Todd Allen

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Definition of the viral targets of protective HIV-1-specific T cell responses
    Beatriz Mothe
    IrsiCaixa AIDS Research Institute HIVACAT, Badalona, Spain
    J Transl Med 9:208. 2011
  2. pmc Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection
    Todd M Allen
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    J Virol 76:10507-11. 2002
  3. pmc Crippling HIV one mutation at a time
    Todd M Allen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Exp Med 205:1003-7. 2008
  4. ncbi request reprint STI and beyond: the prospects of boosting anti-HIV immune responses
    Todd M Allen
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA, USA
    Trends Immunol 23:456-60. 2002
  5. ncbi request reprint Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    AIDS 17:2581-91. 2003
  6. ncbi request reprint Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:173-8. 2006
  7. pmc Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?
    Thorsten U Vogel
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 76:11623-36. 2002
  8. pmc CD8 epitope escape and reversion in acute HCV infection
    Joerg Timm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th St, Rm 6618 B, Boston, MA 02114, USA
    J Exp Med 200:1593-604. 2004
  9. pmc Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution
    Todd M Allen
    Howard Hughes Medical Institute, Partners AIDS Research Center, and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Virol 79:13239-49. 2005
  10. pmc Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes
    Xu G Yu
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Room 5212, Charlestown, MA 02129, USA
    J Virol 81:1619-31. 2007

Detail Information

Publications77

  1. pmc Definition of the viral targets of protective HIV-1-specific T cell responses
    Beatriz Mothe
    IrsiCaixa AIDS Research Institute HIVACAT, Badalona, Spain
    J Transl Med 9:208. 2011
    ..However, current HIV vaccine designs are largely based on viral sequence alignments only, not incorporating experimental data on T cell function and specificity...
  2. pmc Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection
    Todd M Allen
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    J Virol 76:10507-11. 2002
    ..By themselves, these strong CTL responses failed to control SIVmac239 replication...
  3. pmc Crippling HIV one mutation at a time
    Todd M Allen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Exp Med 205:1003-7. 2008
    ..These data suggest that targeting these and other conserved viral regions may be the key to developing an effective HIV-1 vaccine...
  4. ncbi request reprint STI and beyond: the prospects of boosting anti-HIV immune responses
    Todd M Allen
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA, USA
    Trends Immunol 23:456-60. 2002
    ..Alternative approaches to long-term control of viral replication and disease progression are clearly needed...
  5. ncbi request reprint Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    AIDS 17:2581-91. 2003
    ..However, their impact on viral replication during acute HIV-1 infection is not known...
  6. ncbi request reprint Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:173-8. 2006
    ..These data suggest that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination of subdominant yet effective epitopes from circulating viral populations...
  7. pmc Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?
    Thorsten U Vogel
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 76:11623-36. 2002
    ..Differential selection by CTL may therefore be a paradigm of immunodeficiency virus infection...
  8. pmc CD8 epitope escape and reversion in acute HCV infection
    Joerg Timm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th St, Rm 6618 B, Boston, MA 02114, USA
    J Exp Med 200:1593-604. 2004
    ..Together, these data indicate that viral escape from CD8+ T cell responses occurs during human HCV infection and that acute immune selection pressure is of sufficient magnitude to influence HCV evolution...
  9. pmc Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution
    Todd M Allen
    Howard Hughes Medical Institute, Partners AIDS Research Center, and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Virol 79:13239-49. 2005
    ..The stereotypic nature of acquired mutations provides support for biochemical constraints limiting HIV-1 evolution and for the impact of CD8 escape mutations on viral fitness...
  10. pmc Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes
    Xu G Yu
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Room 5212, Charlestown, MA 02129, USA
    J Virol 81:1619-31. 2007
    ..These data show the influence of HLA allele subtypes on TCR selection and indicate that extensive TCR diversity is not a prerequisite to prevention of allowable viral mutations...
  11. pmc Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection
    Bianca R Mothe
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 76:875-84. 2002
    ..In most of the Mamu-A*01-positive macaques tested, CTL responses against epitopes bound by Mamu-A*01 dominated the CD8(+) cellular immune response...
  12. pmc Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection
    Todd M Allen
    Howard Hughes Medical Institute, Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, MA, USA
    J Virol 78:7069-78. 2004
    ..Moreover, reversion of these mutations in the absence of the original immune pressure reveals the potential plasticity of immunologically selected evolutionary changes...
  13. ncbi request reprint Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection
    Hendrik Streeck
    Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA
    J Infect Dis 194:734-9. 2006
    ..However, despite these immunological changes, no differences in viremia or in the CD4+ T cell count were found 6 months after HAART was stopped, when treated subjects were compared with untreated subjects...
  14. pmc De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection
    Todd M Allen
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, 02129, USA
    J Virol 79:12952-60. 2005
    ....
  15. pmc Immune-driven recombination and loss of control after HIV superinfection
    Hendrik Streeck
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 205:1789-96. 2008
    ..These data also support a role for cellular immune pressures in driving the selection of new recombinant forms of HIV...
  16. pmc Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication
    Todd M Allen
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 76:4108-12. 2002
    ..Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls...
  17. ncbi request reprint HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication
    Christoph Hess
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Harvard Medical School, Massachusetts, USA
    Lancet 363:863-6. 2004
    ..Our data show that full maturation of virus-specific CD8+ T cells is possible in the context of HIV-1-infection, and suggest that such maturation might be important in viral control...
  18. pmc Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes
    Huabiao Chen
    Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Virol 83:3138-49. 2009
    ....
  19. pmc Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection
    Andrej Kosmrlj
    Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
    Nature 465:350-4. 2010
    ..Our results provide a conceptual framework that unifies diverse empirical observations, and have implications for vaccination strategies...
  20. pmc Viral sequence evolution in acute hepatitis C virus infection
    Thomas Kuntzen
    Massachusetts General Hospital, Infectious Disease, 13th Street, Charlestown, MA 02129, USA
    J Virol 81:11658-68. 2007
    ....
  21. ncbi request reprint HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nature 420:434-9. 2002
    ..The lack of cross-protective immunity for closely related HIV-1 strains, despite persistent recognition of multiple CD8 epitopes, has important implications for public health and vaccine development...
  22. ncbi request reprint Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques
    Deborah Heydenburg Fuller
    PowderJect Vaccines Inc, Madison, WI 53562, USA
    Virology 364:245-55. 2007
    ..These data demonstrate that immunization with hybrid HBcAg-epitope DNA vaccines is an effective strategy to increase the magnitude and breadth of HIV-specific CTL responses...
  23. pmc Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A
    Mark A Brockman
    Partners AIDS Research Center, Massachusetts General Hospital East, CNY 6625, Charlestown, MA 02129, USA
    J Virol 81:12608-18. 2007
    ....
  24. pmc Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection
    Julian Schulze zur Wiesch
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Blood 110:1559-69. 2007
    ....
  25. pmc Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection
    Tomohiko Koibuchi
    Partners AIDS Research Center, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, USA
    J Virol 79:8171-81. 2005
    ....
  26. ncbi request reprint Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection
    DAVID H O'CONNOR
    Wisconsin Regional Primate Research Center and Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA
    Nat Med 8:493-9. 2002
    ..Our results suggest that acute viral escape from CTLs is a hallmark of SIV infection and that CTLs with high functional avidity can rapidly select for escape variants...
  27. pmc The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    Florencia Pereyra
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
    Science 330:1551-7. 2010
    ..These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection...
  28. pmc Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
    Hendrik Streeck
    Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 5:e100. 2008
    ....
  29. pmc Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication
    Bianca R Mothe
    Wisconsin Regional Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715 1299, USA
    J Virol 77:2736-40. 2003
    ..Of the common MHC class I alleles, animals that expressed Mamu-A*01 exhibited the best control of viral replication...
  30. pmc A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, and Harvard University Center for AIDS Research, Boston, MA 02129, USA
    J Exp Med 204:2813-24. 2007
    ....
  31. ncbi request reprint HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity
    Mathias Lichterfeld
    Partners AIDS Research Center and Howard Hughes Medical Institute, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
    AIDS 18:1383-92. 2004
    ....
  32. ncbi request reprint HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response
    Margaret E Feeney
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 174:7524-30. 2005
    ..Taken together, these findings indicate that the developing immune system of children may exhibit greater plasticity in responding to a continually evolving chronic viral infection...
  33. pmc Transmission and long-term stability of compensated CD8 escape mutations
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
    J Virol 83:3993-7. 2009
    ..Herein, we illustrate the long-term stability of stereotypic escape mutations in the immunodominant HLA-B27-restricted epitope KK10 in p24/Gag following transmission when accompanied by a specific compensatory mutation...
  34. pmc HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition
    Toshiyuki Miura
    Ragon Institute, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:2743-55. 2009
    ..These data suggest a dual mechanism for durable control of HIV replication, consisting of viral fitness loss resulting from CTL escape mutations together with strong CD8 T-cell immune responses to the arising variant epitopes...
  35. pmc Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes
    Arthur Y Kim
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, GRB 504, Boston, Massachusetts 02114, USA
    Gastroenterology 140:686-696.e1. 2011
    ..We aimed to determine the correlations between these alleles and natural outcomes of HCV and determine associated key T-cell responses...
  36. ncbi request reprint Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
    Joerg Timm
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 46:339-49. 2007
    ....
  37. doi request reprint Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129 2000, USA
    AIDS 22:447-56. 2008
    ..To evaluate the recognition of computationally designed, centralized HIV-1 antigens derived from clade B, C and group M sequences by individuals infected with HIV-1-M clades B and C...
  38. pmc Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection
    Zabrina L Brumme
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:9216-27. 2008
    ..Dramatic differences in escape and reversion rates across codons, genes, and HLA restrictions are observed, highlighting the complexity of viral adaptation to the host immune response...
  39. pmc Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
    Victoria Kasprowicz
    Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Virol 84:1656-63. 2010
    ..Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation...
  40. pmc Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Virol 81:12382-93. 2007
    ....
  41. pmc High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
    Victoria Kasprowicz
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 82:3154-60. 2008
    ..Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection...
  42. pmc Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual
    Arthur Y Kim
    Partners AIDS Research Center, Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 199:737-41. 2009
    ..The persistence of drug-resistance mutations argues for baseline resistance genotyping at the time therapy is initiated to accurately predict the efficacy of treatment...
  43. ncbi request reprint Increased sequence diversity coverage improves detection of HIV-specific T cell responses
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Immunol 179:6638-50. 2007
    ..Toggled peptides therefore afford a cost-effective and significantly more complete view of the host immune response to HIV and are directly applicable to other variable pathogens...
  44. pmc The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design
    Marcus Altfeld
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Boston, MA 02129, USA
    J Virol 79:5000-5. 2005
    ....
  45. ncbi request reprint High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection
    Georg M Lauer
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 127:924-36. 2004
    ..Previous studies have largely focused on limited HLA alleles and predefined CD8+ T-cell epitopes, and, thus, comprehensive studies remain to be performed...
  46. pmc Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
    Rika Draenert
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 203:529-39. 2006
    ..These results reveal considerable concordance of adaptive cellular and humoral immune responses and HIV evolution in the same genetic environment, suggesting constraints on mutational pathways to HIV immune escape...
  47. ncbi request reprint Hitting HIV where it hurts: an alternative approach to HIV vaccine design
    Marcus Altfeld
    Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
    Trends Immunol 27:504-10. 2006
    ....
  48. pmc Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution
    Bin Li
    Partners AIDS Research Center, MGH East, CNY 6616, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 81:193-201. 2007
    ....
  49. pmc Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 77:7330-40. 2003
    ..They also demonstrate that CD8 T-cell responses to the variable HIV-1 proteins are more common than previously reported...
  50. pmc Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection
    Arthur Y Kim
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 3:e492. 2006
    ..Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection...
  51. ncbi request reprint Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes
    Julian Schulze zur Wiesch
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 175:3603-13. 2005
    ..This comprehensive characterization of CD4(+) T cell epitopes in resolved HCV infection provides important information to facilitate studies of immunopathogenesis and HCV vaccine design and evaluation...
  52. pmc Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells
    Philip J Norris
    Partners AIDS Research Center and Infectious Disease Unit, The Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    AIDS Res Hum Retroviruses 20:315-25. 2004
    ..Abrogated recognition of variant CD4(+) T cell epitopes presents a potential obstacle to vaccine development...
  53. pmc Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 82:8422-30. 2008
    ..These results indicate that the spontaneous control of HIV replication is not attributable to shared viral genetic defects or shared viral polymorphisms...
  54. pmc HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:140-9. 2009
    ....
  55. pmc Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1
    Yaoyu E Wang
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    J Virol 83:1845-55. 2009
    ....
  56. ncbi request reprint HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Rm 6613, Boston, MA 02129, USA
    Blood 104:487-94. 2004
    ..These results suggest that HIV-1-specific cytotoxicity of CD8(+) T cells is preferentially mediated by a subset of CD8(+) T cells secreting both interferon-gamma and TNF-alpha...
  57. pmc Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses
    DAVID H O'CONNOR
    Wisconsin Regional Primate Research Center and Department of Pathology and Laboratory Medicine, Madison, Wisconsin, USA
    J Virol 77:9029-40. 2003
    ....
  58. pmc Maternal transmission of human immunodeficiency virus escape mutations subverts HLA-B57 immunodominance but facilitates viral control in the haploidentical infant
    Arne Schneidewind
    Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA
    J Virol 83:8616-27. 2009
    ..These parallel in vivo and in vitro data suggest that HLA-B57 confers its advantage primarily by driving and maintaining a fitness-attenuating mutation in p24-Gag...
  59. ncbi request reprint Cytotoxic T-lymphocyte escape monitoring in simian immunodeficiency virus vaccine challenge studies
    DAVID H O'CONNOR
    University of Wisconsin at Madison, Department of Pathology, Madison, Wisconsin 53709, USA
    DNA Cell Biol 21:659-64. 2002
    ..To illustrate the importance of escape analysis, we show that rapid emergence of escape variants postchallenge contributed to the failure of a DNA prime/MVA boost vaccine regimen encoding SIV Tat...
  60. pmc Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
    J Virol 81:4199-214. 2007
    ..These data suggest that high-avidity HIV-1-specific CD8+ T-cell clones are recruited during early infection but are subsequently lost in the presence of persistent high-level viral replication...
  61. pmc HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital, No 5214, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 79:10218-25. 2005
    ..The data support an important role of the presented epitope in mediating relative control of HIV replication and help to better define immune correlates of controlled HIV infection...
  62. pmc Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:5594-605. 2008
    ....
  63. pmc Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance
    Daniel Yerly
    Massachusetts General Hospital and Harvard Medical School, Partners AIDS Research Center, MGH East no 5239, 149 13th St, Charlestown, MA 02143, USA
    J Virol 82:3147-53. 2008
    ..These observations have important implications for vaccine approaches that may need to induce high-avidity responses in vivo...
  64. pmc Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes
    Galit Alter
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
    J Exp Med 204:3027-36. 2007
    ..These data provide the first functional evidence that variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication...
  65. ncbi request reprint Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians
    Xu G Yu
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
    AIDS Res Hum Retroviruses 20:557-64. 2004
    ....
  66. pmc Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase
    Cesar Oniangue-Ndza
    Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA
    J Virol 85:11883-90. 2011
    ....
  67. ncbi request reprint Analysis of the TCR beta variable gene repertoire in chimpanzees: identification of functional homologs to human pseudogenes
    Dirk Meyer-Olson
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 170:4161-9. 2003
    ..Our results predict that the diversity of TCR clonotypes responding to pathogens like HCV will be very similar in both species and will facilitate a molecular dissection of the immune response in chimpanzee models of human diseases...
  68. ncbi request reprint Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression
    Hendrik Streeck
    AIDS 21:889-91. 2007
  69. ncbi request reprint Comparison of vaccine strategies using recombinant env-gag-pol MVA with or without an oligomeric Env protein boost in the SHIV rhesus macaque model
    Patricia L Earl
    Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Virology 294:270-81. 2002
    ..Thus, immunization with MVA/SHIV89.6 alone or with a protein boost stimulated both arms of the immune system and resulted in significant control of viremia and delayed progression to disease after challenge with SHIV-89.6P...
  70. pmc HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1
    Marcus Altfeld
    PLoS Med 3:e403. 2006
    ..Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression...
  71. pmc Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control
    Rosario Zuniga
    Asociacion Civil Impacta Salud y Educacion, Lima, Peru
    J Virol 80:3122-5. 2006
    ..Analyses in a second cohort in the United States confirm these findings and point towards a dominant role of Gag-specific immunity in effective control of HIV infection, providing important guidance for HIV vaccine development...
  72. ncbi request reprint DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued
    Deborah Heydenburg Fuller
    PowderJect Vaccines, Inc, Middleton, WI 53562, USA
    Virology 348:200-15. 2006
    ..Immunizing before infection or with multi-epitopes enhanced these effects. These results demonstrate that DNA immunization during antiretroviral therapy may be an effective strategy to treat HIV infection...
  73. ncbi request reprint HIV-1 superinfection
    Todd M Allen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Allergy Clin Immunol 112:829-35; quiz 836. 2003
    ..Herein we review the published reports of HIV-1 superinfection and highlight studies providing additional insight into the potential for HIV-1 superinfections to affect the global epidemic...
  74. pmc Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire
    Dirk Meyer-Olson
    Infectious Diseases Unit, Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Blood 107:2373-83. 2006
    ..Our findings illustrate the flexibility of a heterogeneous HIV-1-specific CD8+ TCR repertoire in subjects with partial control of viremia...
  75. pmc Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy
    Georg M Lauer
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    J Virol 79:12979-88. 2005
    ..These data suggest that broad CD8(+) T-cell responses alone may be insufficient to contain HCV replication, and also that early therapy is effective independent of such responses...
  76. ncbi request reprint Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry
    Mark A Brockman
    Howard Hughes Medical Institute, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston MA 02129, USA
    J Virol Methods 131:134-42. 2006
    ..In conclusion, this FACS-based method provides a sensitive approach to measure the replication capacity of HIV-1 and may prove useful in studies examining the impact of viral fitness on disease progression...
  77. doi request reprint Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection
    Christoph Neumann-Haefelin
    Department of Medicine II, University Hospital Freiburg, Freiburg, Germany
    Hepatology 47:1824-36. 2008
    ..Of note, only approximately half of the responses were associated with viral sequence variations supported by functional analysis as viral escape mutations. Escape mutations were more often associated with HLA-B alleles...

Research Grants13

  1. Acute CTL Escape and Viral Variation in HIV
    Todd Allen; Fiscal Year: 2003
    ..The proposed project, therefore, will use whole viral genome sequencing along with cellular assays to examine these issues. ..
  2. CD8 T Cell Selective Pressure and HCV Sequence Evolution
    Todd Allen; Fiscal Year: 2009
    ....
  3. CD8 T Cell Selective Pressure and HCV Sequence Evolution
    Todd Allen; Fiscal Year: 2007
    ....
  4. Acute CTL Escape and Viral Variation in HIV
    Todd Allen; Fiscal Year: 2007
    ..The proposed project, therefore, will use whole viral genome sequencing along with cellular assays to examine these issues. ..
  5. Impact of CD8 Escape Mutations on Capsid Structure/Host
    Todd Allen; Fiscal Year: 2006
    ..abstract_text> ..
  6. CD8 T Cell Seletive Pressure and HCV Sequence Evolution
    Todd Allen; Fiscal Year: 2005
    ..abstract_text> ..
  7. Acute CTL Escape and Viral Variation in HIV
    Todd Allen; Fiscal Year: 2006
    ..The proposed project, therefore, will use whole viral genome sequencing along with cellular assays to examine these issues. ..
  8. Protective Role of Subdominant Responses to HIV Restricted by Common HLA Alleles
    Todd M Allen; Fiscal Year: 2010
    ..The potency of these responses will be tested in a new humanized mouse model to identify immune responses critical to the design of an effective HIV vaccine. ..