Manish K Aghi

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombospondin expression can be prevented by specific viral mutations or by administering a thrombospondin-derived peptide
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 67:440-4. 2007
  2. ncbi Increased prevalence of obesity and obesity-related postoperative complications in male patients with meningiomas
    Manish K Aghi
    Neurosurgical Service, Massachusetts General Hospital, Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA
    Neurosurgery 61:754-60; discussion 760-1. 2007
  3. ncbi Benign adult brain tumors: an evidence-based medicine review
    Manish Aghi
    Neurosurgical Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Prog Neurol Surg 19:80-96. 2006
  4. ncbi Gene therapy for glioblastoma
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Neurosurg Focus 20:E18. 2006
  5. ncbi Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 98:38-50. 2006
  6. ncbi Magnetic resonance imaging characteristics predict epidermal growth factor receptor amplification status in glioblastoma
    Manish Aghi
    Neurosurgical Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Clin Cancer Res 11:8600-5. 2005
  7. ncbi Oncolytic viral therapies - the clinical experience
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, White Building Room 502, 02114, USA
    Oncogene 24:7802-16. 2005
  8. ncbi Viral vectors as therapeutic agents for glioblastoma
    Manish Aghi
    Massachusetts General Hospital and Harvard Medical School, Department of Neurosurgery, Molecular Neurosurgery Laboratory, Boston, MA 02114, USA
    Curr Opin Mol Ther 7:419-30. 2005
  9. ncbi Contribution of bone marrow-derived cells to blood vessels in ischemic tissues and tumors
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 502 White Building, 55 Fruit Street, Boston, MA 02114, USA
    Mol Ther 12:994-1005. 2005
  10. ncbi Breast adenocarcinoma metastatic to epidural cervical spine meningioma: case report and review of the literature
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neurooncol 75:149-55. 2005

Detail Information

Publications28

  1. ncbi Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombospondin expression can be prevented by specific viral mutations or by administering a thrombospondin-derived peptide
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 67:440-4. 2007
    ..Incorporating viral mutations, such as those seen in G47Delta or administering thrombospondin-derived peptides, counteracts the angiogenic effect of oncolytic HSV and should be considered when designing oncolytic HSV therapies...
  2. ncbi Increased prevalence of obesity and obesity-related postoperative complications in male patients with meningiomas
    Manish K Aghi
    Neurosurgical Service, Massachusetts General Hospital, Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA
    Neurosurgery 61:754-60; discussion 760-1. 2007
    ..We hypothesized that because obesity affects male steroid hormone synthesis, male patients with meningiomas might exhibit a high obesity rate, which, in turn, might increase their frequency of postoperative complications...
  3. ncbi Benign adult brain tumors: an evidence-based medicine review
    Manish Aghi
    Neurosurgical Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Prog Neurol Surg 19:80-96. 2006
    ....
  4. ncbi Gene therapy for glioblastoma
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Neurosurg Focus 20:E18. 2006
    ..The authors review the principles behind these approaches and their initial results...
  5. ncbi Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 98:38-50. 2006
    ..We hypothesized that temozolomide and G207 treatment limitations could be jointly addressed using temozolomide-induced tumor-protective DNA repair pathways to enhance viral replication...
  6. ncbi Magnetic resonance imaging characteristics predict epidermal growth factor receptor amplification status in glioblastoma
    Manish Aghi
    Neurosurgical Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Clin Cancer Res 11:8600-5. 2005
    ..EGFR overexpression correlates in experimental gliomas with increased angiogenesis, edema, and invasion. No radiographic predictors of molecular glioblastoma subtype are known...
  7. ncbi Oncolytic viral therapies - the clinical experience
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, White Building Room 502, 02114, USA
    Oncogene 24:7802-16. 2005
    ..Here, we review the biology and clinical results of these five species of viruses and discuss lessons learned and challenges for the future...
  8. ncbi Viral vectors as therapeutic agents for glioblastoma
    Manish Aghi
    Massachusetts General Hospital and Harvard Medical School, Department of Neurosurgery, Molecular Neurosurgery Laboratory, Boston, MA 02114, USA
    Curr Opin Mol Ther 7:419-30. 2005
    ..The principles behind these approaches and their initial results are reviewed...
  9. ncbi Contribution of bone marrow-derived cells to blood vessels in ischemic tissues and tumors
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 502 White Building, 55 Fruit Street, Boston, MA 02114, USA
    Mol Ther 12:994-1005. 2005
    ..We also take note of key issues that will need to be understood about the biology of vasculogenesis before cellular therapies utilizing vascular progenitor cells can be finally taken from the bench to the bedside...
  10. ncbi Breast adenocarcinoma metastatic to epidural cervical spine meningioma: case report and review of the literature
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neurooncol 75:149-55. 2005
    ..Metastasis to meningioma must be considered in an epidural spinal lesion in all patients with a known malignancy, with surgical aggressiveness tailored to the intraoperative pathologic diagnosis...
  11. ncbi Subarachnoid hematoma, hydrocephalus, and aseptic meningitis resulting from a high cervical myelogram
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Spinal Disord Tech 17:348-51. 2004
    ..Thus, severe persistent pain after cervical myelography should be evaluated by CT scans of the brain and cervical spine...
  12. ncbi Increased prevalence of obesity and obesity-related postoperative complications in male meningioma patients
    Manish K Aghi
    Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Neurosurg 54:236-40. 2007
  13. pmc Hypoxia enhances the replication of oncolytic herpes simplex virus
    Manish K Aghi
    Department of Neurosurgery, University of California, San Francisco, California 94143 01112, USA
    Mol Ther 17:51-6. 2009
    ....
  14. ncbi Oncolytic herpes simplex virus mutants exhibit enhanced replication in glioma cells evading temozolomide chemotherapy through deoxyribonucleic acid repair
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hopsital, Harvard Medical School, Charlestown, USA
    Clin Neurosurg 53:65-76. 2006
  15. doi Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiation
    Manish K Aghi
    Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143 0112, USA
    Neurosurgery 64:56-60; discussion 60. 2009
    ..We sought to define the long-term recurrence rate of AMs after GTR, along with factors predicting recurrence, including postoperative radiation...
  16. doi β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma
    W Shawn Carbonell
    Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Res 73:3145-54. 2013
    ..We concluded that β1 integrin upregulation in BRGs likely reflects an onset of hypoxia caused by antiangiogenic therapy, and that β1 inhibition is well tolerated in vivo as a tractable strategy to disrupt resistance to this therapy...
  17. ncbi Genetically engineered herpes simplex viral vectors in the treatment of brain tumors: a review
    Manish Aghi
    Molecular Neuro oncology Laboratories, Neurosurgical Service, Massachusetts, General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Invest 21:278-92. 2003
  18. ncbi Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes
    Manish Aghi
    Program in Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Res 66:9054-64. 2006
    ..Although CXCR4 blockade selectively targeted endothelium generated by vasculogenesis, completely inhibiting vessel formation may require combination therapy targeting locally derived and marrow-derived endothelium...
  19. pmc Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors
    Hiroaki Wakimoto
    Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Res 69:3472-81. 2009
    ..This is important for designing new oHSV vectors and clinical trials. Moreover, the new glioma models described in this study provide powerful tools for testing experimental therapeutics and studying invasion and angiogenesis...
  20. pmc Bone involvement predicts poor outcome in atypical meningioma
    Darlene Gabeau-Lacet
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Neurosurg 111:464-71. 2009
    ..The authors identified clinical features associated with progression and death in atypical meningioma (AM)...
  21. doi Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group
    Michael A Vogelbaum
    Brain Tumor and Neuro Oncology Center, Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Neurosurgery 70:234-43; discussion 243-4. 2012
    ..The RANO group identified knowledge gaps relating to the definitions of tumor response and progression after the use of surgical or surgically based treatments...
  22. doi Oncolytic herpes simplex virus engineering and preparation
    Pankaj K Agarwalla
    Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 797:1-19. 2012
    ..We then describe protocols for titering, amplification, and purification of engineered HSV-1-derived oncolytic viruses...
  23. pmc Hypoxia-induced tumor cell autophagy mediates resistance to anti-angiogenic therapy
    Yu Long Hu
    Department of Neurosurgery, Diller Cancer Research Building, University of California at San Francisco UCSF, San Francisco, CA, USA
    Autophagy 8:979-81. 2012
    ..However, further work will clearly be needed to develop more potent and specific autophagy inhibitors and to better understand the regulators of autophagy in malignant cells...
  24. doi Determinants of initial bone graft volume loss in posterolateral lumbar fusion
    Manish K Aghi
    Department of Neurosurgery, University of California, San Francisco, CA, USA
    J Clin Neurosci 18:1193-6. 2011
    ..We concluded that bone graft exhibited resorption 3 months postoperatively on both sides of all patients in this series, and that smoking was significantly associated with increased bone graft resorption...
  25. doi Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitis
    Brian V Nahed
    Department of Neurosurgery, Massachusetts General Hospital, 15 Parkman Street, Boston, Massachusetts 02114 3117, USA
    J Clin Neurosci 17:1085-8. 2010
    ..This example highlights one of the potential complications of rigid cervical collar immobilization in patients with spinal instability...
  26. ncbi Heparin-induced thrombocytopenia Type II in subarachnoid hemorrhage patients: incidence and complications
    Brian L Hoh
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Neurosurgery 57:243-8; discussion 243-8. 2005
    ..In addition, the increase in neuroendovascular procedures with the associated use of heparinization will increase the exposure of SAH patients to heparin...
  27. ncbi Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotype
    Manish Aghi
    Neurosurgical Service, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Neurosurg 104:201-7. 2006
    ..The authors studied the clinical course and genetic basis of unilateral VSs associated with other NF2-related tumors...
  28. doi Management of recurrent and refractory Cushing disease
    Manish K Aghi
    Neurological Surgery, The California Center for Pituitary Disorders, University of California, San Francisco UCSF, CA 94143 0112, USA
    Nat Clin Pract Endocrinol Metab 4:560-8. 2008
    ..Here, we review the treatment options and latest surgical, medical, and radiosurgical advances for patients who have persistent or recurrent Cushing disease after transsphenoidal surgery...