Erik K Alexander

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Preoperative diagnosis of benign thyroid nodules with indeterminate cytology
    Erik K Alexander
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 367:705-15. 2012
  2. doi request reprint Thyroid nodule size and prediction of cancer
    Sophia C Kamran
    MD, Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 75 Francis Street, PBB B4, Room 417, Boston, Massachusetts 02115
    J Clin Endocrinol Metab 98:564-70. 2013
  3. doi request reprint Variation and imprecision of clerkship grading in U.S. medical schools
    Erik K Alexander
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Acad Med 87:1070-6. 2012
  4. doi request reprint Perspective: moving students beyond an organ-based approach when teaching medical interviewing and physical examination skills
    Erik K Alexander
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Acad Med 83:906-9. 2008
  5. ncbi request reprint Using a web-based, iterative education model to enhance clinical clerkships
    Erik K Alexander
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Acad Med 81:925-31. 2006
  6. ncbi request reprint Thyroid nodule shape and prediction of malignancy
    Erik K Alexander
    Thyroid Section, Division of Endocrinology, Hypertension and Diabetes, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Thyroid 14:953-8. 2004
  7. ncbi request reprint Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism
    Erik K Alexander
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 351:241-9. 2004
  8. doi request reprint Approach to the patient with a cytologically indeterminate thyroid nodule
    Erik K Alexander
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 93:4175-82. 2008
  9. ncbi request reprint Assessment of nondiagnostic ultrasound-guided fine needle aspirations of thyroid nodules
    Erik K Alexander
    Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Room 560, Boston, MA 02115, USA
    J Clin Endocrinol Metab 87:4924-7. 2002
  10. ncbi request reprint Peripheral amino acid and fatty acid infusion for the treatment of necrolytic migratory erythema in the glucagonoma syndrome
    Erik K Alexander
    Thyroid and Endocrine Divisions, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachussets, USA
    Clin Endocrinol (Oxf) 57:827-31. 2002

Detail Information

Publications35

  1. doi request reprint Preoperative diagnosis of benign thyroid nodules with indeterminate cytology
    Erik K Alexander
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 367:705-15. 2012
    ..A novel diagnostic test that measures the expression of 167 genes has shown promise in improving preoperative risk assessment...
  2. doi request reprint Thyroid nodule size and prediction of cancer
    Sophia C Kamran
    MD, Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 75 Francis Street, PBB B4, Room 417, Boston, Massachusetts 02115
    J Clin Endocrinol Metab 98:564-70. 2013
    ..A threshold is detected at 2.0 cm, beyond which cancer risk is unchanged. However, the risk of follicular carcinomas and other rare thyroid malignancies increases as nodules enlarge...
  3. doi request reprint Variation and imprecision of clerkship grading in U.S. medical schools
    Erik K Alexander
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Acad Med 87:1070-6. 2012
    ..The authors set out to perform a complete review of clerkship evaluation in U.S. medical schools...
  4. doi request reprint Perspective: moving students beyond an organ-based approach when teaching medical interviewing and physical examination skills
    Erik K Alexander
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Acad Med 83:906-9. 2008
    ....
  5. ncbi request reprint Using a web-based, iterative education model to enhance clinical clerkships
    Erik K Alexander
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Acad Med 81:925-31. 2006
    ....
  6. ncbi request reprint Thyroid nodule shape and prediction of malignancy
    Erik K Alexander
    Thyroid Section, Division of Endocrinology, Hypertension and Diabetes, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Thyroid 14:953-8. 2004
    ..Mathematically, surface area to volume is maximized by a spherical shape. We sought to determine if spherical shape is a predictor of malignancy...
  7. ncbi request reprint Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism
    Erik K Alexander
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 351:241-9. 2004
    ..In this prospective study we attempted to identify precisely the timing and amount of levothyroxine adjustment required during pregnancy...
  8. doi request reprint Approach to the patient with a cytologically indeterminate thyroid nodule
    Erik K Alexander
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 93:4175-82. 2008
    ..Recently, improved understanding and novel investigation of clinical, radiological, cytological, and molecular factors has allowed improved stratification of cancer risk...
  9. ncbi request reprint Assessment of nondiagnostic ultrasound-guided fine needle aspirations of thyroid nodules
    Erik K Alexander
    Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Room 560, Boston, MA 02115, USA
    J Clin Endocrinol Metab 87:4924-7. 2002
    ..Repeat aspiration is often successful and should be the standard approach to such nodules, given their risk of malignancy...
  10. ncbi request reprint Peripheral amino acid and fatty acid infusion for the treatment of necrolytic migratory erythema in the glucagonoma syndrome
    Erik K Alexander
    Thyroid and Endocrine Divisions, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachussets, USA
    Clin Endocrinol (Oxf) 57:827-31. 2002
    ..Despite resolution of the NME, serum amino acid (initially subnormal) and fatty acid (initially normal) levels remained unchanged. Tumour growth and other symptoms related to the glucagonoma syndrome appear unaffected by such infusions...
  11. ncbi request reprint Natural history of benign solid and cystic thyroid nodules
    Erik K Alexander
    Endocrine Division, Brigham and Women s Hospital, and Havard Medical Scjhool, 221 Longwood Avenue, 2nd Floor, Boston, Massachusetts 02115, USA
    Ann Intern Med 138:315-8. 2003
    ..Thyroid nodules are common and most often benign. The natural history of benign thyroid nodules, however, is unclear...
  12. ncbi request reprint Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation
    Leila Yassa
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 111:508-16. 2007
    ..Recent technologic and procedural advances suggest that this shortcoming can be mitigated, although few data confirm this benefit in unselected patients...
  13. ncbi request reprint Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography
    Mary C Frates
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 75 Francis Street, PBB B4, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 91:3411-7. 2006
    ..Controversy remains as to the optimal management of patients with multiple thyroid nodules...
  14. doi request reprint The role of role: learning in longitudinal integrated and traditional block clerkships
    Karen E Hauer
    Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, CA, USA
    Med Educ 46:698-710. 2012
    ..Understanding the ways in which these two clerkship models influence students' roles and responsibilities can inform clinical learning programme design...
  15. doi request reprint Thyroid hormone early adjustment in pregnancy (the THERAPY) trial
    Leila Yassa
    Thyroid Unit, Division of Endocrinology, Metabolism, and Diabetes, Brigham and Women s Hospital, 75 Francis Street, Room PBB B4, Boston, MA 02115, USA
    J Clin Endocrinol Metab 95:3234-41. 2010
    ..Thyroid hormone requirement increases 20-40% during gestation. Women with treated hypothyroidism must increase their l-T(4) in pregnancy to prevent maternal hypothyroidism, although how this should be accomplished is unclear...
  16. ncbi request reprint More is better: students describe successful and unsuccessful experiences with teachers differently in brief and longitudinal relationships
    Karen E Hauer
    Department of Medicine, School of Medicine, University of California, San Francisco, California 94143 0120, USA
    Acad Med 87:1389-96. 2012
    ..The authors compared students' successful and unsuccessful teaching experiences in brief and longitudinal relationships...
  17. doi request reprint Indications for thyroid FNA and pre-FNA requirements: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference
    Edmund S Cibas
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Diagn Cytopathol 36:390-9. 2008
    ..http://thyroidfna.cancer.gov/pages/info/agenda/)..
  18. ncbi request reprint Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors
    Jayesh Desai
    Brigham and Women s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Intern Med 145:660-4. 2006
    ..Because the ret proto-oncogene is also inhibited by this agent, clinical evaluation of thyroid function was performed...
  19. pmc Subclinical hypothyroidism and survival: the effects of heart failure and race
    Connie M Rhee
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 98:2326-36. 2013
    ..Emerging data suggest these associations may depend upon underlying congestive heart failure (CHF) and/or race, but this has not been empirically determined...
  20. doi request reprint Long-term educational impact of a simulator curriculum on medical student education in an internal medicine clerkship
    Nancy M Brim
    Department of Medicine, Brigham and Women s Hospital, G S Beckwith Gilbert and Katharine S Gilbert Medical Education Program in Medical Simulation, Harvard Medical School, Boston, MA 02115, USA
    Simul Healthc 5:75-81. 2010
    ..We report the first long-term experience of mannequin simulation in an internal medicine clerkship...
  21. pmc Does simulator-based clinical performance correlate with actual hospital behavior? The effect of extended work hours on patient care provided by medical interns
    James A Gordon
    Gilbert Program in Medical Simulation, Harvard Medical School, Boston, Massachusetts, USA
    Acad Med 85:1583-8. 2010
    ..This study explored whether the effects of extended work hours on clinical performance, as reported in prior hospital-based studies, could be observed in a simulator-based testing environment...
  22. ncbi request reprint Subacute granulomatous (de Quervain) thyroiditis: grayscale and color Doppler sonographic characteristics
    Mary C Frates
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Ultrasound Med 32:505-11. 2013
    ..To describe the sonographic characteristics of subacute granulomatous (De Quervain) thyroiditis...
  23. doi request reprint Students' workplace learning in two clerkship models: a multi-site observational study
    Bridget C O'Brien
    Department of Medicine, University of California San Francisco UCSF, San Francisco, CA, USA
    Med Educ 46:613-24. 2012
    ..This study is the first to report data from direct observations of workplace learning experiences of students on LICs and traditional block clerkships (BCs), respectively...
  24. ncbi request reprint A simulator-based curriculum to promote comparative and reflective analysis in an internal medicine clerkship
    Graham T McMahon
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital Harvard Medical School, 221 Longwood Avenue, Second Floor, Boston, MA 02115, USA
    Acad Med 80:84-9. 2005
    ..To develop and evaluate a novel curricular framework using high-fidelity patient simulation in an internal medicine clerkship...
  25. pmc A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults
    Anjuli Gupta
    Boston Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115
    J Clin Endocrinol Metab 98:3238-45. 2013
    ....
  26. pmc Hypothyroidism and mortality among dialysis patients
    Connie M Rhee
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 8:593-601. 2013
    ..Hypothyroidism is highly prevalent among ESRD patients, but its clinical significance and the benefits of thyroid hormone replacement in this context remain unclear...
  27. doi request reprint Preventing and treating maternal hypothyroidism during pregnancy
    Laura E Dichtel
    Thyroid Unit, Division of Endocrinology, Hypertension and Diabetes, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Endocrinol Diabetes Obes 18:389-94. 2011
    ..There is currently broad interest in the maternal and fetal complications of hypothyroidism during pregnancy, with significant debate regarding the nuances of screening, despite universal agreement regarding the need for treatment...
  28. doi request reprint Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism
    Connie M Rhee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 172:153-9. 2012
    ..Despite compelling biological plausibility and clinical implication, the association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism has not been rigorously studied...
  29. pmc Genetic and biological subgroups of low-stage follicular thyroid cancer
    Christopher A French
    Division of Endocrinology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Pathol 162:1053-60. 2003
    ..The findings support a model in which separate genetic alterations initiate distinct pathways of oncogenesis in thyroid carcinoma subtypes...
  30. doi request reprint Mini-clinical evaluation exercise as a student assessment tool in a surgery clerkship: lessons learned from a 5-year experience
    Luise I M Pernar
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Surgery 150:272-7. 2011
    ..The goals of this study were to determine the feasibility and value of implementation of the mini-CEX in a surgery clerkship...
  31. doi request reprint Can changes in the principal clinical year prevent the erosion of students' patient-centered beliefs?
    Edward Krupat
    Center for Evaluation, Harvard Medical School, Boston, Massachusetts 02115, USA
    Acad Med 84:582-6. 2009
    ..The authors present data collected in the 2005-2006 academic year from a pilot program aimed at enhancing this experience, thereby enabling students to resist these negative influences...
  32. ncbi request reprint High dose of (131)I therapy for the treatment of hyperthyroidism caused by Graves' disease
    Erik K Alexander
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 87:1073-7. 2002
    ..A higher dose of (131)I may be advisable in such patients...
  33. doi request reprint Diagnostic use of molecular markers in the evaluation of thyroid nodules
    Matthew I Kim
    Thyroid Unit, Division of Endocrinology, Metabolism, and Diabetes, The Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocr Pract 18:796-802. 2012
    ..To describe the molecular markers thus far evaluated for use in the care of patients with clinically relevant thyroid nodules...
  34. ncbi request reprint Smoking and other lifestyle factors and the risk of Graves' hyperthyroidism
    Ingrid A Holm
    Division of Genetics, Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Arch Intern Med 165:1606-11. 2005
    ..We sought to determine whether lifestyle factors, including smoking, alcohol consumption, physical activity level, and body mass index, are risk factors for Graves' hyperthyroidism...
  35. ncbi request reprint RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    J Clin Endocrinol Metab 88:2318-26. 2003
    ..These results suggest that conventional follicular thyroid carcinomas develop through at least two distinct and virtually nonoverlapping molecular pathways initiated by either RAS point mutation or PAX8-PPAR gamma rearrangement...