Manish K Aghi
Affiliation: Massachusetts General Hospital
- Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombospondin expression can be prevented by specific viral mutations or by administering a thrombospondin-derived peptideManish Aghi
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer Res 67:440-4. 2007..Incorporating viral mutations, such as those seen in G47Delta or administering thrombospondin-derived peptides, counteracts the angiogenic effect of oncolytic HSV and should be considered when designing oncolytic HSV therapies...
- Increased prevalence of obesity and obesity-related postoperative complications in male patients with meningiomasManish K Aghi
Neurosurgical Service, Massachusetts General Hospital, Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA
Neurosurgery 61:754-60; discussion 760-1. 2007..We hypothesized that because obesity affects male steroid hormone synthesis, male patients with meningiomas might exhibit a high obesity rate, which, in turn, might increase their frequency of postoperative complications...
- Benign adult brain tumors: an evidence-based medicine reviewManish Aghi
Neurosurgical Service, Massachusetts General Hospital, Boston, MA 02114, USA
Prog Neurol Surg 19:80-96. 2006....
- Gene therapy for glioblastomaManish Aghi
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Neurosurg Focus 20:E18. 2006..The authors review the principles behind these approaches and their initial results...
- Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replicationManish Aghi
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Natl Cancer Inst 98:38-50. 2006..We hypothesized that temozolomide and G207 treatment limitations could be jointly addressed using temozolomide-induced tumor-protective DNA repair pathways to enhance viral replication...
- Magnetic resonance imaging characteristics predict epidermal growth factor receptor amplification status in glioblastomaManish Aghi
Neurosurgical Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Clin Cancer Res 11:8600-5. 2005..EGFR overexpression correlates in experimental gliomas with increased angiogenesis, edema, and invasion. No radiographic predictors of molecular glioblastoma subtype are known...
- Oncolytic viral therapies - the clinical experienceManish Aghi
Department of Neurosurgery, Massachusetts General Hospital, White Building Room 502, 02114, USA
Oncogene 24:7802-16. 2005..Here, we review the biology and clinical results of these five species of viruses and discuss lessons learned and challenges for the future...
- Viral vectors as therapeutic agents for glioblastomaManish Aghi
Massachusetts General Hospital and Harvard Medical School, Department of Neurosurgery, Molecular Neurosurgery Laboratory, Boston, MA 02114, USA
Curr Opin Mol Ther 7:419-30. 2005..The principles behind these approaches and their initial results are reviewed...
- Contribution of bone marrow-derived cells to blood vessels in ischemic tissues and tumorsManish Aghi
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 502 White Building, 55 Fruit Street, Boston, MA 02114, USA
Mol Ther 12:994-1005. 2005..We also take note of key issues that will need to be understood about the biology of vasculogenesis before cellular therapies utilizing vascular progenitor cells can be finally taken from the bench to the bedside...
- Breast adenocarcinoma metastatic to epidural cervical spine meningioma: case report and review of the literatureManish Aghi
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
J Neurooncol 75:149-55. 2005..Metastasis to meningioma must be considered in an epidural spinal lesion in all patients with a known malignancy, with surgical aggressiveness tailored to the intraoperative pathologic diagnosis...
- Subarachnoid hematoma, hydrocephalus, and aseptic meningitis resulting from a high cervical myelogramManish Aghi
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Spinal Disord Tech 17:348-51. 2004..Thus, severe persistent pain after cervical myelography should be evaluated by CT scans of the brain and cervical spine...
- Increased prevalence of obesity and obesity-related postoperative complications in male meningioma patientsManish K Aghi
Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts, USA
Clin Neurosurg 54:236-40. 2007
- Hypoxia enhances the replication of oncolytic herpes simplex virusManish K Aghi
Department of Neurosurgery, University of California, San Francisco, California 94143 01112, USA
Mol Ther 17:51-6. 2009....
- Oncolytic herpes simplex virus mutants exhibit enhanced replication in glioma cells evading temozolomide chemotherapy through deoxyribonucleic acid repairManish Aghi
Department of Neurosurgery, Massachusetts General Hopsital, Harvard Medical School, Charlestown, USA
Clin Neurosurg 53:65-76. 2006
- Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiationManish K Aghi
Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143 0112, USA
Neurosurgery 64:56-60; discussion 60. 2009..We sought to define the long-term recurrence rate of AMs after GTR, along with factors predicting recurrence, including postoperative radiation...
- β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastomaW Shawn Carbonell
Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA
Cancer Res 73:3145-54. 2013..We concluded that β1 integrin upregulation in BRGs likely reflects an onset of hypoxia caused by antiangiogenic therapy, and that β1 inhibition is well tolerated in vivo as a tractable strategy to disrupt resistance to this therapy...
- Genetically engineered herpes simplex viral vectors in the treatment of brain tumors: a reviewManish Aghi
Molecular Neuro oncology Laboratories, Neurosurgical Service, Massachusetts, General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Cancer Invest 21:278-92. 2003
- Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypesManish Aghi
Program in Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Cancer Res 66:9054-64. 2006..Although CXCR4 blockade selectively targeted endothelium generated by vasculogenesis, completely inhibiting vessel formation may require combination therapy targeting locally derived and marrow-derived endothelium...
- Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectorsHiroaki Wakimoto
Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
Cancer Res 69:3472-81. 2009..This is important for designing new oHSV vectors and clinical trials. Moreover, the new glioma models described in this study provide powerful tools for testing experimental therapeutics and studying invasion and angiogenesis...
- Bone involvement predicts poor outcome in atypical meningiomaDarlene Gabeau-Lacet
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Neurosurg 111:464-71. 2009..The authors identified clinical features associated with progression and death in atypical meningioma (AM)...
- Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working GroupMichael A Vogelbaum
Brain Tumor and Neuro Oncology Center, Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
Neurosurgery 70:234-43; discussion 243-4. 2012..The RANO group identified knowledge gaps relating to the definitions of tumor response and progression after the use of surgical or surgically based treatments...
- Oncolytic herpes simplex virus engineering and preparationPankaj K Agarwalla
Harvard Medical School, Boston, MA, USA
Methods Mol Biol 797:1-19. 2012..We then describe protocols for titering, amplification, and purification of engineered HSV-1-derived oncolytic viruses...
- Hypoxia-induced tumor cell autophagy mediates resistance to anti-angiogenic therapyYu Long Hu
Department of Neurosurgery, Diller Cancer Research Building, University of California at San Francisco UCSF, San Francisco, CA, USA
Autophagy 8:979-81. 2012..However, further work will clearly be needed to develop more potent and specific autophagy inhibitors and to better understand the regulators of autophagy in malignant cells...
- Determinants of initial bone graft volume loss in posterolateral lumbar fusionManish K Aghi
Department of Neurosurgery, University of California, San Francisco, CA, USA
J Clin Neurosci 18:1193-6. 2011..We concluded that bone graft exhibited resorption 3 months postoperatively on both sides of all patients in this series, and that smoking was significantly associated with increased bone graft resorption...
- Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitisBrian V Nahed
Department of Neurosurgery, Massachusetts General Hospital, 15 Parkman Street, Boston, Massachusetts 02114 3117, USA
J Clin Neurosci 17:1085-8. 2010..This example highlights one of the potential complications of rigid cervical collar immobilization in patients with spinal instability...
- Heparin-induced thrombocytopenia Type II in subarachnoid hemorrhage patients: incidence and complicationsBrian L Hoh
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurgery 57:243-8; discussion 243-8. 2005..In addition, the increase in neuroendovascular procedures with the associated use of heparinization will increase the exposure of SAH patients to heparin...
- Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotypeManish Aghi
Neurosurgical Service, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
J Neurosurg 104:201-7. 2006..The authors studied the clinical course and genetic basis of unilateral VSs associated with other NF2-related tumors...
- Management of recurrent and refractory Cushing diseaseManish K Aghi
Neurological Surgery, The California Center for Pituitary Disorders, University of California, San Francisco UCSF, CA 94143 0112, USA
Nat Clin Pract Endocrinol Metab 4:560-8. 2008..Here, we review the treatment options and latest surgical, medical, and radiosurgical advances for patients who have persistent or recurrent Cushing disease after transsphenoidal surgery...