Research Topics
Species | C M AlbertSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trialChristine M Albert
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
JAMA 299:2027-36. 2008..Observational data suggest benefits may be greater among women, yet women have been underrepresented in published randomized trials...
Cardiac sodium channel gene variants and sudden cardiac death in womenChristine M Albert
Center for Arrhythmia Prevention, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
Circulation 117:16-23. 2008..Mutations or rare variants in these genes have been proposed as potential contributors to more common forms of SCD, but this hypothesis has not been assessed systematically...- Fish oil--an appetising alternative to anti-arrhythmic drugs?Christine Albert
Division of Preventive Medicine, Brigham and Women s Hospital, and Cardiology Division, Massachusetts General Hospital, Boston, MA 02215, USA
Lancet 363:1412-3. 2004 - Prospective study of sudden cardiac death among women in the United StatesChristine M Albert
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, Mass 02215 1204, USA
Circulation 107:2096-101. 2003..Nonetheless, existing data, although sparse, suggest possible gender differences in risk factors for SCD... - Driving and implantable cardioverter-defibrillator shocks for ventricular arrhythmias: results from the TOVA studyChristine M Albert
Center for Arrhythmia Prevention, Division of Preventive Medicine and Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02215 1204, USA
J Am Coll Cardiol 50:2233-40. 2007..This study examined the risk of implantable cardioverter-defibrillator (ICD) shocks for ventricular tachycardia (VT) or ventricular fibrillation (VF) associated with driving... - Nut consumption and decreased risk of sudden cardiac death in the Physicians' Health StudyChristine M Albert
Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
Arch Intern Med 162:1382-7. 2002..Since components of nuts may have antiarrhythmic properties, part of the benefit may be due to a reduction in sudden cardiac death... - Phobic anxiety and risk of coronary heart disease and sudden cardiac death among womenChristine M Albert
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215 1204, USA
Circulation 111:480-7. 2005..To the best of our knowledge, no studies have looked at this association among women. Anxiety may influence CHD mortality by increasing the risk of ventricular arrhythmia and SCD... - Blood levels of long-chain n-3 fatty acids and the risk of sudden deathChristine M Albert
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
N Engl J Med 346:1113-8. 2002..Whether long-chain n-3 fatty acids are also associated with the risk of sudden death in those without a history of cardiovascular disease is unknown... - Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart diseaseChristine M Albert
Center for Arrhythmia Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
Circulation 112:3232-8. 2005..Alpha-linolenic acid, an intermediate-chain n-3 fatty acid found primarily in plants, may decrease the risk of fatal coronary heart disease (CHD) through a reduction in fatal ventricular arrhythmias and sudden cardiac death (SCD)... - Common variants in cardiac ion channel genes are associated with sudden cardiac deathChristine M Albert
Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Channing Laboratory, and Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 1204, USA
Circ Arrhythm Electrophysiol 3:222-9. 2010.... - Triggering of sudden death from cardiac causes by vigorous exertionC M Albert
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
N Engl J Med 343:1355-61. 2000..However, the role of physical activity in precipitating or preventing sudden death has not been assessed prospectively in a large number of subjects... 
Sex differences in outcome after implantable cardioverter defibrillator implantation in nonischemic cardiomyopathyChristine M Albert
Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
Am Heart J 156:367-72. 2008..In the Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) trial, a reduction in all-cause mortality was seen in men (P = .018) but not for women (P = .76)...- Moderate alcohol consumption and the risk of sudden cardiac death among US male physiciansC M Albert
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
Circulation 100:944-50. 1999..Individuals who consume high amounts of alcohol (>5 drinks/d) have increased risks of ventricular arrhythmia and sudden cardiac death (SCD). However, the relationship is less clear for drinkers of light-to-moderate amounts... - A trial of B vitamins and cognitive function among women at high risk of cardiovascular diseaseJae Hee Kang
Channing Laboratory, Boston, MA 02115, USA
Am J Clin Nutr 88:1602-10. 2008..High homocysteine concentrations may be neurotoxic and contribute to cognitive decline in older persons... - Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trialShumin M Zhang
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
JAMA 300:2012-21. 2008..Folate, vitamin B(6), and vitamin B(12) are thought to play an important role in cancer prevention... - Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarctionQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 88:216-23. 2008..Whereas dietary intake of long-chain n-3 fatty acids has been associated with risk of nonfatal myocardial infarction (MI), few studies have examined the relation for blood concentrations... - Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular StudyWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue E, Boston, MA 02215 1204, USA
Arch Intern Med 169:335-41. 2009..Our objective was to examine the incidence of AMD in a trial of combined folic acid, pyridoxine hydrochloride (vitamin B(6)), and cyanocobalamin (vitamin B(12)) therapy... - Blood pressure and risk of secondary cardiovascular events in women: the Women's Antioxidant Cardiovascular Study (WACS)Peter J Mason
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02215-1204, USA
Circulation 109:1623-9. 2004..CONCLUSIONS: In this population of women with CVD, we observed a strong, continuous, and linear association between SBP and risk of secondary CVD events. SBP was the blood pressure measure most strongly related to CVD risk... - Effect of homocysteine-lowering treatment with folic Acid and B vitamins on risk of type 2 diabetes in women: a randomized, controlled trialYiqing Song
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 58:1921-8. 2009..We investigated whether homocysteine-lowering treatment by B vitamin supplementation prevents the risk of type 2 diabetes... - Dietary intakes of flavonols and flavones and coronary heart disease in US womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Am J Epidemiol 165:1305-13. 2007..93; p for trend = 0.04). The lower risk associated with kaempferol intake was probably attributable to broccoli consumption. These prospective data do not support an inverse association between flavonol or flavone intake and CHD risk... - Relation of vigorous exercise to risk of atrial fibrillationAnthony Aizer
Center for Arrhythmia Prevention, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Cardiol 103:1572-7. 2009..This risk decreased as the population aged and was offset by known beneficial effects of vigorous exercise on other AF risk factors... - Influence of systolic and diastolic blood pressure on the risk of incident atrial fibrillation in womenDavid Conen
Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Circulation 119:2146-52. 2009..The influence of systolic and diastolic blood pressure (BP) on incident atrial fibrillation (AF) is not well studied among initially healthy, middle-aged women... - Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac deathChristine M Albert
Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston 02215-1204, USA
Circulation 105:2595-9. 2002..CONCLUSIONS: These prospective data suggest that CRP levels may be useful in identifying apparently healthy men who are at an increased long-term risk of SCD... - Effects of vitamins C and E and beta-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trialYiqing Song
Division of Preventive Medicine and Cardiology Division, Harvard School of Public Health, Boston, MA 02215, USA
Am J Clin Nutr 90:429-37. 2009..Vitamin C, vitamin E, and beta-carotene are major antioxidants and as such may protect against the development of type 2 diabetes via reduction of oxidative stress... - The Women's Antioxidant Cardiovascular Study: design and baseline characteristics of participantsShari S Bassuk
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
J Womens Health (Larchmt) 13:99-117. 2004..Large-scale randomized trials with clinical end points are necessary to minimize confounding and provide unbiased estimates of the balance of benefits and risks, yet data from such trials are scarce, especially among women... - Waist-height ratio as a predictor of coronary heart disease among womenJohn H Page
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Epidemiology 20:361-6. 2009..We compared the waist-height ratio to waist-hip ratio, waist circumference, and body mass index as predictors of subsequent coronary heart disease (CHD) in a group of predominantly postmenopausal women... - Mild renal insufficiency and risk of congestive heart failure in men and women > or =70 years of ageClaudia U Chae
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
Am J Cardiol 92:682-6. 2003..43, 95% CI 1.17 to 1.74). Thus, mild renal insufficiency was a strong independent predictor of CHF in this cohort, suggesting that serum creatinine may offer a readily accessible tool to identify elderly patients at risk for CHF... - Para-Hisian entrainment: a novel pacing maneuver to differentiate orthodromic atrioventricular reentrant tachycardia from atrioventricular nodal reentrant tachycardiaVivek Y Reddy
Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
J Cardiovasc Electrophysiol 14:1321-8. 2003..We evaluated the utility of entrainment or resetting of tachycardias from the para-Hisian position to help distinguish atrioventricular nodal reentrant tachycardia (AVNRT) from orthodromic atrioventricular tachycardia (AVRT)... - Alcohol consumption and risk of incident atrial fibrillation in womenDavid Conen
Center for Arrhythmia Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
JAMA 300:2489-96. 2008..However, these studies were not powered to investigate the association of alcohol consumption and atrial fibrillation among women... - Heart failure and the risk of shocks in patients with implantable cardioverter defibrillators: results from the Triggers Of Ventricular Arrhythmias (TOVA) studyWilliam Whang
Cardiovascular Division, Bulfinch 001, Massachusetts General Hospital, 55 Fruit St, Boston, Mass 02114, USA
Circulation 109:1386-91. 2004..Left ventricular ejection fraction (LVEF) predicts device discharges in patients with implantable cardioverter-defibrillators (ICDs). The relationship between severity of congestive heart failure (CHF) and ICD discharges is less clear... - Utility of implantable cardioverter defibrillator electrograms to estimate repolarization alternans preceding a tachyarrhythmic eventAntonis A Armoundas
Division of Molecular Cardiobiology, Johns Hopkins University, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 15:594-7. 2004..This study eventually may lead to new methods that would prevent the onset of malignant tachyarrhythmias... - The long- and short-term impact of elevated body mass index on the risk of new atrial fibrillation the WHS (women's health study)Usha B Tedrow
Center for Arrhythmia Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 55:2319-27. 2010..The purpose of this study was to characterize the relationship between changes in body mass index (BMI) and incident atrial fibrillation (AF) in a large cohort of women... - Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intakeAlexander Leaf
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Circulation 112:2762-8. 2005..Therefore, we hypothesized that these n-3 fatty acids might prevent potentially fatal ventricular arrhythmias in high-risk patients... - Depression as a predictor for appropriate shocks among patients with implantable cardioverter-defibrillators: results from the Triggers of Ventricular Arrhythmias (TOVA) studyWilliam Whang
Cardiovascular Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
J Am Coll Cardiol 45:1090-5. 2005..We sought to examine the relationship between symptoms of depression and shock-treated ventricular arrhythmias among implantable cardioverter-defibrillator (ICD) patients... - Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular eventsAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Circulation 113:1578-87. 2006..Although randomized trials of cyclooxygenase-2 (COX-2) inhibitors have shown increased cardiovascular risk, studies of nonselective, nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen have been inconsistent... - Multicenter experience with extraction of the Sprint Fidelis implantable cardioverter-defibrillator leadMelanie Maytin
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 56:646-50. 2010..This study was undertaken to determine the safety and feasibility of extraction of the Sprint Fidelis (Medtronic, Minneapolis, Minnesota) lead... - Survival in octogenarians receiving implantable defibrillatorsBruce A Koplan
Cardiac Arrhythmia Service Division of Cardiology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am Heart J 152:714-9. 2006..Although clinical trials have expanded implantable defibrillator (ICD) indications, octogenarians have been poorly represented in these studies. Overall, survival in this subgroup is ill-defined... - Large, single-center, single-operator experience with transvenous lead extraction: outcomes and changing indicationsSamuel O Jones
Arrhythmia Service, Department of Cardiovascular Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Heart Rhythm 5:520-5. 2008..Lead extraction is increasingly necessary given the exponential growth in cardiac device implantation. Meanwhile, the tools, indications, and outcomes of this procedure continue to change... - Amino-terminal pro-B-type natriuretic peptide and high-sensitivity C-reactive protein as predictors of sudden cardiac death among womenEthan C Korngold
Cardiovascular Division, Massachusetts General Hospital, Boston, MA, USA
Circulation 119:2868-76. 2009..However, there are no data on SCD risk prediction for either of these markers in a population of women unselected on the basis of cardiovascular disease... - Low-carbohydrate-diet score and the risk of coronary heart disease in womenThomas L Halton
Departments of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 355:1991-2002. 2006..When vegetable sources of fat and protein are chosen, these diets may moderately reduce the risk of coronary heart disease... - Fish and long-chain omega-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic womenFrank B Hu
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Mass 02115, USA
Circulation 107:1852-7. 2003.... - Dietary magnesium intake and risk of cardiovascular disease among womenYiqing Song
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 96:1135-41. 2005..In conclusion, the results do not support the hypothesis that magnesium intake reduces the development of CHD, although a modest inverse association with stroke cannot be ruled out... - Caffeine consumption and incident atrial fibrillation in womenDavid Conen
Center for Arrhythmia Prevention, Department of Medicine, Brigham and Womenrsquos Hospital, Harvard Medical School, Boston, MA, USA
Am J Clin Nutr 92:509-14. 2010..It is somewhat controversial whether caffeine consumption is associated with an increased risk of developing atrial fibrillation (AF)... - Folate intake and risk of stroke among womenWael K Al-Delaimy
Department of Epidemiology, Harvard School of Public Health, 665 Huntington Ave, Boston, Mass 02115, USA
Stroke 35:1259-63. 2004..We aim to assess the relation between folate intake and stroke incidence among women participating in the Nurses' Health Study... - Catheter ablation of peri-AV nodal atrial tachycardia from the noncoronary cusp of the aortic valveSaumya Das
Cardiac Arrhythmia Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Cardiovasc Electrophysiol 19:231-7. 2008.... - Lead noise with an active-fixation defibrillation leadR N Gelder
Cardiac Arrhythmia Service, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
Pacing Clin Electrophysiol 23:2113-6. 2000..This is a unique lead problem that resolves with time, but it may result in inappropriate therapies and difficult management decisions in high risk patients with ventricular arrhythmias... - Fish and omega-3 fatty acid intake and risk of coronary heart disease in womenFrank B Hu
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
JAMA 287:1815-21. 2002..Higher consumption of fish and omega-3 fatty acids has been associated with a lower risk of coronary heart disease (CHD) in men, but limited data are available regarding women... - A common variant at 9p21 is associated with sudden and arrhythmic cardiac deathChristopher Newton-Cheh
MPH, Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02115 1204, USA
Circulation 120:2062-8. 2009..We hypothesized that a common variant at chromosome 9p21 related to myocardial infarction would influence SCD risk... - A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular StudyNancy R Cook
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215, USA
Arch Intern Med 167:1610-8. 2007..Few trials have examined interactions among antioxidants, and, to our knowledge, no previous trial has examined the individual effect of ascorbic acid (vitamin C) on CVD... - Birth weight is a significant risk factor for incident atrial fibrillationDavid Conen
Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Circulation 122:764-70. 2010..Few if any studies have assessed the relationship between birth weight and incident atrial fibrillation (AF)... - Physical exertion, exercise, and sudden cardiac death in womenWilliam Whang
Cardiovascular Division, Massachusetts General Hospital, Boston, USA
JAMA 295:1399-403. 2006..Regular exercise may significantly minimize this small transient risk and may lower the overall long-term risk of sudden cardiac death... - Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in womenEsther Lopez-Garcia
Department of Nutrition, Harvard School of Public Health, Harvard Medical School, USA
J Nutr 134:1806-11. 2004.... - Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and womenJennifer K Pai
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Kresge 9th Floor, Boston, MA 02115, USA
Eur Heart J 28:1297-303. 2007..We assessed the association between Y402H and risk of CHD in nested case-control studies among two large prospective cohorts of US male health professionals and female nurses... - Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: The Women's Antioxidant and Cardiovascular StudyJae Hee Kang
Harvard School of Public Health, Boston, Mass, USA
Circulation 119:2772-80. 2009..Cardiovascular factors are associated with cognitive decline. Antioxidants may be beneficial... - Intake of total trans, trans-18:1, and trans-18:2 fatty acids and risk of sudden cardiac death in womenStephanie E Chiuve
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am Heart J 158:761-7. 2009.... - Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US womenJennifer K Pai
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Atherosclerosis 186:132-9. 2006..Genetic variation in CC-chemokine receptor-2 (CCR2) and -5 (CCR5), and their common haplotypes, acting through inflammatory responses, may affect atherosclerosis and risk of coronary heart disease (CHD)... - Omega-3 fatty acids and ventricular arrhythmias: nothing is simpleChristine M Albert
Am Heart J 155:967-70. 2008 - A trial of omega-3 fatty acids for prevention of hypertensionRachel S Dokholyan
Duke Clinical Research Institute, Durham, North Carolina, USA
Am J Cardiol 93:1041-3. 2004..A novel fatty acid supplement was tested in a randomized trial of patients with high normal diastolic BP. The novel fatty acid supplement did not significantly reduce BP in patients with high normal diastolic blood pressure...
Research Grants
- TRIGGERS OF VENTRICULAR ARRHYTHMIAS (TOVA) STUDYChristine Albert; Fiscal Year: 2002..Characterization of triggering of ICD discharge will provide insights valuable for prevention of sudden death due to primary arrhythmias in the general population. ..
- PRE-DETERMINE: Biologic Markers and MRI SCD Cohort StudyChristine Albert; Fiscal Year: 2009....
- Modifiable Determinants of Ventricular ArrythmiasChristine Albert; Fiscal Year: 2007....
- Genetic Determinants of Sudden Cardiac DeathChristine Albert; Fiscal Year: 2006..The findings generated will have substantial implications for our understanding of the SCD syndrome and risk stratification in the general population. ..
- MODIFIABLE RISK FACTORS FOR SUDDEN DEATH IN MEN/WOMENChristine Albert; Fiscal Year: 2002..At the end of the proposed research program, Dr. Albert will have attained advanced epidemiologic skills which can then be applied to independent research in her chosen subspecialty of electrophysiology. ..
- PRE-DETERMINE: Biologic Markers and MRI SCD Cohort StudyAlan H Kadish; Fiscal Year: 2010....