risk factors for VTE in cirrhotics from a national sample...
  54. doi request reprint Laparoscopic resection for inflammatory bowel disease: outcomes from a nationwide sample
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Gastrointest Surg 14:58-65. 2010
    ..While the majority of these are open procedures (OP), there is recent interest in laparoscopic resection (LS). There are no nationwide comparison of outcomes between LS and OP...
  55. doi request reprint Dyssynergic defecation: a treatable cause of persistent symptoms when inflammatory bowel disease is in remission
    Lilani P Perera
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA
    Dig Dis Sci 58:3600-5. 2013
    ..Introduction of biologic agents in inflammatory bowel disease (IBD) has increased the likelihood of disease remission. Despite resolution of active inflammation, a subset of IBD patients report persistent defecatory symptoms...
  56. doi request reprint Trends in ambulatory and emergency room visits for inflammatory bowel diseases in the United States: 1994-2005
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 105:363-70. 2010
    ..Analysis of trends in disease burden is important to study the changing epidemiology of disease. The aim of our study was to examine national trends in IBD-related visits in ambulatory and emergency room (ER) settings...
  57. doi request reprint Physician density and hospitalization for inflammatory bowel disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 17:633-8. 2011
    ..Regular maintenance care may reduce complications or the need for hospitalization. Availability of physicians may be an important determinant of IBD hospitalizations...
  58. ncbi request reprint Outcomes of weekend admissions for upper gastrointestinal hemorrhage: a nationwide analysis
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Clin Gastroenterol Hepatol 7:296-302e1. 2009
    ....
  59. doi request reprint Clostridium difficile and inflammatory bowel disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Gastroenterol Clin North Am 38:711-28. 2009
    ..Also reviewed are clinical situations specific to patients with IBD that are important for the treating physician to recognize...
  60. doi request reprint Impact of Clostridium difficile on inflammatory bowel disease
    Ashwin N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA
    Expert Rev Gastroenterol Hepatol 4:589-600. 2010
    ..There is a need to broaden these studies to the IBD population. There is also the need to prospectively examine whether CDI has long-term disease-modifying consequences in those with underlying IBD...
  61. doi request reprint Deleterious effect of cirrhosis on outcomes after motor vehicle crashes using the nationwide inpatient sample
    Jasmohan S Bajaj
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 103:1674-81. 2008
    ..Cirrhotics have poor post-trauma outcomes on small-scale studies. The aim was to examine the effect of cirrhosis on mortality, charges, and length of stay (LOS) after MVCs using the Nationwide Inpatient Sample (NIS) 2004...
  62. doi request reprint Effects of cancer treatment on inflammatory bowel disease remission and reactivation
    Jordan E Axelrad
    Massachusetts General Hospital Crohn s and Colitis Center, Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 10:1021-7.e1. 2012
    ..Little is known about the effects of cancer therapy for extraintestinal malignancy in patients with inflammatory bowel diseases (IBDs)...
  63. doi request reprint Budesonide induction and maintenance therapy for Crohn's disease during pregnancy
    Dawn B Beaulieu
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 15:25-8. 2009
    ..There is no available data on the safety of using oral budesonide in pregnant patients...
  64. ncbi request reprint Permanent work disability in Crohn's disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 103:154-61. 2008
    ..There are limited data from the United States on work disability from CD. We performed this study to identify clinical factors associated with permanent work disability in a CD tertiary referral cohort...
  65. doi request reprint Higher hospital volume predicts endoscopy but not the in-hospital mortality rate in patients with acute variceal hemorrhage
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Gastrointest Endosc 69:221-9. 2009
    ..Management of AVH requires early initiation of specialized care that may be more readily available at centers that deal with a high volume of AVH...
  66. doi request reprint Effect of hospital volume and teaching status on outcomes of acute liver failure
    Ashwin N Ananthakrishnan
    Department of Population Health, Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Liver Transpl 14:1347-56. 2008
    ..However, teaching hospitals and high-volume centers have equivalent in-hospital survival despite caring for this more severely ill cohort...
  67. doi request reprint Impact of pregnancy on health-related quality of life of patients with inflammatory bowel disease
    Ashwin N Ananthakrishnan
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Dig Dis 13:472-7. 2012
    ..To examine the impact of pregnancy on health-related quality of life (HRQoL) of women with inflammatory bowel disease (IBD)...
  68. ncbi request reprint Severe pulmonary toxicity after azathioprine/6-mercaptopurine initiation for the treatment of inflammatory bowel disease
    Ashwin N Ananthakrishnan
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Clin Gastroenterol 41:682-8. 2007
    ....
  69. doi request reprint Inflammatory bowel disease in the elderly is associated with worse outcomes: a national study of hospitalizations
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 15:182-9. 2009
    ..The aim of our study was to compare outcomes of IBD-related hospitalizations in a nationwide representative cohort of patients 65 years and older with younger patients...
  70. doi request reprint Editorial: improved efficacy of biological maintenance therapy in "early" compared with "late" Crohn's disease: strike while the iron is hot with anti-TNF agents?
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA
    Am J Gastroenterol 105:1583-5. 2010
    ..This editorial describes the data published so far on the correlation between disease duration and treatment response and examines the potential benefits to such treatment algorithms...
  71. doi request reprint Racial differences in liver transplantation outcomes in the MELD era
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 103:901-10. 2008
    ..Racial differences in post-transplant survival in the MELD era have not been previously examined...
  72. doi request reprint Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections
    Christina M Surawicz
    Division of Gastroenterology, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Gastroenterol 108:478-98; quiz 499. 2013
    ..We propose a classification of disease severity to guide therapy that is useful for clinicians. We review current treatment options for patients with recurrent CDI and recommendations for the control and prevention of outbreaks of CDI...
  73. pmc Aspirin protects against Barrett's esophagus in a multivariate logistic regression analysis
    Zehra B Omer
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Gastroenterol Hepatol 10:722-7. 2012
    ..We analyzed characteristics of patients with BE for factors that might be used in screening and management...
  74. doi request reprint A noninvasive clinical scoring model predicts risk of nonalcoholic steatohepatitis in morbidly obese patients
    Alex Ulitsky
    Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Obes Surg 20:685-91. 2010
    ..We investigated a large group of morbidly obese patients to derive a scoring system based on simple clinical and laboratory variables...
  75. ncbi request reprint Disparities in colon cancer screening in the Medicare population
    Ashwin N Ananthakrishnan
    Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Arch Intern Med 167:258-64. 2007
    ..Since 2001, Medicare has provided coverage of colonoscopy for colorectal cancer screening in individuals at average risk, but little is known about the effect of this coverage on screening or disparities in screening practices...
  76. doi request reprint Treatment of ulcerative colitis in the elderly
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Dig Dis 27:327-34. 2009
    ..This article provides an overview of caring for elderly patients with UC, including diagnostic and therapeutic considerations...
  77. ncbi request reprint Caroli's disease: identification and treatment strategy
    Ashwin N Ananthakrishnan
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Curr Gastroenterol Rep 9:151-5. 2007
    ..Surgical resection has been used successfully in patients with monolobar disease. For patients with diffuse involvement, the treatment of choice is orthotopic liver transplantation...
  78. doi request reprint Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity
    Naveen Bilgi
    Division of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Ann Pharmacother 44:926-8. 2010
    ..To report a case of imatinib-induced hepatotoxicity after concurrent ginseng ingestion in a patient with chronic myelogenous leukemia (CML)...